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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cell Death Mechanisms and Therapeutic Opportunities in Glioblastoma

edited by

Swapan K. Ray

submission deadline 15 Dec 2025 | 21 articles | Viewed by 70895 | Submission Open

Keywords: apoptosis; autophagy; cell death mechanisms; cell signaling; glioblastoma; therapeutic opportunities

(This special issue belongs to the Section Cells of the Nervous System)

New Advances in Neuroinflammation

edited by

John W. Chen

and Michael Breckwoldt

submission deadline 15 Dec 2025 | 14 articles | Viewed by 54688 | Submission Open

Keywords: neuroinflammation; biomarkers; neurodegeneration; microglia; astrocytes; oligodendrocytes; neurological diseases; blood-brain barrier; imaging

(This special issue belongs to the Section Cells of the Nervous System)

Focus on Machinery of Cell Death

edited by

Subhadip Mukhopadhyay

, Prashanta Kumar Panda and

Suprabhat Mukherjee

submission deadline 15 Dec 2025 | 6 articles | Viewed by 16822 | Submission Open

Keywords: cell death; autophagy; apoptosis; necrosis; ferroptosis; metabolism; stem cell biology; infection; aging; development; Alzheimer’ s; neurodegeneration; therapy

(This special issue belongs to the Section Cellular Pathology)

Epigenetics and DNA Repair: Regulatory Mechanisms and Therapeutic Opportunities

edited by

Vasily M. Studitsky

submission deadline 15 Dec 2025 | 5 articles | Viewed by 8795 | Submission Open

Keywords: DNA damage; DNA repair; epigenetics; chromatin; remodeling

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Exclusive Review Papers in Parkinson's Research

edited by

Wolfgang Jost

and Ronald F. Pfeiffer

submission deadline 15 Dec 2025 | 1 articles | Viewed by 5320 | Submission Open

Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa

(This special issue belongs to the Section Cellular Aging)

Mitochondria and Metabolism in Cancer Stem Cells (CSCs)

edited by

Michael Lisanti

and Christopher Albanese

submission deadline 15 Dec 2025 | 2 articles | Viewed by 3744 | Submission Open

Keywords: cancer stem cells; circulating tumor cells; drug resistance; metabolism; mitochondria; OXPHSOS; mitochondrial DNA (mtDNA); glycolysis; cell cycle; DNA damage; other metabolic processes; oxidative stress; senescence; therapeutic approaches

(This special issue belongs to the Section Stem Cells)

DNA Methylation in Human Health and Disease: From Molecular Mechanisms to Clinical Applications

edited by

Michele Longo

and

Jyotirmoy Das

submission deadline 15 Dec 2025 | 2 articles | Viewed by 2610 | Submission Open

Keywords: DNA methylation; epigenetics; diseases; biomarkers; functional analysis

(This special issue belongs to the Section Cellular Pathology)

Cell Therapies in Cancer Treatment

edited by

Giovanni Amabile

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1976 | Submission Open

Keywords: cellular therapies; cancer; immune

Mechanisms and Therapies in Chronic Pain

edited by Nikesh Kunder and June Bryan I. de la Peña

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1124 | Submission Open

Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management

(This special issue belongs to the Section Cellular Pathology)

Advanced Research in Neurogenesis and Neuroinflammation

edited by

Muskan Gupta

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1076 | Submission Open

Keywords: neurogenesis; neuroinflammation; neurodegeneration; neurodegenerative diseases; cognitive functions

(This special issue belongs to the Section Cells of the Nervous System)

Physics of Cancer: How Mechanobiology Drives Cancer Progression

edited by

Claudia Tanja Mierke

submission deadline 15 Dec 2025 | Viewed by 201 | Submission Open

Keywords: migration and invasion of cancer cells; cytomechanics and adhesive properties; cellular mechanotransduction; mechanical signals; viscoelasticity and stiffness; physics of cancer

AMPK: From Mechanisms to New Therapies

edited by

Roland Abi Nahed

and

Farah Diab

submission deadline 15 Dec 2025 | Viewed by 187 | Submission Open

Keywords: metabolism; AMPK; cancer; biosensors; reproduction; metabolic disorders; therapies

Functions of Cilia

edited by

Raj Luxmi

submission deadline 15 Dec 2025 | Viewed by 179 | Submission Open

Keywords: cilia; cilia-derived vesicles; ciliopathies; neuronal cilia; motile cilia; primary cilia; ciliary secretion; peptidergic signaling; ectosomes

Recent Advances in the Understanding of Neuropsychiatric Illnesses

edited by

Junnan Li

and

Wanli Smith

submission deadline 15 Dec 2025 | Viewed by 158 | Submission Open

Keywords: neuropsychiatric disorders; neurodegeneration; synaptic plasticity; neuroinflammation; biomarkers; molecular mechanisms; translational neuroscience; intracellular signaling; neuroimaging

(This special issue belongs to the Section Cells of the Nervous System)

Hormone Receptors in Cancers: From Molecular Insights to Clinical Applications

edited by

Edris Choupani

and Kambiz Hassanzadeh

submission deadline 15 Dec 2025 | Viewed by 131 | Submission Open

Keywords: cancer progression; endocrine therapy resistance; estrogen and androgen receptors; hormone receptors; nuclear receptors; receptor signaling pathways

The Cross-Talk Between Obesity and Metabolism

edited by

Hong Shi

submission deadline 15 Dec 2025 | Viewed by 127 | Submission Open

Keywords: obesity; metabolic disorders; insulin resistance; adipose tissue; inflammation; glucose metabolism; lipid metabolism; cardiovascular disease; type 2 diabetes; therapeutic targets

From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria

edited by Amy H. Attaway and Saurabh Mishra

submission deadline 15 Dec 2025 | Viewed by 120 | Submission Open

Keywords: mitochondrial oxidation; ROS; aging; disease

Organ and Tissue Fibrosis: Molecular Signals and Cellular Mechanisms—Second Edition

edited by

Zhuo Wang

submission deadline 15 Dec 2025 | Viewed by 94 | Submission Open

Keywords: fibrosis; scarring; cytokine; myofibroblasts; extracellular matrix; growth factors; mesenchymal transition

(This special issue belongs to the Section Tissues and Organs)

Extracellular Vesicles and Cell Therapies in Regenerative Nephrology and Urology

edited by

Amankeldi Salybekov

and Ciro Tetta

submission deadline 15 Dec 2025 | Viewed by 93 | Submission Open

Keywords: extracellular vesicles (EVs); microRNA (miRNA); acute kidney injury (AKI); chronic kidney disease (CKD); glomerulonephritis; kidney transplantation; fibrosis; mesenchymal stromal cells (MSCs); engineered EVs; single-cell and spatial omics; machine learning and artificial intelligence; ; precision nephrology; GMP manufacturing; regenerative medicine; biomarkers; artificial intelligence (AI)

(This special issue belongs to the Section Cell Microenvironment)

Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts

edited by Simonetta Masieri and

Carlo Cavaliere

submission deadline 15 Dec 2025 | Viewed by 85 | Submission Open

Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins

(This special issue belongs to the Section Tissues and Organs)

The Symphony of Nature—the Precision of Life’s Regulation

edited by Weiguang Wang and Baocheng Liu

submission deadline 15 Dec 2025 | Viewed by 83 | Submission Open

Keywords: protein structure and function; allosteric regulation; conformational switches; enzyme catalysis and modification; molecular machines; molecular regulation; protein folding and misfolding

(This special issue belongs to the Section Cell Methods)

Cancer and Immune System Interactions

edited by

Hong-Jian Zhu

and

Bradley Creamer

submission deadline 16 Dec 2025 | Viewed by 124 | Submission Open

Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor– immune interactions; immune checkpoint regulation; translational oncology

(This special issue belongs to the Section Cell Microenvironment)

Molecular Mechanisms of Tumor Pathogenesis

edited by

Saverio Candido

and Alessandro Lavoro

submission deadline 20 Dec 2025 | 9 articles | Viewed by 20408 | Submission Open

Keywords: cancer; therapeutic targets; biomarkers; epigenetics; DNA methylation; microRNAs; somatic mutations; germline mutations; chromatin remodeling; histone modifications

(This special issue belongs to the Section Cellular Pathology)

Physiology of Telocytes

edited by

Catalin G. Manole

and Mihail E. Hinescu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 4470 | Submission Open

Keywords: telocytes; telopodes; physiology; pathology; tissue homeostasis; regenerative medicine

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms of Cognitive Function and Dysfunction

edited by

Parasuraman Padmanabhan

Balázs Gulyás

and

Domokos Máthé

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2811 | Submission Open

Keywords: cognition; neurodevelopment; neurotransmission; molecular mecanisms; signaling; disorders; therapy

(This special issue belongs to the Section Cells of the Nervous System)

Metabolic Hallmarks in Cancer

edited by

Michael Lisanti

, Ubaldo Martinez-Outshoorn and Marta Mauro-Lizcano

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2623 | Submission Open

Keywords: cancer; metabolic reprogramming; metabolic adaptation; cancer energy metabolism; glycolysis; the Warburg effect; the reverse Warburg effect; glutamine addiction; the pentose phosphate pathway; cellular and molecular mechanisms; tumor microenvironment; novel therapeutic interventions

(This special issue belongs to the Section Cellular Metabolism)

Advances in Human Pluripotent Stem Cells

edited by

Peggy Arthur

Sangeetha Kandoi

and

Nagavendra Kommineni

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1531 | Submission Open

Keywords: human pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells

(This special issue belongs to the Section Stem Cells)

Microglial Functions in Neurodegenerative Diseases: In Search of Potential Therapeutic Targets

edited by

Laura Jiménez Sánchez

and María Martín Estebané

submission deadline 20 Dec 2025 | Viewed by 302 | Submission Open

Keywords: microglia; inflammation; neural damage; mitochondria; potential targets

(This special issue belongs to the Section Cellular Aging)

Advanced Research on Genomic Instability and Gene Expression in Developmental Disorders

edited by

Shenzhao Lu

submission deadline 20 Dec 2025 | Viewed by 204 | Submission Open

Keywords: development; neurological disease; cancer; genetic; epigenetic

State-of-the-Art Insights into the Cell Microenvironment

edited by

Said M. Afify

submission deadline 20 Dec 2025 | Viewed by 144 | Submission Open

Keywords: cell microenvironment; stem cells; organoid and 3D culture models

(This special issue belongs to the Section Cell Microenvironment)

Evaluation of the Properties and Effectiveness of Nutritional Factors Using In Vitro Assays, Including Cell Cultures and Organoids

edited by

Joanna Romanek

and Sylwia Orczewska-Dudek

submission deadline 20 Dec 2025 | Viewed by 133 | Submission Open

Keywords: cell cultures; organoids; novel nutritional factors; extract; cells viability; cells proliferation; cells cytotoxicity; cell signaling; cells apoptosis; oxidative stress

Acute Myeloid Leukemia: Molecular Mechanisms and Novel Therapies

edited by Xiangguo Shi

submission deadline 20 Dec 2025 | Viewed by 123 | Submission Open

Keywords: acute myeloid leukemia (AML); genomics and epigenetics; therapeutic resistance; metabolic reprogramming; clonal evolution

(This special issue belongs to the Section Cellular Pathology)

Targeting Thermogenesis in Metabolic Disorders: Novel Pharmacological and Lifestyle Interventions

edited by

Atefeh Rabiee

submission deadline 20 Dec 2025 | Viewed by 111 | Submission Open

Keywords: thermogenesis modulation; metabolic disorders; obesity; adipose tissue biology; thermogenic mechanisms; mitochondrial function

Clockwork Cells: Decoding the Language of Cell Cycle Regulators

edited by

Guanxiong Yan

, Kyung-sang Lee,

Richard W. Wong

and

Gary S. Stein

submission deadline 20 Dec 2025 | Viewed by 101 | Submission Open

Keywords: cyclins; cyclin-dependent kinases (CDKs); checkpoints; cell proliferation; mitosis; meiosis

(This special issue belongs to the Section Cell Proliferation and Division)

Functional Genomics and Morphological Profiling in Saccharomyces cerevisiae

edited by

Yoshikazu Ohya

and Hisao Moriya

submission deadline 24 Dec 2025 | 1 articles | Viewed by 589 | Submission Open

Keywords: functional genomics; morphological profiling; Saccharomyces cerevisiae; overexpression

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Cellular Differentiation in Health and Disease

edited by Christine K. C. Loo and

Grant A. Ramm

submission deadline 25 Dec 2025 | 1 articles | Viewed by 1773 | Submission Open

Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation

(This special issue belongs to the Section Cell Microenvironment)

Advances in Molecular Genomics and Pathology of Cancers

edited by

Muhammad Kibriya

submission deadline 25 Dec 2025 | Viewed by 206 | Submission Open

Keywords: cancer; somatic mutation; short tandem repeat; gene expression; methylation; cf-DNA; single-cell sequencing; NGS; liquid biopsy; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Dysregulated Synaptic Plasticity in Chronic Pain: Molecular Mechanisms, Circuit Dysfunction, and Translational Approaches

edited by

Neeraj Soni

submission deadline 25 Dec 2025 | Viewed by 123 | Submission Open

Keywords: chronic pain; synaptic plasticity; circuit dysfunction

(This special issue belongs to the Section Cellular Pathology)

Role of T Cells in Immune Disease Treatment

edited by

Ilan Bank

submission deadline 25 Dec 2025 | Viewed by 98 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immunotherapy; immune diseases; T cells; B cells; natural killer T cells

(This special issue belongs to the Section Cellular Immunology)

Host Immunity to Bacterial Infections

edited by Karine Gloux

submission deadline 26 Dec 2025 | Viewed by 320 | Submission Open

Keywords: host immune systemsbacterial pathogens; innate and adaptive immune responses; pathogen evasion; bacterial infections

(This special issue belongs to the Section Cellular Immunology)

Epigenetic Regulation in Neuronal Development, Neurodegeneration and Regeneration

edited by

Guoping Fan

submission deadline 28 Dec 2025 | 1 articles | Viewed by 1299 | Submission Open

Keywords: epigenetic regulation; neuronal development; neuronal regeneration; chromatin remodeling

(This special issue belongs to the Section Cells of the Nervous System)

Neuromodulatory Signaling in Brain Disorders: State-of-the-Art Insights

edited by

Kohji Fukunaga

and

Wenbin Jia

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3587 | Submission Open

Keywords: neuromodulatory signaling; neural circuit; synaptic plasticity; neurotransmitter; signal transduction; neurodegenerative diseases; neuroinflammatory disorder; substance use disorder; neurodevelopmental disorder; targeted therapy

(This special issue belongs to the Section Tissues and Organs)

Fertility Disorders in Testes and Ovaries

edited by

Paweł Kordowitzki

and Joanna Kochan

submission deadline 30 Dec 2025 | 1 articles | Viewed by 661 | Submission Open

Keywords: fertility; ovary; testis; aging; epigenetics; in vitro fertilization; IVF

(This special issue belongs to the Section Tissues and Organs)

Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease

edited by

Elie Seaayfan

and

Martin Kömhoff

submission deadline 30 Dec 2025 | Viewed by 637 | Submission Open

Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein– protein interactions; post-translational modifications; pharmacological interventions

Emerging Roles of Glial Cells in Human Health and Disease

edited by

Dan Frenkel

and

Menachem Hanani

submission deadline 31 Dec 2025 | 10 articles | Viewed by 36832 | Submission Open

Keywords: neurodegenerative diseases; glia cells; astrocyte; microglia; stroke; pain; epilepsy; trauma; demyelinating diseases’ inflammatory diseases; satellite glia; Schwann cells; enteric glia

(This special issue belongs to the Section Cells of the Nervous System)

Gene Therapy for Rare Diseases

edited by

Cord Brakebusch

submission deadline 31 Dec 2025 | 6 articles | Viewed by 31054 | Submission Open

Keywords: gene therapy; gene editing; rare diseases; CRISPR; viral vectors; base editing; prime editing

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

New Insights into Vascular Biology in Health and Disease

edited by Bashir M. Rezk

submission deadline 31 Dec 2025 | 6 articles | Viewed by 16735 | Submission Open

Keywords: vascular diseases; cardiovascular; cancer; hyperhomocyteinemia; endothelial dysfunction; vascular smooth muscle cell; autophagy; alcohol; galectins; angiogenesis; neovascularization

(This special issue belongs to the Section Cells of the Cardiovascular System)

Select Topics in Molecular and Cellular Mechanisms of Mammalian Reproduction

edited by Zhengui Zheng,

Brent M. Bany

and Liang Ma

submission deadline 31 Dec 2025 | 7 articles | Viewed by 12905 | Submission Open

Keywords: reproductive organ development; sexual differentiation; reproductive tract function; fertilization; implantation; placentation; parturition; lactation

(This special issue belongs to the Section Reproductive Cells and Development)

Biological Mechanisms in the Treatment of Neuropsychiatric Diseases

edited by Randall D Marshall and Frank S. Menniti

submission deadline 31 Dec 2025 | 6 articles | Viewed by 11803 | Submission Open

Keywords: neurodevelopmental conditions; rare neurological disease; molecular mechanisms of novel CNS treatments; precision medicine in neuropsychiatry; organoids; molecular mechanisms of effective treatments

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration

edited by

Philippe Hernigou

submission deadline 31 Dec 2025 | 7 articles | Viewed by 9920 | Submission Open

Keywords: bone morphogenic proteins (BMPs); bone union with cell therapy; advances in stem cell therapies for fracture non-union and cartilage regeneration; novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; regeneration and revascularization of bone osteonecrosis; evaluation of osteonecrosis regeneration with MRI and histology; and arteriography; identification and validation of new cartilage biomarkers; diaphyseal regeneration with callostasis; union with the membrane technique

(This special issue belongs to the Section Cellular Pathology)

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