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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Retinoic Acid and Retinoid X Receptors - Series II

edited by

Michael Schubert

and

Pierre Germain

submission deadline 30 Jun 2026 | Viewed by 468 | Submission Open

Keywords: nuclear receptor signaling; retinoic acid receptor; retinoid X receptor; pharmacology; structure/function relationships; genomic and non-genomic signaling; post-translational modification; homeostasis and disease; development; origin and evolution

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk

edited by Aparna Renigunta and

Poornima Mahavadi

submission deadline 30 Jun 2026 | Viewed by 306 | Submission Open

Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation

Nuclear Pore Complex in Nanomedicine: Third Edition

edited by

Richard W. Wong

submission deadline 30 Jun 2026 | Viewed by 256 | Submission Open

Keywords: intracellular transport; NPC; mitosis; nano; cancer; brain

Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke

edited by

William James Antonisamy

Zahoor Shah

and Moorthi Ponnusamy

submission deadline 30 Jun 2026 | Viewed by 196 | Submission Open

Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death

(This special issue belongs to the Section Cells of the Nervous System)

Protein and RNA Regulation in Cells

edited by

Delai Huang

and

Denis Mottet

submission deadline 30 Jun 2026 | Viewed by 192 | Submission Open

Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay

The Role of PPARs in Disease - Volume IV

edited by

Kay-Dietrich Wagner

and

Nicole Wagner

submission deadline 30 Jun 2026 | Viewed by 128 | Submission Open

Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular and Molecular Mechanisms of Hepatobiliary Diseases

edited by

Stefan Hoehme

and

Jan G. Hengstler

submission deadline 30 Jun 2026 | Viewed by 122 | Submission Open

Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models

(This special issue belongs to the Section Tissues and Organs)

Bone and Tooth Biology: Development and Regeneration

edited by Xiaofang Wang

submission deadline 30 Jun 2026 | Viewed by 85 | Submission Open

Keywords: bone; tooth; osteogenesis; odontogenesis; enamel; dentin; cementum; amelogenesis; dentinogenesis; regeneration; stem cells

Mitochondrial Dynamics and Remodelling

edited by Edmund Carvalho

submission deadline 30 Jun 2026 | Viewed by 82 | Submission Open

Keywords: mitochondrial dynamics; fission; fusion; mitophagy; cristae remodeling; bioenergetics; ER– mitochondria contacts; immune reprogramming; signaling pathways; therapeutic targeting

Tau Pathobiology and Excitotoxicity in Neurodegeneration and Epilepsy

edited by Janet Van Eersel

submission deadline 30 Jun 2026 | Viewed by 60 | Submission Open

Keywords: tau; excitotoxicity; dementia; epilepsy; seizures; hyperexcitation

Neural Stem Cells and Progenitors: Mechanisms of Neurogenesis and Regenerative Potential

edited by Lidia De Filippis and Maurizio Gelati

submission deadline 30 Jun 2026 | Viewed by 60 | Submission Open

Keywords: neural stem cells; cancer stem cells; neuroregeneration; neurodegenerative diseases; CNS; neurorepair; neurogenesis; neuroinflammation

The Immunology of Allergy and Asthma

edited by

Charles Pilette

and

Valerie Hox

submission deadline 30 Jun 2026 | Viewed by 41 | Submission Open

Keywords: type 2 immunity; rhinitis; food allergy; anaphylaxis; drug allergy; dermatitis; eczema; airway inflammation; IgE response; tissue remodelling; disease remission

Role of Macrophages in Tissue Repair

edited by

Guochang Hu

submission deadline 30 Jun 2026 | Viewed by 34 | Submission Open

Keywords: macrophages; inflammation; tissue repair; phagocytosis

(This special issue belongs to the Section Tissues and Organs)

Multifaceted Nature of Immune Responses to Viral Infection

edited by Homayon Ghiasi and Susmit Suvas

submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open

Keywords: viral infection; innate and adaptive immunity; protection; RNA and DNA viruses; autoimmunity; immune escape

Inflammation in Target Organs—Second Edition

edited by

Itamar Raz

submission deadline 30 Jun 2026 | Viewed by 4 | Submission Open

Keywords: inflammation; fibrosis; cardio-renal; vascular; liver; brain

(This special issue belongs to the Section Cellular Immunology)

Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease

edited by

Ethan Shevach

and Akshat Sharma

submission deadline 5 Jul 2026 | Viewed by 2259 | Submission Open

Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms

(This special issue belongs to the Section Cellular Pathology)

Biochemical Interaction and Supramolecular Complexes of Receptors in Cell Membranes

edited by

Michela Corsini

and

Stefania Mitola

submission deadline 8 Jul 2026 | Viewed by 666 | Submission Open

Keywords: membrane receptors; molecular complex; membrane microdomains

Experimental Systems to Model Aging Processes

edited by

Natascia Tiso

Giovanni Risato

and Ralf Dahm

submission deadline 10 Jul 2026 | 4 articles | Viewed by 8006 | Submission Open

Keywords: aging; ageing; age-related; longevity; model; animal; signalling pathway; mechanism; in vitro; in vivo; cell culture; marker

(This special issue belongs to the Section Cellular Aging)

Inflammation in the Brain: From Molecular and Cellular Mechanisms to Therapeutic Strategies

edited by Sujatha Kannan and

Elizabeth Winans Tucker

submission deadline 15 Jul 2026 | Viewed by 82 | Submission Open

Keywords: neuroinflammation; microglia; astrocytes; immune signaling; neurodegeneration; neuroimmunology; brain injury; therapeutic strategies

Role of Hippo Signaling in Cancer

edited by

Dimpi Mukhopadhyay

and

Alessio D'Alessio

submission deadline 15 Jul 2026 | Viewed by 74 | Submission Open

Keywords: angiogenesis; cancer metabolism; cancer stemness; chemoresistance; endothelial cell plasticity; epithelial-to-mesenchymal transition (EMT); hippo signaling pathway; immunotherapy; mechanotransduction; targeted cancer therapy; TEAD transcription factors; therapeutic resistance; tumor microenvironment; tumorigenesis; YAP/TAZ; new therapeutic modalities to target YAP/TAZ-driven tumors including ferroptosis

(This special issue belongs to the Section Cell Signaling)

Novel Molecular Targets for the Treatment of Sleep Disorders

edited by

Dae-Wui Yoon

submission deadline 25 Jul 2026 | Viewed by 298 | Submission Open

Keywords: sleep disorders; molecular targets; glymphatic system; neuroinflammation; circadian rhythms; microbiome; biomarkers; pharmacological therapy; gene therapy; neurodegeneration

Mitochondria in Cancer Immune Evasion and Immunotherapy

edited by Loredana Moro and

Flora Guerra

submission deadline 30 Jul 2026 | Viewed by 35 | Submission Open

Keywords: mitochondria; mtDNA; immunity; cancer immune evasion; tumor microenvironment; immune tolerance; lymphocytes; inflammation; immune response

(This special issue belongs to the Section Cellular Immunology)

Advances in the Discovery of Retinal Degeneration

edited by

Ram Prasad

and

Yvonne Adu-Rutledge

submission deadline 31 Jul 2026 | 4 articles | Viewed by 5757 | Submission Open

Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood– retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology

(This special issue belongs to the Section Cellular Pathology)

How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies

edited by

Agnieszka Bojarska-Junak

and

Michal Zarobkiewicz

submission deadline 31 Jul 2026 | 4 articles | Viewed by 5220 | Submission Open

Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention

(This special issue belongs to the Section Cell Microenvironment)

Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities

edited by

Thomas Nicholson

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3927 | Submission Open

Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies

(This special issue belongs to the Section Cellular Pathology)

Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health

edited by

Aaron C. Brown

submission deadline 31 Jul 2026 | Viewed by 295 | Submission Open

Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines

Molecular Research in Osteoporosis

edited by

Virginia Visconti

Annalisa Botta

and

Umberto Tarantino

submission deadline 31 Jul 2026 | Viewed by 223 | Submission Open

Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy

(This special issue belongs to the Section Cellular Pathology)

Immunometabolic Reprogramming in Diabetic Kidney Disease: The Interplay of Innate Immunity, Oxidative Stress, and Cellular Metabolism

edited by

Nela Kelam

, Sandra Kostić and Anita Racetin

submission deadline 31 Jul 2026 | Viewed by 168 | Submission Open

Keywords: diabetic kidney disease; immunometabolism; innate immunity; oxidative stress; metabolic reprogramming; inflammasome; renal fibrosis; mitochondrial dysfunction; non-coding RNAs; multi-omics integration

ALK Signaling Pathways in NSCLC: From Cell Biology to Therapeutic Insights

edited by

Edyta Maria Urbanska

and

Eric Santoni-Rugiu

submission deadline 31 Jul 2026 | Viewed by 58 | Submission Open

Keywords: anaplastic lymphoma kinase (ALK); non-small-cell lung cancer (NSCLC); ALK tyrosine kinase inhibitors (ALK-TKIs); drug resistance; signal transduction and oncogenic pathways; molecular diagnostics (IHC; FISH; NGS); targeted therapy

Extracellular Vesicles: Drivers, Biomarkers, and Therapeutics in Cardiovascular Disease

edited by

Prabhu Mathiyalagan

submission deadline 31 Jul 2026 | Viewed by 45 | Submission Open

Keywords: cardiovascular disease; extracellular vesicles; biomarkers; therapeutics; drug delivery; RNA therapeutics; fibrosis; atherosclerosis; liquid biopsy

Recent Advances in Vitamin D and K in Cancer

edited by

Alexandra M. Crǎciun

Ciprian N. Silaghi

and

Andreea Crintea

submission deadline 31 Jul 2026 | Viewed by 2 | Submission Open

Keywords: vitamin D; vitamin K; VDR signaling; tumor microenvironment; cancer prevention; molecular pathways; apoptosis and proliferation; oxidative stress; immunomodulation; therapeutic resistance

Study on Ovarian Follicle Development

edited by Cecily V. Bishop and Jessica Cristina Lemos Motta

submission deadline 10 Aug 2026 | Viewed by 167 | Submission Open

Keywords: follicular development; ovarian follicle activation; ovarian reserve; in vitro follicle culture; translational reproductive biology

Cellular and Molecular Mechanisms of Abiotic Stress Tolerance in Plants

edited by Aziz Khan and

Xin Zhang

submission deadline 25 Aug 2026 | 2 articles | Viewed by 8497 | Submission Open

Keywords: abiotic stress; molecular mechanism; gene expression; cellular adaptation; signal transduction; plant physiology; molecular pathway; stress resilience; crop productivity; agronomic performance

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Gut Microbiota, Metabolites, and Immune Regulation in Gastrointestinal Diseases

edited by

Sweta Ghosh

and Subir Kumar Juin

submission deadline 31 Aug 2026 | Viewed by 146 | Submission Open

Keywords: gut microbiota; microbial metabolites; inflammation; immunology; gut-barrier; gastrointestinal disease

Turning Points in α-Synuclein Biology: From Function to Dysfunction

edited by

Quan Zhong

and

Ishita Haider

submission deadline 31 Aug 2026 | Viewed by 29 | Submission Open

Keywords: α -synuclein; protein aggregation; pathological conversion; synucleinopathies; Parkinson’ s disease; neurodegeneration; neurotoxicity; proteostasis; mitochondrial dysfunction; autophagy

(This special issue belongs to the Section Cells of the Nervous System)

Novel Insights into G-Protein-Coupled Receptor Biology: From Structure to Signaling Regulation

edited by

Bianca Fiorillo

and Bruno Catalanotti

submission deadline 31 Aug 2026 | Viewed by 11 | Submission Open

Keywords: GPCR signaling; structure– function; allosteric modulation; receptor; homology modeling; computational chemistry; AI-based prediction; signal transduction; cellular regulation

Lipid Homeostasis in Health and Disease

edited by

Vitor Teixeira

submission deadline 20 Sep 2026 | Viewed by 117 | Submission Open

Keywords: lipids; metabolism; homeostasis; disease mechanisms; biomarkers; therapeutic targets; nutrition; cellular signaling; systems biology

Stem Cells and Metabolism in Acute Myeloid Leukemia: Mechanisms, Models, and Therapeutic Opportunities

edited by

Giovannino Silvestri

, Aditi Chatterjee and Maria Baer

submission deadline 25 Sep 2026 | Viewed by 445 | Submission Open

Keywords: AML; leukemic stem cells; hypoxia; metabolism; fatty-acid oxidation; one-carbon metabolism; proteostasis; bone-marrow niche; multi-omics; metabolic inhibitors

Antioxidants in Redox Homeostasis of Plant Development

edited by

Dragana Z. Jakovljević

and

Milan Stankovic

submission deadline 30 Sep 2026 | 3 articles | Viewed by 6799 | Submission Open

Keywords: reactive oxygen species; radical scavenging; oxidative stress; plant growth and development; primary and secondary metabolites

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Stress Signaling and Cell Fate Determination: The Role of Mitochondria

edited by

Daniel Maddison

and

Bilal Malik

submission deadline 30 Sep 2026 | Viewed by 129 | Submission Open

Keywords: mitochondria; cell death; integrated stress response; retrograde signaling; apoptosis; necroptosis; ferroptosis; mitophagy; mitochondrial dynamics; ROS; calcium signaling; inter-organelle communication

Heat Shock Proteins and Human Cancers—2nd Edition

edited by

Alexander Kabakov

submission deadline 30 Sep 2026 | Viewed by 39 | Submission Open

Keywords: heat shock protein; glucose-regulated protein; cancer; tumorigenesis; theranostics; anticancer vaccine

Role of Endothelial Progenitor Cells in Vascular Dysfunction

edited by

Catherine Yzydorczyk

submission deadline 30 Sep 2026 | Viewed by 29 | Submission Open

Keywords: cardiovascular diseases; endothelial progenitor cells; vasculogenesis; angiogenesis; inflammation; oxidative stress; cellular senescence; developmental programming; cellular therapy

Caveolae Function in Cell Membrane Dynamics and Signal Transduction

edited by

Alessio D'Alessio

and

Antonio Filippini

submission deadline 25 Oct 2026 | Viewed by 121 | Submission Open

Keywords: caveolae; caveolin and cavin proteins; plasma membrane organization; endocytosis and vesicular trafficking; mechanotransduction; lipid rafts and cholesterol metabolism; signal transduction; vascular biology and angiogenesis; cancer cell biology; membrane remodeling in disease

Neurotoxicity: Focusing on Molecular and Cellular Mechanisms

edited by

Pablo Martín-Vasallo

, Manuel José Morales and

Rita Martín-Ramírez

submission deadline 31 Oct 2026 | Viewed by 59 | Submission Open

Keywords: neurotoxicity; neuroinflammation; neurodegeneration; chemotherapy-induced neuropathy; neuroprotection; neuronal injury

Role of Inflammasomes in Neurological Disorders

edited by

Juan Pablo de Rivero Vaccari

submission deadline 1 Nov 2026 | Viewed by 24 | Submission Open

Keywords: inflammasome; pyroptosis; caspase-1; ASC specks; IL-1beta; PANoptosis; CNS injury; neurodegenerative diseases; biomarkers; Alzheimer’ s disease; Parkinson’ s disease; multiple sclerosis; amyotrophic lateral sclerosis

(This special issue belongs to the Section Cells of the Nervous System)

Harnessing the Tumor Microenvironment and Signaling Pathways for Precision Cancer Therapy

edited by Behzad M. Toosi and

Andrew Freywald

submission deadline 30 Nov 2026 | 2 articles | Viewed by 5001 | Submission Open

Keywords: tumor microenvironment (TME); signaling pathways; precision cancer therapy; immune evasion; metabolic pathways; tumor– stroma interactions; therapeutic targets; personalized medicine; cancer metastasis; molecular oncology

(This special issue belongs to the Section Cell Microenvironment)

Mechanisms of Transcriptional Regulation in Disease: From Chromatin Dynamics to Therapeutic Innovation

edited by Valentina Caputo and Joana R. Costa

submission deadline 30 Nov 2026 | Submission Open

Keywords: transcription regulation; epigenomics; multi-omics; non-coding genome; chromatin architecture/dynamics; enhancers

(This special issue belongs to the Section Cell and Gene Therapy)

Current Status and Future Challenges of Liquid Biopsy—2nd Edition

edited by

Kenichi Suda

and

Shuta Ohara

submission deadline 1 Oct 2027 | Viewed by 192 | Submission Open

Keywords: minimal residual disease (MRD); ctDNA; cfDNA; heterogeneity; comprehensive genomic profiling; biomarker; diagnosis; personalization; prognostic marker

Displaying special issue 601-650 on page 13 of 13.

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