Molecular Signal Transduction in Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: 28 February 2027 | Viewed by 99
Special Issue Editors
Interests: aging; cancer; cell cycle; cell death; cell senescence; cell signaling; oncogenes; tumor suppressors
Special Issues, Collections and Topics in MDPI journals
Interests: cancer; metastasis; leukemia; AML; JAK-STAT; STAT3
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Dysregulated molecular signal transduction lies at the core of cancer initiation, progression and therapeutic resistance. Genetic and epigenetic alterations disrupt regulatory circuits that normally maintain cell growth and homeostasis, driving the transition to malignancy. As these signaling networks become rewired, they enable tumor cells to override physiological constraints, adapt to metabolic and environmental pressures and remodel their interactions with surrounding stromal and immune cells. This imbalance, arising from disrupted oncogenic and tumor-suppressive signaling, fosters a permissive environment for malignant transformation, disease dissemination and the emergence of treatment-resistant clones.
Our expanding understanding of these altered signaling pathways continues to uncover new mechanistic insights and therapeutic opportunities. Both intrinsic cellular programs and extrinsic cues from the tumor microenvironment shape cancer behavior, and their convergence determines how tumors grow, evolve and respond to therapy. This integrated view of signal transduction has become essential for identifying actionable vulnerabilities, improving biomarker-guided patient stratification and informing rational combination strategies involving targeted agents and immunotherapies.
This Special Issue aims to highlight recent advances in decoding the molecular signaling events that orchestrate tumorigenesis and influence treatment outcomes. We welcome original research, brief reports and review articles that explore canonical and emerging pathways, their biological functions and their translational implications.
Dr. Goberdhan P. Dimri
Dr. Bernhard Zdársky
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- molecular signal transduction
- tumor microenvironment
- tumor suppressor
- kinase signaling
- transcriptional and epigenetic regulation
- immune signaling
- cancer cell communication
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