Pathophysiologic Mechanisms of Eye Diseases and Novel Therapeutic Approaches 2.0

Dear Colleagues,

This Special Issue follows the publication of the first edition on “Pathophysiologic Mechanisms of Eye Diseases and Novel Therapeutic Approaches (https://www.mdpi.com/journal/ijms/special_issues/Eye_Diseases_Mechanism)”.

The eye is a remarkable organ of incredible functional complexity. Each of its structures, including the cornea and ocular surface, trabecular meshwork and sclera, ciliary body, iris and lens, neuroretina, and optic nerve, have their own specialized biology. These structures present problems of interest for every molecular scientist. Developmental geneticists discovered the first “master control gene” in the eye, a long-sought developmental regulator with the capacity to switch on an entire genetic program for organ formation. Neuroscientists have investigated the retina as the most accessible part of the central nervous system. Special features of the cornea have made it an important model for cell biological breakthroughs in regeneration and stem cell biology. The aqueous outflow pathways, a marvel of hydrodynamics, still hold many mysteries currently under intense investigation by molecular biologists, biophysicists, and bioengineers. This Special Issue of IJMS invites articles that provide new insights into the underlying mechanisms of diseases of the eye, as well as work on new diagnostic tools/biomarkers and novel therapeutic strategies. Diseases include dry eye, pinguecula and pterygium, ocular hypertension, cataract, glaucoma, and retinal degeneration. Both preclinical and clinical studies with an emphasis on molecular biology approaches are of interest, and animal models of disease are encouraged.

Prof. Dr. M. Elizabeth Fini
Guest Editor

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