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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Development of Effective Therapy Targeting the Microenvironment of Cancer (2nd Edition)

edited by

Moriaki Kusakabe

and

Kanae Taruno

submission deadline 30 Sep 2026 | 2 articles | Viewed by 4663 | Submission Open

Keywords: cancer; tumor microenvironment; cancer therapy; cancer cell; animal level

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Brain Tumors

edited by

David S. Baskin

submission deadline 30 Sep 2026 | 2 articles | Viewed by 4605 | Submission Open

Keywords: diagnosis; biomarker; treatment; brain tumors

(This special issue belongs to the Section Clinical Research in Cancer)

Cancer Survivors: Late Effects of Cancer Therapy

edited by

Gaurav Kumar

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4361 | Submission Open

Keywords: late effects; cancer survivorship; treatment toxicity; long-term outcomes

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Pre-Clinical Studies of Personalized Medicine for Cancer Research: 2nd Edition

edited by

Nuno Vale

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4300 | Submission Open

Keywords: patient-derived models; genomic profiling; drug screening; biomarker validation; combination therapies; mechanistic studies; tumor heterogeneity; data analysis and interpretation

(This special issue belongs to the Section Molecular Cancer Biology)

Robotic and Thoracoscopic Surgery for Thoracic Oncology

edited by

Elisa Meacci

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3776 | Submission Open

Keywords: robotic-assisted thoracic surgery; video-assisted thoracoscopic surgery (VATS); lung cancer surgery; esophageal cancer; thymic tumors; minimally invasive surgery; pleural tumors; chest wall tumors; mediastinal surgery; thoracic oncology

(This special issue belongs to the Section Clinical Research in Cancer)

Management of Orbital Tumors

edited by

Peerooz Saeed

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3512 | Submission Open

Keywords: orbital tumor; diagnostic; multidisciplinary approaches; personalized treatment; imaging techniques

(This special issue belongs to the Section Clinical Research in Cancer)

Multimodal Artificial Intelligence/Machine Learning Applications in Malignant Tumors: Diagnosis, Prognosis, and Management

edited by

Sam Payabvash

and Stefan Haider

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3445 | Submission Open

Keywords: machine learning; radiomics; cancer imaging; malignancy; survival

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Radiotherapy for Head and Neck Squamous Cell Carcinoma (2nd Edition)

edited by

Cesare Guida

and Ida D'Onofrio

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3222 | Submission Open

Keywords: head and neck squamous cell carcinoma; radiotherapy; biomarker; chemoradiotherapy; head and neck cancers

(This special issue belongs to the Section Cancer Therapy)

Advances in Pathogenesis and Pathology Diagnosis of Gynecologic Cancers

edited by

Wenxin Zheng

submission deadline 30 Sep 2026 | 3 articles | Viewed by 3061 | Submission Open

Keywords: gynecologic cancers; molecular pathology; tumor pathogenesis; diagnostic biomarkers; precision medicine; endometrial carcinoma; ovarian cancer; cervical cancer; histopathology; translational research

Cancer and Melatonin: Updates on Current Findings

edited by

Rita Rezzani

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3039 | Submission Open

Keywords: cancer; melatonin; oxidative stress; inflammation; antioxidant defense

Novel Advancements in Prostate Cancer Surgery: Indications and Techniques

edited by Valerio Santarelli and

Alessandro Sciarra

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3009 | Submission Open

Keywords: radical prostatectomy; prostate cancer; technology; minimally invasive surgery

(This special issue belongs to the Section Cancer Therapy)

Clinical Trials and Translational Research in Multiple Myeloma

edited by Laszlo Varoczy

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2914 | Submission Open

Keywords: multiple myeloma; disease evolution; translational research; personalizing therapy; clinical trial

(This special issue belongs to the Section Clinical Research in Cancer)

Chromatin-Remodeling Factors in Cancer Cells

edited by

Sudhakar Jha

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2873 | Submission Open

Keywords: chromatin remodeling; transcription factors; epigenetic therapy; cancer epigenomics; SWI/SNF complex; CRISPR functional screens; single-cell epigenomics; gene regulation in cancer; therapy resistance; targeted cancer therapies

(This special issue belongs to the Section Cancer Pathophysiology)

Pediatric Surgery in Oncology: Innovations, Challenges, and Future Directions

edited by Abdelhafeez H. Abdelhafeez and Kokila Lakhoo

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2697 | Submission Open

Keywords: pediatric surgical oncology; intraoperative image guidance; minimally invasive surgery; fluorescence guidance; augmented reality; precision cancer surgery

(This special issue belongs to the Section Pediatric Oncology)

Hematologic Malignancies: Clinical Features and Prognostic Indicators

edited by Danijela Leković

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2644 | Submission Open

Keywords: leukemia; myelodysplastic syndrome; myeloproliferative neoplasms; lymphoma; multiple myeloma; diagnosis; prognosis; molecular markers; infections; survival; machine learning

(This special issue belongs to the Section Clinical Research in Cancer)

miRNAs in Targeted Cancer Therapy

edited by Mustafa Özen

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2487 | Submission Open

Keywords: miRNA; micro-RNA; targeted therapy; cancer treatment; solid tumors; hematological malignancies; non-coding RNAs; epigenetic regulation; cancer therapeutics; gene therapy

(This special issue belongs to the Section Cancer Therapy)

Screening, Early Detection and Therapeutic Advances in Gastrointestinal Cancers

edited by

Arkadeep Dhali

and

Saikat Mandal

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2486 | Submission Open

Keywords: gastrointestinal cancer; screening; advanced endoscopy; imaging platforms; circulating biomarkers; molecular profiling

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in PET/CT Imaging in Cancer Management

edited by Jasna M. Mihailovic and Mihaela Raluca Mititelu

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2443 | Submission Open

Keywords: PET/CT imaging; oncology; staging; restaging; treatment monitoring; recurrence detection

(This special issue belongs to the Section Methods and Technologies Development)

Advanced Strategies for Precision Therapy in Urinary Cancers

edited by Menghuan Tang and

Zhaoqing Cong

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2400 | Submission Open

Keywords: urological oncology; precision drug delivery system; nanomaterials; stimuli-responsive delivery; immunotherapy; radioligand therapy

(This special issue belongs to the Section Cancer Therapy)

Targeting RNA to Improve Cancer Precision Medicine

edited by

Gabriella Misso

, Anna Grimaldi and Chiara Tammaro

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2376 | Submission Open

Keywords: cancer; RNA therapy; RNA delivery; RNA; miRNA; mRNA; siRNA; oligonucleotides; aptamers; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Ablation Treatment for Malignant Tumors

edited by

Madelon Dijkstra

Martijn Meijerink

and

Susan Van Der Lei

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2243 | Submission Open

Keywords: ablative therapies; thermal ablation; image-guided therapy; minimally invasive; radiofrequency ablation (RFA); microwave ablation (MWA); cryoablation; irreversible electroporation (IRE); malignant tumors; oligometastatic disease; immunotherapy combinations; interventional oncology

(This special issue belongs to the Section Cancer Therapy)

Senescence and Cell Plasticity in Cancer Development

edited by

Eva María Verdugo-Sivianes

and Elena Aguado-Domínguez

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2034 | Submission Open

Keywords: cellular senescence; cell plasticity; stem cells; SASP; therapy resistance; tumor microenvironment; cancer development

(This special issue belongs to the Section Molecular Cancer Biology)

Breast Cancer and Pregnancy: Clinical, Translational, and Psychosocial Perspectives

edited by

Alba Di Leone

and

Elena Jane Mason

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1989 | Submission Open

Keywords: pregnancy-associated breast cancer; postpartum breast cancer; pregnancy after breast cancer; oncofertility; fertility preservation; breast surgery; maternal outcomes; fetal outcomes; genetic risk; survivorship

(This special issue belongs to the Section Clinical Research in Cancer)

Advances in Cancer Targeted Therapy

edited by Ponniah Selvakumar

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1911 | Submission Open

Keywords: targeted therapy; cancer treatment; molecular targets; signaling pathways; angiogenesis inhibition; artificial intelligence (AI); single-cell technologies; informatics; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Mitochondria and Cancer: From Hidden Culprits to Healing Targets

edited by

Nicola Amodio

and

Marianna Scrima

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1811 | Submission Open

Keywords: mitochondria; mitochondrial dynamics; cancer-associated mitochondrial defects; mitochondrial metabolism

(This special issue belongs to the Section Cancer Pathophysiology)

Cell Cycle Dysregulation in Cancers

edited by Radoslav Janostiak

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1810 | Submission Open

Keywords: cell cycle regulation; proliferation-quiescence decision; post translational regulation; quiescence maintenance; senescence escape; environmental stress adaptation; minimal residual disease; cell cycle checkpoints

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical and Surgical Outcomes in the Management of Extremity Soft Tissue Sarcomas (2nd Edition)

edited by

Matthew T. Houdek

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1688 | Submission Open

Keywords: soft tissue sarcoma; outcome; limb salvage; radiotherapy; surgery

(This special issue belongs to the Section Cancer Therapy)

Imaging and Liquid Biopsy Biomarkers for Cancer Diagnosis and Treatment (2nd Edition)

edited by

Mark Jesus M. Magbanua

and

Wen Li

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1655 | Submission Open

Keywords: cancer imaging; liquid biopsy; cancer diagnosis; treatment response; prognosis; metastasis; circulating tumor cells; disseminated tumor cells; circulating tumor DNA; circulating tumor RNA

(This special issue belongs to the Section Methods and Technologies Development)

Artificial Intelligence (AI), Robotics, and Cancer Surgery

edited by Zaid M. Abdelsattar

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1652 | Submission Open

Keywords: cancer surgery; artificial intelligence; robotics surgery; surgical outcome; decision-making

(This special issue belongs to the Section Methods and Technologies Development)

Gut Microbiota and Inflammation in Colorectal Tumor Development and Progression

edited by

Giovanni Monteleone

and Irene Marafini

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1644 | Submission Open

Keywords: gut microbiota; colorectal cancer; inflammation; tumor microenvironment; mucosal immunity; microbial metabolites; immune–microbiota interactions; inflammatory bowel disease; cancer progression

Lung Cancer—Molecular Insights and Targeted Therapies (Third Edition)

edited by

Sonia Molina-Pinelo

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1637 | Submission Open

Keywords: lung cancer; non-small-cell lung cancer; small-cell lung cancer; biomarkers; oncogene-drive tumors; molecular mechanisms; targeted therapies; immunotherapy; precision medicine; preclinical models

(This special issue belongs to the Section Molecular Cancer Biology)

A New Era in the Treatment of Early-Stage Non-Small Cell Lung Cancer (2nd Edition)

edited by

Tsutani Yasuhiro

submission deadline 30 Sep 2026 | 3 articles | Viewed by 1569 | Submission Open

Keywords: minimally invasive surgery; video-assisted thoracic surgery; robotic-assisted thoracic surgery; sublobar resection; segmentectomy; neoadjuvant therapy; adjuvant therapy; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Supportive Care in Cancer

edited by

Jeffrey R. Hanna

and

Cherith J. Semple

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1540 | Submission Open

Keywords: supportive care; psychosocial; cancer; intersectionality; rehabilitation; communication; survivorship

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Cancer Immunotherapy-Related Adverse Events and Therapy-Related Accelerated Aging

edited by

Grace Lu-Yao

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1537 | Submission Open

Keywords: immune-related adverse events (irAEs); accelerated aging; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Stress, Epigenetic Regulation, and DNA Damage: Insights into Cancer Development and Therapeutic Challenges

edited by Yanying Huo

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1527 | Submission Open

Keywords: ROS; oxidative stress; metabolic stress; DNA damage repair; genomic instability; cancer

(This special issue belongs to the Section Cancer Pathophysiology)

Decoding and Remodeling the Suppressive Tumor Immune Microenvironment in Head and Neck Cancer

edited by Andrew G. Sikora and Jennifer L. Anderson

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1523 | Submission Open

Keywords: tumor immune microenvironment (TIME); cancer-mediated immunosuppression; myeloid cells; regulatory T cells; cytokines; anti-tumor immunity; immune modulation

(This special issue belongs to the Section Tumor Microenvironment)

TGF-β Signaling in the Tumor Microenvironment: Dual Roles in Cancer Progression and Therapy

edited by

Byung-Gyu Kim

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1464 | Submission Open

Keywords: TGF-β signaling; tumor microenvironment; solid tumors; hematologic malignancies; immune modulation; therapeutic resistance; TGF-β pathway inhibitors; cancer immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

Biomarkers in the Management of Gynecological Cancer

edited by Ferenc Bánhidy,

Keszthelyi Márton

and Balázs Lintner

submission deadline 30 Sep 2026 | 3 articles | Viewed by 1409 | Submission Open

Keywords: gynecologic cancer; biomarkers; cervical cancer; endometrial cancer; ovarian cancer; vulvar cancer; diagnostic biomarkers; prognostic biomarkers; predictive biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Approaches in Metastatic Renal Cell Carcinoma Management

edited by

Ausvydas Patasius

and

Vincas Urbonas

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1390 | Submission Open

Keywords: metastatic renal cell carcinoma; immune checkpoint inhibitors; combination therapy; predictive biomarkers

Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, and Beyond in Peritoneal Disease: Advancing Clinical Care and Therapeutics

edited by

Benjamin D. Powers

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1355 | Submission Open

Keywords: peritoneal surface malignancies; peritoneal carcinomatosis; colorectal cancer; appendiceal cancer; pseudomyxoma peritonei; ovarian cancer; mesothelioma; gastric cancer; small bowel cancer; cytoreductive surgery; HIPEC; PIPAC; photodynamic therapy; chemotherapy; chemoresistance; novel therapies; rare diseases

(This special issue belongs to the Section Cancer Therapy)

Current Status of Neuroendocrine Tumors with a Special Focus on Diagnosis and Novel Treatments—3rd Edition

edited by

Dan Granberg

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1354 | Submission Open

Keywords: neuroendocrine tumors; somatostatin analogues; PRRT; chemotherapy; 68Gallium-DOTATOC; PET; CT; targeted therapies; mTOR; inhibitors; angiogenesis

(This special issue belongs to the Section Cancer Therapy)

Strategies and Techniques in Diagnosing, Treating and Surveying Sarcoma

edited by H. Thomas Temple

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1233 | Submission Open

Keywords: sarcoma; diagnosis; therapy; treatment; surgery; molecular; radiomics

The Molecular Mechanisms of DNA Replication and Repair

edited by Taru Muranen

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1223 | Submission Open

Keywords: DNA replication; DNA repair; double helix; drug resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Computational Cancer Biology: Machine Learning for Multi-Omics Integration and Prognosis

edited by Aftab Alam

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1196 | Submission Open

Keywords: multi-omics integration; computational oncology; prognostic biomarkers; machine learning; precision medicine

(This special issue belongs to the Section Methods and Technologies Development)

Translational Advances in Reproductive Cancers: From Targets to Therapies

edited by

Kamila Domińska

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1142 | Submission Open

Keywords: reproductive cancers; signal transduction pathways; hormonal regulation; targeted therapy; therapeutic limitations

(This special issue belongs to the Section Molecular Cancer Biology)

The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Third Edition)

edited by

Huey-Jen Lin

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1118 | Submission Open

Keywords: CD8+ tumor-infiltrating lymphocytes; cytotoxic T lymphocytes -associated protein 4; dendritic cells; immune evasion; hypoxia-inducible factors; myeloid-derived suppressor cells; natural killer; programmed death receptor and ligand; regulatory T cells; tumor-associated macrophages; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

New Clinical Insights into Gynecological Malignancies

edited by

Amelia Jernigan

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1050 | Submission Open

Keywords: innovative care; data science; precision medicine; uterine cancer; ovarian cancer; vulvar cancer; vaginal cancer

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Myeloma: From Molecular Pathways to Drug Development

edited by Natalia Neparidze

submission deadline 30 Sep 2026 | 1 articles | Viewed by 977 | Submission Open

Keywords: myeloma; plasma cell disorders; monoclonal gammopathy; bispecifics; T cell engagers; CART therapy; monoclonal antibodies; MRD

(This special issue belongs to the Section Cancer Drug Development)

Breast Cancer Microenvironment: Molecular Mechanisms and Therapeutic Targeting

edited by Yi Fang

submission deadline 30 Sep 2026 | 1 articles | Viewed by 942 | Submission Open

Keywords: breast cancer; tumor microenvironment; biomarkers; therapeutic targeting; tumor-stromal interactions; precision oncology

(This special issue belongs to the Section Tumor Microenvironment)

Head and Neck Cancer Therapies: Current and Innovative Options

edited by

Ye Guo

submission deadline 30 Sep 2026 | 1 articles | Viewed by 930 | Submission Open

Keywords: head and neck cancer; multimodal therapy; precision oncology; immunotherapy; antibody–drug conjugates; bispecific antibodies; HPV; salivary gland cancers and sinonasal carcinomas

(This special issue belongs to the Section Cancer Therapy)

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