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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cancer Induced Organ Dysfunctions (Cachexia)

edited by

Sham S. Kakar

and Sarama Saha

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1296 | Submission Open

Keywords: cancer; cachexia; organ dysfunction; cancer-induced cachexia; cancer-induced organ dysfunction; muscle wasting

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Antibody–Drug Conjugates (ADCs) in Cancers

edited by

Jayanth Panyam

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1100 | Submission Open

Keywords: antibody– drug conjugates (ADCs); therapeutic efficacy; drug delivery; structural features; disposition; linker design; payload optimization

(This special issue belongs to the Section Cancer Drug Development)

Cervical Cancer Screening: Current Practices and Future Perspectives

edited by Kimon Chatzistamatiou

submission deadline 20 Mar 2026 | 1 articles | Viewed by 613 | Submission Open

Keywords: cervical cancer screening; cervical carcinogenesis; human papillomavirus; HPV primary screening; self-sampling; triage of HPV-positive; post-conization follow-up; screening for immunocompromised women; screening for vac-cinated women

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Cancer Survivors: Late Effects of Cancer Therapy

edited by

Gaurav Kumar

submission deadline 20 Mar 2026 | Viewed by 157 | Submission Open

Keywords: late effects; cancer survivorship; treatment toxicity; long-term outcomes

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Neuroendocrine Tumors: From Diagnosis to Therapy (2nd Edition)

edited by

Damiano Caruso

Francesco Panzuto

Michela Polici

and Daniela Prosperi

submission deadline 20 Mar 2026 | Viewed by 147 | Submission Open

Keywords: neuroendocrine neoplasms; CT; MR; PET/CT; target therapy; quantitative biomarkers

(This special issue belongs to the Section Cancer Therapy)

Artificial Intelligence in Ocular Oncology

edited by

Bertil E. Damato

submission deadline 20 Mar 2026 | Viewed by 116 | Submission Open

Keywords: ocular tumor; eye cancer; artificial intelligence; ophthalmology

(This special issue belongs to the Section Methods and Technologies Development)

Radiation Therapy in Lung Tumors: Recent Trends and Current Issues

edited by

Paul Jules van Houtte

and Sara Ramella

submission deadline 21 Mar 2026 | Viewed by 90 | Submission Open

Keywords: lung cancer; immunotherapy; chemotherapy; PET-CT; surgery; oligo-metastases

(This special issue belongs to the Section Cancer Therapy)

Bacterial Infections and Cancer Risk: From Biological Mechanisms to Clinical Realities

edited by

Skander Hathroubi

and Shuai Hu

submission deadline 25 Mar 2026 | 1 articles | Viewed by 1726 | Submission Open

Keywords: bacterial infections; cancer risk; biological mechanisms; treatment modalities; therapeutic strategies

(This special issue belongs to the Section Infectious Agents and Cancer)

Acute Myeloid Leukemia: Updates on Diagnosis and Novel Management Strategies

edited by Ana Vidović

submission deadline 25 Mar 2026 | Viewed by 67 | Submission Open

Keywords: acute myeloblastic leukemia; diagnosis; prognosis; intensive chemotherapy; target therapy; allogeneic stem cell transplantation

(This special issue belongs to the Section Clinical Research of Cancer)

Roles of Urokinase Receptors in Cell Biology: Modulating Tumor Cell Migration and Invasion

edited by

Agata Kabała-Dzik

submission deadline 28 Mar 2026 | Viewed by 150 | Submission Open

Keywords: urokinase-type plasminogen receptor; uPAR; inflammation; cancer; migration; invasion

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Pathology in Cancer: From Diagnosis to Precision Medicine

edited by

Georgia Levidou

submission deadline 28 Mar 2026 | Viewed by 24 | Submission Open

Keywords: cancer biomarkers; precision medicine; histopathology; clinical pathology; diagnosis; prognostic/predictive biomarker

(This special issue belongs to the Section Cancer Pathophysiology)

Cancer Immunotherapy: Focus on Immune Checkpoint Inhibitors and Immune Modulators

edited by

Katsuaki Ieguchi

submission deadline 30 Mar 2026 | 4 articles | Viewed by 11096 | Submission Open

Keywords: PD-1; PD-L1; CTLA-4; immune checkpoint molecule; immune checkpoint inhibitor; tumor microenvironment; drug resistance; biomarker; BiTE; BiCE

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Quality and Clinical Outcomes Improvement in the Management of Oncology Patients (2nd Edition)

edited by

Dimitrios E. Magouliotis

submission deadline 30 Mar 2026 | 1 articles | Viewed by 1154 | Submission Open

Keywords: oncology; surgical oncology; quality improvement; clinical outcomes; patient safety

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Neoadjuvant Therapy for Pancreatic Cancer

edited by Brice Chanez

submission deadline 30 Mar 2026 | Viewed by 189 | Submission Open

Keywords: induction treatment; biomarkers; chemotherapy

(This special issue belongs to the Section Cancer Therapy)

Women’s Health and Gynaecological Cancers: From Nutrition and Environmental Factors to Novel Diagnostics and Therapies

edited by

and

submission deadline 31 Mar 2026 | 10 articles | Viewed by 30799 | Submission Open

Keywords: breast cancer; ovarian cancer; cervical cancer; endometrial cancer; nutrition; obesity; environmental factors; women's health; gynaecological cancers

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Emerging Trends in Global Cancer Epidemiology: 2nd Edition

edited by Syed Ahsan Raza

submission deadline 31 Mar 2026 | 8 articles | Viewed by 27558 | Submission Open

Keywords: cancer epidemiology; global cancer research; incidence; prevention and control strategies; risk factors; data sources and methods; social and environmental impact; population health; emerging trends; survival and mortality

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Recent Advances in Hepatobiliary Cancers: From Diagnosis to Treatment (2nd Edition)

edited by

Ilyas Sahin

submission deadline 31 Mar 2026 | 11 articles | Viewed by 27516 | Submission Open

Keywords: hepatobiliary cancers; hepatocellular carcinoma; cholangiocarcinoma; gallbladder cancer; immunotherapy; targeted therapy; precision medicine

(This special issue belongs to the Section Cancer Therapy)

PET/CT and Conventional Imaging in Cancers

edited by

Francesco Dondi

and

Domenico Albano

submission deadline 31 Mar 2026 | 7 articles | Viewed by 15213 | Submission Open

Keywords: PET/CT; CT; MR; conventional imaging; positron emission tomography; neoplasm; cancer

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Invasive Breast Cancer: Treatment and Prognosis (2nd Edition)

edited by

Eleni Timotheadou

and Emmanouil Saloustros

submission deadline 31 Mar 2026 | 7 articles | Viewed by 13276 | Submission Open

Keywords: ER+/HER2– breast cancer; HER2+ breast cancer; triple-negative breast cancer; treatment toxicity and quality of life; survivorship issues

(This special issue belongs to the Section Cancer Therapy)

Biomarkers for Gynecological Cancers

edited by

Apriliana Kartikasari

submission deadline 31 Mar 2026 | 6 articles | Viewed by 10361 | Submission Open

Keywords: biomarkers; cervical; ovarian; uterine; endometrial; vaginal; vulvar; fallopian tube

(This special issue belongs to the Section Cancer Biomarkers)

Gastric Cancer Surgery: Gastrectomy, Risk, and Related Prognosis

edited by

Wojciech Piotr Polkowski

submission deadline 31 Mar 2026 | 5 articles | Viewed by 9895 | Submission Open

Keywords: gastric cancer; surgical treatment; gastrectomy; outcome; minimally invasive surgical

(This special issue belongs to the Section Clinical Research of Cancer)

Cardio-Oncology: An Emerging Paradigm in Modern Medicine: 2nd Edition

edited by Rohit Moudgil

submission deadline 31 Mar 2026 | 5 articles | Viewed by 8077 | Submission Open

Keywords: cardio-oncology; CTRCD; arrhythmias; anthracyclines; anti-her2 therapies; immune checkpoint inhibitors; artificial intelligence; guidelines; emerging research

(This special issue belongs to the Section Cancer Therapy)

Advances in Pathology of Lymphoma and Leukemia

edited by

Siba El Hussein

submission deadline 31 Mar 2026 | 6 articles | Viewed by 7266 | Submission Open

Keywords: leukemia; lymphoma; immunohistochemical stains; next-generation sequencing; cytogenetics; flow cytometry analysis

(This special issue belongs to the Section Cancer Pathophysiology)

Colorectal Cancer Liver Metastases

edited by

Piero Boraschi

and

Francescamaria Donati

submission deadline 31 Mar 2026 | 2 articles | Viewed by 6072 | Submission Open

Keywords: liver metastases; colorectal cancer; treatment; imaging; oncologic strategy

(This special issue belongs to the Section Cancer Metastasis)

Advancements in Treatment Approaches for AML

edited by

Semra Aydin

and

Raheel Iftikhar

submission deadline 31 Mar 2026 | 3 articles | Viewed by 5997 | Submission Open

Keywords: AML treatment; allogeneic HSCT; novel targeted therapeutic agents; diagnostic; treatment strategies

(This special issue belongs to the Section Methods and Technologies Development)

Current Use of Hematopoietic Cell Transplantation in Hematologic Malignancies

edited by Marina Díaz-Beyá and Maria Queralt Salas

submission deadline 31 Mar 2026 | 4 articles | Viewed by 5807 | Submission Open

Keywords: allogeneic hematopoietic cell transplantation; hematologic malignancies; minimal residual disease; patient selection; conditioning regimens; graft-versus-host disease prophylaxis; immunotherapy; targeted treatments; real-world data; acute myeloid leukemia; myelodysplastic syndrome; chronic myelomonocytic leukemia; allogeneic hematopoietic cell transplantation

(This special issue belongs to the Section Transplant Oncology)

Advances in Renal Cell Carcinoma

edited by Philipp Ivanyi and Hendrik Eggers

submission deadline 31 Mar 2026 | 3 articles | Viewed by 5073 | Submission Open

Keywords: renal cell carcinoma; treatment; metastatic; prediction; medical treatment; immunotherapy; multimodal therapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Immunotherapy in Urothelial Carcinoma

edited by

Akinori Minato

submission deadline 31 Mar 2026 | 2 articles | Viewed by 4856 | Submission Open

Keywords: bladder cancer; upper tract urothelial carcinoma; immune checkpoint inhibitors; tumor microenvironment; biomarkers for immunotherapy; combination therapy; neo-adjuvant/adjuvant immunotherapy; resistance mechanisms; novel immunotherapeutic approaches; personalized medicine

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

The Oral Microbiome and Its Link to Oral Cancer: Exploring the Role of Infectious Agents

edited by

Tomoaki Shintani

submission deadline 31 Mar 2026 | 1 articles | Viewed by 4282 | Submission Open

Keywords: oral microbiome; oral cancer; infectious agents; microbial dysbiosis; host– microbe interactions

(This special issue belongs to the Section Infectious Agents and Cancer)

Significance of KRAS Gene Mutations in Colorectal Cancer (2nd Edition)

edited by

Grazia Palomba

and

Maria Cristina Sini

submission deadline 31 Mar 2026 | 2 articles | Viewed by 4040 | Submission Open

Keywords: KRAS; colorectal cancer; target therapy; mechanism; treatment targets

(This special issue belongs to the Section Molecular Cancer Biology)

The EGFR-Tyrosine Kinase Inhibitors (EGFR-TKIs) and Immune Checkpoint Inhibitors (ICIs) for Non-Small Cell Lung Cancer

edited by

Greta Alì

and

Maria Giovanna Mastromarino

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3456 | Submission Open

Keywords: non-small cell lung cancer; target therapy; EGFR-tyrosine kinase inhibitors; immunotherapy; immune checkpoint inhibitors; molecular analysis; surgery; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Treatment Options and Risk Factors of Pancreatic Neuroendocrine Neoplasms

edited by Anna Caterina Milanetto and

Claudio Pasquali

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3391 | Submission Open

Keywords: pancreatic neuroendocrine neoplasms; CT scan; MRI; PET/CT; target therapy; radioligand therapy; chemotherapy; microwave ablation; radiofrequency ultrasound ablation; hepatic arterial embolization

(This special issue belongs to the Section Cancer Therapy)

Intratumoral Heterogeneity in Brain Cancers

edited by Michael Oldham

submission deadline 31 Mar 2026 | 1 articles | Viewed by 3102 | Submission Open

Keywords: intratumoral heterogeneity; brain; clonal evolution; tumor microenvironment; multiomics

(This special issue belongs to the Section Molecular Cancer Biology)

Development of Biomarkers and Antineoplastic Drugs in Solid Tumors

edited by

Rosa Falcone

, Sofia Verkhovskaia and Michela Roberto

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2640 | Submission Open

Keywords: solid tumors; drugs; biomarkers; immunotherapy; targeted therapy; artificial intelligence

(This special issue belongs to the Section Cancer Drug Development)

Cancer Drug Discovery and Development: 2nd Edition

edited by Gary Piazza

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2624 | Submission Open

Keywords: signal transduction inhibitors; small-molecule inhibitors; antibodies; PROTOC; immunotherapy; medicinal chemistry; chemical optimization; high-throughput screening

(This special issue belongs to the Section Cancer Drug Development)

Cellular and Molecular Mechanisms of Malignant Nervous System Cancers

edited by

April Weissmiller

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2297 | Submission Open

Keywords: medulloblastoma; pediatric glioma; neuroblastoma; diagnosis and prognostic markers; IDH; TERT; and EGFR mutations; DNA methylation; treatment approaches and strategies (chemotherapy; radiation therapy; immunotherapy; and targeted therapy); resistance mechanisms; tumor microenvironment; molecular characteristics of tumor heterogeneity

(This special issue belongs to the Section Molecular Cancer Biology)

Minimally Invasive Therapies in Urologic Cancers

edited by Eric M. Walser and

Guglielmo Manenti

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2138 | Submission Open

Keywords: laparoscopic surgery; robotic-assisted surgery; ablation; high-intensity focused ultrasound; partial nephrectomy; minimally invasive procedures; urologic cancers

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Viruses in the Development of Cancer

edited by

George Eric Blair

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1892 | Submission Open

Keywords: DNA and RNA tumour viruses; HPV; EBV; KSHV; HCV; HBV; HTLV1; McPyV

(This special issue belongs to the Section Infectious Agents and Cancer)

Neoadjuvant Chemoradiotherapy for Gastrointestinal Cancer

edited by Daniel Martin

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1872 | Submission Open

Keywords: gastrointestinal cancers; neoadjuvant chemoradiotherapy; rectal cancer; esophageal cancer; pancreatic cancer; gastric cancer; immunotherapy; precision medicine; image guided radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Multiple Myeloma: Diagnosis and Therapy

edited by

Yvonne A. Efebera

and

Nidhi Sharma

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1786 | Submission Open

Keywords: multiple myeloma; plasma cell disorders; relapsed and refractory multiple myeloma; blood and marrow transplant

(This special issue belongs to the Section Cancer Therapy)

Exercise Interventions for People Living with Cancer: Advances in Knowledge and Implementation

edited by

Lara Edbrooke

and Chris Swain

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1475 | Submission Open

Keywords: cancer; survivorship; exercise; physical activity; implementation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

The Development of Immunotherapies to Treat Lymphoma

edited by

Christina Kalpadakis

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1270 | Submission Open

Keywords: lymphoma immunotherapy; CAR T-cell therapy; immune checkpoint inhibitors; monoclonal antibodies; personalized immunotherapy

Genetic Alterations and the Tumor Microenvironment

edited by Shanye Yin

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1184 | Submission Open

Keywords: tumor microenvironment; cancer immunology; immune checkpoint blockade; somatic mutations; T cell signaling; immune evasion; macrophage polarization; cancer immunotherapy resistance; single-cell transcriptomics; spatial analysis

(This special issue belongs to the Section Tumor Microenvironment)

Robotic and Thoracoscopic Surgery for Thoracic Oncology

edited by

Elisa Meacci

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1047 | Submission Open

Keywords: robotic-assisted thoracic surgery; video-assisted thoracoscopic surgery (VATS); lung cancer surgery; esophageal cancer; thymic tumors; minimally invasive surgery; pleural tumors; chest wall tumors; mediastinal surgery; thoracic oncology

(This special issue belongs to the Section Clinical Research of Cancer)

Diagnosis and Therapy in Urothelial Cancer

edited by

Giuseppe Palermo

submission deadline 31 Mar 2026 | 1 articles | Viewed by 631 | Submission Open

Keywords: urothelial cancer; bladder cancer; biomarkers; robotic surgery; immunotherapy; upper tract urothelial carcinoma

(This special issue belongs to the Section Cancer Therapy)

Modern Pathology, Artificial Intelligence and Personalized Therapy in Gastrointestinal Cancer

edited by Wenqing Cao

submission deadline 31 Mar 2026 | Viewed by 610 | Submission Open

Keywords: molecular pathology; biomarkers; digital pathology; targeted therapy; gastric cancer; colon; liver; pancreas

(This special issue belongs to the Section Cancer Therapy)

Advances in the Management and Prognosis of Brain Metastases

edited by

Guixiang Liao

and

Muhammad Khan

submission deadline 31 Mar 2026 | Viewed by 465 | Submission Open

Keywords: immunotherapy; target therapy; stereotactic radiotherapy; prognosis; quality of life

(This special issue belongs to the Section Cancer Therapy)

Advances on Imaging and Treatment of Head and Neck Cancer

edited by Yading Yuan, Vishruta A. Dumane,

Haibo Lin

and Luqman Dad

submission deadline 31 Mar 2026 | Viewed by 429 | Submission Open

Keywords: head and neck cancer; medical imaging; robotic surgery; image-guided radiation therapy; proton radiotherapy; online adaptive radiotherapy; artificial intelligence; machine learning

(This special issue belongs to the Section Cancer Therapy)

Novel Strategies to Fight Metastatic Breast Cancer

edited by