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Molecular Research on Reproductive Physiology and Endocrinology—2nd Edition

A Special Issue of International Journal of Molecular Sciences (ISSN 1422-0067) belonging to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 28 February 2027 | Viewed by 626

Editor

Department of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University, 71-210 Szczecin, Poland
Interests: male fertility; semen analysis; sperm chromatin; sperm DNA fragmentation; oxidative stress; reactive oxygen species
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce this Special Issue, which will highlight the latest research in reproductive physiology and endocrinology. The foundation of modern therapy lies in a deep understanding of the biological processes occurring in the reproductive system under physiological and pathological conditions. Although these studies are called basic science, they use advanced molecular methods to explore changes at the genetic and epigenetic levels, as well as the influence of environmental factors on these changes.

In addition, the study of reproductive endocrinology cannot be ignored; reproductive endocrine disorders can occur due to abnormal changes in any part of the hypothalamic–pituitary–gonadal axis and can include a variety of symptoms, including infertility, hirsutism, virilization, oligomenorrhea and amenorrhea in women, and infertility and changes in sexual function in men. In particular, understanding the role of hormones and their regulatory mechanisms in infertility is vital. We will focus on the effects of obesity, hypothyroidism, polycystic ovary syndrome, reproductive hormones, and IVF on reproductive health.

This Special Issue aims to provide a comprehensive overview of recent advances in reproductive physiology and reproductive endocrinology to help us better understand the functioning of the reproductive system and reveal the processes leading to its dysfunction. We encourage the submission of original research articles and reviews, especially those that provide results at the molecular level.

Volume I of the Special Issue:Molecular Research on Reproductive Physiology and Endocrinology

Dr. Kamil Gill
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproductive
  • endocrinology
  • reproductive hormones
  • embryology
  • molecular research
  • IVF
  • obesity

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Published Papers (1 paper)

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Research

21 pages, 5419 KB  
Article
Elevated Estradiol and DHT Levels in the Prostatic Stroma as Key Drivers of Benign Prostatic Hyperplasia Pathogenesis
by Tomislav Pejčić, Milka Jadranin, Siniša Đurašević, Milica Kalaba, Biljana Dojčinović, Milica Zeković, Uroš Bumbaširević, Darko Jovanović, Darko Laketić, Živoslav Tešić and Tomislav Tosti
Int. J. Mol. Sci. 2026, 27(15), 6785; https://doi.org/10.3390/ijms27156785 - 29 Jul 2026
Cited by 1 | Viewed by 478
Abstract
While dihydrotestosterone (DHT) has traditionally been considered the principal steroid in benign prostatic hyperplasia (BPH) pathogenesis, the role of estradiol (E2) and its relationship with local androgen accumulation remain unclear. This study investigated whether transition zone (TZ) tissue concentrations of E2, testosterone, and [...] Read more.
While dihydrotestosterone (DHT) has traditionally been considered the principal steroid in benign prostatic hyperplasia (BPH) pathogenesis, the role of estradiol (E2) and its relationship with local androgen accumulation remain unclear. This study investigated whether transition zone (TZ) tissue concentrations of E2, testosterone, and DHT are associated with prostate enlargement. TZ tissue cores were collected from 80 men undergoing prostate biopsy. Patients were stratified by total prostate volume (TPV): small (<30 mL) and enlarged (≥30 mL) prostate groups. Steroids were quantified using liquid chromatography-high resolution mass spectrometry. Tissue concentrations of E2, testosterone, and DHT were significantly higher in enlarged prostates (E2: 0.031 vs. 0.012 ng/g; testosterone: 0.804 vs. 0.517 ng/g; DHT: 7.903 vs. 3.526 ng/g; all p < 0.05). Across the cohort, TPV strongly correlated with DHT (R = 0.870, p < 0.001), E2 (R = 0.845, p < 0.001), and testosterone (R = 0.817, p < 0.001). These findings demonstrate a strong association between local steroid accumulation and prostate enlargement, supporting the hypothesis that coordinated androgenic and estrogenic activity shapes the hormonal microenvironment driving BPH progression. This pattern aligns with a model of local steroidal hyperfunction that may amplify stromal–epithelial signaling in the enlarged prostate. Full article
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