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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Predictive Biomarkers in Breast Cancer

edited by

Giuseppina Rosaria Rita Ricciardi

and Maria Vita Sanò

submission deadline 31 Oct 2025 | Viewed by 63 | Submission Open

Keywords: breast cancer; HER2-positive; TNBC; ER+; HER2-negative; HER2-low; PD-L1; 18F-FES PET; hormonotherapy; immunotherapy; immune checkpoint inhibitors; liquid biopsy; circulating tumor cells; ctDNA; antibody drug conjugates; PARP inhibitors; CDK4/6 inhibitors; predictive biomarkers

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Diagnosis and Treatment of Neurodevelopmental Disorders

edited by

Alessandra Gabellone

submission deadline 31 Oct 2025 | Viewed by 52 | Submission Open

Keywords: neurodevelopmental disorders; psychopathological; biomarkers for early diagnosis; machine learning; fMRI; EEG; MRI; eye-tracking

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Diagnosis of Digestive Diseases

edited by Noriaki Manabe

submission deadline 31 Oct 2025 | Viewed by 51 | Submission Open

Keywords: diagnosis of gastrointestinal disease; functional gastrointestinal disorders; organic diseases; personalized medicine; physiological function evaluation

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Neonatal Diagnostics

edited by Yogen Singh

submission deadline 31 Oct 2025 | Viewed by 51 | Submission Open

Keywords: neonatal imaging; point-of-care ultrasound (POCUS); targeted neonatal echocardiography; hemodynamic evaluation; functional MRI (fMRI); diffusion tensor imaging (DTI); genomic testing; neonatal intensive care units (NICUs)

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Neurological Diseases: Novel Biomarkers for Diagnosis and Management

edited by

Costanza Maria Cristiani

submission deadline 31 Oct 2025 | Viewed by 49 | Submission Open

Keywords: biomarkers; laboratory medicine; neuroimaging; neurological diseases; treatment; management; clinical diagnostics

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Cardiovascular Diseases: Advances in Echocardiography and Cardiac Computed Tomography

edited by Vasileios Kamperidis

submission deadline 31 Oct 2025 | Viewed by 47 | Submission Open

Keywords: heart failure; echocardiography; valvular heart disease; strain imaging; cardiac computed tomography; atherosclerosis; cardiomyopathy; 3D imaging; coronary artery disease; CT FFR; perfusion imaging; stress echocardiography; TEE

(This special issue belongs to the Section Medical Imaging and Theranostics)

Computer-Aided Diagnosis in Endoscopy 2025

edited by

Chang Seok Bang

submission deadline 10 Nov 2025 | 1 articles | Viewed by 551 | Submission Open

Keywords: AI; deep learning; endoscopy; machine learning

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Applications of PET/CT in Clinical Diagnostics

edited by Jasna M. Mihailovic and Partha S Choudhury

submission deadline 13 Nov 2025 | 2 articles | Viewed by 1658 | Submission Open

Keywords: F-18; fluorodeoxyglucose; PET/CT imaging; oncology; radiotracers beyond F-18 fluorodeoxyglucose; clinical diagnostics

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in the Laboratory Diagnosis

edited by

Giuseppe Lippi

and Camilla Mattiuzzi

submission deadline 30 Nov 2025 | 11 articles | Viewed by 17420 | Submission Open

Keywords: laboratory diagnosis; biomarkers; clinical chemistry; laboratory analysis; artificial intelligence

(This special issue belongs to the Section Clinical Laboratory Medicine)

Advances in the Diagnosis and Treatment of Infections of the Central Nervous System

edited by

Teresa Perillo

and Raffaella Capasso

submission deadline 30 Nov 2025 | 1 articles | Viewed by 14568 | Submission Open

Keywords: central nervous system infections; meningitis; HIV; tuberculosis; magnetic resonance imaging

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Research Update on Nuclear Medicine

edited by

Francesco Dondi

submission deadline 30 Nov 2025 | 4 articles | Viewed by 14234 | Submission Open

Keywords: nuclear medicine; diagnostic radiology; PET/CT; SPECT; PET; imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in the Diagnosis and Management of Pediatric Diseases

edited by

Elena Tarca

submission deadline 30 Nov 2025 | 11 articles | Viewed by 12462 | Submission Open

Keywords: pediatrics; pediatric surgery; neonatal medicine; congenital malformations; pediatric trauma; pediatric oncology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Frontline of Breast Imaging

edited by

Gary J. Whitman

submission deadline 30 Nov 2025 | 4 articles | Viewed by 8720 | Submission Open

Keywords: breast imaging; breast ultrasound; mammography; digital breast tomosynthesis; digital mammography; contrast-enhanced mammography; breast MRI; molecular breast imaging; imaging-guided interventional breast procedures

(This special issue belongs to the Section Medical Imaging and Theranostics)

Vascular Diagnostic Imaging

edited by

Hyo-Suk Ahn

submission deadline 30 Nov 2025 | 4 articles | Viewed by 8369 | Submission Open

Keywords: flow-mediated dilation (FMD); optical coherence tomography (OCT); intravascular ultrasound (IVUS)

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnosis and Management of Arrhythmias

edited by Laura Vitali-Serdoz, Martina Nesti and Dirk Bastian

submission deadline 30 Nov 2025 | 6 articles | Viewed by 7200 | Submission Open

Keywords: arrhythmia; electrocardiogram (ECG); cardiac implantable devices; antiarrhythmic drugs; cardiac monitoring; implantable loop recorder; digital health; wearable devices; electrophysiology study; catheter ablation; ventricular tachycardia; atrial fibrillation; supraventricular tachycardia; syncope

(This special issue belongs to the Section Medical Imaging and Theranostics)

Artificial Intelligence and Pattern Recognition Methods for the Automatic Detection and Evaluation of Neurological Disorders, 2nd Edition

edited by

Juan Rafael Orozco-Arroyave

submission deadline 30 Nov 2025 | 6 articles | Viewed by 6656 | Submission Open

Keywords: machine learning; neurodegenerative diseases; diagnosis; detection and evaluation; monitoring

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Recent Advances in Clinical Biochemical Testing

edited by

Aw Tar-Choon

submission deadline 30 Nov 2025 | 3 articles | Viewed by 6287 | Submission Open

Keywords: clinical chemistry; diagnostic testing; biomarkers; point-of-care testing; mass spectrometry; immunoassays; microfluidics

(This special issue belongs to the Section Clinical Laboratory Medicine)

Predictive and Prognostic Markers in Critically Ill Patients, 2nd Edition

edited by

Silvia De Rosa

and Sergio Lassola

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6135 | Submission Open

Keywords: acute brain injury; acute kidney injury; acute mesenteric ischemia; acute pancreatitis; acute respiratory failure; heart failure; infectious disease

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Hematology: Diagnostic Techniques and Assays

edited by Chihyun Cho

submission deadline 30 Nov 2025 | 5 articles | Viewed by 5723 | Submission Open

Keywords: diagnostic; hematology; technique; assay; blood; genetic; molecular

(This special issue belongs to the Section Clinical Laboratory Medicine)

Sarcoidosis: From Diagnosis to Management

edited by Huzaifa I. Adamali

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5149 | Submission Open

Keywords: sarcoidosis; granulomas; interstitial lung disease; lung; heart; skin; liver; neurological; joints; diagnosis imaging; PET/CT; chest X-ray

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Recent Advances in Diagnosis and Treatment of Kidney Diseases: 2nd Edition

edited by

Kenji Tsuji

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5136 | Submission Open

Keywords: chronic kidney disease; diabetic kidney disease; glomerulonephritis; polycystic kidney diseases; renal pathology; biomarker; kidney regeneration; hemodialysis; peritoneal dialysis; diagnosis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnosis and Management of Cardiovascular Disorders

edited by Michael Genuardi and

Juan Ortega-legaspi

submission deadline 30 Nov 2025 | 4 articles | Viewed by 4832 | Submission Open

Keywords: cardiovascular disorders; heart failure; hemodynamics; cardiomyopathy

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Updates on Stroke: Diagnosis and Management

edited by Joseph Domenico Gabrieli

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4399 | Submission Open

Keywords: ischemic stroke; atheromatous disease; thrombolysis; machine learning; neurovascular anatomy; imaging; thrombectomy; diagnosis and management; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Lung Cancer Diagnosis

edited by

Houssein Youness

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4294 | Submission Open

Keywords: lung cancer; diagnosis; biomarkers; artificial intelligence; machine learning; robotic bronchoscopy; bronchoscopic imaging; endobronchial ultrasound (EBUS); quality indicators; molecular profiling; genetic profiling; next-generation sequencing (NGS); tissue acquisition; low-dose CT screening; early detection; risk assessment; personalized medicine; diagnostic accuracy; medical imaging; lung nodules

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Diagnostics of Chronic Kidney Disease

edited by

Tomasz Gołębiowski

and

Andrzej Konieczny

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4093 | Submission Open

Keywords: chronic kidney disease; diabetic nephropathy; glomerulonephritis; acid– base disorders; uremic toxin; artificial intelligence; metabolic bone disease; vascular access; arteriovenous fistula; catheter; hemodialysis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Clinical Diagnosis and Management in Orthopaedics and Traumatology

edited by Attilio Basile

submission deadline 30 Nov 2025 | 5 articles | Viewed by 4063 | Submission Open

Keywords: joint replacement; surgical navigation; outcome assessment; fracture repair; imaging technologies

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in the Diagnosis and Management of Urologic Diseases

edited by

Uroš Bumbaširević

and Otas Durutovic

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4021 | Submission Open

Keywords: urologic diseases; diagnosis; management; urologic oncology; endourology; minimally invasive surgery; urolithiasis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Artificial Intelligence for Health and Medicine

edited by

Daniele Giansanti

submission deadline 30 Nov 2025 | 7 articles | Viewed by 3998 | Submission Open

Keywords: artificial intelligence; deep learning; healthcare; image segmentation; disease prediction; monitoring

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Application of Artificial Intelligence to Advance Individualized Diagnosis and Treatment in Emergency and Critical Care Medicine, 2nd Edition

edited by

Zhongheng Zhang

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3726 | Submission Open

Keywords: critical care; sepsis; artificial intelligence; predictive analytics; clustering; acute kidney injury; emergency medicine; transcriptome

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Microbial Infections and Critical Care Medicine: Diagnosis and Management

edited by Eleni K. Mouloudi,

Serafeim Chrysovalantis Kotoulas

and Eleni Massa

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3443 | Submission Open

Keywords: microbial infections; superbugs; antimicrobial resistance; multi-drug resistance; critical care; diagnosis; management

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Advances in Sarcopenia: Predictive Biomarkers, Clinical Characteristics, and Therapeutic Strategies

edited by Jong Geol Do

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3220 | Submission Open

Keywords: sarcopenia; predictive biomarkers; digital health technologies; interdisciplinary treatment approaches; aging population management

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Eye Imaging

edited by

Antonio Ferreras

submission deadline 30 Nov 2025 | 4 articles | Viewed by 3093 | Submission Open

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Fetal Imaging

edited by Eldad Katorza

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2657 | Submission Open

(This special issue belongs to the Section Medical Imaging and Theranostics)

Recent Advances in MRI of Multiple Sclerosis

edited by

Tim Duong

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2120 | Submission Open

Keywords: primary progressive MS (PPMS); secondary progressive MS (SPMS); relapsing– remitting MS (RRMS); MRI; demyelination; dys-myelination; neurocognitive function; EDSS score

(This special issue belongs to the Section Medical Imaging and Theranostics)

Medical Images Segmentation and Diagnosis

edited by

Steven L. Fernandes

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1974 | Submission Open

Keywords: medical images; segmentation; diagnosis; prognosis; AI

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Musculoskeletal Imaging 2025, 2nd Edition

edited by Parham Pezeshk

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1785 | Submission Open

Keywords: imaging; radiology; diagnostic; musculoskeletal; artificial intelligence

(This special issue belongs to the Section Medical Imaging and Theranostics)

Echocardiography Applications in Cardiovascular Diseases

edited by

Corina Maria Vasile

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1617 | Submission Open

Keywords: echocardiography; congenital heart disease; imaging techniques; artificial intelligence; automatization

(This special issue belongs to the Section Medical Imaging and Theranostics)

Paradigm Shift in the Field of Spinal Diagnosis and Treatment in 2025

edited by

Masato Tanaka

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1430 | Submission Open

Keywords: artificial intelligence; mixed reality; navigation; emerging technologies (robot-assisted surgery); functional MRI; fusion images; new innovative diagnostic tools; scoliosis; adult spinal surgery; spinal tumor; spondylodiscitis; minimally invasive surgery (MIS); aging spine

(This special issue belongs to the Section Medical Imaging and Theranostics)

Cardiothoracic Imaging: Recent Techniques and Applications in Diagnostics, Third Edition

edited by

Giacomo Sica

and

Stefania Tamburrini

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1408 | Submission Open

Keywords: emergency; cardiac imaging; thoracic imaging; aorta; MRI; CT; radiomics; artificial intelligence; ILD

(This special issue belongs to the Section Medical Imaging and Theranostics)

Insights into Hereditary Gastrointestinal Cancer

edited by Gautam Naresh Mankaney

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1072 | Submission Open

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Metabolic Diseases: Diagnosis, Management, and Pathogenesis

edited by Dee Pei

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1047 | Submission Open

Keywords: metabolic disease; obesity; aging; machine learning; pathophysiology; prevalence; ethnic differences

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Application of Diagnostic Tools for Dentistry and Maxillofacial Surgery

edited by

Yiu Yan Leung

submission deadline 30 Nov 2025 | 2 articles | Viewed by 950 | Submission Open

Keywords: diagnostic tools and technologies in dentistry and maxillofacial surgery; diagnostic accuracy; digital imaging techniques; digital radiography; cone-beam computed tomography (CBCT); CAD/CAM technology

(This special issue belongs to the Section Medical Imaging and Theranostics)

Ultrasound Imaging in Medicine in 2025

edited by

Michael Bachmann Nielsen

submission deadline 30 Nov 2025 | 1 articles | Viewed by 947 | Submission Open

Keywords: 3D ultrasound; blood flow velocity; ultrasonography; contrast-enhanced ultrasound; elasticity imaging; endoscopic ultrasound; intervention

(This special issue belongs to the Section Medical Imaging and Theranostics)

Echocardiography in the Intensive Care Unit

edited by

Carlo Caiati

submission deadline 30 Nov 2025 | 1 articles | Viewed by 829 | Submission Open

Keywords: echocardiography; intensive care unit (ICU); critical care; cardiac function; coronary artery disease; sepsis; shock

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advanced Ultrasound Techniques in Diagnosis

edited by

Laith Riyadh Sultan

submission deadline 30 Nov 2025 | 1 articles | Viewed by 744 | Submission Open

Keywords: super-resolution imaging; microvascular imaging (MVI); contrast-enhanced ultrasound; AI-guided ultrasound; quantitative analysis; diagnostic imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Physiological Sound Processing for Medical Diagnostics: Innovations, Challenges, and Applications

edited by

Oliver Faust

and Prabal Datta Barua

submission deadline 30 Nov 2025 | 1 articles | Viewed by 738 | Submission Open

Keywords: heart sounds; lung sounds; cough analysis; sleep apnea and snoring; wearable devices; explainability and ethical AI; standardization and clinical validation

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Explainable Machine Learning in Clinical Diagnostics

edited by

Kai-Chih Pai

submission deadline 30 Nov 2025 | 1 articles | Viewed by 342 | Submission Open

Keywords: interpretable machine learning (IML); explainable machine learning; clinical medicine; knowledge integration; global/local explanations

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Theragnostic Applications of Nanotechnologies

edited by

Viviana Frantellizzi

Giuseppe De Vincentis

and Maria Silvia De Feo

submission deadline 30 Nov 2025 | Viewed by 296 | Submission Open

Keywords: nanotechnologies; theragnostics; nuclear medicine; personalized therapy; CT; MRI; radionuclides; nanoparticles; PET

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Surgical Pathology—Dedicated to Professor Janez Plecnik

edited by

Cesar A. Moran

submission deadline 30 Nov 2025 | Viewed by 277 | Submission Open

Keywords: tumor; immunohistochemistry; molecular pathology; oncology; thorax; gastrointestinal; gynecological; dermatopathology/soft tissue pathology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

AI-Powered Solutions for Personalized Healthcare Monitoring with Wearables

edited by Kuo-Chung Chu,