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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pain and Palliative Care in Patients with Cancers

edited by

Arpad Szallasi

and

Anna Horváth

submission deadline 20 Apr 2027 | 3 articles | Viewed by 3828 | Submission Open

Keywords: cancer pain; palliative care; opioid tolerance

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Emerging Biomarkers for Immune Checkpoint Inhibitor Sensitivity and Resistance in Non-Small-Cell Lung Cancer

edited by Minglei Zhuo

submission deadline 20 Apr 2027 | Viewed by 573 | Submission Open

Keywords: non-small-cell lung cancer; immune checkpoint inhibitors; immunotherapy resistance; predictive biomarkers; tumor microenvironment; PD-L1; circulating biomarkers; microbiota; translational oncology; combination strategies

(This special issue belongs to the Section Cancer Biomarkers)

Computational Oncology: Machine Learning, Digital Biomarkers, and Clinical Decision Support

edited by

Akash Kumar Bhoi

Paolo Barsocchi

and

Victor Hugo C. De Albuquerque

submission deadline 20 Apr 2027 | Viewed by 239 | Submission Open

Keywords: computational oncology; machine learning; deep learning; digital biomarkers; clinical decision support; precision oncology; explainable artificial intelligence; radiomics; multi-omics integration; cancer diagnosis and prognosis

(This special issue belongs to the Section Cancer Informatics and Big Data)

Prostate-Specific Membrane Antigen (PSMA)-Targeted Radionuclide Therapy in Cancer

edited by

Ning Zhou

and

Sashi Debnath

submission deadline 25 Apr 2027 | 1 articles | Viewed by 1776 | Submission Open

Keywords: PSMA-TRNT; radioligand therapy; radionuclide therapy; theranostics; prostate-specific membrane antigen (PSMA); PSMA targeted; PSMA ligands; prostate cancer (PCa); metastatic castration-resistant prostate cancer (mCRPC)

(This special issue belongs to the Section Methods and Technologies Development)

Oxidative Stress and Antioxidants: Mechanisms and Therapeutic Advances in Cancer

edited by

Saurabh Kumar Jha

, Ankur Sharma and

Prakash Gangadaran

submission deadline 28 Apr 2027 | Viewed by 27 | Submission Open

Keywords: oxidative stress; antioxidants; therapeutic; cancer; apoptosis; anticancer drugs; nano antioxidants

Surgery and Clinical Outcomes in Head and Neck Squamous Cell Carcinoma

edited by

Wendell G. Yarbrough

and Mihir R. Patel

submission deadline 29 Apr 2027 | 1 articles | Viewed by 91 | Submission Open

Keywords: head and neck tumors; surgery; therapy; biomarkers; salivary tumors; thyroid tumors

(This special issue belongs to the Section Clinical Research in Cancer)

Prevention, Early Detection, and Surgical Oncology in Hepatocellular Carcinoma, Pancreatic Cancer, and Gastrointestinal Cancer

edited by

Mingyao Chen

and

Kuang-Chun Hu

submission deadline 30 Apr 2027 | 7 articles | Viewed by 14306 | Submission Open

Keywords: early image detection in cancer; biomarker of cancer; surgical treatment; gastrointestinal cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Interrogating Molecular Regulators and Chemical Agents in Brain Tumor Progression

edited by Shilpi Singh

submission deadline 30 Apr 2027 | 3 articles | Viewed by 8026 | Submission Open

Keywords: brain tumor progression; molecular mechanisms; small molecule inhibitors; natural compounds; synthetic drugs; biomarkers; oncogenic pathways; metabolic reprogramming

(This special issue belongs to the Section Tumor Microenvironment)

Tumor Microenvironment Dynamics in Hepatocellular Carcinoma

edited by Joseph Franses and Adam Burgoyne

submission deadline 30 Apr 2027 | 3 articles | Viewed by 6852 | Submission Open

Keywords: liver cancer; immune therapy; biomarkers; treatment resistance; cellular interactions

(This special issue belongs to the Section Tumor Microenvironment)

Personalizing Head and Neck Cancer Care

edited by

Inge Wegner

and

G. B. Halmos

submission deadline 30 Apr 2027 | 3 articles | Viewed by 5473 | Submission Open

Keywords: head and neck cancer; personalized treatment; targeted therapy; prehabilitation; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Insulin Resistance, Diabetes, and Cancer: An Overview of the Pathogenetic Mechanisms

edited by

Kumar Ganesan

and

Kunka Mohanram Ramkumar

submission deadline 30 Apr 2027 | 2 articles | Viewed by 3090 | Submission Open

Keywords: insulin resistance; type 2 diabetes; hyperinsulinemia; IGF-1 signaling; tumor microenvironment; metabolic inflammation; adipokines; antidiabetic drugs; cancer metabolism; phytocompounds; bioactive molecules; hormone regulation; intracellular signalling pathways

(This special issue belongs to the Section Cancer Pathophysiology)

Advanced Strategies for Precision Therapy in Urinary Cancers

edited by Menghuan Tang and

Zhaoqing Cong

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2490 | Submission Open

Keywords: urological oncology; precision drug delivery system; nanomaterials; stimuli-responsive delivery; immunotherapy; radioligand therapy

(This special issue belongs to the Section Cancer Therapy)

Socio-Demographic Factors and Cancer Research: 2nd Edition

edited by

Mitchell S. Fourman

and Amanda N. Goldin

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2055 | Submission Open

Keywords: socio-economic disparity; cancer delivery; cancer survival; metastatic cancer; culture-specific cancer outcomes; AI; machine learning

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Clinical Treatment and Outcomes of Gastrointestinal Cancer

edited by Mary Linton Peters

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1960 | Submission Open

Keywords: gastrointestinal cancer; ctDNA; chemotherapy; immunotherapy; financial toxicity; clinical trial participation

(This special issue belongs to the Section Clinical Research in Cancer)

Current Applications and Cutting-Edge Innovations in Neuroendoscopy for Oncological Neurosurgery: Where Are We and Where Are We Going?

edited by Giuseppe Roberto Giammalva, Giovanni Tringali and

Giuseppe Cinalli

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1958 | Submission Open

Keywords: neuroendoscopy; endoventricular surgery; skull base surgery; endoscopic assisted neurosurgery; innovations

(This special issue belongs to the Section Methods and Technologies Development)

Unraveling Immune Dynamics and Novel Therapeutic Strategies in the Tumor Microenvironment

edited by Shahidul M. Islam

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1789 | Submission Open

Keywords: tumor microenvironment; immune dynamics; tumor heterogeneity; immune checkpoints; CAR T; cancer immunology; adoptive cell transfer; resistance; biomarkers; combination therapy; machine learning; molecular modeling

(This special issue belongs to the Section Tumor Microenvironment)

Combination Therapies in Breast Cancer Chemotherapy: Chemoradiation, Targeted Agents, and Immunotherapy

edited by

Piotr J. Wysocki

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1643 | Submission Open

Keywords: breast cancer; combination therapy; endocrine therapy; chemoradiation; monoclonal antibodies; antibody–drug conjugates (ADCs); small-molecule kinase inhibitors; immunotherapy; predictive biomarkers; therapy resistance; precision oncology; translational research

(This special issue belongs to the Section Cancer Therapy)

Mesothelioma Today: Global Trends, Clinical Challenges, and Policy Responses

edited by

Pierpaolo Ferrante

and Marco Tomasetti

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1320 | Submission Open

Keywords: malignant mesothelioma; asbestos exposure; occupational cancer; epidemiology; public health policy

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Tumour–Immune Interactions in Cancer Therapy

edited by

and

submission deadline 30 Apr 2027 | Viewed by 1128 | Submission Open

Keywords: tumour‑immune interactions; tumour immune microenvironment; immune escape; treatment response; therapy resistance; tumour heterogeneity; immunotherapy; chemotherapy; radiotherapy; targeted therapy; functional genomics; organoids; antigen presentation; translational research; clinical trials; single‑cell & spatial analysis

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Research in Gynecological Cancers

edited by

Federica Perelli

submission deadline 30 Apr 2027 | 2 articles | Viewed by 951 | Submission Open

Keywords: gynecologic oncology; hereditary cancer syndrome; BRCA mutation; gynecologic surgery; gynecologic ultrasound; gynecologic oncology prevention; molecular biomarkers; minimally invasive surgery; STIC (serous tubal intraepithelial carcinoma); ovarian cancer; fertility-sparing surgery

(This special issue belongs to the Section Clinical Research in Cancer)

Cytoskeleton in Tumor Growth and Progression

edited by David Gau

submission deadline 30 Apr 2027 | 1 articles | Viewed by 889 | Submission Open

Keywords: actin cytoskeleton; microtubules; mechano-transduction; tumor microenvironment; angiogenesis; mitochondria

(This special issue belongs to the Section Molecular Cancer Biology)

Decoding the Tumor Microenvironment: From Mechanisms to Therapeutic Opportunities

edited by

Michele Zanoni

, Giacomo Miserocchi and

Tania Rossi

submission deadline 30 Apr 2027 | 1 articles | Viewed by 830 | Submission Open

Keywords: tumor microenvironment (TME); cancer immunology; tumor–stroma interactions Immune; evasion; therapy resistance; spatial and single-cell omics; biomarker discovery; translational oncology; 3D models

(This special issue belongs to the Section Tumor Microenvironment)

From Metronomic Chemotherapy to Time-Optimized Cancer Treatments

edited by

Piotr J. Wysocki

submission deadline 30 Apr 2027 | 1 articles | Viewed by 735 | Submission Open

Keywords: metronomic chemotherapy; time-dependent treatment; chemotherapy; immunotherapy; pharmacokinetics; pharmacodynamics

Role of Pathology in Detection, Prognosis and Treatment of Gastrointestinal Cancers

edited by

Cristina Díaz del Arco

and Luís Ortega-Medina

submission deadline 30 Apr 2027 | Viewed by 508 | Submission Open

Keywords: gastrointestinal cancer; pathology; histopathology; molecular pathology; biomarkers; prognosis; precision medicine; digital pathology; cancer detection; targeted therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Deep Learning for Cancer Image Classification in Smaller Patient Cohorts

edited by

Marko Radulovic

submission deadline 30 Apr 2027 | Viewed by 420 | Submission Open

Keywords: deep learning; deep radiomics; diagnosis; prognosis; prediction

(This special issue belongs to the Section Cancer Informatics and Big Data)

Emerging Biomarkers for Precision Oncology in Gastrointestinal Cancers

edited by

Alessandro Ottaiano

submission deadline 30 Apr 2027 | Viewed by 338 | Submission Open

Keywords: gastrointestinal cancers; precision oncology; cancer biomarkers; liquid biopsy; next-generation sequencing; predictive biomarkers; tumor microenvironment; cancer immunotherapy biomarkers; molecular profiling; translational oncology

(This special issue belongs to the Section Cancer Biomarkers)

New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor: 2nd Edition

edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo

submission deadline 30 Apr 2027 | Viewed by 325 | Submission Open

Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology

(This special issue belongs to the Section Cancer Therapy)

Local, Systemic and Combined Therapy for Hepatocellular Carcinoma

edited by Xiaoqun Dong

submission deadline 30 Apr 2027 | Viewed by 314 | Submission Open

Keywords: hepatocellular carcinoma; immunotherapy; cell therapy; targeted therapy; local therapy; combination therapy; oncolytic virus; precision oncology; drug resistance; translational research

(This special issue belongs to the Section Cancer Therapy)

Advances in Surgery for Gynecologic Cancer

edited by

Emmanouil Kalampokas

submission deadline 30 Apr 2027 | Viewed by 298 | Submission Open

Keywords: sentinel lymph node mapping; cervical cancer; robotic-assisted laparoscopy; cytoreductive surgery; nerve-sparing techniques; image-guided surgery; enhanced recovery after surgery; molecular staging; individualized surgery; endometrial cancer

Decoding Glioblastoma: Mechanisms, Innovations, and Therapeutic Advancements

edited by

Frances Chow

, Jerica M. Lomax and Yoon Jae Choi

submission deadline 30 Apr 2027 | Viewed by 242 | Submission Open

Keywords: glioblastoma; tumor heterogeneity; resistance; glioma stem cells; multi-omics; molecular targeting; tumor microenvironment; immunotherapy; spatial transcriptomics; epigenetic regulation; metabolic reprogramming; liquid biopsy; radiomics; advanced imaging; nuclear medicine

Advances in Supportive Care in Radiation Oncology

edited by Lukas Käsmann

submission deadline 30 Apr 2027 | Viewed by 237 | Submission Open

Keywords: supportive care; radiation oncology; symptom management; patient-reported outcomes; radiation dermatitis; oral mucositis; cancer survivorship; integrative oncology; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Epigenomic and Transcriptional Mechanisms in Cancer Progression and Therapy Response

edited by Benjamin L. Kidder

submission deadline 30 Apr 2027 | Viewed by 234 | Submission Open

Keywords: cancer progression; genetic mutations; epigenomic plasticity; tumor heterogeneity; gene regulatory networks; epigenomic mechanisms

(This special issue belongs to the Section Molecular Cancer Biology)

Digestive Tract Cancers: A State-of-the-Art Perspective on Epidemiology, Risk Factors, Molecular Mechanisms, Prevention, Diagnosis and Management

edited by Paraskevi A Farazi

submission deadline 30 Apr 2027 | Viewed by 223 | Submission Open

Keywords: colorectal; pancreatic; liver; biliary; esophageal; stomach cancers; epidemiology; risk factors; molecular mechanisms; prevention; diagnosis; treatment

Beyond Breast Cancer—Rehabilitation for Survivorship

edited by

Elisabeth Kenne Sarenmalm

and

Jenny Nyqvist-Streng

submission deadline 30 Apr 2027 | Viewed by 215 | Submission Open

Keywords: breast cancer; rehabilitation; person-centered: clinical follow-up; physiotherapy; psycho-social support; existential support; patient education and self-management

Innovations in Pathological and Clinical Research in Colorectal Cancer

edited by

Seiichi Shinji

and

Toshiyuki Ishiwata

submission deadline 30 Apr 2027 | 1 articles | Viewed by 199 | Submission Open

Keywords: colorectal cancer; clinicopathological prognostic biomarkers; pathology-guided therapeutic strategies

The Relationship Between Cancers Metabolism and Immunotherapy

edited by Suguru Saito

submission deadline 30 Apr 2027 | Viewed by 193 | Submission Open

Keywords: anti-tumor immunity; metabolism; immunotherapy; macrophages; T cells; exhaustion

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Melanoma Combination Therapy: New Horizons, Challenges and Clinical Breakthroughs

edited by Gino K. In, Sanjay Chandrasekaran and

Vincent T. Ma

submission deadline 30 Apr 2027 | 1 articles | Viewed by 167 | Submission Open

Keywords: advanced melanoma; combination checkpoint blockade; targeted therapy; peri-operative therapy; adoptive cellular therapy; intratumoral therapy; rare melanomas; abscopal effect

(This special issue belongs to the Section Cancer Therapy)

The Roles of Endoscopies in Gastrointestinal Neoplasm

edited by

Hajime Isomoto

and Hideki Kobara

submission deadline 30 Apr 2027 | Viewed by 150 | Submission Open

Keywords: gastrointestinal cancer; image enhanced endoscopy; early cancer detection; endoscopic submucosal dissection (ESD); endoscopic resection; AI-assisted diagnosis; surveillance endoscopy

(This special issue belongs to the Section Methods and Technologies Development)

Modern Radiation Therapy on Refractory Cancer Treatment: Technological Innovations, New Paradigms, Personalized Medicine and Recent Clinical Advances

edited by

Hualin Zhang

submission deadline 30 Apr 2027 | Viewed by 124 | Submission Open

Keywords: adaptive therapy; personalized radiation therapy; refractory cancer; spatially fractionated radiation therapy; minibeam; microbeam; flash therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in the Surgical Management of Pancreatic Cancer

edited by Richard Zheng and

Avinoam Nevler

submission deadline 30 Apr 2027 | Viewed by 96 | Submission Open

Keywords: pancreatic cancer; pancreatic surgery; pancreatectomy; PDAC; outcomes; minimally invasive surgery; enhanced recovery after surgery (ERAS)

(This special issue belongs to the Section Cancer Therapy)

Nanocarrier in Cancer Therapy

edited by

Koyeli Girigoswami

submission deadline 30 Apr 2027 | Viewed by 88 | Submission Open

Keywords: nanocarriers; cancer therapy; nanomedicine; targeted drug delivery; stimuli-responsive nanocarriers; tumor microenvironment; nanoparticles; theranostics; drug resistance; precision oncology

(This special issue belongs to the Section Methods and Technologies Development)

Emerging Imaging and Radiotherapy Techniques for CNS Tumors

edited by

Tugce Kutuk

and

Joshua D. Palmer

submission deadline 30 Apr 2027 | Viewed by 52 | Submission Open

Keywords: CNS tumors; neuro-oncology; advanced imaging; molecular imaging; MRI; PET imaging; stereotactic radiosurgery (SRS); adaptive radiotherapy; proton therapy; stereotactic body radiotherapy (SBRT)

(This special issue belongs to the Section Methods and Technologies Development)

Molecular Mechanisms and Tumor Heterogeneity in Osteosarcoma

edited by Le Thi Thanh Thuy and

Hidetomi Terai

submission deadline 30 Apr 2027 | Viewed by 51 | Submission Open

Keywords: osteosarcoma; tumor heterogeneity; single-cell RNA sequencing/tumor microenvironment; immune checkpoint proteins and circulating biomarkers; therapeutic targets and translational treatment

(This special issue belongs to the Section Molecular Cancer Biology)

The Role of Immune Checkpoint Inhibitors in Cancer Therapy

edited by

Min Zhou

submission deadline 30 Apr 2027 | Viewed by 51 | Submission Open

Keywords: immune checkpoint inhibitors; immune checkpoint blockade; PD-1/PD-L1; CTLA-4; LAG-3; bispecific antibodies; predictive biomarkers; immunotherapy resistance; combination immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Recent Advances in Pediatric Neuro-Oncology: Optimism for the Future

edited by James Rutka

submission deadline 30 Apr 2027 | Viewed by 18 | Submission Open

Keywords: neuro-oncology; neuroimaging; neurosurgery; molecular genetics; neuropathology; chemotherapy; radiation therapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Pediatric Oncology)

Palliative and Supportive Care in Oncology: An Update (2nd Edition)

edited by

Marco Cesare Maltoni

, Romina Rossi,

Antonino Musolino

, Andrea Carlini and Lucia Angelini

submission deadline 30 Apr 2027 | Viewed by 11 | Submission Open

Keywords: palliative care; supportive care; quality of life; integrative medicine; palliative radiotherapy; end of life care; cancer care; quality of care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Interventional Cancer Pain Management: Current Evidence, Unresolved Questions, and Future Directions

edited by

Giustino Varrassi

and

Matteo Luigi Giuseppe Leoni

submission deadline 30 Apr 2027 | Viewed by 10 | Submission Open

Keywords: cancer pain; pain management; neoplasm metastasis; analgesia; neurosurgical procedures; palliative care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

DNA Methylation, Epigenetic Heterogeneity and Biomarkers in Gynecologic Cancers

edited by

Pavol Žúbor

submission deadline 30 Apr 2027 | Viewed by 1 | Submission Open

Keywords: DNA methylation; cancer epigenetics; gynecologic cancers; epigenetic biomarkers; molecular biomarkers; single-cell epigenomics; spatial epigenomics; intratumoral heterogeneity; clonal evolution; tumor evolution; therapy resistance; liquid biopsy; circulating tumor DNA; multi-omics; precision oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Functional Preservation and Personalized Surgery in Early-Stage Lung Cancer

edited by

Francesco Petrella

submission deadline 30 Apr 2027 | Submission Open

Keywords: early-stage lung cancer; non-small cell lung cancer (NSCLC); functional preservation; personalized surgery; precision surgery; parenchyma-sparing surgery; segmentectomy; sublobar resection; wedge resection; minimally invasive surgery; robotic-assisted thoracic surgery; video-assisted thoracoscopic surgery (VATS); pulmonary function; quality of life; patient-reported outcomes; frailty; surgical risk stratification; tumor biology; molecular profiling; biomarkers; radiomics; artificial intelligence; image-guided surgery; intraoperative navigation; fluorescence-guided surgery; surgical margins; lymph-node assessment; neoadjuvant therapy; adjuvant therapy; stereotactic body radiotherapy (SBRT); multidisciplinary treatment; personalized medicine

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Physical Activity in Cancer Prevention, Treatment and Rehabilitation

edited by

Iwona Malicka

and

Aleksandra Kowaluk

submission deadline 1 May 2027 | Viewed by 225 | Submission Open

Keywords: cancer; hematooncology; adults; children; physical activity; exercise; interventions; supportive care; prevention; recovery; quality of life

Displaying special issue 901-950 on page 19 of 21.

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