Lipids, Lipoproteins and Lipid-Targeting Therapies in the Regulation of Immune Function and Inflammation

Dear Colleagues,

Lipid-related pathways are known to play a critical role in the regulation of immune cell activity. Endogenous and exogenous (e.g., dietary) lipids can regulate leukocyte activation, differentiation, and inflammatory potential, with important implications for the pathophysiology of chronic inflammatory and cardiometabolic diseases, as well as defense against pathogens. Recent evidence further suggests that lipoproteins play an important role in regulating immune outcomes—including growing research highlighting the protective role of high-density lipoproteins (HDLs) in infectious diseases such as sepsis and COVID-19, and their capacity to carry over 250 proteins—and many have immunomodulatory properties. Moreover, pharmaceutical and lifestyle intervention-based therapies that target lipid metabolism or lipoprotein profiles show promise in the management of conditions characterized by immune dysfunction. This Special Issue invites authors to submit reviews and research articles that present new knowledge on the mechanisms by which lipids, lipoproteins, and lipid-targeting therapies modulate immune function and inflammation, in addition to advances in the methodologies and technological approaches to characterizing lipid–immune pathways. Topics may include, but are not limited to, the immunomodulatory effects of endogenous and exogenous lipids; the immunomodulatory properties of lipoproteins; HDL proteomics and lipidomics; the immunomodulatory and anti-inflammatory effects of lipid-targeting therapies (e.g., statins, LXR agonists, fibrates); the immunomodulatory and anti-inflammatory effects of lifestyle interventions (e.g., diet, exercise) that target lipid metabolism and cardiometabolic health; lipid and immune pathways in chronic inflammatory and cardiometabolic diseases; lipid and immune pathways in infectious disease; lipid and immune pathways in conditions of immune dysfunction (e.g., autoimmunity, allergy); and advances in methods and technologies for characterizing lipid–immune pathways and their application.

Dr. Catherine J. Andersen
Guest Editor

Manuscript Submission Information

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