New Insights in the Role of Myeloid-Derived Suppressor Cells (MDSCs) in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 569
Special Issue Editor
Interests: pprimary myelofibrosis; myeloproliferative neoplasms; vascular endothelial growth factor; immunomodulation; chronic myeloproliferative neoplasms; inflammation; myeloid derived suppressor cells, endothelial cells, myeloid cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent years, myeloid-derived suppressor cells (MDSCs) have attracted increasing interest as major players in modulating tumor onset and progression of cancer. Although the physiopathology of MDSCs is still partially elusive, there is common agreement that these cells contribute to tumors pathogenesis through their immunosuppressive and pro-neoangiogenic activities. In keeping with this notion, previous studies demonstrated that the frequency of circulating MDSCs represents a reliable predictor of a negative outcome and response to therapy both in solid cancers and in hematological malignancies. Therefore, MDSCs could become potential targets for future therapeutic strategies aimed at favoring their differentiation into mature cells or at counteracting their immunosuppressive and neoangiogenic activity or at inhibiting their ability to migrate from the bone marrow (BM) to peripheral organs.
In this Special Issue of Cancers, we welcome original research articles, reviews and perspectives that provide an overview of the most recent advances involving MDSCs in hematological malignancies and solid cancers. Proposed submission topics could include (but are not limited to) the following: (1) autocrine/paracrine mechanisms that link MDSCs and the chronic inflammatory milieu; (2) involvement of MDSCs in neo-angiogenic processes and metastasis propagation; (3) pre-clinical studies on MDSCs as a therapeutic target; (4) study of mechanisms of mobilization MDSCs from the BM into circulation.
Dr. Rita Campanelli
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- myeloid-derived suppressor cells
- hematological malignancies
- solid cancers
- inflammation
- angiogenesis
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