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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Nursing and Supportive Care for Cancer Survivors

edited by

Michela Piredda

submission deadline 12 Jun 2026 | 3 articles | Viewed by 5795

Keywords: cancer survivorship; oncology nursing; symptom management; quality of life; supportive care; psycho-existential distress; pain catastrophizing; palliative care; caregiver support; advanced cancer; patient-centred care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Brain Metastases: From Mechanisms to Treatment

edited by Dawen Zhao and Michael Chan

submission deadline 15 Jun 2026 | 9 articles | Viewed by 23700 | Submission Open

Keywords: brain metastasis; the tumor microenvironment; blood– tumor barrier; novel biomarkers and therapeutics; radiation therapy

(This special issue belongs to the Section Cancer Metastasis)

Recent Studies on Oral Cancer: Diagnostic Technologies, Pathology, and Surgery

edited by

Luisa Limongelli

Gianfranco F. Favia

and

Fabio Dell’Olio

submission deadline 15 Jun 2026 | 4 articles | Viewed by 10399 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; oral potentially malignant disorders; diagnostic technologies; oral surgery; maxillo-facial surgery; oncology; radiology; immunohistochemistry; molecular biology

(This special issue belongs to the Section Clinical Research of Cancer)

Application of Large-Scale Genome Data in Identifying Clinically Actionable Targets in Cancer

edited by

Arezou A. Ghazani

submission deadline 15 Jun 2026 | 3 articles | Viewed by 6634 | Submission Open

Keywords: genome; cancers; oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Current Updates and Future Directions in Neuroendocrine Neoplasms (NENs): Understanding Biology, Diagnosis, Management and Research Efforts in NENs (2nd Edition)

edited by

Jaydira del Rivero

and Aman Chauhan

submission deadline 15 Jun 2026 | 2 articles | Viewed by 5599 | Submission Open

Keywords: neuroendocrine neoplasms; NENs; neuroendocrine carcinomas; tumor biology; clinical management; therapeutic management

(This special issue belongs to the Section Cancer Therapy)

Metastatic Progression of Human Melanoma: 2nd Edition

edited by

Jozsef Timar

and

Andrea Ladányi

submission deadline 15 Jun 2026 | 2 articles | Viewed by 5448 | Submission Open

Keywords: human melanoma; metastasis models; oncogenic signaling; organ metastasis; genomics; immune microenvironment; prognosticators; predictors of target therapies

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in Genomics and Molecular Diagnostics in Gynecological Pathology

edited by

Maria Olinca

and

Radu Pirlog

submission deadline 15 Jun 2026 | 2 articles | Viewed by 4757 | Submission Open

Keywords: tumor genomics; molecular diagnosis; targeted therapies; biomarkers

(This special issue belongs to the Section Molecular Cancer Biology)

New Perspectives in Skin Cancer: From Biology to Therapy

edited by Marija Buljan

submission deadline 15 Jun 2026 | 1 articles | Viewed by 1192 | Submission Open

Keywords: skin cancer; melanoma and non-melanoma skin cancer; tumor biology; early diagnosis; targeted therapy; immunotherapy; epidemiology

Thoracic Cancer Surgery: From Classic to Robotic Approaches

edited by Sai Yendamuri and

Kenneth Patrick Seastedt

submission deadline 15 Jun 2026 | Viewed by 258 | Submission Open

Keywords: thoracic surgery; robotic surgery; image-guided technologies; minimally invasive surgery

(This special issue belongs to the Section Cancer Therapy)

Surgical Strategies in the Era of Perioperative Immunotherapy for Thoracic Cancer

edited by Tomoyuki Hishida

submission deadline 15 Jun 2026 | Viewed by 251 | Submission Open

Keywords: lung cancer; perioperative treatment; immunotherapy; innmue checkpoint inhibitors; surgery

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Current Progress in Radiotherapy and Particle Therapy of Cancer

edited by

Carla Hajj

submission deadline 16 Jun 2026 | Viewed by 454 | Submission Open

Keywords: radiotherapy; particle therapy; proton therapy; heavy ion therapy; radiobiological; carbon ion therapy

(This special issue belongs to the Section Cancer Therapy)

Novel Insights into Cancer-Related Cognitive Impairment

edited by Danielle Tometich

submission deadline 20 Jun 2026 | 3 articles | Viewed by 9792 | Submission Open

Keywords: cognitive impairment; cognitive dysfunction; cancer survivorship; quality of life; neuropsychological assessment; cognitive rehabilitation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

IBD-Associated Cancer

edited by Takayuki Ogino

submission deadline 20 Jun 2026 | 2 articles | Viewed by 2138 | Submission Open

Keywords: IBD-associated cancer; Crohn’ s disease; ulcerative colitis; colorectal cancer; small bowel cancer; chemotherapy; radiotherapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

p53 Family in Cancer: How Close Are We to the Clinic? (2nd Edition)

edited by

Lucília Saraiva

and

Marco M. Candeias

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1523 | Submission Open

Keywords: p53; p63; p73; proteins; protein-coding and non-coding genes; genetics; drug discovery; cancer; targeted anticancer therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Pleural and Peritoneal Mesothelioma

edited by

Rossella Bruno

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1281 | Submission Open

Keywords: pleural mesothelioma; peritoneal mesothelioma; differential diagnosis; biomarkers; next-generation sequencing; gene expression

(This special issue belongs to the Section Molecular Cancer Biology)

Genetic Predisposition to Hematological Malignancies

edited by

Danika Di Giacomo

submission deadline 20 Jun 2026 | 1 articles | Viewed by 617 | Submission Open

Keywords: leukemia predisposition; germline variants; inherited syndromes; myelodysplastic syndrome (MDS); acute myeloid leukemia (AML); precision medicine

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in the Ubiquitin–Proteasome System (UPS) in Cancer Biology

edited by

Tarek A. Abbas

submission deadline 20 Jun 2026 | Viewed by 439 | Submission Open

Keywords: ubiquitin– proteasome system (UPS); cancer biology; E3 ubiquitin ligases; deubiquitinating enzymes (DUBs); protein degradation; proteasome inhibitors; ubiquitination signaling; genome stability and DNA repair; PROTACs and molecular glues; targeted cancer therapeutics

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Strategies in the Prevention/Treatment of Colorectal Cancer: 2nd Edition

edited by

William H. Gmeiner

submission deadline 20 Jun 2026 | Viewed by 439 | Submission Open

Keywords: colorectal cancer; chemotherapy; chemoprevention; targeted therapy; kinase inhibitor; immunotherapy

Advances in Squamous Cell Carcinoma: From Pathogenesis to Treatment

edited by Carolin Götz

submission deadline 20 Jun 2026 | Viewed by 306 | Submission Open

Keywords: squamous cell carcinoma (SCC); oncological surgery; carcinogenesis; tumor microenvironment; HPV; immunotherapy; molecular targets; precision oncology; biomarkers; head and neck cancer; translational oncology

(This special issue belongs to the Section Cancer Pathophysiology)

The Next Cutting-Edge Technologies in Abdominal Solid Tumor Treatment

edited by Jerome Canady, Saravana R.K. Murthy, Aviram Nissan and

Michael Keidar

submission deadline 20 Jun 2026 | Viewed by 289 | Submission Open

Keywords: multi-visceral surgical resection for complex advanced gastrointestinal tumors; cytoreductive surgery; colon and gynecological cancers; pancreatic cancer; cold atmospheric plasma (CAP); robotic AI CAP surgical delivery systems; targeted immunotherapies; irreversible electroporation; HIPEC (hyperthermic intraperitoneal chemotherapy); PIPAC (pressurized intraperitoneal aerosol chemotherapy)

(This special issue belongs to the Section Methods and Technologies Development)

Angiogenesis and Anti-Angiogenic Therapies in Cancer

edited by

Girolamo Ranieri

and Giovanni Mastrandrea

submission deadline 24 Jun 2026 | Viewed by 315 | Submission Open

Keywords: angiogenesis; anti-angiogenic therapies; cancer; tumor vasculature; therapeutic strategies

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Soft Tissue and Bone Sarcoma (2nd Edition)

edited by

Catrin Sian Rutland

submission deadline 25 Jun 2026 | 13 articles | Viewed by 10938 | Submission Open

Keywords: bone sarcoma; soft tissue sarcoma; prognosis; diagnosis; detection; molecular biomarkers; histopathology; treatment

(This special issue belongs to the Section Cancer Therapy)

Digital Pathology in Precision Oncology: Emerging Tools for Diagnosis and Treatment Guidance

edited by Daniela Hartmann and

Maximilian Deussing

submission deadline 25 Jun 2026 | 2 articles | Viewed by 1980 | Submission Open

Keywords: dermatology ; digital pathology ; ex vivo confocal microscopy ; artificial intelligence ; machine learning ; virtual biopsy ; teledermatology ; histopathological images; image analysis algorithms

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Immune Deficiency-Associated Lymphoma

edited by

Régis Thierry Costello

submission deadline 25 Jun 2026 | Viewed by 209 | Submission Open

Keywords: lymphoma; immune; HIV infection

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in the Diagnosis, Stratification, and Targeted Treatment of Myeloproliferative Neoplasms

edited by

Bojana Beleslin Čokić

submission deadline 25 Jun 2026 | Viewed by 205 | Submission Open

Keywords: myeloproliferative neoplasms; molecular diagnostics; targeted therapy; mutational profiling; biomarkers; disease progression; therapy resistance; translational research; personalized medicine

Epigenetic and Metabolic Alterations in the Tumor Microenvironment: 2nd Edition

edited by

Ciro Isidoro

and

Danny N. Dhanasekaran

submission deadline 26 Jun 2026 | 2 articles | Viewed by 5793 | Submission Open

Keywords: tumor microenvironment; hypoxia; inflammation; cytokines; epigenetics; metabolic cross-talk; cancer stroma cells; epigenetic alterations; cancer cell dormancy; cancer cell proliferation; cancer cell migration; cancer cell stemness

(This special issue belongs to the Section Tumor Microenvironment)

New Strategies for Molecular Targeted Therapy in Multiple Myeloma

edited by Daniele Caracciolo

submission deadline 26 Jun 2026 | 1 articles | Viewed by 2539 | Submission Open

Keywords: multiple myeloma; molecular target; drug target; signaling pathway; immunotherapeutic strategy; drug resistance

(This special issue belongs to the Section Cancer Therapy)

Clinical Epidemiology and Risk Prediction for Gastrointestinal Cancers

edited by

Holli Loomans-Kropp

submission deadline 30 Jun 2026 | 12 articles | Viewed by 48903 | Submission Open

Keywords: gastrointestinal cancers; genetic risk; polygenic risk scores; exposome; lifestyle risk factors; biomarkers; chemoprevention

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

New Perspectives in the Management of Breast Cancer

edited by

Sonia Santander Ballestín

and

María José Luesma

submission deadline 30 Jun 2026 | 15 articles | Viewed by 42819 | Submission Open

Keywords: breast cancer; treatment; nutrition; physical exercise; psychosocial impact

(This special issue belongs to the Section Cancer Therapy)

Advances in Clinical Trials: Outcome, Innovations, Challenges, and Ethical Practice in Cancer Research 2025–2026

edited by

Naoto T. Ueno

and David R. Gandara

submission deadline 30 Jun 2026 | 10 articles | Viewed by 39305 | Submission Open

Keywords: phase I; phase II; phase III; phase IV; clinical trials; features; design; implementation; outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Hematologic Malignancies and Related Disorders: Challenges from Diagnosis to Treatment

edited by

Ioanna Sakellari

and

Eleni Gavriilaki

submission deadline 30 Jun 2026 | 10 articles | Viewed by 35831 | Submission Open

Keywords: hematopoietic cell transplantation; cell therapy; acute myeloid leukemia; graft-versus-host disease; hematologic malignancies; thrombosis; complement; lymphoma; myeloma; COVID-19

(This special issue belongs to the Section Cancer Therapy)

New Challenges for Gastric Cancer—Gut Microbiota, Post-eradication and Chemotherapy

edited by Kazunari Murakami and

Kazuhiro Mizukami

submission deadline 30 Jun 2026 | 7 articles | Viewed by 31892 | Submission Open

Keywords: gastric cancer; microbiota; Helicobacter pylori; after Helicobacter pylori eradication therapy; chemotherapy; immune checkpoint inhibitor

(This special issue belongs to the Section Cancer Therapy)

Advances in the Prevention and Treatment of Liver Cancer

edited by Ewa Janczewska

submission deadline 30 Jun 2026 | 8 articles | Viewed by 28229 | Submission Open

Keywords: new screening techniques; enhanced imaging; biomarker tests; radiofrequency ablation; transarterial chemoembolization

(This special issue belongs to the Section Cancer Therapy)

Advances in Bacteria and Cancer

edited by

Alain P. Gobert

submission deadline 30 Jun 2026 | 6 articles | Viewed by 24921 | Submission Open

Keywords: pathogenic bacteria; microbiota; tumor-associated bacteria; probiotics; oncogenesis; metastasis; chemotherapy; cancerous cells; tumor microenvironment; cell signaling

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Epidermal Growth Factor Receptor-Driven Non-Small-Cell Lung Cancer: Diagnostic Technologies and Therapeutic Strategies

edited by

Fang Wei

submission deadline 30 Jun 2026 | 4 articles | Viewed by 23416 | Submission Open

Keywords: EGFR-targeted therapy; non-small-cell lung cancer diagnosis; diagnostic technologies and devices; biological discoveries in NSCLC; AI-assisted diagnosis in oncology; clinical practice in NSCLC detection; therapeutic– diagnostic integration; early-stage lung cancer monitoring; advanced NSCLC diagnostic approaches; precision medicine in lung cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Gynecologic Oncology: Clinical and Translational Research

edited by

Gennaro Daniele

, Pasquale Lombardi and Gaia Giannone

submission deadline 30 Jun 2026 | 8 articles | Viewed by 22292 | Submission Open

Keywords: gynecological cancer; ovarian cancer; translational research; effectiveness; toxicity; immunotherapy; PARP inhibitors

(This special issue belongs to the Section Cancer Therapy)

Human Papillomavirus (HPV) and Related Cancer

edited by

Beata Biesaga

submission deadline 30 Jun 2026 | 9 articles | Viewed by 21661 | Submission Open

Keywords: HPV; carcinogenesis; methods of virus identification diagnostics; prognostification

(This special issue belongs to the Section Infectious Agents and Cancer)

Advances in B-Cell Lymphoma: From Diagnostics to Cure

edited by

Leo I. Gordon

and Megan E. Melody

submission deadline 30 Jun 2026 | 8 articles | Viewed by 21278 | Submission Open

Keywords: B-cell lymphoma; treatment; molecular profiling; immunotherapies; cellular therapies

(This special issue belongs to the Section Cancer Therapy)

News and How Much to Improve in Management of Soft Tissue Sarcomas

edited by Vicente Artigas-Raventós and

José Manuel Asencio

submission deadline 30 Jun 2026 | 11 articles | Viewed by 20289 | Submission Open

Keywords: soft tissue sarcomas; prevalent types; multidisciplinary board; reference centers; news diagnosis methods and treatments; implication of IA and 3D in sarcomas; implication of minimally aggressive surgical techniques

(This special issue belongs to the Section Cancer Therapy)

Role of Cancer Biomarkers for Diagnosis, Prognosis and Targeted Therapy in Gastrointestinal Cancers

edited by

Ali Zaidi

submission deadline 30 Jun 2026 | 9 articles | Viewed by 19887 | Submission Open

Keywords: liquid biopsy; esophageal cancer; gastric cancer; colorectal cancer; pancreatic cancer; hepatocellular cancer; appendiceal cancer; cancer biomarker; DNA sequencing; transcriptomics; proteomics; immunohistochemistry

(This special issue belongs to the Section Cancer Biomarkers)

Study on Epidemiology of Childhood Cancer

edited by

Francesco Giusti

and

Carmen Martos

submission deadline 30 Jun 2026 | 5 articles | Viewed by 19693 | Submission Open

Keywords: childhood cancer; epidemiology; childhood cancer registries; incidence; prevalence; mortality; survival; time trends; special analysis; environmental factors; perinatal factors; inequalities

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

New Insights into Thyroid Cancer Surgery

edited by

Maurizio Iacobone

and Francesca Torresan

submission deadline 30 Jun 2026 | 6 articles | Viewed by 19167 | Submission Open

Keywords: total thyroidectomy; differentiated thyroid cancer; lymph node dissection; parathyroid autofluorescence; medullary thyroid carcinoma; recurrent laryngeal nerve neuromonitoring

(This special issue belongs to the Section Cancer Therapy)

Physiotherapy in Advanced Cancer and Palliative Care

edited by Nele Adriaenssens

submission deadline 30 Jun 2026 | 4 articles | Viewed by 18221 | Submission Open

Keywords: advanced cancer; palliative care; palliative needs; physiotherapy; physical therapy modalities; quality of life; physical autonomy

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Spine Oncology: Research and Clinical Studies

edited by Oluwaseun O. Akinduro

submission deadline 30 Jun 2026 | 8 articles | Viewed by 17598 | Submission Open

Keywords: metastatic spine cancer; targeted therapy; stereotactic body radiotherapy; proton radiotherapy; chordoma; chondrosarcoma; spondylectomy

(This special issue belongs to the Section Clinical Research of Cancer)

Updates on Urologic Oncology: From Diagnosis to Localized and Systemic Therapy Options (2nd Edition)

edited by

Giuseppe Palermo

submission deadline 30 Jun 2026 | 6 articles | Viewed by 17417 | Submission Open

Keywords: bladder cancer; prostate cancer; renal cancer; urologic cancer treatment; urologic cancer diagnosis; urologic cancer innovation; urologic neoplasm therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

The Progress of Pancreatectomy for Pancreatic Cancer Treatment

edited by

Reinhold Függer

and

Matthias Biebl

submission deadline 30 Jun 2026 | 7 articles | Viewed by 17337 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDAC); pancreatectomy timing in multimodal regimen; minimally invasive pancreatectomy for PDAC; pancreatectomy and resectability; extended pancreatectomy; vascular resection and reconstruction; outcome research— pancreatectomy for cancer in unselected patient cohorts; interaction of postoperative complications and preoperative or adjuvant therapy; postoperative pancreatic fistula

(This special issue belongs to the Section Clinical Research of Cancer)

Perspectives on the Efficacy and Biomarkers of Immunotherapy and Targeted Therapy for Patients with Colorectal Cancer

edited by

Ibrahim Halil Sahin

submission deadline 30 Jun 2026 | 6 articles | Viewed by 16652 | Submission Open

Keywords: colorectal cancer; precision medicine; targeted therapeutics; immunotherapy; KRAS; BRAF; HER2; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Application of Artificial Intelligence-Based Approaches in Cancer Diagnosis, Treatment and Prognosis

edited by

Wei Wu

submission deadline 30 Jun 2026 | 6 articles | Viewed by 16186 | Submission Open

Keywords: cancer genomics; artificial intelligence; machine learning; deep learning; tumor microenvironment; graph-based convolutional neural network; computational cancer biology

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Neutrophils in Tumor Progression and Metastasis

edited by

Rakesh K. Singh

and Leah M. Cook

submission deadline 30 Jun 2026 | 5 articles | Viewed by 15919 | Submission Open

Keywords: neutrophils; innate immunity; tumor; microenvironment; metastasis; targeted therapeutics

(This special issue belongs to the Section Cancer Metastasis)

The Applications of Artificial Intelligence in Gastroenterology

edited by

Marcello F. Maida

Ciro Celsa

and Louis H. S. Lau

submission deadline 30 Jun 2026 | 3 articles | Viewed by 15739 | Submission Open

Keywords: artificial intelligence; gastroenterology; endoscopy; inflammatory bowel diseases

(This special issue belongs to the Section Cancer Therapy)

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