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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Therapeutic Targets for Cardiovascular Diseases

edited by

Tamer Elbayoumi

and

Molly (Mingyi) Yao

submission deadline 15 Jan 2026 | 4 articles | Viewed by 16647

Keywords: cardiovascular disease prevention and treatment; ischemic cardiomyopathies; endothelium injury/damage; cardiac remuscularization and repair; cardiovascular/angiogenic targets and biomarkers; targeted delivery platforms/systems/formulations; precision nanomedicine; targeted nano-theranostic applications; localized and systemic administration; safety and efficacy

(This special issue belongs to the Section Cells of the Cardiovascular System)

Organ Regeneration: Cells, Organoids and Organs

edited by Jia Huang

submission deadline 15 Jan 2026 | 2 articles | Viewed by 2988

Keywords: organ regeneration; stem cells; organoids; tissue engineering; 3D bioprinting; regenerative medicine; interspecies chimera; blastocyst complementation; vascularization; immune compatibility

(This special issue belongs to the Section Tissues and Organs)

Oral Stem Cells in Regenerative Biology

edited by

Oriana Trubiani

submission deadline 15 Jan 2026 | Viewed by 207

Keywords: stem cells; differentiation; regenerative medicine; angiogenesis; inflammation; secretome; oral tissue induced pluripotent stem cells

(This special issue belongs to the Section Stem Cells)

Signaling Pathways in Endometrial Cancer Cells

edited by

Tomohiko Fukuda

submission deadline 20 Jan 2026 | 4 articles | Viewed by 13566 | Submission Open

Keywords: endometrial cancer; cellular signaling; cell metabolism; DNA damage repair pathway; the PI3K/AKT/mTOR pathway; the RAS/MAPK pathway; molecular classification

(This special issue belongs to the Section Cell Signaling)

New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition

edited by

Piotr Cierpikowski

and

Julia Bar

submission deadline 20 Jan 2026 | 6 articles | Viewed by 11575 | Submission Open

Keywords: head and neck cancer; oral cancer; biomarker; prognosis; carcinogenesis; oral premalignant lesions; cancer stem cells; signaling pathways; molecular targeted therapy

(This special issue belongs to the Section Cellular Pathology)

Adipose-Derived Stem Cells: Current Applications and Future Directions

edited by

Yasuhito Ishigaki

submission deadline 20 Jan 2026 | 4 articles | Viewed by 8801 | Submission Open

Keywords: cell therapy; regenerative medicine; adipose-derived stem cells (ADSCs); exosome; cytokine

(This special issue belongs to the Section Stem Cells)

Mitochondria at the Crossroad of Health and Disease—Second Edition

edited by

Nickolay Brustovetsky

submission deadline 20 Jan 2026 | 4 articles | Viewed by 3545 | Submission Open

Keywords: mitochondria; oxidative phosphorylation; mitochondrial ion transport; permeability transition pore; mitochondrial ROS generation; mitochondrial quality control; mitochondrial traffic; mitochondrial morphology; mitochondrial dynamics; mitophagy

(This special issue belongs to the Section Cellular Aging)

Pathophysiology of Signal Transduction in Cardiovascular and Pulmonary Disease: 2nd Edition

edited by

Yung-Hsin Yeh

and

Ying-Ju Lai

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3070 | Submission Open

Keywords: cardiac arrhythmia; atrium; ventricle; pulmonary; vascular; signal transduction

(This special issue belongs to the Section Cellular Pathology)

Neurotoxicity and Neurodegenerative Diseases: The Potential of Regenerative Medicine

edited by Elisabetta Mormone, Paola Crociani and

Gianluigi Ubaldo Mazzoccoli

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2008 | Submission Open

Keywords: inflammation; iPSCs; MSCs; neural stem cells niche; neurodegeneration; regenerative medicine; ROS; PRP

(This special issue belongs to the Section Cellular Aging)

Applications of Proteomics in Human Diseases and Treatments

edited by

Giovanni Cuda

and

Marco Gaspari

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1688 | Submission Open

Keywords: biomarkers; clinical proteomics; single-cell proteomics; next-generation proteomics; biofluids; high-throughput proteomics

(This special issue belongs to the Section Cell Methods)

Study on Human Mesenchymal Stem Cells—2nd Edition

edited by

Michela Noseda

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1032 | Submission Open

Keywords: mesenchymal stem cells; disease; cardiac; therapy

(This special issue belongs to the Section Stem Cells)

Role of Cell Organelles in Normal Aging, Senescence, and Cancer

edited by

Michael Lisanti

and Christopher Albanese

submission deadline 20 Jan 2026 | Viewed by 572 | Submission Open

Keywords: aging; accumulated damage; ROS-induced damage; protein aggregation; senescence; cancer; senescence escape; cell organelles; mitochondria; lysosomes; SASP; inflammation; IL1-beta/IL-6/IL-8

(This special issue belongs to the Section Cellular Aging)

The Evolving Landscape of Cell and Gene Therapy—Opportunities, Challenges and the Road Ahead

edited by

Rai Ajit K. Srivastava

submission deadline 20 Jan 2026 | Viewed by 269 | Submission Open

Keywords: cell therapy; gene therapy/gene editing; micro RNAs; rare diseases; metabolic disease; cancer; diabetes; proatherogenic lipoproteins; drug discovery; ASO

Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting

edited by

Mehdi Sanati

submission deadline 20 Jan 2026 | Viewed by 200 | Submission Open

Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment

Soluble Interleukin-6 Receptor (sIL-6R): Role in Health and Disease

edited by

Rebecca Aicheler

and

Richard Webb

submission deadline 25 Jan 2026 | 1 articles | Viewed by 2304 | Submission Open

Keywords: sIL-6R; IL-6 signalling; IL-6ST; genetic polymorphism; health; disease; exercise physiology; therapeutics; mental health

(This special issue belongs to the Section Cell Signaling)

Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies

edited by

Qiwei Wang

submission deadline 25 Jan 2026 | 2 articles | Viewed by 2119 | Submission Open

Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies

(This special issue belongs to the Section Cellular Immunology)

Plant Stress and Acclimation Responses During Global Warming

edited by

Stanisław Karpiński

submission deadline 25 Jan 2026 | 1 articles | Viewed by 669 | Submission Open

Keywords: acclimatory responses in plants; chloroplast retrograde and nuclear anterograde signaling; excess light and heat shock responses; global warming and regulation of gene expression; energy dissipation as heat and cell death regulation; photosynthesis; stomatal conductance and transpiration regulation during heat waves

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

The Role of T Cells in Type 1 Diabetes

edited by

Ismail Syed

and

Mayur S. Parmar

submission deadline 25 Jan 2026 | Viewed by 593 | Submission Open

Keywords: T cells; inflammation; T cell receptor; type 1 diabetes

(This special issue belongs to the Section Cellular Immunology)

Targeting Immune Dysfunction in Aging and Age-Related Diseases

edited by

Anna Aiello

and

Anna Calabrò

submission deadline 25 Jan 2026 | Viewed by 248 | Submission Open

Keywords: immunosenescence; inflammaging; immune dysfunction; aging; age-related diseases (ARDs); immune– metabolic interactions; immunomodulators; immunoceuticals; senotherapeutics; lifestyle interventions

Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms

edited by Masmoudi-Kouki Olfa and

Gérard Lizard

submission deadline 25 Jan 2026 | Viewed by 220 | Submission Open

Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling

(This special issue belongs to the Section Stem Cells)

Immune Cell Signaling Networks in Tumor and Regenerative Stem Cell Niches

edited by

Luigi Racioppi

submission deadline 25 Jan 2026 | Viewed by 132 | Submission Open

Keywords: tumor microenvironment; stem cell niche; macrophage polarization; T-cell activation; immune checkpoints; targetable signaling pathways; engineered biomaterials; immune signaling in 3D culture; organ-on-chip models; single-cell omics

(This special issue belongs to the Section Stem Cells)

The Developments and Applications of Vibrational Spectroscopy in Cellular Research

edited by

Maria Lasalvia

submission deadline 25 Jan 2026 | Viewed by 112 | Submission Open

Keywords: vibrational spectroscopy; FT-IR spectroscopy; Raman spectroscopy; biomedical diagnostics; cancer research; Alzheimer’ s disease; neurodegeneration; tissue engineering; spectroscopic biomarkers; label-free imaging

(This special issue belongs to the Section Cell Methods)

Insights into the Pathophysiology of NeuroCOVID: Current Topics

edited by

Christian Barbato

Antonio Minni

and

Carla Petrella

submission deadline 26 Jan 2026 | 1 articles | Viewed by 1668 | Submission Open

Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases

(This special issue belongs to the Section Cellular Pathology)

The Roles of the Extracellular Matrix in Cardiac Structure and Function: A Commemorative Issue in Honor of Dr. Thomas K. Borg

edited by

Wayne Carver

and Edie Goldsmith

submission deadline 30 Jan 2026 | 7 articles | Viewed by 8391 | Submission Open

Keywords: collagen; integrin; extracellular matrix; cardiomyocyte; fibroblast; heart bioengineering

(This special issue belongs to the Section Cell Microenvironment)

Neuronal Development and Disease: From Molecular Bases to Neurological Disorders

edited by Ramiro Almeida

submission deadline 30 Jan 2026 | 4 articles | Viewed by 6726 | Submission Open

Keywords: neuronal development; neurological disorders; neurogenesis; neuroinflammation; synaptic plasticity

(This special issue belongs to the Section Cellular Neuroscience)

Mechanisms Underlying Cardiovascular Aging

edited by Soheil Saeedi

submission deadline 30 Jan 2026 | 2 articles | Viewed by 3916 | Submission Open

Keywords: cardiovascular aging; cellular senescence; epigenetic clock; endothelial cells; perivascular adipose tissue (PVAT); premature aging; senolytics; rejuvenating strategies

(This special issue belongs to the Section Cells of the Cardiovascular System)

Stem Cells, Disease Mechanisms, and Therapeutic Innovations in Breast and Endometrial Disorders

edited by

Walid Shaalan

, Benedikt Schaefgen and

Nourhan Hassan

submission deadline 30 Jan 2026 | Viewed by 362 | Submission Open

Keywords: endometrial stem cells; breast cancer; endometrial diseases; tumor microenvironment; matrix remodeling; regenerative medicine; bioengineering; stem cell therapy; molecular pathogenesis; disease modeling

(This special issue belongs to the Section Stem Cells)

Tumor Immune Responsiveness in the Era of T Cell Immunotherapy

edited by

Xin Li

and

Wenjian Wang

submission deadline 30 Jan 2026 | Viewed by 266 | Submission Open

Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation

Ubiquitin Ligases in Health and Diseases

edited by Haitao Luan

submission deadline 30 Jan 2026 | Viewed by 157 | Submission Open

Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting

(This special issue belongs to the Section Cell Signaling)

Advanced Technology for Cellular Imaging

edited by Alessandro Grinzato,

Vittoria Raimondi

and

J. Bernard Heymann

submission deadline 31 Jan 2026 | 9 articles | Viewed by 23589 | Submission Open

Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction

(This special issue belongs to the Section Cell Methods)

Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases

edited by

Prathapan Ayyappan

submission deadline 31 Jan 2026 | 7 articles | Viewed by 22795 | Submission Open

Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods

(This special issue belongs to the Section Cells of the Cardiovascular System)

Neuroinflammation in Brain Health and Diseases

edited by Debashis Dutta and Nemil Bhatt

submission deadline 31 Jan 2026 | 9 articles | Viewed by 20873 | Submission Open

Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics

(This special issue belongs to the Section Cellular Neuroscience)

Imaging Methods in Cell Biology

edited by

Claudia Moscheni

and

Nicoletta Gagliano

submission deadline 31 Jan 2026 | 6 articles | Viewed by 17707 | Submission Open

Keywords: cellular organelles; molecular function; molecular interaction; disease- and drug-related subcellular phenomena; single-molecule imaging; light microscopy; electron microscopy; fluorescence microscopy; fluorescence correlation methods; fluorescence lifetime imaging microscopy (FLIM); Raman microscopy; spatial biology

(This special issue belongs to the Section Cell Methods)

Cancer-Associated Fibroblasts: Challenges and Directions

edited by

Paul J. Higgins

and

Ramesh Mukkamala

submission deadline 31 Jan 2026 | 5 articles | Viewed by 17334 | Submission Open

Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents

(This special issue belongs to the Section Cell Microenvironment)

CRISPR-Based Genome Editing in Translational Research—Third Edition

edited by

Jie Xu

Dongshan Yang

and Jifeng Zhang

submission deadline 31 Jan 2026 | 5 articles | Viewed by 8231 | Submission Open

Keywords: genome; gene editing; CRISPR/Cas9

Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance

edited by

Xinyu Wang

Lei Zhu

and Yuancheng Li

submission deadline 31 Jan 2026 | 4 articles | Viewed by 7884 | Submission Open

Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product

(This special issue belongs to the Section Cell Microenvironment)

Renewing Reasons to Believe in Gene Therapies for Epilepsy

edited by Casper Gøtzsche

submission deadline 31 Jan 2026 | 2 articles | Viewed by 7529 | Submission Open

Keywords: epilepsy; seizure; gene therapy; gene editing; disease modification; transformative; unmet need

(This special issue belongs to the Section Cellular Neuroscience)

Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy

edited by

Javier S. Castresana

submission deadline 31 Jan 2026 | 2 articles | Viewed by 5101 | Submission Open

Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy

(This special issue belongs to the Section Stem Cells)

Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases

edited by Patricia Morcillo

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2591 | Submission Open

Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers

(This special issue belongs to the Section Cellular Aging)

Cell Behavior Under Blood Flow

edited by Alexander Gural, Ivana Pajic-Lijakovic and

Gregory Barshtein

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2128 | Submission Open

Keywords: blood flow; shear stress; red blood cells; white blood cells; platelets; endothelial cells; cell stimulation; mechanical stress

The Role of Macrophages in Leishmaniasis: Current Perspective

edited by Devki Nandan

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1091 | Submission Open

Keywords: Leishmania; leishmaniasis; macrophage biology; host– pathogen interactions

Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond

edited by Valeria Gerbino

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1036 | Submission Open

Keywords: autophagy; neurodegeneration; amyotrophic lateral sclerosis (ALS); protein aggregation; cellular homeostasis; lysosomal dysfunction; neuronal health; therapeutic targets; molecular pathways; neuroprotective strategies

(This special issue belongs to the Section Cellular Neuroscience)

Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities

edited by Fabio Guolo

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1022 | Submission Open

Keywords: acute myeloid leukemia (AML); hematologic malignancy; AML classification; myeloid precursors; hematopoiesis; high-risk AML; biomarkers

(This special issue belongs to the Section Cellular Immunology)

Single-Molecule Tracking for Live Cells

edited by

Zeno Földes-Papp

submission deadline 31 Jan 2026 | Viewed by 439 | Submission Open

Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory

Diagnostic and Therapeutic Application of Extracellular Vesicles (EV)

edited by

Maria Magdalena Barreca

and

Chiara Corrado

submission deadline 31 Jan 2026 | Viewed by 350 | Submission Open

Keywords: extracellular vesicles (EVs); diseases biomarkers; therapeutic targets; drugs delivery; engineered extracellular vesicles; EVs therapeutic applications

Mechanisms That Link Olfactory Perception with Aging

edited by

Tuhin Subhra Chakraborty

, Anindya Ganguly and Jordan A. Munroe

submission deadline 31 Jan 2026 | Viewed by 340 | Submission Open

Keywords: olfaction; aging; neuroscience

(This special issue belongs to the Section Cellular Aging)

Human Organoids: A New Frontier in Disease Modeling

edited by