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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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State-of-the-Art Strategies for Non-Coding RNA Function Detection and Regulation in Cancer

edited by

Antonis Giakountis

and

Nikolaos Balatsos

submission deadline 20 Oct 2025 | 3 articles | Viewed by 6928 | Submission Open

Keywords: long non-coding RNAs; miRNAs; regulatory non-coding variants; ribodiagnostics; RNA therapeutics; targeted therapy; cancer

(This special issue belongs to the Section Tumor Microenvironment)

Advanced Research in Oncology in 2025

edited by

Dimitrios Moris

submission deadline 20 Oct 2025 | 5 articles | Viewed by 3919 | Submission Open

Keywords: cancer; tumour; oncology

Advances in Salivary Gland Carcinoma: 2nd Edition

edited by

Giulio Cantù

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2475 | Submission Open

Keywords: salivary gland tumors; head and neck cancer; facial nerve preservation; facial nerve reconstruction; facial nerve sacrifice; parotid cancer; parotidectomy; prognostic factors

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical Applications of Ultrasound in Cancer Imaging and Treatment

edited by Gregory Jan Czarnota

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2275 | Submission Open

Keywords: ultrasound; imaging; CT; MRI; treatment

(This special issue belongs to the Section Methods and Technologies Development)

Potential Biomarkers in Immune Checkpoint Inhibitors

edited by Goulnar Kasymjanova

submission deadline 20 Oct 2025 | Viewed by 120 | Submission Open

Keywords: advanced metastatic cancer; personalized immunotherapy; predictive biomarkers; circulating tumor DNA; resistance mechanisms; tumor microenvironment (TME); adverse events; real-world evidence

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Protein Structure and Cancer—2nd Edition

edited by

Michalis Aivaliotis

submission deadline 20 Oct 2025 | Viewed by 88 | Submission Open

Keywords: protein structure dynamics; structural cancer biology; protein pathways in cancer; structure– function alterations; in silico protein structure prediction; protein interactions; cancer mutations and protein structure alterations

(This special issue belongs to the Section Molecular Cancer Biology)

Cancer Epigenetic Biomarkers: 2nd Edition

edited by

Fabio Coppedè

submission deadline 22 Oct 2025 | 1 articles | Viewed by 1198 | Submission Open

Keywords: cancer; biomarker; epigenetics; DNA methylation; miRNA; diagnostic biomarkers; pharmacoepigenetics; epigenetic drugs

(This special issue belongs to the Section Cancer Biomarkers)

Prostate Cancer: Contemporary Standards and Challenges

edited by

Filip Ionescu

and

Jingsong Zhang

submission deadline 23 Oct 2025 | Viewed by 280 | Submission Open

Keywords: prostate cancer; molecular pathogenesis; precision oncology; biomarkers; treatment de-escalation

(This special issue belongs to the Section Cancer Therapy)

New Developments in Adolescent and Young Adult Oncology

edited by

Olga Husson

and

Winette T.A. van der Graaf

submission deadline 24 Oct 2025 | 1 articles | Viewed by 1803 | Submission Open

Keywords: adolescent and young adult oncology; epidemiology; health-related quality of life; late effects; survivorship; clinical care

(This special issue belongs to the Section Clinical Research of Cancer)

Radiation Therapy for Brain Tumors

edited by

Jim Zhong

submission deadline 25 Oct 2025 | 3 articles | Viewed by 8613 | Submission Open

Keywords: radiosurgery; hypofractionated radiosurgery; spectroscopic MRI; proton radiation; image-guided radiotherapy; radiotherapy for benign tumors; radiotherapy for gliomas; gamma knife

(This special issue belongs to the Section Cancer Therapy)

Research on Surgical Treatment for Ovarian Cancer

edited by Antonios Apostolos K. Tentes and Theo Panoskaltsis

submission deadline 25 Oct 2025 | 4 articles | Viewed by 4972 | Submission Open

Keywords: ovarian cancer; surgical; cancer treatment

(This special issue belongs to the Section Cancer Therapy)

Prevention, Screening and Early Detection of Cancer

edited by

Nadir Arber

and

Shiran Shapira

submission deadline 25 Oct 2025 | 3 articles | Viewed by 2681 | Submission Open

Keywords: cancer prevention; screening; early detection; risk factors; lifestyle modification; biomarkers; genetic testing; lifestyle interventions; cancer risk factors; liquid biopsy; pan-cancer screening tests

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Study on Acute Myeloid Leukemia

edited by Olga K. Weinberg

submission deadline 25 Oct 2025 | 2 articles | Viewed by 1170 | Submission Open

Keywords: acute myeloid leukemia (AML); cancer treatment; genetic

(This special issue belongs to the Section Cancer Therapy)

The State of the Art in the Diagnosis, Staging, Treatment and Prognosis of Gastrointestinal and Urogenital Malignancies

edited by

Agnieszka Kulczyńska-Przybik

and

Sara Pączek

submission deadline 30 Oct 2025 | 3 articles | Viewed by 6616 | Submission Open

(This special issue belongs to the Section Clinical Research of Cancer)

Radiopharmaceuticals for Cancers

edited by Joseph Lau and Hwan Lee

submission deadline 30 Oct 2025 | 2 articles | Viewed by 5127 | Submission Open

Keywords: radiopharmaceutical; positron emission tomography; single photon emission computed tomography; targeted radionuclide therapy; dosimetry; cancer; in vitro and in vivo characterization

(This special issue belongs to the Section Cancer Drug Development)

G Protein-Coupled Receptors in Cancer Progression

edited by

Songhai Chen

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1565 | Submission Open

Keywords: GPCRs; heterotrimeric G proteins; signal transduction; mutations; cancer development

(This special issue belongs to the Section Tumor Microenvironment)

Prevention, Early Detection, and Surgical Oncology in Hepatocellular Carcinoma, Pancreatic Cancer, and Gastrointestinal Cancer

edited by

Mingyao Chen

and

Kuang-Chun Hu

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1067 | Submission Open

Keywords: early image detection in cancer; biomarker of cancer; surgical treatment; gastrointestinal cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Treg Cell Immunotherapy in Cancer

edited by

Maria Velegraki

submission deadline 30 Oct 2025 | Viewed by 810 | Submission Open

Keywords: treg cells; cancer immunotherapy; immune evasion; antitumor immune responses; targeting therapeutic interventions

(This special issue belongs to the Section Cancer Therapy)

Cancer Immunotherapy as Part of Precision Clinical Medicine

edited by

Peter Lang

and

Christo Kole

submission deadline 30 Oct 2025 | Viewed by 206 | Submission Open

Keywords: cancer; immunotherapy; tumor microenvironment; molecular biology and genetics

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Management of Pancreatic Cancer

edited by

Traian Dumitrascu

submission deadline 31 Oct 2025 | 17 articles | Viewed by 26769 | Submission Open

Keywords: pancreatic cancer; adenocarcinoma; neuroendocrine carcinomas; molecular and pathological aspects; diagnosis; medical treatment; palliative therapy

(This special issue belongs to the Section Cancer Therapy)

Neurofibromatosis

edited by Rianne Oostenbrink,

Ignaci Blanco

and Enrico Opocher

submission deadline 31 Oct 2025 | 9 articles | Viewed by 10302 | Submission Open

Keywords: neurofibromatosis; schwannomatosis; tumor; longitudinal history; treatment; biomarker; outcomes

(This special issue belongs to the Section Cancer Therapy)

Novel Prognostic Biomarkers in Human Cancers: From Discovery to Application

edited by

Zakaria Y. Abd Elmageed

submission deadline 31 Oct 2025 | 4 articles | Viewed by 9777 | Submission Open

Keywords: tumor biomarkers; investigational markers; prognosis; biochemical relapse; overall survival; clinical trials; advancement in biomarker discovery; bioinformatics and marker discovery; AI and biomarker discovery

(This special issue belongs to the Section Cancer Biomarkers)

Molecular Mechanisms in Head and Neck Cancer

edited by Désirée Gül, Jan Hagemann and

Roland Hans Stauber

submission deadline 31 Oct 2025 | 5 articles | Viewed by 9470 | Submission Open

Keywords: head and neck cancer; translational research; molecular pathways; cellular signaling; biomarkers; liquid biopsies; transcriptome; proteome; survival

(This special issue belongs to the Section Molecular Cancer Biology)

Treatment Outcomes in Older Adults with Cancer

edited by

Mackenzi Pergolotti

submission deadline 31 Oct 2025 | 6 articles | Viewed by 8970 | Submission Open

Keywords: older adults with cancer; geriatric oncology; geriatric assessment; supportive care; palliative care; cancer rehabilitation; nutrition; physical activity; functional status; survivorship

(This special issue belongs to the Section Cancer Therapy)

Clinical Research Advances in Endometrial Carcinoma

edited by Salvatore Lopez

submission deadline 31 Oct 2025 | 5 articles | Viewed by 8852 | Submission Open

Keywords: endometrial cancer; uterine serous carcinoma; immunotherapy; MMRd; POLE; endometrioid carcinoma; target therapies; surgery; preclinical research

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in TNBC: New Markers for Innovative Treatments

edited by

Pia Giovannelli

submission deadline 31 Oct 2025 | 3 articles | Viewed by 8005 | Submission Open

Keywords: TNBC treatment; TNBC target; signaling pathways in TNBC; epigenetic modifications in TNBC; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Advances and Challenges in the Diagnosis and Treatment of Urological Malignancies (2nd Edition)

edited by

Bartosz Małkiewicz

Jakub Dobruch

and

Łukasz Nowak

submission deadline 31 Oct 2025 | 7 articles | Viewed by 7771 | Submission Open

Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Targeted Therapies for EGFR in Non-Small Cell Lung Cancer

edited by

Federico Pio Fabrizio

submission deadline 31 Oct 2025 | 3 articles | Viewed by 6940 | Submission Open

Keywords: EGFR; non-small cell lung cancer; molecular mechanisms; targeted therapies; resistance mechanisms

(This special issue belongs to the Section Cancer Therapy)

Advances in Uveal Melanoma

edited by

Takami Sato

and

Mizue Terai

submission deadline 31 Oct 2025 | 4 articles | Viewed by 6452 | Submission Open

Keywords: uveal melanoma; eye cancer; liver metastasis; Gα q/11 mutations; BAP1; SF3B1; PRAME; dormancy; liver-directed treatment; T-cell engager

(This special issue belongs to the Section Molecular Cancer Biology)

New Insights into Targeted Drugs for Breast Cancer (Volume II)

edited by

Jennifer Diamond

and Jennifer Richer

submission deadline 31 Oct 2025 | 4 articles | Viewed by 6185 | Submission Open

Keywords: breast cancer targeted therapies treatment resistance HER2 hormone receptor-positive triple-negative breast cancer

(This special issue belongs to the Section Cancer Drug Development)

A New Era in the Treatment of Early-Stage Non-Small Cell Lung Cancer

edited by

Tsutani Yasuhiro

submission deadline 31 Oct 2025 | 3 articles | Viewed by 5717 | Submission Open

Keywords: minimally invasive surgery; video-assisted thoracic surgery; robotic-assisted thoracic surgery; sublobar resection; segmentectomy; neoadjuvant therapy; adjuvant therapy; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Combination Therapies for Brain Tumors

edited by Jason H. Huang and Ekokobe Fonkem

submission deadline 31 Oct 2025 | 5 articles | Viewed by 5421 | Submission Open

Keywords: novel diagnostics; therapies; glioblastoma; meningioma; astrocytoma

(This special issue belongs to the Section Cancer Therapy)

The Role of Genes in Prostate Cancer

edited by Olivier Cussenot

submission deadline 31 Oct 2025 | 3 articles | Viewed by 5097 | Submission Open

Keywords: prostate cancer; genes; microenvironment

(This special issue belongs to the Section Tumor Microenvironment)

Gastrointestinal Cancer Surgery

edited by Florian Primavesi and

Daniel Neureiter

submission deadline 31 Oct 2025 | 4 articles | Viewed by 4360 | Submission Open

Keywords: gastrointestinal cancer surgery; precision surgery; personalized medicine; robotics; pathology; colorectal cancer; stomach cancer; pancreatic cancer; hepatocellular cancer; biliary tract cancer

(This special issue belongs to the Section Cancer Therapy)

Advancements in “Cancer Biomarkers” for 2025–2026

edited by

Maxim V. Berezovski

submission deadline 31 Oct 2025 | 4 articles | Viewed by 3993 | Submission Open

Keywords: RNA biomarkers; miRNA biomarkers; DNA biomarkers; cell-free DNA (cfDNA); protein biomarkers; metabolomic biomarkers; mutational biomarkers; circulating tumor cells (CTCs); tumor-derived extracellular vesicle (tEV) biomarkers; cellular biomarkers; imaging biomarkers; clinical biomarkers; biomarkers of drug response; biomarkers of genetic predisposition to cancer; epigenetic biomarkers; biomarkers of cancer outcomes; mass spectrometry; next-generation sequencing (NGS); flow cytometry; positron emission tomography (PET); computed tomography (CT); magnetic resonance imaging (MRI); X-rays; ultrasound; electrocardiography (ECG/EKG); endoscopy; biopsy; pulmonary function tests (PFTs); histopathology; cytopathology; immunohistochemistry (IHC); in situ hybridization (ISH); fluorescence in situ hybridization (FISH); liquid biopsy; electron microscopy; digital pathology and image analysis

(This special issue belongs to the Section Cancer Biomarkers)

Neurosurgical Management of Gliomas

edited by Nicolas Reyns

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3897 | Submission Open

Keywords: neurosurgery; neurological surgery; brain surgery; gliomas

(This special issue belongs to the Section Cancer Therapy)

Neo-Adjuvant Treatment of Breast Cancer

edited by Raphael Catane

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3552 | Submission Open

Keywords: neo-adjuvant; breast cancer; chemotherapy; hormonal therapy; immunotherapy; breast cancer survival; breast cancer surgery; Norton– Simon hypothesis

(This special issue belongs to the Section Cancer Therapy)

Molecular Genetics, Signaling Pathways, and Therapeutic Strategies for Liver Cancer

edited by

Wai-Hung Ho Daniel

and Yuman Tsui

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3375 | Submission Open

Keywords: liver cancer; NGS; single-cell sequencing; cancer genomics; cellular and molecular landscapes; tumor microenvironment; tumor heterogeneity; liver cancer stem cell; liquid biopsy; biomarkers

(This special issue belongs to the Section Molecular Cancer Biology)

Recent Advances in Diagnosis and Management of Colorectal Cancer

edited by Shing Wai Wong, Stephen Thompson and Zhen Hao Ang

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3249 | Submission Open

Keywords: colorectal cancer; diagnosis; management; screening; surgery; radiotherapy; chemotherapy; immunotherapy; robotics; targeted therapy; prevention; prognosis

(This special issue belongs to the Section Clinical Research of Cancer)

Digital Pathology Systems Enabling the Quality of Cancer Patient Care

edited by Peter J. Schüffler

submission deadline 31 Oct 2025 | 4 articles | Viewed by 3177 | Submission Open

Keywords: digital pathology; computational pathology; artificial intelligence; multimodal AI; foundation models; quality control; quality assurance; medical image analysis; computer-aided diagnosis; integrated digital pathology

(This special issue belongs to the Section Cancer Pathophysiology)

Research Advances in Cancer Nanomedicine

edited by

Stefano Leporatti

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2804 | Submission Open

Keywords: cancer; nanotechnology; nanomedicine; drug delivery; biosensors; lab-on-chip; nanomechanics; nano-immuno therapy; CAR-T nano-technology

(This special issue belongs to the Section Methods and Technologies Development)

The Roles of Deep Learning in Cancer Radiotherapy

edited by Zhen Tian

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2700 | Submission Open

Keywords: radiotherapy; deep learning; artificial Intelligence; tumor detection; image segmentation; treatment planning; outcome prediction; radiomics

(This special issue belongs to the Section Cancer Informatics and Big Data)

Radiomics in Cancer Imaging: Theory and Applications in Solid Tumours

edited by

Francesco Bianconi

and

Barbara Palumbo

submission deadline 31 Oct 2025 | 3 articles | Viewed by 2351 | Submission Open

Keywords: radiomics for the diagnosis; prognostication and treatment planning of solid tumours; methods; translational research and clinical applications; conventional and deep learning radiomics; interpretability of radiomics features and prediction models; image processing (including acquisition; segmentation and feature extraction); imaging methods (including CT; MRI; PET; SPECT and US)

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Diagnostic Biomarkers in Cancers Study

edited by Zejuan Li and

Xin Yi

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2098 | Submission Open

Keywords: cancer; diagnostics; biomarker

(This special issue belongs to the Section Cancer Biomarkers)

News and How Much to Improve in Management of Soft Tissue Sarcomas

edited by Vicente Artigas-Raventós and

José Manuel Asencio

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1450 | Submission Open

Keywords: soft tissue sarcomas; prevalent types; multidisciplinary board; reference centers; news diagnosis methods and treatments; implication of IA and 3D in sarcomas; implication of minimally aggressive surgical techniques

(This special issue belongs to the Section Cancer Therapy)

Human Papillomavirus (HPV) and Related Cancer

edited by

Beata Biesaga

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1277 | Submission Open

Keywords: HPV; carcinogenesis; methods of virus identification diagnostics; prognostification

(This special issue belongs to the Section Infectious Agents and Cancer)

Prognosis and Treatment of Cutaneous Melanoma (2nd Edition)

edited by

Eduardo Nagore

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1025 | Submission Open

Keywords: prognosis; melanoma; adjuvant; germline; somatic; genetic; epigenetic; neoadjuvant

(This special issue belongs to the Section Cancer Therapy)

Advances in Pancreatoduodenectomy

edited by Chang Moo Kang and Jae Hoon Lee

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1022 | Submission Open

Keywords: surgical innovations and techniques in pancreatoduodenectomy; surgical anatomy to understand pancreatoduodenectomy; advances in preoperative imaging and planning; perioperative care and complications management; oncologic outcomes and long-term survival studies; multidisciplinary approaches to enhance patient outcomes; emerging technologies and their impact on surgical precision

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in the Clinical Management of Genitourinary Tumors

edited by

Felix Busch

and Markus Graf

submission deadline 31 Oct 2025 | 1 articles | Viewed by 851 | Submission Open

Keywords: urogenital neoplasms; prostatic neoplasms; kidney neoplasms; ureteral neoplasms; urethral neoplasms; testicular neoplasms; urinary bladder neoplasms; disease management; artificial intelligence; precision medicine

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Targets for CAR T Therapy in Hematologic Malignancies

edited by

Ugo Testa

submission deadline 31 Oct 2025 | 1 articles | Viewed by 683 | Submission Open

Keywords: cancer immunotherapy; chimeric antigen receptor T-cell (CAR-T); leukemia; lymphoma; myeloma

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 451-500 on page 10 of 23.

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