Arteriogenesis, Angiogenesis and Vascular Remodeling

Dear Colleagues,

Arteriogenesis, also frequently called collateral formation or even therapeutic angiogenesis, comprises those processes that lead to the formation and growth of collateral blood vessels that can act as natural bypasses to restore blood flow to distal tissues in occluded arteries. Both in coronary occlusive artery diseases as well as in peripheral occlusive arterial disease, arteriogenesis may play an important role in the restoration of blood flow.

Blood flow restoration in arteries affected by atherosclerosis can also be achieved by balloon angioplasty, with or without stenting, or bypass surgery. Unfortunately, these interventions may also lead to the induction of vascular remodeling leading to intimal hyperplasia and re-occlusion of the treated vessels. In these inflammatory-driven vascular remodeling processes, many cell types, both vascular cells and immune cells, many cytokines and growth factors, as well as various noncoding RNAs or progenitor cells may be involved. Consequently, many questions regarding the exact molecular mechanisms involved in the regulation of the vascular remodeling response in arteriogenesis and angiogenesis still need to be answered, and these answers will contribute to defining new therapeutic options.

Despite the big clinical potential and the many promising clinical trials on arteriogenesis and therapeutic angiogenesis, the exact molecular mechanisms involved in the multifactorial processes of vascular remodeling related to arteriogenesis and angiogenesis are still not completely understood.

This Special Issue of International Journal of Molecular Sciences is devoted to all molecular aspects of arteriogenesis and collateral formation. It will contain articles that collectively provide a balanced, state-of-the-art views on various aspects of arteriogenesis and the underlying regulation of vascular remodeling. We seek submissions of high-quality articles on all aspects of arteriogenesis, including but not limited to regulatory mechanisms, the cell types involved, state-of-the-art models and therapeutic options.

Potential topics include, but are not limited to, the following:

• Genetic and environmental mechanisms controlling formation and maintenance of the native collateral circulation
• Mechanisms controlling pathophysiological formation and maintenance of the angiogenic blood vessels
• Mechanisms controlling pathophysiological vascular remodeling
• Arteriogenesis, therapeutic angiogenesis and peripheral arterial disease
• The formation of collateral arterial networks: insights from the developing embryo
• Multiple pathways converge in the development of a collateral circulation
• Arteriogenesis and collateral formation
• Cell and gene therapy in peripheral arterial disease
• Epigenetic and epitranscriptomic mechanisms in arteriogenesis, angiogenesis and vascular remodeling
• Non-coding rna in vascular remodeling during arteriogenesis and angiogenesis
• Bone marrow derived cells in arteriogenesis and therapeutic angiogenesis
• Local and sustained drug delivery in arteriogenesis
• Mechanisms controlling arteriogenesis, angiogenesis and vascular remodeling

Prof. Dr. Elisabeth Deindl
Prof. Dr. Paul Quax
Guest Editors

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