Recent Insights into the Role of Metal Ions in the Nervous System

Dear Colleagues,

Metal ions play indispensable roles in nervous system development, function, and plasticity, acting as essential cofactors in enzymatic reactions, modulators of synaptic transmission, and regulators of intracellular signalling pathways. In recent years, advances in molecular neuroscience, imaging, genetics, and metallomics have substantially expanded our understanding of how metal ions such as zinc, copper, iron, magnesium, calcium, and lithium influence neuronal excitability, circuit maturation, neuroimmune interactions, and behaviour.

This Special Issue, “Recent Insights into the Role of Metal Ions in the Nervous System”, will highlight emerging discoveries helping to elucidate the physiological roles of metal ions across molecular, cellular, circuit, and systems-level neuroscience. Topics of interest include, but are not limited to, metal ion homeostasis, metal-dependent synaptic and neuromodulatory mechanisms, interactions between metal ions and neurotransmitter systems, and the contribution of metal dyshomeostasis to neurodevelopmental, neuropsychiatric, and neurodegenerative disorders.

We welcome original research articles, reviews, and perspectives that integrate experimental, computational, or translational approaches to advance our mechanistic understanding of metal ion signalling in the nervous system and to identify novel therapeutic targets or biomarkers.

Prof. Dr. Richard H. Dyck
Guest Editor

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