Vitiligo is an acquired depigmenting disorder in which melanocyte loss has traditionally been interpreted through an autoimmune lens. However, immune activation alone does not fully explain why melanocytes become selectively vulnerable, why oxidative...
Extracellular vesicles (EVs) mediate endocrine and metabolic signalling. EV responses to shifts in substrate utilisation, from euketonaemia to hypoketonaemia, remain poorly understood. Chronic hyperinsulinaemia suppresses ketogenesis, causing hypoket...
This review proposes that selected micronutrients may contribute to mitohormetic readiness, defined here as the pre-existing biochemical and regulatory capacity of a cell, tissue, or organism to sense, buffer, and transduce a bounded mitochondrial st...
Peripheral blood mononuclear cell (PBMC) bioenergetic profiling has emerged as a promising minimally invasive tool for assessing immunometabolic health, yet traditional venepuncture presents practical barriers for certain populations and longitudinal...
In response to the evolving landscape of scholarly publishing and to more fully encompass the rapidly expanding field of translational and applied bioenergetics, Clinical Bioenergetics has refined and expanded its aims, scope, and focus areas [...]
Mitochondria are highly dynamic structures that undergo constant remodelling by the process of fission and fusion. Using simulation methods, we study the effects of neuron loss in humans due to the proliferation of deletion mutations. We implement tw...
Mitochondrial toxicity is a major concern in drug development and safety assessment. Machine learning models trained on mitochondrial membrane potential (MMP) assay data offer promising toxicity predictions, but cross-scaffold and cross-assay transfe...
Background: Physical inactivity is a major contributor to cardiometabolic disease and mortality. Although mitochondrial dysfunction characterizes overt pathology, whether sedentarism constitutes a distinct and measurable bioenergetic disease state, r...
Mitochondria have emerged as critical regulators of cancer biology, transcending their classical role as cellular powerhouses to orchestrate complex metabolic, signaling, and survival pathways essential for tumorigenesis. This review examines the mul...
Cutaneous melanoma is the most lethal form of skin cancer because of its aggressiveness, rapid metastasis, and high therapeutic resistance. The 2018 World Health Organization (WHO) classification emphasized that melanoma comprises distinct subtypes d...
(1) Background: Mild traumatic brain injury (mTBI), the most prevalent form of traumatic brain injury, often results from repetitive impacts to the head and is associated with long-term neurological impairment. The pathophysiology of mTBI is multifac...
Background: Metabolic syndrome is associated with early impairments in cellular bioenergetics that are not fully captured by conventional body composition measures. Molecular hydrogen, produced endogenously through gut microbial fermentation and meas...
Energy homeostasis arises from a complex interplay between gut-derived hormones, the central nervous system, and pancreatic function. Beyond the classical incretin axis, a broad spectrum of gut peptides acts in concert to coordinate appetite regulati...
Vascular inflammation and endothelial dysfunction are key drivers in the development of cardiovascular and neurovascular diseases. Mitochondrial dysfunction and oxidative stress further amplify inflammatory cascades, emphasising the need for targeted...
The impairment of biological tissue caused by ischemia is a key area of research in both natural sciences and medical research. The utilization of oxygen in the process of tissue respiration is closely linked to mitochondrial function, i.e., the dire...
Objective: Resistance exercise can induce muscle damage that impairs sports performance and cellular repair. Myokines, particularly mitochondrial myokines, play an important role in regulating energy metabolism and muscle recovery. The ACTN3 R577X po...
Myeloid malignancies exhibit profound metabolic dependence on mitochondrial oxidative phosphorylation (OXPHOS) for survival and proliferation. Antileukemic therapies such as Venetoclax combined with Azacitidine or cytarabine induce rapid mitochondria...
A constantly increasing incidence of chronic diseases is a challenge for healthcare worldwide, being directly associated with physical inactivity, which is considered an important cause of most chronic diseases. In contrast, physical exercise has bee...
Background: Chronic rhinosinusitis (CRS) affects nearly 9% of the global population with a rising incidence over recent decades. Neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease pose significant global burden, and em...
Nicotinamide adenine dinucleotide (NAD+) is an important coenzyme essential for metabolism, energy production, gene regulation, and cellular communication. With aging, NAD+ levels decrease, which may be partly responsible for age-related disease and...
Traditionally, referred to as the “Powerhouse of the Eukaryotic Cell”, mitochondria are essential for host defense in addition to producing ATP. Through processes like mitochondrial antiviral signaling (MAVS), the generation of reactive o...
Vanadium is a transition metal whose environmental presence has increased due to human activities such as fossil fuel combustion and industrial processes. A central mechanism of its toxicity involves mitochondrial dysfunction, as vanadium exposure di...
Psychiatric disorders such as major depressive disorder, bipolar disorder, and schizophrenia are now recognized as complex systemic conditions in which mitochondrial dysfunction and oxidative stress are key contributors to their pathophysiology. Mito...
Tumor cells often exhibit mitochondrial dysfunction and a pronounced glycolytic shift (the “Warburg effect”) that alters the tumor microenvironment. These metabolic changes, including mitochondrial DNA mutations and impaired oxidative pho...
Mitochondrial integrity is indispensable for pulmonary cellular homeostasis, with its dysfunction increasingly being implicated as a central mechanism in the etiology of respiratory disorders. We present a comprehensive overview of the integral role...
Background/Objectives: Traumatic brain injury (TBI) affects millions of people worldwide, with approximately 2.8 million cases occurring in the United States each year. These injuries may be mild, moderate, or severe based on intensity of impact. The...
The literature on creatine biomarkers in various bodily fluids remains limited. The purpose of this review is to explore the available data regarding the presence of molecules considered biomarkers of creatine metabolism—namely creatine, guanid...
Mitochondrial energy deficits have emerged as a critical factor in various clinical conditions, including inherited metabolic disorders, intoxications, cardiometabolic diseases, neurodegenerative disorders, and cancer [...]
