Diagnosis and Management of Meningitis—2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Diagnostic Microbiology and Infectious Disease".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 549

Special Issue Editor


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Guest Editor
National Meningitis Reference Laboratory, Department of Public Health Policy, School of Public Health, University of West Attica, Athens, Greece
Interests: bacterial meningitis; N. meningitidis; S. pneumoniae; H. influenzae
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Special Issue Information

Dear Colleagues,

This Special Issue will provide scholars with a platform to explore the latest advancements in diagnosing and treating meningitis. It presents a comprehensive overview of meningitis types, symptoms, diagnostic methods, and management strategies, emphasizing the importance of prompt diagnoses and aggressive treatments to minimize long-term neurological sequelae. It will also highlight innovative diagnostic tools and therapies that are improving outcomes for patients with meningitis.

We will focus on articles covering a range of topics, including novel diagnostic approaches, utilizing our available diagnostic armamentarium for surveillance, vaccine implementation, antimicrobial sensitivity/resistance patterns, and novel treatment, as well as management approaches. It is, therefore, my pleasure to invite submissions of high-quality research-based or review papers related to the aforementioned topics to create a timely and highly relevant collection of articles tackling this pertinent public health problem.

Prof. Dr. Georgina Tzanakaki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bacterial meningitis
  • invasive meningococcal disease
  • molecular diagnostics
  • molecular typing
  • laboratory surveillance
  • molecular epidemiology

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Published Papers (1 paper)

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Research

12 pages, 2532 KiB  
Article
Molecular Identification of Meningitis/Septicemia Due to Streptococcus spp. in Greece (2015–2024)
by Constantinos Karamalis, Athanasia Xirogianni, Stelmos Simantirakis, Marina Delegkou, Anastasia Papandreou and Georgina Tzanakaki
Diagnostics 2025, 15(13), 1632; https://doi.org/10.3390/diagnostics15131632 - 26 Jun 2025
Viewed by 383
Abstract
Background/Objectives: Meningitis due to the species Streptococcus is a severe central nervous system infection caused by various microorganisms belonging to Streptococcus spp. Its accurate identification is critical for effective clinical management. This study aimed to identify Streptococcus spp. causing meningitis in Greece [...] Read more.
Background/Objectives: Meningitis due to the species Streptococcus is a severe central nervous system infection caused by various microorganisms belonging to Streptococcus spp. Its accurate identification is critical for effective clinical management. This study aimed to identify Streptococcus spp. causing meningitis in Greece over a nine-year period using PCR and sequencing-based methods. Methods: A total of 189 clinical samples, collected between 2015 and 2024 from patients suffering from meningitis and/or septicemia, were analyzed by the use of a combination of multiplex polymerase chain reaction (PCR) assays and tuf gene sequencing for further species identification. Results: Sample analysis identified 70 samples as S. pyogenes (18.52%) (GAS) and S. agalactiae (18.52%) (GBS), while 119 (62.96%) were recorded as non-typable Streptococcus spp. Further analysis using sequencing methods revealed that the most frequent Streptococcus spp. belonged to the mitis group (42.86%) and the pyogenic group (20.17%). A higher prevalence was observed in children aged 0–14 years old and adults over 50 years old. Conclusions: This study highlights the use of molecular diagnostics in identifying other Streptococcus spp., providing insights into age-related susceptibility and epidemiological trends. Future studies are needed to explore the pathogenic role of the identified Lactococcus spp. Full article
(This article belongs to the Special Issue Diagnosis and Management of Meningitis—2nd Edition)
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