Neural Stem Cells and Progenitors: Mechanisms of Neurogenesis and Regenerative Potential
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 June 2026 | Viewed by 72
Special Issue Editors
Interests: neuroscience; immunology; rare diseases; inflammation
Interests: biological science; neuroscience; neural stem cells
Special Issue Information
Dear Colleagues,
Neural stem cells (NSCs) play a fundamental role in the development of the central nervous system (CNS), both during prenatal and postnatal stages, and contribute to tissue repair and maintenance throughout aging. NSCs possess key properties such as self-renewal, proliferation, and multipotency, and can be cultured in vitro as three-dimensional neurospheres. Under appropriate conditions, NSCs give rise to transiently amplifying neural progenitor cells (NPCs), which can differentiate into the three major neural cell types: neurons, astrocytes, and oligodendrocytes.
Over the past three decades, both NSCs and NPCs have served as valuable systems for disease modeling, enabling studies on brain tumors and neurological disorders, as well as potential sources for regenerative therapies targeting neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), stroke, and multiple sclerosis (MS). These advances have significantly deepened our understanding of neurogenesis and the therapeutic potential of stem cell-based approaches in the CNS.
This Special Issue aims to highlight recent progress in NSC isolation and characterization, NPC differentiation methodologies, and preclinical evidence demonstrating their in vivo functions and therapeutic applications. We welcome original research articles, reviews, and methodological papers that provide new insights into NSC and NPC biology, neurogenesis, and regenerative medicine.
Dr. Lidia De Filippis
Dr. Maurizio Gelati
Guest Editors
Manuscript Submission Information
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Keywords
- neural stem cells
- cancer stem cells
- neuroregeneration
- neurodegenerative diseases
- CNS
- neurorepair
- neurogenesis
- neuroinflammation
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