Novel MSC Perspectives: From Cell Regulation to Tissue Regeneration 4.0

Dear Colleagues,

Developments in our understanding of mesenchymal stem cell (MSC) biology, gene regulation and intercellular interactions hold promise for the evolution of therapeutic approaches in tissue regeneration both in humans and in animals. Due to their exclusive capacity to self renew and commitment towards defined cell lineages, MSCs offer novel perspectives and tools for clinical application in a safe and effective manner. Recent knowledge on the crosstalk between MSCs and the microenvironment has highlighted that key soluble modulators, specific signaling pathways and/or the employment of biomaterials are able to foster a wide array of MSC properties including migration, behavior and also gene expression and cell fate. This provides new insights into the genetic manipulation, reprogramming and/or gene editing of MSCs, also addressing the physical, biological and biochemical properties of MSCs in order to boost their regenerative capabilities and tissue repair. Last but not least, studies concerning MSC extracellular vesicles and MSC secretome for tissue regeneration and immune modulation will enrich the knowledge on MSC functions, opening new possibilities for stem-cell-free advanced strategies. Accordingly, we invite investigators to contribute their novel findings in the field of MSCs, helping to bridge the gap between biology and applied regenerative medicine to encourage the progression of MSC-based translational research.

Gruppo Italiano Staminali Mesenchimali (GISM)

Dr. Alessandra Pelagalli
Prof. Dr. Heba Abdelrazik
Guest Editors

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