Organogenesis and Regeneration: From Basic Research to Medical Study

Dear Colleagues,

An organ is a multi-cellular organism whose formation requires cell–cell coordination to establish an accurate structure and function. Various cellular behaviors, such as cell division, cell differentiation, cell movement, cell–cell communication, pattern formation, etc., are involved in the process of organogenesis, and all must be tightly controlled. Numerous studies have explored the underlying mechanisms that govern the development and formation of different organs. However, we are still far from fully understanding these processes.

Regeneration is the capacity of adult animals to restore their lost/damaged tissues/organs after injury. This capacity largely differs among species, from whole-body regeneration in Hydra and planarians, body parts—such as the limbs and tail—regeneration in salamanders and Xenopus, to organ—such as the heart—regeneration in adult zebrafish and neonatal mice. Regeneration achieves faithful restoration of tissue/organs in structures and functions and requires precise control.

Organogenesis and regeneration may employ similar molecular and cellular mechanisms, but they also possess their own unique aspects. Deciphering the innate mechanisms of development and regeneration may help explore new therapeutic strategies to benefit human health.

This Life and Cells joint Special Issue “Organogenesis and Regeneration: From Basic Research to Medical Study” will include both original research articles and review articles about organogenesis and regeneration. Basic research to clinic reports are all welcome.

You may choose our Joint Special Issue in Life.

Prof. Dr. Long Zhao
Prof. Dr. Ying Su
Dr. Juhui Qiu
Dr. Yanchao Han
Guest Editors

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• organogenesis
• regeneration
• development
• proliferation
• differentiation
• blastema
• signaling pathway