Novel Insights into Mechanisms of Cancer-Associated Thrombosis
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 1131
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cancer-associated thrombosis (CAT) represents a major cause of mortality in cancer patients and presents a significant clinical challenge. The pathophysiology of CAT involves a multifaceted interplay of cancer-related factors, including the enhanced expression and release of procoagulant proteins such as the Von Willebrand Factor and tissue factor and alterations in blood flow due to tumour burden. The pathophysiology may then be further exacerbated by surgery, chemotherapy and novel therapies such as proteasome inhibitors and CAR-T cell therapy. While venous thrombosis is the most common type of CAT, patients can also experience arterial thrombosis and in extreme cases disseminated intravascular coagulation and thrombotic microangiopathy. Anticoagulation therapy is the cornerstone of management, with low-molecular-weight heparin (LMWH) being the preferred agent due to its efficacy and lower bleeding risk compared to traditional vitamin K antagonists. Clinical guidelines recommend prophylactic anticoagulation in high-risk patients, especially during periods of hospitalization or following major surgeries. Ongoing research is required to elucidate the precise mechanisms of CAT further and refine treatment protocols, emphasizing personalized approaches to optimize patient outcomes and mitigate the complications associated with CAT in the cancer population. This Special Issue will highlight our current understanding of the mechanisms behind CAT from the molecular level through to patient cohorts.
Dr. Tom A J Mckinnon
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer
- thrombosis
- venous
- arterial
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
