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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Investigations in Neurodevelopmental Disorders
edited by Giorgio Medici
submission deadline 30 Dec 2025 | 9 articles | Viewed by 39718
Keywords: neurodevelopmental disorders; brain; neurons; synapses; molecular research; regulatory networks; molecular pathways; biomarkers; therapies
(This special issue belongs to the Section Molecular Neurobiology)
Recent Research on Hypertension and Related Complications
edited by
submission deadline 30 Dec 2025 | 7 articles | Viewed by 31106
Keywords: arterial hypertension; cardiovascular disease; pathophysiology; molecular mechanisms; complications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Musculoskeletal Disorders: From Molecular Pathology to Novel Therapeutic Approach submission deadline 30 Dec 2025 | 10 articles | Viewed by 27447
Keywords: joints; skeletal muscles; tendons; ligaments; fascia; articular cartilage; intervertebral discs; physiotherapy; novel therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Treatments in Neurodegenerative Diseases submission deadline 30 Dec 2025 | 7 articles | Viewed by 22980
Keywords: neurodegenerative diseases; regenerative therapy; neuroprotection; neurodegeneration; pathogenetic mechanisms; cell therapy
(This special issue belongs to the Section Molecular Neurobiology)
Traumatic Brain Injury/Chronic Traumatic Encephalopathy as Cause of Alzheimer’s Disease: Physics and Molecular Biology in the Genesis of Neurodegeneration?
edited by
submission deadline 30 Dec 2025 | 7 articles | Viewed by 22191
Keywords: traumatic brain injury (TBI); chronic traumatic encephalopathy (CTE); head impacts; Alzheimer's disease (AD); neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Biomedical Applications of Mesenchymal Stem Cells submission deadline 30 Dec 2025 | 8 articles | Viewed by 21716
Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; cartilage
(This special issue belongs to the Section Molecular Pharmacology)
Neurobiological Mechanisms of Addictive Disorders submission deadline 30 Dec 2025 | 8 articles | Viewed by 20349
(This special issue belongs to the Section Molecular Neurobiology)
The Characterization and Application of Enzymes in Bioprocesses submission deadline 30 Dec 2025 | 9 articles | Viewed by 20305
Keywords: biocatalysts; enzymatic characterization; enzymatic action; protein engineering; biocatalysts application; bioprocessing
(This special issue belongs to the Section Biochemistry)
Potential Prevention and Treatment of Neurodegenerative Disorders submission deadline 30 Dec 2025 | 5 articles | Viewed by 20109
Keywords: neurodegenerative disorders; molecular biomarkers; oxidative stress; therapeutic strategies; disease prevention
(This special issue belongs to the Section Molecular Neurobiology)
Challenges and Innovation in Neurodegenerative Diseases, 2nd Edition
edited by
submission deadline 30 Dec 2025 | 7 articles | Viewed by 18256
Keywords: neurodegenerative diseases; pathogenesis; biomarkers; disease model; natural product; new drug discovery; therapy; machine learning; stem cell therapy
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms and Signalling Pathways in Cardiovascular Pathophysiology
edited by Ernesto Alejandro Aiello
submission deadline 30 Dec 2025 | 5 articles | Viewed by 17946
Keywords: heart; vascular; signaling; cardiovascular disease; mechanism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Animal Research Model for Neurological Diseases, 2nd Edition submission deadline 30 Dec 2025 | 5 articles | Viewed by 16075
Keywords: experimental models; mouse; rat; zebrafish; neurological disease; Alzheimer’ s disease; Parkinson’ s disease; neurodegeneration; neuroregeneration
(This special issue belongs to the Section Molecular Neurobiology)
Host-Pathogen Interaction, 6th Edition
edited by
submission deadline 30 Dec 2025 | 5 articles | Viewed by 14300
Keywords: microorganisms; pathogen; bacteria; yeasts; protozoa; host organisms
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms and Therapeutic Innovations in Neurodegenerative Diseases: 2nd Edition
edited by Melania Maria Serafini and
submission deadline 30 Dec 2025 | 4 articles | Viewed by 12677
Keywords: Alzheimer’ s disease; strokes; multiple sclerosis; amyotrophic lateral sclerosis; polyneuropathies; pain; diabetic retinopathy; neuroinflammation; dietary supplements; microbiome
(This special issue belongs to the Section Molecular Neurobiology)
Genetic and Molecular Mechanisms of Obesity submission deadline 30 Dec 2025 | 3 articles | Viewed by 12040
Keywords: obesity; insulin signal transduction; insulin sensitivity; co-morbidities; genetics; epigenetics; miRNAs; DNA methylation; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Cancer and Cell Metabolism—2nd Edition submission deadline 30 Dec 2025 | 8 articles | Viewed by 11820
Keywords: cell metabolism; cancer metabolism; cancer cell; oxidative stress; gene expression; signaling pathways; metabolic regulation; tumor growth; energy metabolism; metabolic phenotype; metabolic substrates
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Plant Natural Products for Human Health and Disease
edited by
submission deadline 30 Dec 2025 | 2 articles | Viewed by 10507
Keywords: medicinal plants; phytochemistry; bioactive compounds; metabolomics; proteomics; antioxidants; signal transduction; immunomodulation; phytopharmacology; ethnopharmacology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
IJMS 25th Anniversary: Updates and Progress on Bioactives and Nutraceuticals
edited by
submission deadline 30 Dec 2025 | 6 articles | Viewed by 10328
Keywords: natural products; bioactive; nutraceutical; nutrient; health; dietary; functional food; vitamins; phytochemicals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Mitochondrial Biology and Human Diseases submission deadline 30 Dec 2025 | 4 articles | Viewed by 9826
Keywords: mitochondria; mitochondrial gene expression; bioenergetics; mitochondriopathies; human diseases
(This special issue belongs to the Section Molecular Biology)
Pathogenicity and Antibiotic Resistance of Helicobacter pylori
edited by
submission deadline 30 Dec 2025 | 2 articles | Viewed by 9362
Keywords: Helicobacter pylori; antibiotic resistance; antibiotic tolerance; point mutations; efflux pumps; biofilm formation; coccoid forms; membrane vesicles; virulence factors
(This special issue belongs to the Section Molecular Microbiology)
Central and Local Modulators of Reproduction and Fertility: An Update (4th Edition) submission deadline 30 Dec 2025 | 4 articles | Viewed by 9276
Keywords: reproduction; fertility; HPG axis; testis; ovary; spermatogenesis; ovogenesis; gametes; GnRH; gonadotropins; sex steroids; kisspeptins; GnIH; metabolic sensors; leptin; endocannabinoids; autocrine/paracrine regulators; protein/peptide hormones; lipid mediators; epigenetics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Omics Technologies in Molecular Biology
edited by
submission deadline 30 Dec 2025 | 3 articles | Viewed by 8887
Keywords: omics technologies; genomics; transcriptomics; proteomics; metabolomics; lipidomics; phenomics; enviromics; big data; machine learning; molecular biology
(This special issue belongs to the Section Molecular Biology)
Advances in Molecular Research on Autoimmune Diseases, 2nd Edition
edited by
submission deadline 30 Dec 2025 | 5 articles | Viewed by 8701
Keywords: autoimmune markers; immunology; pathogenesis; immunogenetics; animal models; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
Plant and Environmental Interactions (Abiotic Stress)
edited by
submission deadline 30 Dec 2025 | 6 articles | Viewed by 7845
Keywords: stress response; signal transduction; metabolism and secondary metabolism; material/vesicle transportation; rhizospheric microorganism; interactions between plants and microorganisms
(This special issue belongs to the Section Molecular Plant Sciences)
Non-small Cell Lung Cancer: From Molecular Mechanisms to Therapeutic Strategies
edited by
submission deadline 30 Dec 2025 | 3 articles | Viewed by 7565
Keywords: NSCLC; predictive and prognostic biomarkers; immunotherapy; targeted therapy; special populations
(This special issue belongs to the Section Molecular Oncology)
Reproductive Toxicity of Chemicals submission deadline 30 Dec 2025 | 6 articles | Viewed by 7264
Keywords: reproductive health; fertility; anthropogenic chemicals; impaired fertility; reproductive toxicity; embryo; toxicants; hormone disruption; chemical exposure
(This special issue belongs to the Section Molecular Toxicology)
Molecular Pathogenesis and Therapies for Retinal and Optic Nerve Diseases
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 7091
Keywords: neurovascular unit; neurovascular cell death; neuroprotection; vasoprotection; regeneration; molecular and cellular pathologies; current and future therapies; drug delivery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Phenolic Accumulation and Application in Human Diseases submission deadline 30 Dec 2025 | 3 articles | Viewed by 7075
Keywords: antioxidant effects; anticancer/antiproliferative activity; anti-inflammatory activity; antimicrobial effects bioactive polyphenols; chemical identification of plant compounds; chemistry and mechanisms of action; health beneficial effect; medicinal plant; molecular targets; natural products; phytochemicals; structure– activity relationship
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Effect of Food-Derived Compounds on Brown Fat Cell Function
edited by
submission deadline 30 Dec 2025 | 3 articles | Viewed by 6953
Keywords: brown adipocyte; beige adipocyte; nutrients; food-derived components; thermogenesis; energy homeostasis; inflammation; obesity; diabetes; insulin resistance; metabolic syndrome; adipokines; lipid and carbohydrate metabolism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Bone Development and Differentiation in Health and Disease submission deadline 30 Dec 2025 | 3 articles | Viewed by 6533
Keywords: bone differentiation; signaling pathways; bone diseases; bone formation; osteoblast; osteocyte; osteoclast
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Influence of Environmental Factors on Disease and Health Outcomes
edited by
submission deadline 30 Dec 2025 | 3 articles | Viewed by 5992
Keywords: environmental factors; ecophysiological determinations; genetic predispositions; gene expression; defensive responses; pathophysiological abnormalities; lifestyle diseases; polymorphisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Immune Regulation and T Cell Dynamics
edited by Tatiana Akimova
submission deadline 30 Dec 2025 | 2 articles | Viewed by 5537
Keywords: autoimmunity; T cells; FOXP3; Treg; regulatory T cells; transplantation; tolerance; T cell activation; exhaustion; T cell-mediated immunity; T cell immunotherapy
(This special issue belongs to the Section Molecular Immunology)
The Role of Extracellular Matrix in Cancer submission deadline 30 Dec 2025 | 1 articles | Viewed by 5312
Keywords: extracellular matrix; cancer; collagen; integrins; metastasis
(This special issue belongs to the Section Molecular Oncology)
Heart Failure: From Molecular Mechanisms to Clinically Translational Innovations submission deadline 30 Dec 2025 | 1 articles | Viewed by 5059
Keywords: heart failure; pathophysiology; cellular and molecular mechanisms; traditional biomarkers: limits and benefits; emerging molecular biomarkers; innovative therapies; i.e.; personalized therapies; targeted therapies; etc.; the application of artificial intelligence; multi-omics technologies; imaging innovative biomarkers; clinical translation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Genetic Research on Psychiatric Disorders
edited by Lawrence Shih-Hsin Wu
submission deadline 30 Dec 2025 | 1 articles | Viewed by 4438
Keywords: genetics; bipolar disorder; schizophrenia; major depressive disorder; autism; substance abuse; genomics
(This special issue belongs to the Section Molecular Neurobiology)
Neuroimmune Axis in Cancer and Inflammatory Diseases submission deadline 30 Dec 2025 | 1 articles | Viewed by 4231
Keywords: neuro-immune axis; cancer progression; drug resistance; cancer therapy
(This special issue belongs to the Section Molecular Oncology)
Advances in Primary Nephropathies: Pathogenesis, Inflammatory Response and Advanced Treatments
edited by and Juliana Bordignon-Draibe
submission deadline 30 Dec 2025 | 2 articles | Viewed by 4129
Keywords: primary glomerular diseases; membranous nephropathy; IgA nephropathy; glomerular inflammatory mechanisms; aberrantly glycosylated IgA1; galactose-deficient IgA1 (Gd-IgA1); alternative complement pathway; C5; factor B; factor D; APRIL; BAFF; phospholipase A2 receptor (PLA2R); thrombospondin type I domain-containing 7A (THSD7A); exostosins 1 and 2 (EXT1/2); neural epidermal growth factor-like 1 protein (NELL-1); semaphorin 3B (Sema3B); neural cell adhesion molecule 1 (NCAM1)
(This special issue belongs to the Section Molecular Immunology)
Neurogenetic Disorders: Neurogenetics, Pathogenesis, and Gene Therapy submission deadline 30 Dec 2025 | 1 articles | Viewed by 3822
Keywords: precision medicine; gene therapy; neurogenetics; rare monogenic diseases; inherited nervous system disorders; mitochondrial diseases (e.g.; LHON; MELAS); lysosomal storage disorders (e.g.; Tay– Sachs; Gaucher); hereditary neuropathies (e.g.; CMT; hATTR); motor neuron diseases (e.g.; SMA; ALS); spinocerebellar ataxias (e.g.; SCA); biomarkers in neurology
(This special issue belongs to the Section Molecular Neurobiology)
The Emerging Role of Quantum Sciences and Radiation Biology in Biomedical Applications, 2nd Edition submission deadline 30 Dec 2025 | 2 articles | Viewed by 3777
Keywords: quantum sciences; radiation biology; biomedical applications
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Advances in Drug Delivery Systems: From Nanoparticles to Precision Medicine
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 3561
Keywords: polymer-based nanoparticles; lipid nanoparticles; PLGA and chitosan nano/microparticles for gene therapy; targeted drug delivery; nucleic acid-loaded nanoparticles; siRNA nanoparticles; nanoparticle-mediated mirna delivery; nanoparticles in cancer therapy; nanoparticles in vaccine design; nanoparticle-mediated gene therapy
(This special issue belongs to the Section Molecular Pharmacology)
Insights into Mitochondrial Iron Metabolism: Connections to Cancer and Other Pathologies
edited by Michael Petronek
submission deadline 30 Dec 2025 | 1 articles | Viewed by 3250
Keywords: iron metabolism; mitochondrial iron; cellular homeostasis; iron– sulfur cluster biogenesis; heme synthesis; mitochondrial ferritin; cancer biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innate Immunity: New Insights into Genetic and Signaling Networks
edited by
submission deadline 30 Dec 2025 | 2 articles | Viewed by 3210
Keywords: innate immunity; innate immune response; signaling pathways; genetic variations
(This special issue belongs to the Section Molecular Immunology)
Recent Advances in Hypertension and Cardiovascular Disease: 2nd Edition
edited by
submission deadline 30 Dec 2025 | 2 articles | Viewed by 2915
Keywords: hypertension; hypertension pathophysiology; hypertension molecular mechanisms; cardiovascular disease; cardiovascular pathophysiology; cardiovascular molecular mechanisms; cardiovascular biomarkers; heart failure; coronary artery disease; chronic kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Pathogenesis and Treatment of Heart Failure submission deadline 30 Dec 2025 | 2 articles | Viewed by 2900
Keywords: heart failure; biomarkers; pathways of heart failure; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Cancer Stem Cell Research: 2nd Edition
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 2867
Keywords: cancer stem cell; biomarker; signaling; cancer-associated fibroblast; artificial intelligence; cell therapy; antibody therapy; cell therapy; gene expression
(This special issue belongs to the Section Molecular Oncology)
Plant Stress Biology
edited by Rui Li
submission deadline 30 Dec 2025 | 3 articles | Viewed by 2837
Keywords: abiotic stress; biotic stress; stress response mechanisms; oxidative stress; phytohormones signaling; stress tolerance
(This special issue belongs to the Section Molecular Plant Sciences)
Cutting-Edge Advances in Natural Bioactive Compounds submission deadline 30 Dec 2025 | 2 articles | Viewed by 2615
Keywords: natural bioactive compounds; discovery and isolation; chemical characterization; biological activities; mechanisms of action; pharmaceuticals; nutraceuticals; agricultural applications; cosmetic innovations
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Mechanisms of Diabetic Cardiomyopathy
edited by Martin Michel
submission deadline 30 Dec 2025 | 1 articles | Viewed by 2592
Keywords: diabetes; cardiomyopathy; animal models; novel treatments; pathophyiology; SGLT2 inhibitors; neprilysin inhibitors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
25th Anniversary of IJMS: Updates and Advances in Molecular Plant Sciences
edited by
submission deadline 30 Dec 2025 | 4 articles | Viewed by 2506
Keywords: plant science; plant biochemistry; mechanisms; plant development; stress responses; plant physiology; genetics
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in Anti-Cancer Drugs, 2nd Edition submission deadline 30 Dec 2025 | 1 articles | Viewed by 2452
Keywords: combination therapy in cancer; small-molecule inhibitors in cancer; anti-cancer agents derived from natural sources; immunotherapy advances in cancer therapy; targeting metastatic dormancy; modulation of the tumor microenvironment; 3D model approaches in cancer research; predictive biomarkers for cancer chemoresistance
(This special issue belongs to the Section Molecular Oncology)
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