Carcinogenesis Model

Dear Colleagues,

Accumulated genetic alterations can initiate and drive carcinogenesis, which are subjected to promotion by epigenetic changes through interactions with many different types of cells in the tissue microenvironment. By genetic engineering and/or chemical treatments, researchers have created many in vivo animal models, which successfully recapitulated multistep carcinogenesis from normal cells to premalignant lesions, full-blown tumors and metastases. They have not only contributed to deepening our understanding of the mechanisms underlying carcinogenesis, but also allowed us to investigate genes and compounds that could potentially affect development or maintenance of tumors. More recently, genome-editing technologies significantly accelerated generation of mutant animals, let alone mice, and organoid-based ex vivo carcinogenesis models have been also documented by us and other researchers. In light of such rapid advances in the field of carcinogenesis models, we need to put together various different types of models -including those generated by conventional or novel methods- to further promote cancer research. In this Topical Collection of Cancers, we welcome original research articles or comprehensive review articles focusing on development of, or by using, any types of models reflecting any steps of carcinogenesis, in any species or organs. I hope that such collection of studies will further increase our knowledge on carcinogenesis and provide powerful tools to fight against cancer.

Dr. Yoshitaka Hippo
Collection Editor

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