Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Phytofactories: From Lab to Applications submission deadline 15 Mar 2026 | Viewed by 309 | Submission Open
Keywords: plant cell suspension cultures; phytofactories; bioprocess; specialty molecules; metabolic engineering; germplasm preservation
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Role of Ras-Regulated Signal Pathways
edited by
submission deadline 15 Mar 2026 | Viewed by 287 | Submission Open
Keywords: Ras-regulated signaling pathway; MAPK/ERK pathway; PI3K/AKT pathway; Ral-GDS pathway
(This special issue belongs to the Section Cell Signaling)
Glioblastoma Horizons: Exploring Mechanisms and Advancing Therapeutic Strategies
edited by Yang Wu and Julio Plata-Bello
submission deadline 15 Mar 2026 | Viewed by 283 | Submission Open
Keywords: glioblastoma heterogeneity; tumor microenvironment; 3D cell culture models; therapeutic resistance mechanisms; immunotherapy
Retinal Pigment Epithelium Dysfunction in Retinal Disorders: Pathophysiology and Therapeutic Strategies
edited by and Sushma Kalmodia
submission deadline 15 Mar 2026 | Viewed by 98 | Submission Open
Keywords: retinal pigment epithelium (RPE); inherited retinal disease; RPE dysfunction
(This special issue belongs to the Section Tissues and Organs)
Host–Pathogen Interactions and Immune Responses
edited by Harish Chandra
submission deadline 15 Mar 2026 | Viewed by 96 | Submission Open
Keywords: multidrug-resistant bacteria; environmental mycobacteria; exosomes; oxidative stress; catalases; antimicrobial resistance; polycyclic aromatic hydrocarbons (PAHs); cellular signaling
(This special issue belongs to the Section Cellular Immunology)
Brain Injury: Traumatic and Non-Traumatic Pathophysiology, Translational Approaches and Novel Treatment Strategies
edited by Thomas Kapapa, and Andreas Pfnür
submission deadline 15 Mar 2026 | Viewed by 84 | Submission Open
Keywords: traumatic brain injury; stroke; blood– brain barrier; neuroinflammation; neuroimmunology
(This special issue belongs to the Section Tissues and Organs)
Targeting Metabolic Vulnerabilities to Selectively Eliminate Cancer Cells
edited by Nina Semenova and
submission deadline 15 Mar 2026 | Viewed by 72 | Submission Open
Keywords: cancer cell metabolism; cancer cell signaling pathways; cancer epigenetic regulation; nutrient deprivation; tumor microenvironment; chemotherapy; chemoresistance; radiotherapy; cell death
Molecular Pathogenesis and Therapeutic Breakthroughs in Cutaneous Malignancies: From Melanoma to Lymphoma
edited by
submission deadline 15 Mar 2026 | Viewed by 54 | Submission Open
Keywords: skin cancer; melanoma; Merkel cell carcinoma; skin lymphoma; squamous cell carcinoma; Mycosis fungoides; adnexal tumors; Sebaceous carcinoma; cutaneous soft tissue tumors
Primary and Continued Cell Cultures
edited by
submission deadline 20 Mar 2026 | 5 articles | Viewed by 46111 | Submission Open
Keywords: primary normal cells; primary tumor cells; patient-derived cells; CRC (conditionally reprogrammed cells); organoids; circulating tumor cells; human diseases; toxicity; cancer models; drug discovery
(This special issue belongs to the Section Cell Methods)
Organoids as an Experimental Tool
edited by , and Anjali A. J. Roeth
submission deadline 20 Mar 2026 | 10 articles | Viewed by 29862 | Submission Open
Keywords: organoid culture models; primary cell and cancer spheroid models; organotypic models; organoid research for animal replacement (3R); chip-based methods; general 3D cell culture protocols; in silico approaches; microinjection apical-out organoids; organoid manipulation techniques; organoid intelligence; organoids in diagnostics; imaging in organoids
(This special issue belongs to the Section Tissues and Organs)
The Role of Cellular Senescence in Health, Disease, and Aging
edited by
submission deadline 20 Mar 2026 | 8 articles | Viewed by 24526 | Submission Open
Keywords: apoptosis; cancer; cell cycle; DNA damage; metabolic diseases; oxidative stress; senolysis; senescence; therapeutic approach
(This special issue belongs to the Section Cellular Aging)
Highlights in Red Blood Cell Research submission deadline 20 Mar 2026 | 3 articles | Viewed by 21551 | Submission Open
Keywords: red blood cells; anemia; transfusion; erythropoiesis; signaling
New Advances and Perspectives in Nanotechnology for the Treatment of Cancer Cells submission deadline 20 Mar 2026 | 8 articles | Viewed by 21042 | Submission Open
Keywords: nanotechnology; immunotherapeutics; cancer biotherapeutics; proliferation; regulating factors; cell culture; biomedical application; nutraceuticals; cancer treatment
(This special issue belongs to the Section Cell Methods)
Insight into Cardiomyopathy
edited by Sobuj Mia
submission deadline 20 Mar 2026 | 1 articles | Viewed by 17154 | Submission Open
Keywords: heart failure; ventricular dysfunction; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac fibrosis; cardiac hypertrophy; biomarkers
(This special issue belongs to the Section Cells of the Cardiovascular System)
Advances and Breakthroughs in Stem Cell Research submission deadline 20 Mar 2026 | 2 articles | Viewed by 8331 | Submission Open
Keywords: stem cell; induced pluripotent stem cell; iPSC; hematopoietic stem cell
(This special issue belongs to the Section Stem Cells)
New Concepts Relating Mesenchymal Tumors Based on Genetics and Epigenetics
edited by
submission deadline 20 Mar 2026 | 4 articles | Viewed by 8208 | Submission Open
Keywords: mesenchymal tumors; soft tissue; sarcoma; genetics; epigenetics
(This special issue belongs to the Section Cell Microenvironment)
Targeting Tumor Microenvironments for Enhanced Cancer Immunotherapy
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 2389 | Submission Open
Keywords: tumor microenvironment; cancer immunotherapy; immune modulation; immunosuppressive mechanisms; combination therapies
(This special issue belongs to the Section Cell Microenvironment)
Human Immunodeficiency Virus/Simian Immunodeficiency Virus and Host Interactions
edited by and Susanta Pahari
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1628 | Submission Open
Keywords: HIV/SIV/SHIV infection; rhesus macaques; host immunity; chronic inflammation; mucosal immunity; immune evasion; therapeutic intervention; immune checkpoints; microbiota; substance use
(This special issue belongs to the Section Cellular Immunology)
Protein Misfolding and Aggregation: From Molecular Mechanisms to Human Diseases
edited by Xinrui Gui and Jinjun Wu
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1505 | Submission Open
Keywords: protein aggregation; amyloid fibrils; protein quality control; neurodegenerative diseases
(This special issue belongs to the Section Cellular Biophysics)
Targeting Cellular Microenvironment in Aging and Disease
edited by and Egor Dzyubenko
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1420 | Submission Open
Keywords: proteoglycans; glycans; glycoproteins; matricellular proteins; integrins; matrix metalloproteinases; extracellular vesicles; EV release; exosomes; extracellular scaffold; ECM remodeling; fibrosis; ECM gene therapy; ECM pharmacology; synthetic ECM
(This special issue belongs to the Section Cellular Aging)
Cell Biology: The State of the Art and Perspectives in Japan 2025
edited by
submission deadline 20 Mar 2026 | Viewed by 636 | Submission Open
Keywords: cell biology; physiology; molecular biology
Cancer Cell Signaling, Autophagy and Tumorigenesis
edited by Debanjan Bhattacharya
submission deadline 20 Mar 2026 | Viewed by 207 | Submission Open
Keywords: cancer cell signaling; autophagy; tumorigenesis; PI3K/AKT/mTOR pathway; Ras/Raf/MEK/ERK (MAPK) pathway
Chronic Obstructive Pulmonary Disease (COPD): From Molecular and Cellular Mechanisms to Therapeutic Opportunities
edited by , Bradley W. Richmond and
submission deadline 20 Mar 2026 | Viewed by 161 | Submission Open
Keywords: chronic obstructive pulmonary disease (COPD); small airway disease; vascular remodeling; emphysema
(This special issue belongs to the Section Cellular Immunology)
Cell and Molecular Mechanisms of Cytogenesis submission deadline 20 Mar 2026 | Viewed by 129 | Submission Open
Keywords: cytogenesis; central nervous system; neurogenesis; gliogenesis; neuroplasticity; signaling pathways; cell proliferation; differentiation; CNS homeostasis; neuropsychiatric and neurodegenerative disorders
Novel Insights into Endothelial Cells in Vascular Disease
edited by
submission deadline 20 Mar 2026 | Viewed by 77 | Submission Open
Keywords: endothelial cells; vascular diseases; vascular signaling
Cellular and Molecular Mechanisms of Neurotoxicity
edited by , , Tiziana Cotrufo and
submission deadline 20 Mar 2026 | Viewed by 49 | Submission Open
Keywords: neurotoxicity; neurodegeneration; neuronal cell death; neurodegenerative disorders; nerve regeneration; heavy metals; air pollution; endogenous neurotoxins; oxidative stress; glutamate
Lipid Homeostasis: Mechanisms, Regulation, and Implications for Health and Disease
edited by and Museer Ahmad Lone
submission deadline 25 Mar 2026 | 3 articles | Viewed by 2546 | Submission Open
Keywords: lipid metabolism; lipid synthesis and degradation; triglyceride storage; fatty acid oxidation; cholesterol homeostasis; adipogenesis; lipid droplets; lipid signaling pathways; lipid transport proteins; phospholipid balance; sphingolipid metabolism; sterol regulatory element-binding proteins (SREBPs); AMP-activated protein kinase (AMPK); peroxisome proliferator-activated receptors (PPARs); insulin signaling and lipid storage; endoplasmic reticulum stress and lipids; lipoprotein metabolism; non-alcoholic fatty liver disease (NAFLD); lipidomics; autophagy and lipid recycling; lysosomal lipid degradation; lipid-binding proteins; oxidized lipids; lipid imbalance and disease; energy homeostasis and lipid storage; lipid transport vesicles; membrane lipid composition; lipid peroxidation; lipid-related genetic disorders; nutrient sensing and lipid regulation
(This special issue belongs to the Section Cellular Biophysics)
The Silent Regulators: Non-Coding RNAs in Cell Function and Disease submission deadline 25 Mar 2026 | 2 articles | Viewed by 1571 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs (lncRNAs); regulatory RNAs; RNA interference; epigenetic regulation; RNA editing; cellular signaling; disease biomarkers; RNA therapeutics
(This special issue belongs to the Section Cell and Gene Therapy)
Gene Editing Therapies for Hereditary Diseases submission deadline 25 Mar 2026 | Viewed by 238 | Submission Open
Keywords: gene therapy; base editing; prime editing; genome editing; hereditary diseases
(This special issue belongs to the Section Cell and Gene Therapy)
Ischemic Heart Disease: From Cellular Level to Clinical Approaches submission deadline 25 Mar 2026 | Viewed by 138 | Submission Open
Keywords: ischemic heart disease; myocardial ischemia; reperfusion injury; oxidative stress; mitochondrial dysfunction; cardiomyocyte death; endothelial dysfunction; inflammation; fibrosis; epigenetics; non-coding RNAs; immunometabolism; single-cell transcriptomics; angiogenesis; ischemic preconditioning; nanomedicine; molecular cardiology; targeted therapy
Cell and Molecular Mechanisms of Bacterial Meningitis submission deadline 25 Mar 2026 | Viewed by 106 | Submission Open
Keywords: bacterial meningitis; innate immunity; inflammation; immune response; central nervous system; neuron; microglia; astrocytes; granulocytes; blood– brain barrier
From Signals to Shape: Molecular Control of Cellular Plasticity Through Epigenetic, Transcriptomic, and Immune Mechanisms submission deadline 25 Mar 2026 | Viewed by 93 | Submission Open
Keywords: cellular plasticity; epigenetics; transcriptomics; mechanotransduction; immune signaling; cell fate regulation; RNA methylation; biomaterials interaction; molecular cytology; cell adaptation
Mitochondria: Multifaceted Regulators of Cell Death
edited by Rasa Banienė and Sonata Trumbeckaite
submission deadline 25 Mar 2026 | Viewed by 92 | Submission Open
Keywords: mitochondria; cell death; multifaceted regulators; reactive oxygen species (ROS); cell metabolism; mitochondrial transfer
Breaking the Balance: Cellular Stress, Proteostasis, Aggregates and Neurodegeneration
edited by
submission deadline 25 Mar 2026 | Viewed by 75 | Submission Open
Keywords: proteostasis; cellular stress; protein aggregation; neurodegeneration; autophagy; unfolded protein response; oxidative stress; aging; molecular chaperones; protein quality control
Cancer Stem Cells in Triple-Negative Breast Cancer submission deadline 25 Mar 2026 | Viewed by 70 | Submission Open
Keywords: cancer stem cells; TNBC; signal pathways; epithelial– mesenchymal transition; tumor microenvironment; targeted therapy; biomarkers
Molecular Mechanisms of Trophoblast Differentiation
edited by Milica Jovanović Krivokuća and
submission deadline 25 Mar 2026 | Viewed by 67 | Submission Open
Keywords: trophoblast differentiation; cytotrophoblast; syncytiotrophoblast; extravillous trophoblast; trophoblast stem cells; molecular mechanisms; signaling pathways; epigenetic regulation
Biomarkers and Therapeutic Targets in Insulin Resistance
edited by
submission deadline 30 Mar 2026 | 1 articles | Viewed by 1875 | Submission Open
Keywords: insulin resistance; biomarkers; therapeutic targets; type 2 diabetes; metabolic syndrome; obesity; molecular mechanisms; pharmacologic treatments; precision medicine; cardiovascular diseases
(This special issue belongs to the Section Cellular Pathology)
Neuroimaging of Cerebrovascular Diseases
edited by Dragan Stojanov
submission deadline 30 Mar 2026 | Viewed by 143 | Submission Open
Keywords: neuroimaging; cerebrovascular diseases; stroke; intracerebral hemorrhage; SAHA neurysms; AVM; small vessels diseases; CT; MRI; advance MRI techniques; DSA; AI
Mechanisms of miRNA Metabolism and Extracellular Transport submission deadline 30 Mar 2026 | Viewed by 121 | Submission Open
Keywords: miRNA metabolism; miRNA transport; miRNA exchange; miRNA storage; mRNA biogenesis; extracellular vesicles and miRNA; non-EV miRNA export; miRNA binding proteins; miRNA sponge and inhibitors; miRNA biomarkers
Novel Insights into Cancer Immune Responsiveness submission deadline 30 Mar 2026 | Viewed by 97 | Submission Open
Keywords: cancers; tumors; immune cells; tumor immunology; cancer immunology; onco-immunology; immunotherapies; resistance; immunotherapy resistance; immune checkpoint; CAR; antibody; cancer vaccines
Novel Insights into Molecular and Cellular Mechanisms Underlying Chronic Pain submission deadline 30 Mar 2026 | Viewed by 95 | Submission Open
Keywords: pain; pain management; sexual dimorphism; neurons; non-neuronal factors
(This special issue belongs to the Section Cellular Pathology)
Nanoparticle-Mediated Immunotherapy: Reshaping the Tumor Microenvironment for Enhanced Cancer Treatment
edited by
submission deadline 30 Mar 2026 | Viewed by 94 | Submission Open
Keywords: tumor microenvironment; drug delivery; nanoparticle
(This special issue belongs to the Section Cell Methods)
Cellular and Molecular Mechanisms of Cardiomyopathy submission deadline 30 Mar 2026 | Viewed by 89 | Submission Open
Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis
(This special issue belongs to the Section Tissues and Organs)
Impact of Chronic Substance Exposure on Hematopoiesis and Immunity
edited by and
submission deadline 30 Mar 2026 | Viewed by 58 | Submission Open
Keywords: Substance Use Alcohol Immunity Inflammation Hematopoietic stem and progenitor cells Monocytes Neutrophils Macrophages T cells
Molecular Mechanisms and Biomarker Development in Prostate Cancer
edited by Vikas Mehta and Behtash Ghazi Nezami
submission deadline 30 Mar 2026 | Viewed by 31 | Submission Open
Keywords: androgen receptor; prostate molecular alterations; biomarkers
Potential of CAR-Based Cellular Immunotherapy for Non-oncologic Disorders submission deadline 31 Mar 2026 | 5 articles | Viewed by 23117 | Submission Open
Keywords: adoptive cell transfer; CAR-T cells; cell engineering; CAR products; CAR-T cell therapy; non-oncologic disorders; autoimmune diseases; cardiometabolic diseases; inflammatory organ fibrosis; senescent cell pathologies; infections
(This special issue belongs to the Section Cellular Immunology)
Flow Cytometry in Immunology Research
edited by and Ekaterina Kopitman
submission deadline 31 Mar 2026 | 2 articles | Viewed by 11057 | Submission Open
Keywords: multi-parametric analysis; full-spectrum flow cytometry; imaging flow cytometry; immuno-phenotyping; immune synapse; cytokines; activation markers; cancer immunology; host-pathogen interactions; functional immune assays
(This special issue belongs to the Section Cell Methods)
Organoids and Models from Stem Cells
edited by Tiziana A. L. Brevini and
submission deadline 31 Mar 2026 | 3 articles | Viewed by 5822 | Submission Open
Keywords: cellular microenvironment; 3D culture; organoid
(This special issue belongs to the Section Stem Cells)
Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches
edited by Yuxiang Xie and Jingqi Yan
submission deadline 31 Mar 2026 | 1 articles | Viewed by 3628 | Submission Open
Keywords: axonal transport; motor proteins; autophagy– lysosome pathway; neurodegenerative diseases; therapeutic strategies
(This special issue belongs to the Section Cells of the Nervous System)
mRNA Vaccines and Therapeutics in Melanoma: From Mechanisms to Cellular Impact submission deadline 31 Mar 2026 | 2 articles | Viewed by 2554 | Submission Open
Keywords: mRNA vaccines; melanoma; tumor immunology; mRNA vaccine designs; delivery systems
(This special issue belongs to the Section Cellular Pathology)
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