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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathological Mechanisms and Therapeutic Strategies of Alzheimer’s Disease

edited by Boris DeCourt, Travis Thompson and

Andrew C. Shin

submission deadline 19 Feb 2027 | 1 articles | Viewed by 2185 | Submission Open

Keywords: Alzheimer’s disease; amyloid beta; biomarkers; gut-brain axis; mechanisms; neurotransmitter imbalance; pathology; tau; treatments

(This special issue belongs to the Section Cellular Aging)

Cellular Signaling and Metabolic Adaptations in the Tumor Microenvironment

edited by Shashi Anand

submission deadline 19 Feb 2027 | 1 articles | Viewed by 961 | Submission Open

Keywords: cancer metabolic plasticity; tumor microenvironment; metabolic vulnerabilities; oncogenic signaling pathways; hypoxia and nutrient stress; therapeutic resistance

(This special issue belongs to the Section Cellular Metabolism)

Pathogenic Angiogenic Mechanisms in Alzheimer's Disease

edited by

Anastasios Georgakopoulos

submission deadline 19 Feb 2027 | Viewed by 42 | Submission Open

Keywords: pathological angiogenesis; endothelial dysfunction; blood–brain barrier breakdown; cerebral hypoperfusion; Alzheimer’s disease pathogenesis

(This special issue belongs to the Section Cellular Pathology)

Cell and Molecular Mechanisms of Cytogenesis

edited by

Luisa Alexandra Meireles Pinto

and

Teresa Correia Soares Canedo Calado

submission deadline 25 Feb 2027 | 1 articles | Viewed by 10151 | Submission Open

Keywords: cytogenesis; central nervous system; neurogenesis; gliogenesis; neuroplasticity; signaling pathways; cell proliferation; differentiation; CNS homeostasis; neuropsychiatric and neurodegenerative disorders

Antigen Processing in Autoimmunity and Cancer—Mechanisms and Translational Perspectives

edited by Peter Van Endert

submission deadline 25 Feb 2027 | 2 articles | Viewed by 5285 | Submission Open

Keywords: major histocompatibility molecule; antigen processing; antigen presentation; protease; endoplasmic reticulum aminopeptidase; antitumor immunity; autoimmunity; immunotherapy

Recent Advances in Vitamin D and K in Cancer

edited by

Alexandra M. Crǎciun

Ciprian N. Silaghi

and

Andreea Crintea

submission deadline 25 Feb 2027 | Viewed by 376 | Submission Open

Keywords: vitamin D; vitamin K; VDR signaling; tumor microenvironment; cancer prevention; molecular pathways; apoptosis and proliferation; oxidative stress; immunomodulation; therapeutic resistance

Ion Channels and Transporters—Structure and Function

edited by Tiziano Mazza, Jonathan Paul Lambert and

Alessia Nisco

submission deadline 25 Feb 2027 | Viewed by 110 | Submission Open

Keywords: ion channels; membrane transporters; SLC; ABC; structure-function relationship; Cryo-EM; X-ray crystallography; molecular mechanism; computational biology

Kidney Disease: The Role of Cellular Mechanisms in Renal Pathology

edited by

Jinu Kim

submission deadline 26 Feb 2027 | 4 articles | Viewed by 5223 | Submission Open

Keywords: kidney fibrosis; acute kidney injury (AKI); chronic kidney disease (CKD); epithelial-to-mesenchymal transition (EMT); renal cell populations; stem cell therapy; renal regeneration; inflammation in kidney disease; cell-based models; renal repair mechanisms

(This special issue belongs to the Section Tissues and Organs)

Cancer and Immune System Interactions

edited by

Hong-Jian Zhu

and

Bradley Creamer

submission deadline 26 Feb 2027 | 4 articles | Viewed by 4209 | Submission Open

Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor–immune interactions; immune checkpoint regulation; translational oncology

(This special issue belongs to the Section Cell Microenvironment)

Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts

edited by Simonetta Masieri and

Carlo Cavaliere

submission deadline 26 Feb 2027 | 1 articles | Viewed by 3390 | Submission Open

Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins

(This special issue belongs to the Section Tissues and Organs)

Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting

edited by

Mehdi Sanati

submission deadline 26 Feb 2027 | 1 articles | Viewed by 3380 | Submission Open

Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment

A New Frontier for Cancer Diagnosis and Therapy

edited by

Concettina La Motta

Md Manirujjaman

and

A.S.M. Waliullah

submission deadline 26 Feb 2027 | 2 articles | Viewed by 3176 | Submission Open

Keywords: cancer diagnosis; precision oncology; liquid biopsy; molecular biomarkers; immunotherapy; targeted therapy; nanomedicine; multi-omics; artificial intelligence; tumor heterogeneity

(This special issue belongs to the Section Cellular Immunology)

Mitochondrial Dynamics in Health and Disease Metabolism: Mechanisms and Functional Consequences

edited by

Che-Chia Hsu

submission deadline 26 Feb 2027 | 3 articles | Viewed by 2826 | Submission Open

Keywords: mitochondrial fission; mitochondrial fusion; mitophagy; mitochondrial transport; mitochondrial transfer; mitochondrial diseases

(This special issue belongs to the Section Mitochondria)

Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk

edited by Aparna Renigunta and

Poornima Mahavadi

submission deadline 26 Feb 2027 | 2 articles | Viewed by 2480 | Submission Open

Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation

Application of Stem Cells and Cellular Engineering in Musculoskeletal Tissue Regeneration

edited by

Alessandra Colombini

submission deadline 26 Feb 2027 | 2 articles | Viewed by 1979 | Submission Open

Keywords: mesenchymal stem cells (MSCs); tissue specific progenitors; cellular engineering; musculoskeletal tissue regeneration; tissue engineering; biomaterials; 3D culture systems; mechanobiology; extracellular vesicles; translational regenerative medicine

(This special issue belongs to the Section Stem Cells)

Mechanisms and Biomarkers of Neurotoxicity: From Molecular Pathways to Therapeutic Interventions

edited by Nyzil Massey, Shreesh Raj Sammi and

Diou Luo

submission deadline 26 Feb 2027 | 1 articles | Viewed by 1768 | Submission Open

Keywords: neurotoxicity mechanisms; neuroinflammation; oxidative stress; biomarkers; neuroimaging; electrophysiology; glial activation; neurodegeneration; translational therapeutics; environmental neurotoxicology

(This special issue belongs to the Section Cellular Neuroscience)

Cellular and Molecular Mechanisms in Reproductive Biology and Fertility

edited by

Giorgio Maria Baldini

and Antonio Malvasi

submission deadline 26 Feb 2027 | 1 articles | Viewed by 1345 | Submission Open

Keywords: gametogenesis; fertilization; fertility; endocrinology; implantation; gametogenesis regulation; embryo–maternal interaction; reproductive signaling; IVF; in vitro fertilization; ovarian stimulation

(This special issue belongs to the Section Reproductive Cells and Development)

Molecular and Cellular Mechanisms of Pheochromocytoma and Paraganglioma

edited by

Mouna Tabebi

and

Oliver Gimm

submission deadline 26 Feb 2027 | Viewed by 283 | Submission Open

Keywords: pheochromocytoma; paraganglioma; tumor biology; molecular mechanisms; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Genomics and Cellular Mechanisms in Ovarian Cancer

edited by Hao Huang

submission deadline 28 Feb 2027 | 3 articles | Viewed by 5203 | Submission Open

Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment

(This special issue belongs to the Section Tissues and Organs)

Molecular Signatures and Cellular Pathways of Immune Dysfunction in HIV and Tuberculosis

edited by

Sandeep Rai Kaushik

, Pradeep Kumar Sheokand,

Nejat Düzgüneş

, Ekta Saini and Prashant Bajpai

submission deadline 28 Feb 2027 | Viewed by 375 | Submission Open

Keywords: immune cell dysfunction; immune persistence; T cell exhaustion; chronic infection; host–pathogen interactions; cellular immunity; molecular immune signaling; single-cell immunology; immune cell plasticity; infection-induced immune remodeling

(This special issue belongs to the Section Cellular Immunology)

Molecular Signal Transduction in Cancer

edited by

Goberdhan P. Dimri

and

Bernhard Zdársky

submission deadline 28 Feb 2027 | Viewed by 206 | Submission Open

Keywords: molecular signal transduction; tumor microenvironment; tumor suppressor; kinase signaling; transcriptional and epigenetic regulation; immune signaling; cancer cell communication

(This special issue belongs to the Section Cell Signaling)

Molecular Biomarkers in Tumors: Prognosis and Mechanisms

edited by

Karolina Golabek

submission deadline 28 Feb 2027 | Viewed by 105 | Submission Open

Keywords: molecular biomarkers; tumor prognosis; tumor microenvironment; genomic alterations; therapeutic resistance; liquid biopsy; extracellular vesicles; multi-omics

(This special issue belongs to the Section Cellular Pathology)

Corneal Biology and Pathophysiology: From Homeostasis to Disease

edited by

Mithun Santra

, Anil Tiwari and Gary (Hin-Fai) Yam

submission deadline 28 Feb 2027 | Viewed by 67 | Submission Open

Keywords: corneal regeneration; corneal tissue homeostasis; corneal pathophysiology; corneal therapeutics

(This special issue belongs to the Section Cellular Pathology)

The Role of Oxidative Stress in Cardiovascular Diseases—3rd Edition

edited by

Liya Yin

and

Jiemei Wang

submission deadline 28 Feb 2027 | Viewed by 65 | Submission Open

Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular and Molecular Mechanisms of Vascular-Related Diseases—Second Edition

edited by

Bingmei Fu

and

Ye Zeng

submission deadline 28 Feb 2027 | Viewed by 41 | Submission Open

Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system; drug delivery via vascular system

(This special issue belongs to the Section Cellular Pathology)

Adipose Tissue Functioning in Health and Diseases—Second Edition

edited by

Richard C. Chang

submission deadline 28 Feb 2027 | Viewed by 34 | Submission Open

Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance

(This special issue belongs to the Section Tissues and Organs)

Recent Advances in Immunology of Asthma

edited by

Kȩstutis Malakauskas

and

Andrius Januskevicius

submission deadline 28 Feb 2027 | Viewed by 16 | Submission Open

Keywords: asthma; airway inflammation; immunology; cytokines; airway remodeling; biomarkers; type 2 inflammation; eosinophils

(This special issue belongs to the Section Cellular Immunology)

Novel Insights into Amyotrophic Lateral Sclerosis (ALS)

edited by Zane Zeier

submission deadline 1 Mar 2027 | Viewed by 268 | Submission Open

Keywords: TDP-43 proteinopathy; protein aggregation; RNA metabolism; DNA damage; cryptic splicing; nucleocytoplasmic transport; liquid–liquid phase separation; mitochondrial dysfunction; mitophagy; neuroinflammation; microglial activation; astrogliosis; glutamate excitotoxicity; multi-omics; integrative omics

Cellular Stress Responses, Lysosomal Damage and Non-Canonical Autophagy

edited by

Jingyue Jia

and Alf Håkon Lystad

submission deadline 1 Mar 2027 | Viewed by 233 | Submission Open

Keywords: lysosomal damage; cellular stress responses; non-canonical autophagy; lysosomal homeostasis

(This special issue belongs to the Section Autophagy)

How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies

edited by

Agnieszka Bojarska-Junak

and

Michal Zarobkiewicz

submission deadline 10 Mar 2027 | 6 articles | Viewed by 20054 | Submission Open

Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention

(This special issue belongs to the Section Cell Microenvironment)

Gut Microbiota, Metabolites, and Immune Regulation in Gastrointestinal Diseases

edited by

Sweta Ghosh

and Subir Kumar Juin

submission deadline 15 Mar 2027 | 3 articles | Viewed by 6297 | Submission Open

Keywords: gut microbiota; microbial metabolites; inflammation; immunology; gut-barrier; gastrointestinal disease

Biochemical Interaction and Supramolecular Complexes of Receptors in Cell Membranes

edited by

Michela Corsini

and

Stefania Mitola

submission deadline 15 Mar 2027 | 1 articles | Viewed by 3082 | Submission Open

Keywords: membrane receptors; molecular complex; membrane microdomains

Phytofactories: From Lab to Applications

edited by

and

submission deadline 15 Mar 2027 | 2 articles | Viewed by 3056 | Submission Open

Keywords: plant cell suspension cultures; phytofactories; bioprocess; specialty molecules; metabolic engineering; germplasm preservation

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Aquaporins at the Crossroads of Human Health and Disease

edited by

Anna Patrizia Gena

submission deadline 15 Mar 2027 | 2 articles | Viewed by 1920 | Submission Open

Keywords: aquaporins; membrane molecular transport; channels proteins in health and disease; novel drug targets; cellular biophysics

Autophagy-Related Proteins in Stress Responses

edited by

Aurore Claude-Taupin

submission deadline 19 Mar 2027 | 1 articles | Viewed by 1447 | Submission Open

Keywords: stress response; ATG; endocytosis; exocytosis; autophagy

(This special issue belongs to the Section Autophagy)

Molecular Mechanisms and Novel Therapeutics for Glioblastoma

edited by Hirotaka Ito and

Raziye Piranlioglu

submission deadline 20 Mar 2027 | 2 articles | Viewed by 1814 | Submission Open

Keywords: glioblastoma; molecular mechanisms; oncolytic virus therapy; immunotherapy; tumor microenvironment; translational research; neurosurgery

(This special issue belongs to the Section Cellular Neuroscience)

The Circulating Tumor Microenvironment (cTME): Emerging Taxonomies and Multimodal Landscapes

edited by

Noriyoshi Sawabata

submission deadline 20 Mar 2027 | 1 articles | Viewed by 837 | Submission Open

Keywords: circulating tumor microenvironment (cTME); circulating tumor-associated cells (C-TACs); circulating tumor emboli (CTE); extracellular vesicles; metastatic cascade; experimental cytology; functional assays; precision oncology; liquid biopsy; next-generation sequencing (NGS)

(This special issue belongs to the Section Cell Microenvironment)

Sickle Cell Disease: Current Advances in Molecular Mechanisms and Therapeutic Strategies

edited by

Marisa Silva

and Paula Faustino

submission deadline 20 Mar 2027 | Viewed by 349 | Submission Open

Keywords: sickle cell disease; genetic modifiers; gene editing; SCD pathophysiology; SCD biomarkers; SCD treatment; SCD management

(This special issue belongs to the Section Cellular Pathology)

Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by

David E. Stec

and Olufunto Badmus

submission deadline 26 Mar 2027 | 2 articles | Viewed by 1281 | Submission Open

Keywords: NAFLD; MASLD; hepatic steatosis; obesity; insulin resistance; fibrosis; cirrhosis

(This special issue belongs to the Section Cellular Pathology)

Uncovering Placental Inflammatory Pathways Affecting the Developing Brain

edited by

Guillaume Sébire

and

Math Chevin

submission deadline 26 Mar 2027 | Viewed by 260 | Submission Open

Keywords: neuroplacentology; neuroinflammation; hypoxia–ischemia; developing brain; ASD; CP; ADHD; learning disabilities; preclinical model; cell culture

(This special issue belongs to the Section Reproductive Cells and Development)

Cellular and Molecular Mechanisms in Gynecological Disorders—Second Edition

edited by

Qiwei Yang

submission deadline 30 Mar 2027 | 3 articles | Viewed by 6600 | Submission Open

Keywords: uterus; ovary; fallopian tubes; cervix; vagina; endometriosis; polycystic ovary syndrome; primary ovarian insufficiency; ovarian cysts; adenomyosis; endometriosis; leiomyoma (uterine fibroids); endometrial cancer; leiomyosarcoma; female infertility; breast cancer; cell atlas; biomarkers; stem cells; pathways; transcriptome; proteomics; epigenome

(This special issue belongs to the Section Cellular Pathology)

Cancer Cytopathology: Structural Features and Intracellular Events in Malignancy

edited by

Toshimichi Onuma

and

Jianjun Wei

submission deadline 30 Mar 2027 | Viewed by 378 | Submission Open

Keywords: cancer cells; cytopathology; tumor microenvironment; cell culture; biopsies

(This special issue belongs to the Section Cellular Pathology)

Molecular Research in Osteoporosis

edited by

Virginia Visconti

Annalisa Botta

and

Umberto Tarantino

submission deadline 31 Mar 2027 | 3 articles | Viewed by 2887 | Submission Open

Keywords: osteoporosis; osteosarcopenia; bone–muscle crosstalk; genetics, epigenetics; transcriptomics; biomarkers; therapeutic strategy

(This special issue belongs to the Section Cellular Pathology)

Toxicology in Cells: Cellular Mechanisms, Molecular Responses, and Modern Models

edited by Maria Jurczuk and

Patrice X. Petit

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2184 | Submission Open

Keywords: cellular toxicology; oxidative stress; apoptosis; autophagy; biomarkers; nanotoxicology; organ-on-chip; toxicogenomics; epigenetic regulation; mitochondrial dysfunction

Advances in Toxoplasma gondii Treatment, Immunology and Host–Parasite Interaction

edited by

Namrata Anand

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1147 | Submission Open

Keywords: T. gondii; treatment strategies; secretory proteins; immune response; exosomes; nanoparticle; congenital infection; host–parasite interaction

(This special issue belongs to the Section Cellular Immunology)

Immunometabolic Reprogramming in Diabetic Kidney Disease: The Interplay of Innate Immunity, Oxidative Stress, and Cellular Metabolism

edited by

Nela Kelam

, Sandra Kostić and Anita Racetin

submission deadline 31 Mar 2027 | 1 articles | Viewed by 842 | Submission Open

Keywords: diabetic kidney disease; immunometabolism; innate immunity; oxidative stress; metabolic reprogramming; inflammasome; renal fibrosis; mitochondrial dysfunction; non-coding RNAs; multi-omics integration

Plant Organelle Biology: Dynamics, Communication, and Metabolism

edited by

Alessio Papini

and

Giovanni Stefano

submission deadline 31 Mar 2027 | Viewed by 292 | Submission Open

Keywords: plant organelles; organelle dynamics; organelle communication; organelle metabolism; chloroplasts; mitochondria; peroxisomes; organelle signaling; cellular homeostasis; inter-organelle interactions; plant cell biology; organelle biogenesis; organelle degradation; plant stress responses

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Multipotent Mesenchymal Stromal Cells in the Tumor Microenvironment: Recent Advances and Emerging Concepts

edited by Yuri Petrenko

submission deadline 31 Mar 2027 | Viewed by 290 | Submission Open

Keywords: multipotent mesenchymal stromal cells; tumor microenvironment; cancer stem cells; metabolic rewiring; biomechanical cues; 3D modelling; paracrine interactions; vascularization; differentiation

(This special issue belongs to the Section Stem Cells)

Reprogramming Myeloid Cells: From Epigenetic Mechanisms to Therapeutic Applications in Inflammation and Disease

edited by Liwu Li

submission deadline 31 Mar 2027 | Viewed by 238 | Submission Open

Keywords: myeloid cell reprogramming; epigenetic regulation; inflammation; macrophage polarization; innate immune; monocyte; neutrophils

Cell Migration and Invasion—Second Edition

edited by Veronika Miskolci

submission deadline 31 Mar 2027 | Viewed by 70 | Submission Open

Keywords: cell migration; cell invasion; cancer metastasis; molecular mechanisms; therapeutic strategies; signaling pathways

(This special issue belongs to the Section Cell Motility and Adhesion)

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