Safety, Toxicity, and Therapeutic Potential of Natural Products and Complex Mixtures

Dear Colleagues,

Natural products and complex mixtures remain a cornerstone of nutrition, medicine, and pharmaceutical development, yet their safety, toxicity, and therapeutic efficacy are often insufficiently characterized. This Special Issue aims to compile cutting-edge research addressing the biological activity, toxicological profiles, and mechanistic actions of natural compounds and multi-component matrices, including plant extracts, food-derived bioactives, nutraceuticals, and traditional formulations. Emphasis is placed on integrative approaches combining biochemical, molecular, toxicological, and systems-level analyses to better understand dose–response relationships, bioavailability, redox balance, and long-term safety. Both experimental and clinical studies with biomolecular experiments are welcome, as well as innovative methodologies that bridge basic research with translational and applied perspectives. By consolidating high-quality contributions, this Special Issue seeks to advance the evidence-based evaluation and responsible use of natural products in health and disease.

Dr. Fotios Tekos
Prof. Dr. Demetrios Kouretas
Guest Editors

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