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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oxidative Stress and Antioxidants: Mechanisms and Therapeutic Advances in Cancer
edited by , Ankur Sharma and
submission deadline 28 Apr 2027 | Viewed by 45 | Submission Open
Keywords: oxidative stress; antioxidants; therapeutic; cancer; apoptosis; anticancer drugs; nano antioxidants
Surgery and Clinical Outcomes in Head and Neck Squamous Cell Carcinoma
edited by and Mihir R. Patel
submission deadline 29 Apr 2027 | 1 articles | Viewed by 408 | Submission Open
Keywords: head and neck tumors; surgery; therapy; biomarkers; salivary tumors; thyroid tumors
(This special issue belongs to the Section Clinical Research in Cancer)
Prevention, Early Detection, and Surgical Oncology in Hepatocellular Carcinoma, Pancreatic Cancer, and Gastrointestinal Cancer
edited by and
submission deadline 30 Apr 2027 | 7 articles | Viewed by 14473 | Submission Open
Keywords: early image detection in cancer; biomarker of cancer; surgical treatment; gastrointestinal cancer
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Interrogating Molecular Regulators and Chemical Agents in Brain Tumor Progression
edited by Shilpi Singh
submission deadline 30 Apr 2027 | 3 articles | Viewed by 8136 | Submission Open
Keywords: brain tumor progression; molecular mechanisms; small molecule inhibitors; natural compounds; synthetic drugs; biomarkers; oncogenic pathways; metabolic reprogramming
(This special issue belongs to the Section Tumor Microenvironment)
Tumor Microenvironment Dynamics in Hepatocellular Carcinoma
edited by Joseph Franses and Adam Burgoyne
submission deadline 30 Apr 2027 | 3 articles | Viewed by 6890 | Submission Open
Keywords: liver cancer; immune therapy; biomarkers; treatment resistance; cellular interactions
(This special issue belongs to the Section Tumor Microenvironment)
Personalizing Head and Neck Cancer Care
edited by and
submission deadline 30 Apr 2027 | 3 articles | Viewed by 5541 | Submission Open
Keywords: head and neck cancer; personalized treatment; targeted therapy; prehabilitation; quality of life
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Insulin Resistance, Diabetes, and Cancer: An Overview of the Pathogenetic Mechanisms submission deadline 30 Apr 2027 | 2 articles | Viewed by 3157 | Submission Open
Keywords: insulin resistance; type 2 diabetes; hyperinsulinemia; IGF-1 signaling; tumor microenvironment; metabolic inflammation; adipokines; antidiabetic drugs; cancer metabolism; phytocompounds; bioactive molecules; hormone regulation; intracellular signalling pathways
(This special issue belongs to the Section Cancer Pathophysiology)
Advanced Strategies for Precision Therapy in Urinary Cancers
edited by Menghuan Tang and
submission deadline 30 Apr 2027 | 3 articles | Viewed by 2540 | Submission Open
Keywords: urological oncology; precision drug delivery system; nanomaterials; stimuli-responsive delivery; immunotherapy; radioligand therapy
(This special issue belongs to the Section Cancer Therapy)
Socio-Demographic Factors and Cancer Research: 2nd Edition
edited by and Amanda N. Goldin
submission deadline 30 Apr 2027 | 3 articles | Viewed by 2139 | Submission Open
Keywords: socio-economic disparity; cancer delivery; cancer survival; metastatic cancer; culture-specific cancer outcomes; AI; machine learning
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Current Applications and Cutting-Edge Innovations in Neuroendoscopy for Oncological Neurosurgery: Where Are We and Where Are We Going?
edited by Giuseppe Roberto Giammalva, Giovanni Tringali and
submission deadline 30 Apr 2027 | 1 articles | Viewed by 2014 | Submission Open
Keywords: neuroendoscopy; endoventricular surgery; skull base surgery; endoscopic assisted neurosurgery; innovations
(This special issue belongs to the Section Methods and Technologies Development)
Clinical Treatment and Outcomes of Gastrointestinal Cancer
edited by Mary Linton Peters
submission deadline 30 Apr 2027 | 2 articles | Viewed by 1983 | Submission Open
Keywords: gastrointestinal cancer; ctDNA; chemotherapy; immunotherapy; financial toxicity; clinical trial participation
(This special issue belongs to the Section Clinical Research in Cancer)
Unraveling Immune Dynamics and Novel Therapeutic Strategies in the Tumor Microenvironment
edited by Shahidul M. Islam
submission deadline 30 Apr 2027 | 1 articles | Viewed by 1852 | Submission Open
Keywords: tumor microenvironment; immune dynamics; tumor heterogeneity; immune checkpoints; CAR T; cancer immunology; adoptive cell transfer; resistance; biomarkers; combination therapy; machine learning; molecular modeling
(This special issue belongs to the Section Tumor Microenvironment)
Combination Therapies in Breast Cancer Chemotherapy: Chemoradiation, Targeted Agents, and Immunotherapy
edited by
submission deadline 30 Apr 2027 | 2 articles | Viewed by 1705 | Submission Open
Keywords: breast cancer; combination therapy; endocrine therapy; chemoradiation; monoclonal antibodies; antibody–drug conjugates (ADCs); small-molecule kinase inhibitors; immunotherapy; predictive biomarkers; therapy resistance; precision oncology; translational research
(This special issue belongs to the Section Cancer Therapy)
Mesothelioma Today: Global Trends, Clinical Challenges, and Policy Responses
edited by and Marco Tomasetti
submission deadline 30 Apr 2027 | 2 articles | Viewed by 1369 | Submission Open
Keywords: malignant mesothelioma; asbestos exposure; occupational cancer; epidemiology; public health policy
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Tumour–Immune Interactions in Cancer Therapy submission deadline 30 Apr 2027 | Viewed by 1147 | Submission Open
Keywords: tumour‑immune interactions; tumour immune microenvironment; immune escape; treatment response; therapy resistance; tumour heterogeneity; immunotherapy; chemotherapy; radiotherapy; targeted therapy; functional genomics; organoids; antigen presentation; translational research; clinical trials; single‑cell & spatial analysis
(This special issue belongs to the Section Molecular Cancer Biology)
Clinical Research in Gynecological Cancers
edited by
submission deadline 30 Apr 2027 | 2 articles | Viewed by 1003 | Submission Open
Keywords: gynecologic oncology; hereditary cancer syndrome; BRCA mutation; gynecologic surgery; gynecologic ultrasound; gynecologic oncology prevention; molecular biomarkers; minimally invasive surgery; STIC (serous tubal intraepithelial carcinoma); ovarian cancer; fertility-sparing surgery
(This special issue belongs to the Section Clinical Research in Cancer)
Cytoskeleton in Tumor Growth and Progression
edited by David Gau
submission deadline 30 Apr 2027 | 1 articles | Viewed by 935 | Submission Open
Keywords: actin cytoskeleton; microtubules; mechano-transduction; tumor microenvironment; angiogenesis; mitochondria
(This special issue belongs to the Section Molecular Cancer Biology)
Decoding the Tumor Microenvironment: From Mechanisms to Therapeutic Opportunities
edited by , Giacomo Miserocchi and
submission deadline 30 Apr 2027 | 1 articles | Viewed by 916 | Submission Open
Keywords: tumor microenvironment (TME); cancer immunology; tumor–stroma interactions Immune; evasion; therapy resistance; spatial and single-cell omics; biomarker discovery; translational oncology; 3D models
(This special issue belongs to the Section Tumor Microenvironment)
From Metronomic Chemotherapy to Time-Optimized Cancer Treatments
edited by
submission deadline 30 Apr 2027 | 1 articles | Viewed by 770 | Submission Open
Keywords: metronomic chemotherapy; time-dependent treatment; chemotherapy; immunotherapy; pharmacokinetics; pharmacodynamics
Advances in the Diagnosis, Pathology and Treatment of Metastatic Brain Tumors
edited by
submission deadline 30 Apr 2027 | 1 articles | Viewed by 753 | Submission Open
Keywords: brain metastases; diagnostic imaging; molecular pathology; targeted therapy; immunotherapy; precision oncology; multimodal treatment; translational research
(This special issue belongs to the Section Cancer Metastasis)
Role of Pathology in Detection, Prognosis and Treatment of Gastrointestinal Cancers
edited by and Luís Ortega-Medina
submission deadline 30 Apr 2027 | Viewed by 510 | Submission Open
Keywords: gastrointestinal cancer; pathology; histopathology; molecular pathology; biomarkers; prognosis; precision medicine; digital pathology; cancer detection; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Innovations in Pathological and Clinical Research in Colorectal Cancer submission deadline 30 Apr 2027 | 1 articles | Viewed by 469 | Submission Open
Keywords: colorectal cancer; clinicopathological prognostic biomarkers; pathology-guided therapeutic strategies
Melanoma Combination Therapy: New Horizons, Challenges and Clinical Breakthroughs
edited by Gino K. In, Sanjay Chandrasekaran and
submission deadline 30 Apr 2027 | 1 articles | Viewed by 455 | Submission Open
Keywords: advanced melanoma; combination checkpoint blockade; targeted therapy; peri-operative therapy; adoptive cellular therapy; intratumoral therapy; rare melanomas; abscopal effect
(This special issue belongs to the Section Cancer Therapy)
Deep Learning for Cancer Image Classification in Smaller Patient Cohorts
edited by
submission deadline 30 Apr 2027 | Viewed by 432 | Submission Open
Keywords: deep learning; deep radiomics; diagnosis; prognosis; prediction
(This special issue belongs to the Section Cancer Informatics and Big Data)
Emerging Biomarkers for Precision Oncology in Gastrointestinal Cancers submission deadline 30 Apr 2027 | Viewed by 342 | Submission Open
Keywords: gastrointestinal cancers; precision oncology; cancer biomarkers; liquid biopsy; next-generation sequencing; predictive biomarkers; tumor microenvironment; cancer immunotherapy biomarkers; molecular profiling; translational oncology
(This special issue belongs to the Section Cancer Biomarkers)
New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor: 2nd Edition
edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo
submission deadline 30 Apr 2027 | Viewed by 326 | Submission Open
Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology
(This special issue belongs to the Section Cancer Therapy)
Local, Systemic and Combined Therapy for Hepatocellular Carcinoma
edited by Xiaoqun Dong
submission deadline 30 Apr 2027 | Viewed by 318 | Submission Open
Keywords: hepatocellular carcinoma; immunotherapy; cell therapy; targeted therapy; local therapy; combination therapy; oncolytic virus; precision oncology; drug resistance; translational research
(This special issue belongs to the Section Cancer Therapy)
Advances in Surgery for Gynecologic Cancer submission deadline 30 Apr 2027 | Viewed by 308 | Submission Open
Keywords: sentinel lymph node mapping; cervical cancer; robotic-assisted laparoscopy; cytoreductive surgery; nerve-sparing techniques; image-guided surgery; enhanced recovery after surgery; molecular staging; individualized surgery; endometrial cancer
Advances in Diagnosis and Clinical Trials of Bladder Cancer
edited by Mutsuo Furihata
submission deadline 30 Apr 2027 | Viewed by 253 | Submission Open
Keywords: bladder cancer; pathological diagnosis; tumorigenesis; 5-aminolevulinic acid; photodynamic therapies; robot-assisted radical cystectomy; fluorescence navigation; artificial intelligence
Decoding Glioblastoma: Mechanisms, Innovations, and Therapeutic Advancements
edited by , Jerica M. Lomax and Yoon Jae Choi
submission deadline 30 Apr 2027 | Viewed by 250 | Submission Open
Keywords: glioblastoma; tumor heterogeneity; resistance; glioma stem cells; multi-omics; molecular targeting; tumor microenvironment; immunotherapy; spatial transcriptomics; epigenetic regulation; metabolic reprogramming; liquid biopsy; radiomics; advanced imaging; nuclear medicine
Advances in Supportive Care in Radiation Oncology
edited by Lukas Käsmann
submission deadline 30 Apr 2027 | Viewed by 245 | Submission Open
Keywords: supportive care; radiation oncology; symptom management; patient-reported outcomes; radiation dermatitis; oral mucositis; cancer survivorship; integrative oncology; quality of life
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Epigenomic and Transcriptional Mechanisms in Cancer Progression and Therapy Response
edited by Benjamin L. Kidder
submission deadline 30 Apr 2027 | Viewed by 235 | Submission Open
Keywords: cancer progression; genetic mutations; epigenomic plasticity; tumor heterogeneity; gene regulatory networks; epigenomic mechanisms
(This special issue belongs to the Section Molecular Cancer Biology)
Digestive Tract Cancers: A State-of-the-Art Perspective on Epidemiology, Risk Factors, Molecular Mechanisms, Prevention, Diagnosis and Management
edited by Paraskevi A Farazi
submission deadline 30 Apr 2027 | Viewed by 226 | Submission Open
Keywords: colorectal; pancreatic; liver; biliary; esophageal; stomach cancers; epidemiology; risk factors; molecular mechanisms; prevention; diagnosis; treatment
Beyond Breast Cancer—Rehabilitation for Survivorship submission deadline 30 Apr 2027 | Viewed by 220 | Submission Open
Keywords: breast cancer; rehabilitation; person-centered: clinical follow-up; physiotherapy; psycho-social support; existential support; patient education and self-management
The Relationship Between Cancers Metabolism and Immunotherapy
edited by Suguru Saito
submission deadline 30 Apr 2027 | Viewed by 199 | Submission Open
Keywords: anti-tumor immunity; metabolism; immunotherapy; macrophages; T cells; exhaustion
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
The Roles of Endoscopies in Gastrointestinal Neoplasm
edited by and Hideki Kobara
submission deadline 30 Apr 2027 | Viewed by 157 | Submission Open
Keywords: gastrointestinal cancer; image enhanced endoscopy; early cancer detection; endoscopic submucosal dissection (ESD); endoscopic resection; AI-assisted diagnosis; surveillance endoscopy
(This special issue belongs to the Section Methods and Technologies Development)
Modern Radiation Therapy on Refractory Cancer Treatment: Technological Innovations, New Paradigms, Personalized Medicine and Recent Clinical Advances
edited by
submission deadline 30 Apr 2027 | Viewed by 134 | Submission Open
Keywords: adaptive therapy; personalized radiation therapy; refractory cancer; spatially fractionated radiation therapy; minibeam; microbeam; flash therapy
(This special issue belongs to the Section Cancer Therapy)
Advances in the Surgical Management of Pancreatic Cancer
edited by Richard Zheng and
submission deadline 30 Apr 2027 | Viewed by 106 | Submission Open
Keywords: pancreatic cancer; pancreatic surgery; pancreatectomy; PDAC; outcomes; minimally invasive surgery; enhanced recovery after surgery (ERAS)
(This special issue belongs to the Section Cancer Therapy)
Nanocarrier in Cancer Therapy
edited by
submission deadline 30 Apr 2027 | Viewed by 98 | Submission Open
Keywords: nanocarriers; cancer therapy; nanomedicine; targeted drug delivery; stimuli-responsive nanocarriers; tumor microenvironment; nanoparticles; theranostics; drug resistance; precision oncology
(This special issue belongs to the Section Methods and Technologies Development)
The Role of Immune Checkpoint Inhibitors in Cancer Therapy
edited by
submission deadline 30 Apr 2027 | Viewed by 58 | Submission Open
Keywords: immune checkpoint inhibitors; immune checkpoint blockade; PD-1/PD-L1; CTLA-4; LAG-3; bispecific antibodies; predictive biomarkers; immunotherapy resistance; combination immunotherapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Emerging Imaging and Radiotherapy Techniques for CNS Tumors submission deadline 30 Apr 2027 | Viewed by 57 | Submission Open
Keywords: CNS tumors; neuro-oncology; advanced imaging; molecular imaging; MRI; PET imaging; stereotactic radiosurgery (SRS); adaptive radiotherapy; proton therapy; stereotactic body radiotherapy (SBRT)
(This special issue belongs to the Section Methods and Technologies Development)
Molecular Mechanisms and Tumor Heterogeneity in Osteosarcoma
edited by Le Thi Thanh Thuy and
submission deadline 30 Apr 2027 | Viewed by 57 | Submission Open
Keywords: osteosarcoma; tumor heterogeneity; single-cell RNA sequencing/tumor microenvironment; immune checkpoint proteins and circulating biomarkers; therapeutic targets and translational treatment
(This special issue belongs to the Section Molecular Cancer Biology)
Interventional Cancer Pain Management: Current Evidence, Unresolved Questions, and Future Directions submission deadline 30 Apr 2027 | Viewed by 32 | Submission Open
Keywords: cancer pain; pain management; neoplasm metastasis; analgesia; neurosurgical procedures; palliative care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
DNA Methylation, Epigenetic Heterogeneity and Biomarkers in Gynecologic Cancers
edited by
submission deadline 30 Apr 2027 | Viewed by 32 | Submission Open
Keywords: DNA methylation; cancer epigenetics; gynecologic cancers; epigenetic biomarkers; molecular biomarkers; single-cell epigenomics; spatial epigenomics; intratumoral heterogeneity; clonal evolution; tumor evolution; therapy resistance; liquid biopsy; circulating tumor DNA; multi-omics; precision oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Palliative and Supportive Care in Oncology: An Update (2nd Edition)
edited by , Romina Rossi, , Andrea Carlini and Lucia Angelini
submission deadline 30 Apr 2027 | Viewed by 25 | Submission Open
Keywords: palliative care; supportive care; quality of life; integrative medicine; palliative radiotherapy; end of life care; cancer care; quality of care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Recent Advances in Pediatric Neuro-Oncology: Optimism for the Future
edited by James Rutka
submission deadline 30 Apr 2027 | Viewed by 21 | Submission Open
Keywords: neuro-oncology; neuroimaging; neurosurgery; molecular genetics; neuropathology; chemotherapy; radiation therapy; targeted therapy; immunotherapy
(This special issue belongs to the Section Pediatric Oncology)
Functional Preservation and Personalized Surgery in Early-Stage Lung Cancer
edited by
submission deadline 30 Apr 2027 | Viewed by 14 | Submission Open
Keywords: early-stage lung cancer; non-small cell lung cancer (NSCLC); functional preservation; personalized surgery; precision surgery; parenchyma-sparing surgery; segmentectomy; sublobar resection; wedge resection; minimally invasive surgery; robotic-assisted thoracic surgery; video-assisted thoracoscopic surgery (VATS); pulmonary function; quality of life; patient-reported outcomes; frailty; surgical risk stratification; tumor biology; molecular profiling; biomarkers; radiomics; artificial intelligence; image-guided surgery; intraoperative navigation; fluorescence-guided surgery; surgical margins; lymph-node assessment; neoadjuvant therapy; adjuvant therapy; stereotactic body radiotherapy (SBRT); multidisciplinary treatment; personalized medicine
(This special issue belongs to the Section Methods and Technologies Development)
The Role of Physical Activity in Cancer Prevention, Treatment and Rehabilitation submission deadline 1 May 2027 | Viewed by 238 | Submission Open
Keywords: cancer; hematooncology; adults; children; physical activity; exercise; interventions; supportive care; prevention; recovery; quality of life
Gynecological Oncology and Robotic Surgery submission deadline 10 May 2027 | Viewed by 367 | Submission Open
Keywords: gynecologic oncology; robotic-assisted surgery; minimally invasive surgery; artificial intelligence; surgical innovation; multidisciplinary care
(This special issue belongs to the Section Methods and Technologies Development)
The Clinical Trials and Management of Acute Myeloid Leukemia: 2nd Edition
edited by
submission deadline 14 May 2027 | 2 articles | Viewed by 7814 | Submission Open
Keywords: acute myeloid leukemia; clinical trials; translational research; targeted therapies; novel agents
(This special issue belongs to the Section Clinical Research in Cancer)
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