Recent Advances in Myeloma: From Molecular Pathways to Drugs

Dear Colleagues,

In this Special Issue, we will highlight recent advances and developments in the field of myeloma pathobiology and therapeutics. The last decade has seen many notable successes in this field. These include the development of monoclonal antibodies, antibody–drug conjugates, bispecific T-cell engager antibodies, chimeric antigen T cells (CARTs), targeted small molecules, and combinations therapies. Still, much remains to be elucidated regarding the origins, classification, and risk stratification of myeloma, and opportunities for prevention, among other research areas. Many challenges need to be addressed, including determining the best front-line treatments, the role of stem cell transplantation, and the optimal sequencing of novel regimens, namely, where to position novel bispecific and CART cell therapies in the course of treatment and how to harness the available arsenal of the drugs in a manner that leads to cure. Effective treatment cannot be achieved without an understanding of the underlying origins and etiopathogenesis of the disease. This Special Issue will address many of these areas of active research to provide new insights.

Dr. Natalia Neparidze
Guest Editor

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