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Advanced Strategies for Precision Therapy in Urinary Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 967

Editors


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Guest Editor
Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA 95817, USA
Interests: nano medicine; drug delivery; cancer therapy; phototherapy; mitochondria-targeting

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Guest Editor
1. Department of Urology, Stony Brook University, Stony Brook, NY 11794, USA
2. Stony Brook Cancer Center, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
Interests: drug delivery; microrobots; nano medicine; bladder cancer; drug development
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Special Issue Information

Dear Colleagues,

Urological malignancies, including renal cell carcinoma, bladder cancer, and prostate cancer, present a complex landscape of metabolic heterogeneity and distinct anatomical barriers. Despite the success of immune checkpoint inhibitors and antibody-drug conjugates (ADCs), clinical outcomes are often limited by the urothelial-blood barrier, high interstitial fluid pressure, and the highly immunosuppressive tumor microenvironment (TME). This Special Issue focuses on the engineering of functionalized delivery systems and molecular therapeutics designed to bypass these hurdles. We invite submissions on the following topics: (1) stimuli-responsive drug delivery systems designed to navigate urological physiological barriers; (2) next-generation biologics, including mRNA and circular RNA platforms for targeted gene modulation; (3) advanced theranostic strategies utilizing radioligand therapy (e.g., PSMA-targeted agents) and multimodal imaging; (4) strategies to overcome immunosuppression within the urological tumor microenvironment. Our goal is to collect original research that provides practical, high-efficiency solutions, as well as high-quality reviews that offer comprehensive insights and future perspectives on the precision management of urinary cancers.

Dr. Menghuan Tang
Dr. Zhaoqing Cong
Guest Editors

Manuscript Submission Information

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Keywords

  • urological oncology
  • precision drug delivery system
  • nanomaterials
  • stimuli-responsive delivery
  • immunotherapy
  • radioligand therapy

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Published Papers (1 paper)

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Review

26 pages, 2028 KB  
Review
Nature-Inspired Solutions: Biomimetic Materials and Adaptive Devices for Precision Urinary Oncology
by Chunlian Zhong, Lifeng Yin, Michael Hung, Shanshan Yao, Menghuan Tang and Zhaoqing Cong
Cancers 2026, 18(9), 1429; https://doi.org/10.3390/cancers18091429 - 30 Apr 2026
Viewed by 715
Abstract
Urinary cancers present a severe clinical challenge due to high recurrence rates. Standard intravesical therapies suffer from limited efficacy because of the urinary tract’s robust physiological defenses, namely, the dynamic washout effect during voiding and highly restrictive urothelial barriers, such as the anti-adhesive [...] Read more.
Urinary cancers present a severe clinical challenge due to high recurrence rates. Standard intravesical therapies suffer from limited efficacy because of the urinary tract’s robust physiological defenses, namely, the dynamic washout effect during voiding and highly restrictive urothelial barriers, such as the anti-adhesive glycosaminoglycan layer and intercellular tight junctions. This review aims to explore how biomimetic engineering can overcome these obstacles by transitioning drug delivery from passive carriers to active, nature-inspired systems. We conducted a comprehensive review of the recent literature focusing on biomimetic strategies for intravesical drug delivery and urinary cancer theranostics. The analyzed approaches are categorized into chemical biomimicry (such as adhesion and camouflage) and structural/functional biomimicry (including adaptive devices and microrobots). Biomimetic strategies significantly enhance targeted drug retention and tissue penetration. Chemical biomimicry, utilizing mussel-inspired catechol chemistry and cell membrane camouflage, effectively bypasses the urothelial anti-adhesive defenses and reduces the immune clearance. Structural and functional biomimicry, such as naturally derived carriers and actively propelled magnetic or biohybrid microrobots, enables the precise spatial localization and controlled payload release in dynamic fluid environments. Furthermore, lab-on-a-chip technologies and patient-derived organoids (PDOs) offer scalable platforms for screening cargo-specific efficacies and tailoring treatments, providing a crucial bridge to personalized precision medicine. Integrating nature-inspired designs with advanced nanotechnologies provides a highly promising pathway with which to overcome the mechanical and biological barriers of the urinary tract. These biomimetic innovations hold the potential to shift the therapeutic paradigm for urinary oncology, paving the way for more efficient, targeted, and personalized precision medicine. Full article
(This article belongs to the Special Issue Advanced Strategies for Precision Therapy in Urinary Cancers)
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