The Molecular and Cellular Mechanisms of Neurodegenerative Diseases, 2nd Edition

Dear Colleagues,

Neurodegenerative diseases are a group of age-related complex diseases in the central nervous system including Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and prion diseases. They are characterized by protein aggregates in particular cell types and brain regions, selective neuronal loss, neuroinflammation, progressive degeneration of the nervous system, and neurobehavior changes. Over the last decade, our understanding of neurodegenerative dieases has witnessed significant advances, especially at the molecular and cellular levels, although there are no effective therapeutics to prevent or halt these devastating diseases to date.

The goal of this Special Issue is to gain a better understanding of the cellular and molecular mechanisms in the pathogenesis of different neurodegenerative disorders, with a focus on protein homeostasis, unfolded protein response, synaptic dysfunction, neuroinflammation, alterations in brain metabolism, mitochondrial dysfunction, and oxidative stress mechanisms at the molecular and cellular levels.

We would like to invite you to submit original research articles and reviews that focus on, but are not limited to, innovative and important findings that provide a comprehensive view of the molecular mechanisms underlying the pathogenesis of neurodegenerative diseases. Studies involving transcriptomic, proteomic, and metabolomic approaches are encouraged.

Dr. Hongjun (Harry) Fu
Guest Editor

Manuscript Submission Information

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