Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.4
5.2
Journals
Cancers
Special Issues
Molecular Diversity of Gliomas: Epidemiology, Pathology and Genetic/Epigenetic Heterogeneity
share announcement

Molecular Diversity of Gliomas: Epidemiology, Pathology and Genetic/Epigenetic Heterogeneity

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".

Deadline for manuscript submissions: 1 June 2025 | Viewed by 1386

Special Issue Editor

Dr. Maria-Magdalena Georgescu

E-Mail Website
Guest Editor
NeuroMarkers PLLC, Houston, TX, USA
Interests: brain tumors; glioblastoma; diffuse midline glioma; genomics and molecular classification; signaling pathways; PTEN tumor suppressor; NHERF1; diagnostic markers; therapy targets; glioma epidemiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to bring together the latest molecular studies on diffuse glioma/glioblastoma diversity. We welcome papers defining the molecular epidemiology of gliomas in various ethnic populations, with the aim of covering various evolution paradigms explaining the generation of heterogeneity in gliomas, including interactions with microenvironment, correlations between pathology and genetic/epigenetic changes; new markers and technologies for tracing heterogeneity; and therapy approaches addressing heterogeneity in gliomas. Mechanistic and descriptive in-depth molecular studies on the spatiotemporal evolution of adult and pediatric diffuse gliomas, including multifocality, clonal selection, cell migration and metastasis, will also be considered for publication. Finally, studies generating models of heterogeneous gliomas in animal or organoid systems are highly encouraged.

Dr. Maria-Magdalena Georgescu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glioma molecular heterogeneity
  • glioblastoma demographics
  • glioma spatiotemporal evolution
  • glioma genomics
  • glioma epigenomics
  • glioma pathology
  • animal and organoid models of glioma heterogeneity

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

21 pages, 2205 KiB  
Article
Translation into Clinical Practice of the G1-G7 Molecular Subgroup Classification of Glioblastoma: Comprehensive Demographic and Molecular Pathway Profiling
by Maria-Magdalena Georgescu
Cancers 2024, 16(2), 361; https://doi.org/10.3390/cancers16020361 - 15 Jan 2024
Viewed by 1197
Abstract
Glioblastoma is the most frequent and malignant primary neoplasm of the central nervous system. In a recent breakthrough study on a prospective Discovery cohort, I proposed the first all-inclusive molecular classification of glioblastoma into seven subgroups, G1-G7, based on MAPK pathway activation. New [...] Read more.
Glioblastoma is the most frequent and malignant primary neoplasm of the central nervous system. In a recent breakthrough study on a prospective Discovery cohort, I proposed the first all-inclusive molecular classification of glioblastoma into seven subgroups, G1-G7, based on MAPK pathway activation. New data from a WHO-grade-4 diffuse glioma prospective Validation cohort offers, in this study, an integrated demographic–molecular analysis of a 213-patient Combined cohort. Despite cohort differences in the median age and molecular subgroup distribution, all the prospectively-acquired cases from the Validation cohort mapped into one of the G1-G7 subgroups defined in the Discovery cohort. A younger age of onset, higher tumor mutation burden and expanded G1/EGFR-mutant and G3/NF1 glioblastoma subgroups characterized the glioblastomas from African American/Black relative to Caucasian/White patients. The three largest molecular subgroups were G1/EGFR, G3/NF1 and G7/Other. The fourth largest subgroup, G6/Multi-RTK, was detailed by describing a novel gene fusion ST7–MET, rare PTPRZ1–MET, LMNA–NTRK1 and GOPC–ROS1 fusions and their overexpression mechanisms in glioblastoma. The correlations between the MAPK pathway G1-G7 subgroups and the PI3-kinase/PTEN, TERT, cell cycle G1 phase and p53 pathways defined characteristic subgroup pathway profiles amenable to personalized targeted therapy. This analysis validated the first all-inclusive molecular classification of glioblastoma, showed significant demographic and molecular differences between subgroups, and provided the first ethnic molecular comparison of glioblastoma. Full article
(This article belongs to the Special Issue Molecular Diversity of Gliomas: Epidemiology, Pathology and Genetic/Epigenetic Heterogeneity)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop