Genomic Analysis of Breast Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 650
Special Issue Editors
Interests: breast cancer; genomics; transcriptomics
Special Issues, Collections and Topics in MDPI journals
Interests: breast cancer; TNBC; mRNA analysis; drug development; clinical trials
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over the past 20 years, advances in genomic analysis of breast cancer have allowed for the constant evolution of clinically relevant subtypes, from immunohistochemically defined groups to molecular profiles. Advanced comprehensive genomic profiling and multiple targeted therapeutics promoted research on molecular tumor characteristics and led to the development of a new approach for metastatic breast cancer (mBC). Broad implementation of comprehensive genomic profiling across an institution is feasible. During this period, the number of genotype selection trials for breast cancer has steadily increased.
While several independent studies suggest better outcomes for the use of molecularly targeted agents compared to conventional therapies, others did not improve outcomes. These conflicting results highlight one of the major problems in precision oncology: the accurate practical interpretation of biomarkers for patient selection.
There are still new opportunities for the improvement of precision medicine for mBC, as evidence supporting this approach is still missing. This is because effectively implementing such precision medicine is not easy and requires solutions that consider technical issues, inter- and intra-tumor diversity, and spatial and temporal evolution.
In addition, a better understanding of the role of genomic alterations and proteins in key signaling pathways in breast cancer progression is needed for more effective treatment.
This Special Issue focuses on the role of comprehensive genomic profiling in mBC, including both translational and clinical aspects of understanding them to find a potential strategy for breast cancer.
In this Special Issue, original research articles and reviews are welcome.
We look forward to your contributions.
Dr. Hiroshi Tada
Dr. Hiroko Masuda
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- breast cancer
- comprehensive genomic profiling
- molecular-matched therapy
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