New Perspectives in the Treatment of Thoracic Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 1 September 2025 | Viewed by 694

Special Issue Editors


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Guest Editor
Division of Thoracic Surgery, Cardiothoracic Department, University Hospital of Udine, 33100 Udine, Italy
Interests: lung cancer; thymic malignancies; pulmonary metastases; thoracic ultrasonography

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Guest Editor
Department of Cardio-Thoracic and Vascular Surgery, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Torino, Italy
Interests: lung cancer; thoracic surgery; thymic malignancies; minimally invasive thoracic surgery
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Special Issue Information

Dear Colleagues,

Thoracic cancers encompass a wide category of malignancies that arise from several different organs. While primary or secondary lung tumors represent the vast majority of intrathoracic cancers, with an impressively high burden of morbidity and mortality, tumors arising from the thymus or pleura are less common but offer engaging insights on the relationship between cancer and host. Historically, tumors in early stages are usually treated with surgery upfront, while multimodality approaches represent the key in the management of more advanced cancer conditions. However, recent technological advancements, the introduction of novel, highly effective anticancer molecules, and the inceptive application of artificial intelligence (AI) protocols in medical sciences have enhanced our understanding and re-drawn our perspectives in the treatment of intrathoracic malignancies.

The scope of this Special Issue is therefore to discover the most recent achievements and findings in the treatment of thoracic malignancies and to explore their potential impact in redefining the current management guidelines of these conditions.

Dr. Francesco Londero
Dr. Francesco Guerrera
Guest Editors

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Keywords

  • lung cancer
  • pulmonary metastases
  • thymic malignancies
  • malignant mesothelioma
  • immunotherapy
  • target therapy
  • artificial intelligence

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Published Papers (1 paper)

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15 pages, 1334 KiB  
Systematic Review
Treatment-Related Adverse Events in Extended Stage Small Cell Lung Cancer Patients Receiving First-Line Chemoimmunotherapy Versus Chemotherapy Alone: A Systematic Review and Meta-Analysis
by Elsa Vitale, Alessandro Rizzo, Lorenza Maistrello, Deniz Can Guven, Omar Cauli, Domenico Galetta and Vito Longo
Cancers 2025, 17(9), 1571; https://doi.org/10.3390/cancers17091571 - 5 May 2025
Viewed by 419
Abstract
Introduction: Nowadays the prognosis of extended stage (ES) small cell lung cancer (SCLC) patients is poor. However, a high response rate to first-line chemotherapy (CT) and the addition of immune checkpoint inhibitors (ICIs) have notably ameliorated the outcome of these patients. The aim [...] Read more.
Introduction: Nowadays the prognosis of extended stage (ES) small cell lung cancer (SCLC) patients is poor. However, a high response rate to first-line chemotherapy (CT) and the addition of immune checkpoint inhibitors (ICIs) have notably ameliorated the outcome of these patients. The aim of our study is to compare treatment-related adverse events (TRAEs) between ES- SCLC patients receiving first-line ICIs adding CT and those receiving only CT. Methods: All phase III clinical trials published between 15 June 2008, and 30 June 2024, likenessing ICIs adding systemic CT and only CT in treatment-naïve ES-SCLC patients were retrieved. Results: Twenty-six types of adverse events were included, grouped into ten categories, for a total of 43,391 observations (observations in immune group n = 22,643 and in placebo group n = 20,748) and 9831 events. Our analysis suggested a statistically significant increase in hematological events in patients receiving ICIs plus CT compared with CT alone. Conversely, blood pressure alterations such as hypertension were more frequent in patients treated with CT alone. Conclusions: Despite our analysis confirming the manageable safety profile of chemoimmunotherapy, this remains an issue to be further investigated. Full article
(This article belongs to the Special Issue New Perspectives in the Treatment of Thoracic Cancers)
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