Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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MicroRNAs: Regulators of Cellular Fate
edited by
submission deadline 29 Jan 2027 | 4 articles | Viewed by 4478 | Submission Open
Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker
Cellular Signaling Networks in Development, Homeostasis, and Disease
edited by , and Chia-Yang Liu
submission deadline 29 Jan 2027 | 3 articles | Viewed by 3398 | Submission Open
Keywords: cell fate determination; cell migration and survival; cell proliferation and differentiation; development and homeostasis; developmental disorders; disease mechanisms; regenerative medicine; signal transduction; signaling crosstalk; spatial transcriptomics
(This special issue belongs to the Section Cell Signaling)
Cellular Responses During Wound and Regeneration submission deadline 29 Jan 2027 | 3 articles | Viewed by 3126 | Submission Open
Keywords: inflammation; wound and regeneration; clotting; reduction–oxidation reactions; fibroblasts; proliferation; endothelial; extracellular matrix
(This special issue belongs to the Section Stem Cells)
Recent Advances in the Understanding of Neuropsychiatric Illnesses
edited by and
submission deadline 29 Jan 2027 | 2 articles | Viewed by 2949 | Submission Open
Keywords: neuropsychiatric disorders; neurodegeneration; synaptic plasticity; neuroinflammation; biomarkers; molecular mechanisms; translational neuroscience; intracellular signaling; neuroimaging
(This special issue belongs to the Section Cellular Neuroscience)
Mitochondrial Dynamics and Remodelling
edited by Edmund Carvalho
submission deadline 29 Jan 2027 | 1 articles | Viewed by 2040 | Submission Open
Keywords: mitochondrial dynamics; fission; fusion; mitophagy; cristae remodeling; bioenergetics; ER–mitochondria contacts; immune reprogramming; signaling pathways; therapeutic targeting
Advances in Tissue Engineering Approaches for Bone Repair and Regeneration submission deadline 29 Jan 2027 | 2 articles | Viewed by 2028 | Submission Open
Keywords: bone tissue engineering; bone regeneration; biomaterials and scaffolds; bone cancer; 3D printing; bioprinting
(This special issue belongs to the Section Tissues and Organs)
AI and Multi-Modal Data Integration in Neurobiology and Neurological Diseases
edited by Jeon Lee
submission deadline 29 Jan 2027 | 1 articles | Viewed by 1801 | Submission Open
Keywords: artificial intelligence; multi-modal integration; multi-omics; neurobiology; neurological disease; molecular characterization; neuronal biomarker; cellular pathway
(This special issue belongs to the Section Cellular Neuroscience)
Recent Insights into the Role of Metal Ions in the Nervous System
edited by Richard H. Dyck
submission deadline 29 Jan 2027 | 1 articles | Viewed by 1206 | Submission Open
Keywords: metal ions; neurobiology; zinc signalling; copper homeostasis; iron metabolism; calcium signalling; magnesium; lithium; metallomics; synaptic transmission; neuromodulation; ion transporters; metal-binding proteins; oxidateive stress; mitochondrial function; neurodevelopment; synaptic plasticity; neuroinflammation; neurodegeneration; neuropsychiatric disorders; autism spectrum disorder; schizophrenia; Alzheimer disease; Parkinson disease; imaging of metal ions; metal ion dysregulation
(This special issue belongs to the Section Cellular Neuroscience)
Synaptic Condensates: Liquid–Liquid Phase Separation of Pre- and Postsynaptic Scaffold Proteins in Synapse Development and Memory Formation
edited by Norbert Bencsik and
submission deadline 29 Jan 2027 | 1 articles | Viewed by 866 | Submission Open
Keywords: liquid–liquid phase separation (LLPS); synaptic plasticity; synapse development; postsynaptic density (PSD); scaffold proteins; synaptic dysfunction; neural circuits
(This special issue belongs to the Section Cellular Neuroscience)
ALK Signaling Pathways in NSCLC: From Cell Biology to Therapeutic Insights submission deadline 29 Jan 2027 | Viewed by 479 | Submission Open
Keywords: anaplastic lymphoma kinase (ALK); non-small-cell lung cancer (NSCLC); ALK tyrosine kinase inhibitors (ALK-TKIs); drug resistance; signal transduction and oncogenic pathways; molecular diagnostics (IHC, FISH, NGS); targeted therapy
Gene Regulation in Epithelial Cells
edited by Jennifer Zhang
submission deadline 29 Jan 2027 | 1 articles | Viewed by 430 | Submission Open
Keywords: epithelial cells; gene regulation; epigenetic regulation; epithelium–immune crosstalk; epithelium–microbial interaction
(This special issue belongs to the Section Cell and Gene Therapy)
Neuromuscular Disorders: Advances in Cellular and Molecular Understanding, Emerging Therapies, and Outcome Measures
edited by and
submission deadline 29 Jan 2027 | Viewed by 412 | Submission Open
Keywords: neuromuscular disorders; pathophysiology; biomarkers; treatment; impairment and disability measures; outcome measures
(This special issue belongs to the Section Tissues and Organs)
Immunotherapy-Induced Cardiotoxicity: Unraveling the Immune Landscape of Myocarditis
edited by
submission deadline 29 Jan 2027 | Viewed by 373 | Submission Open
Keywords: immunotherapy; immune checkpoints; adoptive cell therapy; cardiac adverse events; cardiac inflammation; immune checkpoint inhibitor associated myocarditis; cardiac immune landscape; innate immune response; adaptive immune response; myeloid cells; macrophages; antigen presentation & phagocytosis; T cells; T cell clonality; cytokines; chemokines; chemotaxis; immune crosstalk; immune–stromal crosstalk; multi-omics
Advances in the Gut–Liver–Brain Axis in Human Health and Disease
edited by
submission deadline 29 Jan 2027 | Viewed by 339 | Submission Open
Keywords: gut–liver–brain axis; microbiota; liver metabolism; neuroinflammation; metabolic disease; neurodegeneration; gut–brain communication
Targeted Therapy and Immunotherapy in Breast Cancer: Molecular Mechanisms and Translational Advances
edited by Saranya Chumsri, Hatem H. Soliman and
submission deadline 29 Jan 2027 | Viewed by 334 | Submission Open
Keywords: breast cancer; targeted therapy; immunotherapy; biomarkers of response; therapeutic resistance
(This special issue belongs to the Section Cellular Immunology)
The Study of Skeletal Diseases
edited by Weiguang Wang
submission deadline 29 Jan 2027 | Viewed by 312 | Submission Open
Keywords: skeletal diseases; bone; cartilage; synovium; tendon; ligament; spine; craniofacial skeleton; immune–skeletal interaction; vascular and neural networks; stem and progenitor cells; artificial intelligence (AI); single-cell and spatial genomics; imaging and bioengineering; regenerative medicine
(This special issue belongs to the Section Cellular Pathology)
Molecular Drivers of Oncogenesis and Tumor Evolution: Mechanisms and Cellular Pathways submission deadline 29 Jan 2027 | Viewed by 284 | Submission Open
Keywords: oncogenesis; cancer progression; cancer biology; tumor immunology; tumor microenvironment; metastasis; angiogenesis; metabolic reprogramming; therapy resistance
State of the Art and Future Prospects in Central Nervous System Cancer Therapeutics
edited by Kristen Batich
submission deadline 29 Jan 2027 | Viewed by 273 | Submission Open
Keywords: neuro-oncology; central nervous system; immunotherapy; antigen presentation; cancer vaccines
(This special issue belongs to the Section Cellular Neuroscience)
Advances in 3D Biology for Translational Medicine: Promises and Challenges
edited by David C. Hay, and
submission deadline 30 Jan 2027 | Viewed by 172 | Submission Open
Keywords: tissue engineering; spheroids; organoids; informatics; in vitro modelling; phenotyping; in vivo transplant
Advances in Osteosarcoma: Tumor Biology and Therapeutic Innovation submission deadline 31 Jan 2027 | 2 articles | Viewed by 1142 | Submission Open
Keywords: osteosarcoma; immunotherapy; biomarker
(This special issue belongs to the Section Cellular Pathology)
New Insights into Plant Bioactive Compounds submission deadline 31 Jan 2027 | 2 articles | Viewed by 993 | Submission Open
Keywords: abiotic and biotic stresses; defense mechanism; signaling pathway; secondary metabolites; biostimulants; nanotechnology; bioactivity; reactive oxygen species
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Stem Cell Reprogramming and Cellular Differentiation
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 510 | Submission Open
Keywords: stem cell differentiating stage factors; cell reprogramming; cell differentiation; stem cells; epigenetic regulation; cellular plasticity
(This special issue belongs to the Section Stem Cells)
Retinal Diseases: Cellular and Molecular Mechanisms
edited by and
submission deadline 31 Jan 2027 | Viewed by 302 | Submission Open
Keywords: retinal disease; age-related macular degeneration; glaucoma; genetic risk factors; WES; WGS; GWAS; functional analysis of mutations; retinal cell signaling; pathogenic mechanisms
(This special issue belongs to the Section Cellular Pathology)
Therapeutic Advances in Leukemia: Unraveling Molecular and Immune Mechanisms
edited by , Justyna Woś and
submission deadline 31 Jan 2027 | Viewed by 252 | Submission Open
Keywords: molecular diagnostics; targeted therapy; immunotherapy; genetic mutations; leukemia pathogenesis; leukemia treatment; epigenetic regulation; cancer biomarkers; hematologic malignancies
(This special issue belongs to the Section Cellular Immunology)
Neuroinflammation and Oxidative Stress in Retinal Neurodegeneration
edited by Hanhan Liu, and Pietro Bertelli
submission deadline 31 Jan 2027 | Viewed by 134 | Submission Open
Keywords: retinal degeneration; oxidative stress; neuroinflammation; mitochondrial dysfunction; gliosis
(This special issue belongs to the Section Cellular Neuroscience)
Cellular and Functional Regulation of Skeletal Muscle Performance and Dysfunction
edited by and Maha Dahawi
submission deadline 31 Jan 2027 | Viewed by 107 | Submission Open
Keywords: muscle wasting and dysfunction; chronic and critical illness; patients physical performance
(This special issue belongs to the Section Tissues and Organs)
Protein Modification and Signal Transduction in Cells
edited by Shawn Shun-Cheng Li
submission deadline 31 Jan 2027 | Viewed by 102 | Submission Open
Keywords: post-translational modification (PTM); signal transduction; phosphorylation; acetylation; methylation; ubiquitination; SUMOylation; glycosylation; cancer; drug targets; immunotherapy
(This special issue belongs to the Section Cell Signaling)
Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease—2nd Edition
edited by , Leila Gobejishvili, and Michy P. Kelly
submission deadline 31 Jan 2027 | Viewed by 82 | Submission Open
Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction
(This special issue belongs to the Section Cell Microenvironment)
Cardiac Fibroblasts, Fibrosis, and Cardiac Remodeling
edited by Alexander Widiapradja
submission deadline 31 Jan 2027 | Viewed by 42 | Submission Open
Keywords: fibroblasts; remodeling; fibrosis; extra cellular matrix; cardiac fibrosis; cardiac remodeling
(This special issue belongs to the Section Cells of the Cardiovascular System)
Critical Topics in Plant, Algae and Fungi Cell Biology
edited by
submission deadline 1 Feb 2027 | 1 articles | Viewed by 666 | Submission Open
Keywords: cells; molecules; signaling; functions; development; methods; technologies
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Stem Cells in Congenital Heart Disease: Novel Approaches and Regenerative Strategies
edited by , and Wei Shi
submission deadline 1 Feb 2027 | 1 articles | Viewed by 624 | Submission Open
Keywords: stem cell; congenital heart defect; iPSC; maturation; regeneration; cardiac arrhythmia; heart failure
(This special issue belongs to the Section Stem Cells)
Inflammation in Target Organs—Second Edition
edited by and Sarah Weksler-Zangen
submission deadline 1 Feb 2027 | Viewed by 343 | Submission Open
Keywords: inflammation; fibrosis; cardio-renal; vascular; liver; brain
(This special issue belongs to the Section Cellular Immunology)
From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring the Therapeutic Strategies
edited by , Elena Dozio and Lucia la Sala
submission deadline 1 Feb 2027 | Viewed by 116 | Submission Open
Keywords: obesity; inflammasomes; immune system; microbiota
(This special issue belongs to the Section Tissues and Organs)
Stem Cells and Beyond: Innovations in Tissue Repair and Regeneration—Second Edition
edited by Aurora Almadori
submission deadline 1 Feb 2027 | Viewed by 96 | Submission Open
Keywords: adipose-derived stem cells; mesenchymal stem cells; induced pluripotent stem cells; stromal vascular fraction; platelet-rich plasma; exosomes; polynucleotides; cytokines; growth factors; extracellular matrix; cell signaling; wound healing; aging; immune response; inflammation; scarring
(This special issue belongs to the Section Stem Cells)
Pathogenesis and Novel Therapies for Epithelial Carcinoma
edited by Jung Wook Park
submission deadline 2 Feb 2027 | Viewed by 38 | Submission Open
Keywords: transformation; malignant; oncogene; tumor suppressor; molecular mechanisms; epigenetic; metabolic; immune; biomarkers; personalized medicine; primary cells; small-molecule inhibitor
(This special issue belongs to the Section Cellular Pathology)
NF-κB Signaling in Inflammation: Molecular Mechanisms and Therapeutic Targets
edited by Gaetano Spinelli and
submission deadline 3 Feb 2027 | Viewed by 445 | Submission Open
Keywords: NF-κB signaling; inflammation; canonical and non-canonical pathways; immune regulation; post-translational modifications; signal transduction; inflammatory diseases; autoimmune disorders; cancer; tumor microenvironment; oncogenesis; metabolic diseases; neuroinflammation; therapeutic targets; drug development
Emerging Mechanisms and Therapeutic Strategies in Head and Neck Cancer submission deadline 10 Feb 2027 | 6 articles | Viewed by 8946 | Submission Open
Keywords: tumor microenvironment; epithelial–mesenchymal transition (EMT); tumor–stroma interaction; treatment resistance; radiotherapy sensitization; targeted therapy; precision oncology
Immune Cell Signaling Networks in Tumor and Regenerative Stem Cell Niches
edited by
submission deadline 10 Feb 2027 | 1 articles | Viewed by 820 | Submission Open
Keywords: tumor microenvironment; stem cell niche; macrophage polarization; T-cell activation; immune checkpoints; targetable signaling pathways; engineered biomaterials; immune signaling in 3D culture; organ-on-chip models; single-cell omics
(This special issue belongs to the Section Stem Cells)
The Power of Small Molecules in Cancer
edited by
submission deadline 10 Feb 2027 | Viewed by 89 | Submission Open
Keywords: small molecule; cancer therapy; kinase inhibitors
(This special issue belongs to the Section Cell and Gene Therapy)
Cellular and Molecular Mechanisms of Tumor Biology
edited by
submission deadline 10 Feb 2027 | Viewed by 10 | Submission Open
Keywords: tumorigenesis; signaling pathways; tumor immune responses; tumor microenvironment; tumor metabolism; tumor therapy; tumor stem cells; invasion and metastasis
(This special issue belongs to the Section Cellular Pathology)
Ischemic Heart Disease: From Cellular Level to Clinical Approaches submission deadline 15 Feb 2027 | 3 articles | Viewed by 5072 | Submission Open
Keywords: ischemic heart disease; myocardial ischemia; reperfusion injury; oxidative stress; mitochondrial dysfunction; cardiomyocyte death; endothelial dysfunction; inflammation; fibrosis; epigenetics; non-coding RNAs; immunometabolism; single-cell transcriptomics; angiogenesis; ischemic preconditioning; nanomedicine; molecular cardiology; targeted therapy
Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health
edited by
submission deadline 15 Feb 2027 | 2 articles | Viewed by 3294 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines
The Role of Mitochondria in Health, Disease, and Ageing submission deadline 15 Feb 2027 | 2 articles | Viewed by 2188 | Submission Open
Keywords: mitochondrial dysfunction; metabolism; mitochondrial genetics; aging and senescence; bioenergetics; mitophagy; neurodegeneration; cardiomyopathy; metabolic syndrome; ocular diseases
(This special issue belongs to the Section Mitochondria)
NAMs (New Approach Methodologies) and Neural Stem Cells
edited by Tongguang Wang
submission deadline 15 Feb 2027 | 2 articles | Viewed by 1858 | Submission Open
Keywords: neural stem cells (NSCs); brain organoids; neurodevelopmental disorders; human pluripotent stem cells (hPSCs); translational neuroscience; new approach methodologies
(This special issue belongs to the Section Stem Cells)
Remyelination: From Molecular Mechanism to Therapy submission deadline 15 Feb 2027 | 1 articles | Viewed by 1575 | Submission Open
Keywords: demyelination; oligodendroglia differentiation; regenerative therapies; myelin disease; neurodegeneration
Role of Macrophages in Tissue Repair
edited by
submission deadline 15 Feb 2027 | 1 articles | Viewed by 1049 | Submission Open
Keywords: macrophages; inflammation; tissue repair; phagocytosis
(This special issue belongs to the Section Tissues and Organs)
Organoids as Next-Generation Preclinical Models of Disease Progression
edited by Ralf Weiskirchen, Anjali A. J. Roeth and
submission deadline 15 Feb 2027 | 1 articles | Viewed by 677 | Submission Open
Keywords: patient-derived organoids; longitudinal disease modelling; neurodegeneration progression; drug resistance; precision medicine; chronic inflammation; tumor evaluation
Harnessing the Immune System: Emerging Therapeutic Strategies in Cancer
edited by Kishan Shamjibhai Italiya
submission deadline 15 Feb 2027 | Viewed by 268 | Submission Open
Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; adoptive cell therapy; cancer vaccines; T cell therapy; immuno-oncology; tumor immune evasion; immune modulation; antitumor immunity
(This special issue belongs to the Section Cellular Immunology)
Multi-Omics in the Cellular Microenvironment
edited by Emilio S. Rivera and Katerina Djambazova
submission deadline 15 Feb 2027 | Viewed by 263 | Submission Open
Keywords: cellular microenvironment; single-cell analysis; multi-omics; immunofluorescence microscopy; imaging mass spectrometry
(This special issue belongs to the Section Cell Methods)
Oxidative Stress in Disease and Health
edited by Tatsuya Mimura
submission deadline 17 Feb 2027 | Viewed by 11 | Submission Open
Keywords: oxidative stress; reactive oxygen species; redox homeostasis; antioxidant defense; cellular signaling; mitochondrial dysfunction; cellular metabolism; apoptosis; ferroptosis; autophagy; inflammation; cellular senescence; aging; redox biology
(This special issue belongs to the Section Cellular Pathology)
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