Natural Active Products: Molecular Mechanisms and Advanced Therapies

Dear Colleagues,

Natural products (NPs) play a key role in drug discovery, and especially in cancer pharmacotherapy, due to their multitarget effects. When compared with purely synthetic materials obtained from combinatorial chemistry, NP-based structures display greater chemical diversity and occupy larger regions of the chemical space. Consequently, the interest in NPs as drug leads is being revitalized, particularly for tackling inflammatory diseases.

This Special Issue (SI) is open to both original research and updated review articles focusing on the discovery of NPs and/or derivatives with anticancer and/or anti-inflammatory properties. Detailed analyses of their activities and molecular mechanisms of action, assessments of their effectiveness in comparison to toxicity, and targeted therapy studies are among the subjects of particular interest. Studies reporting the effects of complex extracts from natural origin are outside the scope of this SI unless the precise active components and molecular formulas of the natural substances are disclosed in the manuscript.

Dr. Renato B. Pereira
Guest Editor

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• natural products
• natural products isolation
• semisynthetic derivatives
• virtual screening
• molecular docking
• cellular mechanisms
• anti-inflammatory agents
• cancer
• targeted therapy
• structure–activity relationships