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Cancers
Special Issues
Biomarkers for Gynecological Cancers
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Biomarkers for Gynecological Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Biomarkers".

Deadline for manuscript submissions: 30 July 2025 | Viewed by 1523

Special Issue Editor

Dr. Apriliana Kartikasari

E-Mail Website
Guest Editor
School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC 3083, Australia
Interests: ovarian cancer; biomarkers; therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gynecological cancers, such as cervical, ovarian, and endometrial cancers, pose significant challenges in early detection and treatment. Biomarkers, as biomolecules that can predict or indicate the risk, presence, or absence of a biological event, have emerged as a potential tool to indicate disease risk, presence, progression, response to therapy, and patient outcomes. Thus, identifications of reliable biomarkers in gynecological cancers are essential for improving their early and accurate detection, personalizing treatment regimens, and improving survival outcomes. These biomarkers could originate from the tumor tissues, whole body, or body fluid, including blood, urine, stool, and saliva. Such biomarkers could offer insights to guide clinical decisions and improve patient outcomes. However, high accuracy in the detection of biomarkers and the standardization of tests and the interpretation of their results is crucial to integrating them into routine clinical practice in order to enhance the precision of cancer detection and treatment.

We are pleased to invite you to participate in this Special Issue, focusing on the latest findings regarding biomarkers and their detection in gynecological cancers. Original research articles and reviews regarding biomarkers as susceptibility/risk, diagnosis, prognosis, or treatment response factors, as well as their detection and standardization approaches, are welcome. We look forward to receiving your contributions.

Dr. Apriliana Kartikasari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • cervical
  • ovarian
  • uterine
  • endometrial
  • vaginal
  • vulvar
  • fallopian tube

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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12 pages, 4516 KiB  
Article
Expression Characteristics of 3-Marker Panel (PAX2, PTEN, and β-Catenin) in Benign Interval and Secretory Endometrium and Secretory Endometrial Precancer
by Shuang Niu, Kyle Molberg, Jackson Chen, Lesley Conrad, Elena Lucas and Hao Chen
Cancers 2025, 17(9), 1495; https://doi.org/10.3390/cancers17091495 - 29 Apr 2025
Abstract
Background/Objectives: Despite advancements in treatment options, endometrial cancer remains a significant threat to women, underscoring the importance of early detection of atypical hyperplasia/endometrioid intraepithelial neoplasia (AH/EIN), the widely accepted histological precursor to endometrial carcinoma. Even with refinements in morphological criteria for the [...] Read more.
Background/Objectives: Despite advancements in treatment options, endometrial cancer remains a significant threat to women, underscoring the importance of early detection of atypical hyperplasia/endometrioid intraepithelial neoplasia (AH/EIN), the widely accepted histological precursor to endometrial carcinoma. Even with refinements in morphological criteria for the diagnosis of AH/EIN, accurate diagnosis remains challenging for pathologists, particularly in cases with secretory changes. Morphological alterations resulting from secretory-related changes further complicate the application of diagnostic criteria, emphasizing the need for reliable biomarkers. Previous studies have demonstrated that a panel consisting of three immunohistochemical markers, PAX2, PTEN, and β-catenin, can be effectively utilized for the identification of AH/EIN in various non-secretory scenarios. Methods: In this study, a total of 69 AH/EIN within secretory endometrium were analyzed using this panel. Benign interval endometrium (n = 57) and secretory phase endometrium (n = 71) were also analyzed for PAX2, PTEN, and β-catenin expression as controls. Results: The 3-marker panel successfully identified 93% of secretory AH/EIN, comparable to its performance in identifying non-secretory bona fide AH/EIN (92.8%) and AH/EIN within endometrial polyps (92.4%). Of note, β-catenin expression in benign interval endometrium commonly displayed weak nuclear staining (67%), which could pose a diagnostic pitfall when using the 3-marker panel. Overall, the results demonstrate the diagnostic utility of the 3-marker panel in clinical practice in identifying AH/EIN within challenging secretory phase endometrium cases. Conclusions: Combined with previous research highlighting its effectiveness in other challenging contexts—such as AH/EIN in polyps, small-sized EIN (subdiagnostic EIN), and progestin-treated EIN—this study provides strong evidence supporting the panel’s broad applicability in resolving major diagnostic challenges related to the precise diagnosis of AH/EIN. Full article
(This article belongs to the Special Issue Biomarkers for Gynecological Cancers)
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18 pages, 2620 KiB  
Systematic Review
Circulating microRNAs as Diagnostic Biomarkers to Detect Specific Stages of Ovarian Cancer: A Comprehensive Meta-Analysis
by Apriliana Ellya Ratna Kartikasari, Paul Michel-Lara, Hayden Exton, Kaan Tekin-Sari, Ebtesam Motlaq M. Alnefai, Arnan Mitchell, Cesar Sanchez-Huertas and Magdalena Plebanski
Cancers 2024, 16(24), 4190; https://doi.org/10.3390/cancers16244190 - 16 Dec 2024
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Abstract
Ovarian cancer (OC) is one of the most common gynecological cancers [...] Full article
(This article belongs to the Special Issue Biomarkers for Gynecological Cancers)
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