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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research on Current Progress in Penile Cancer
edited by Juan J. Chipollini and Ahmet Murat Aydin
submission deadline 25 Apr 2026 | 4 articles | Viewed by 15083 | Submission Open
(This special issue belongs to the Section Cancer Therapy)
Hepatocellular Carcinoma: Current Treatment Strategies for Advanced Disease and Recurrence: 2nd Edition
edited by
submission deadline 25 Apr 2026 | 2 articles | Viewed by 4483 | Submission Open
Keywords: hepatocellular carcinoma; surgery; anticancer drugs; radiation therapy; recurrence
(This special issue belongs to the Section Cancer Therapy)
Clinical Applications of Integrative Analysis of Validated Somatic and Germline Genomic Results in Oncology
edited by
submission deadline 25 Apr 2026 | 2 articles | Viewed by 4028 | Submission Open
Keywords: tumor and constitutional genome integration; clinical application of somatic and germline findings; precision oncology
(This special issue belongs to the Section Molecular Cancer Biology)
PD-1/PD-L1 Immune Checkpoint Therapy: From Predictive Biomarkers to Noninvasive Imaging 2nd Edition submission deadline 25 Apr 2026 | Viewed by 462 | Submission Open
Keywords: PD-1; PD-L1; anti-cancer immune response; immune checkpoint; immunotherapy; biomarker; immuno-PET radiotracers; drug combinations
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Clinical Benefit of Hybrid PET/MRI Molecular Imaging in Oncology
edited by Ana María García-Vicente and
submission deadline 25 Apr 2026 | Viewed by 150 | Submission Open
Keywords: PET/MRI; hybrid imaging; gynecological cancer; prostate cancer; glioma; brain metastases; brain meningioma; sarcoma; liver cancer; hepato-biliary cancer; pancreatic cancer; rectal cancer; breast cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Surgical Treatment of Hepato-Pancreato-Biliary Cancers
edited by Mariano C. Giglio
submission deadline 27 Apr 2026 | 1 articles | Viewed by 1945 | Submission Open
Keywords: pancreatic cancer; hepatocellular carcinoma; colorectal liver metastases; liver surgery; pancreatic surgery; hepato-biliary cancers
(This special issue belongs to the Section Cancer Therapy)
Head and Neck Cancer: Advanced PET/CT and MRI Imaging with a Focus on Current and Emerging Molecular Theranostics
edited by Bennett Chin, Jorge Oldan and Steven P. Rowe
submission deadline 28 Apr 2026 | 6 articles | Viewed by 19573 | Submission Open
Keywords: head and neck cancer; thyroid cancer; PET/SPECT/CT molecular imaging; radionuclide therapy; nuclear medicine
(This special issue belongs to the Section Cancer Therapy)
Immune Biomarkers in Solid Tumors: From Peripheral Blood Parameters to Tissue-Based Indicators for Prognosis and Therapy Response submission deadline 28 Apr 2026 | 2 articles | Viewed by 4237 | Submission Open
Keywords: immune biomarkers; solid tumors; peripheral blood immune parameters; circulating immune cells; cytokines; tissue-based biomarkers; immune checkpoint molecules; prognostic biomarkers; predictive biomarkers; tumor microenvironment; immunotherapy response; translational oncology
(This special issue belongs to the Section Cancer Biomarkers)
Novel Therapeutic Strategies in Salivary Gland Tumor submission deadline 30 Apr 2026 | 8 articles | Viewed by 22383 | Submission Open
Keywords: parotid gland; parotid tumors; facial nerve; novel therapeutic options; distant metastasis; liquid biopsy; prognostic factors; parotid robotic surgery; microRNA; imaging
(This special issue belongs to the Section Cancer Therapy)
Advancements in Molecular Research of Prostate Cancer
edited by
submission deadline 30 Apr 2026 | 7 articles | Viewed by 17718 | Submission Open
Keywords: prostate cancer; molecular targets; tumor heterogeneity; targeted interception and therapies; noninvasive biomarkers; precision oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Immune Microenvironment and Immunotherapy in Malignant Brain Tumors
edited by Masaki Terabe and
submission deadline 30 Apr 2026 | 5 articles | Viewed by 16383 | Submission Open
Keywords: glioma; brain metastasis; primary brain cancer; tumor immunity; neuroimmunology; immune microenvi-ronment; T cells; myeloid cells; cancer neuroscience
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Uveal Melanoma
edited by and
submission deadline 30 Apr 2026 | 8 articles | Viewed by 14407 | Submission Open
Keywords: uveal melanoma; eye cancer; liver metastasis; Gα q/11 mutations; BAP1; SF3B1; PRAME; dormancy; liver-directed treatment; T-cell engager
(This special issue belongs to the Section Molecular Cancer Biology)
The Future of Machine Learning in Predicting the Treatment Responses of Cancers
edited by Alfredo Vellido, and
submission deadline 30 Apr 2026 | 4 articles | Viewed by 12494 | Submission Open
Keywords: cancer treatment response; medical decision support systems; cancer outcome prediction; personalized medicine; pre-clinical models; artificial intelligence; machine learning; deep learning; progression-free survival; disease-free survival; event-free survival; overall survival; adverse event; quality of life; surrogate endpoint
(This special issue belongs to the Section Methods and Technologies Development)
Quality of Life and Management of Pediatric Cancer submission deadline 30 Apr 2026 | 5 articles | Viewed by 12187 | Submission Open
Keywords: pediatric palliative care; oncology; quality of life; early management
(This special issue belongs to the Section Pediatric Oncology)
Targeted Therapy in Head and Neck Cancer
edited by , Angelo Camaioni and Luca de Campora
submission deadline 30 Apr 2026 | 5 articles | Viewed by 11666 | Submission Open
Keywords: salivary glands; thyroid; laryngeal cancer; molecular oncology; reconstruction; microsurgery; oral cancer; HPV; oropharyngeal cancer
(This special issue belongs to the Section Cancer Therapy)
Human Microbiome, Diet and Cancerogenesis
edited by Ewa Brzeziańska-Lasota
submission deadline 30 Apr 2026 | 3 articles | Viewed by 11600 | Submission Open
Keywords: microbiota; dysbiosis; oncobiome; cell disruptors; cell signaling; epigenetics; diet; dietary intervention; microbiota disorders; cancerogenesis
(This special issue belongs to the Section Tumor Microenvironment)
Epidemiology of Cancer and Risk Factors: Pushing Boundaries in Public Health Research and Policy
edited by
submission deadline 30 Apr 2026 | 5 articles | Viewed by 9375 | Submission Open
Keywords: cancer epidemiology; risk factors; public health policy; cancer prevention; early detection; genetic determinants; environmental exposures; behavioral health; interdisciplinary approaches; innovative methodologies
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Prognosis and Treatment of Cutaneous Melanoma (2nd Edition)
edited by
submission deadline 30 Apr 2026 | 3 articles | Viewed by 9300 | Submission Open
Keywords: prognosis; melanoma; adjuvant; germline; somatic; genetic; epigenetic; neoadjuvant
(This special issue belongs to the Section Cancer Therapy)
Surgical Oncology for Hepato-Pancreato-Biliary Cancer
edited by Zaed Z. R. Hamady
submission deadline 30 Apr 2026 | 6 articles | Viewed by 8426 | Submission Open
Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach
(This special issue belongs to the Section Clinical Research of Cancer)
Neuroblastoma: Molecular Insights and Clinical Implications
edited by Mary Beth Madonna
submission deadline 30 Apr 2026 | 2 articles | Viewed by 7467 | Submission Open
Keywords: neuroblastoma; molecular mechanisms; targeted therapies; immunotherapies; small molecule therapies
(This special issue belongs to the Section Molecular Cancer Biology)
Radiomics in Cancer Imaging: Theory and Applications in Solid Tumours submission deadline 30 Apr 2026 | 3 articles | Viewed by 7122 | Submission Open
Keywords: radiomics for the diagnosis; prognostication and treatment planning of solid tumours; methods; translational research and clinical applications; conventional and deep learning radiomics; interpretability of radiomics features and prediction models; image processing (including acquisition; segmentation and feature extraction); imaging methods (including CT; MRI; PET; SPECT and US)
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Combination Therapy in Lymphoma
edited by and Alberto Arribas
submission deadline 30 Apr 2026 | 2 articles | Viewed by 6415 | Submission Open
Keywords: combination therapy; non-Hodgkin lymphoma; Hodgkin lymphoma; targeted agents; antibody drug conjugates; bispecific agents; cellular therapies; immune checkpoint inhibitors and epigenetic agents
(This special issue belongs to the Section Cancer Therapy)
Cancer Immunotherapy as Part of Precision Clinical Medicine
edited by and
submission deadline 30 Apr 2026 | 2 articles | Viewed by 4308 | Submission Open
Keywords: cancer; immunotherapy; tumor microenvironment; molecular biology and genetics
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Mesothelioma Epidemiology, Pathogenesis, Emerging Treatments and Pre-Clinical Models submission deadline 30 Apr 2026 | 3 articles | Viewed by 4139 | Submission Open
Keywords: mesothelioma; epidemiology; pathogenesis; emerging treatments; risk factors; biomarkers; surgical techniques; targeted therapies; immunotherapies; pre-clinical models
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Acute Myeloid Leukemia: Updates on Diagnosis, Treatment and Management submission deadline 30 Apr 2026 | 2 articles | Viewed by 4064 | Submission Open
Keywords: acute myeloid leukemia; treatment; targeted therapy; molecular profiling; resistance
(This special issue belongs to the Section Methods and Technologies Development)
Interrogating Molecular Regulators and Chemical Agents in Brain Tumor Progression
edited by Shilpi Singh
submission deadline 30 Apr 2026 | 2 articles | Viewed by 3968 | Submission Open
Keywords: brain tumor progression; molecular mechanisms; small molecule inhibitors; natural compounds; synthetic drugs; biomarkers; oncogenic pathways; metabolic reprogramming
(This special issue belongs to the Section Tumor Microenvironment)
Integrating Bioinformatics, AI, Imaging, and Clinical Informatics in Cancer Research
edited by Jason Li
submission deadline 30 Apr 2026 | 1 articles | Viewed by 3788 | Submission Open
Keywords: bioinformatics; multiomics; genomics; transcriptomics artificial intelligence; deep learning; clinical informatics; medical imaging; functional genomics; multi-discipline
(This special issue belongs to the Section Cancer Informatics and Big Data)
Molecular PET Imaging in Cancer Metabolic Studies submission deadline 30 Apr 2026 | 1 articles | Viewed by 3764 | Submission Open
Keywords: PET imaging; PET/CT; PET/MRI; cancer metabolism; tumor microenvironment; cancer antigens; radiotracers
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Molecular and Genetic Biomarkers in Head and Neck Squamous Cell Carcinoma
edited by and Michal Masternak
submission deadline 30 Apr 2026 | 1 articles | Viewed by 3664 | Submission Open
Keywords: head and neck squamous cell carcinoma (HNSCC); molecular biomarkers; genetic biomarkers; multi-omics approaches; HNSCC carcinogenesis; prognostic biomarkers; translational medicine; molecular pathology
(This special issue belongs to the Section Molecular Cancer Biology)
Biomarkers for Therapy Response in Gastrointestinal Malignancies: Predicting Outcomes and Personalizing Care submission deadline 30 Apr 2026 | 3 articles | Viewed by 3229 | Submission Open
Keywords: immunotherapy; biomarkers; resistance mechanisms; predictive markers; clinical trials; translational research
(This special issue belongs to the Section Cancer Biomarkers)
CT/MRI/PET in Cancer submission deadline 30 Apr 2026 | 3 articles | Viewed by 3119 | Submission Open
Keywords: PET imaging; CT; MRI; cancer; characterization; treatment monitoring; biomarkers; predictive value; AI integration
(This special issue belongs to the Section Methods and Technologies Development)
Myeloma: Pathogenesis and Targeted Therapies
edited by Fenghuang (Frank) Zhan, Gang An and Cody Ashby
submission deadline 30 Apr 2026 | 2 articles | Viewed by 3053 | Submission Open
Keywords: multiple myeloma; drug resistance; car-t cell therapy; immunotherapy targets; biomarkers; genetic alterations; molecular pathogenesis
(This special issue belongs to the Section Tumor Microenvironment)
Health Disparities and Outcomes in Cancer Survivors submission deadline 30 Apr 2026 | 3 articles | Viewed by 3043 | Submission Open
Keywords: cancer survivorship; quality of life; social behavioral determinants of health (SBDH); health disparities; symptom management
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Chemo-Radio-Immunotherapy for Colorectal Cancer
edited by Shoichi Hazama
submission deadline 30 Apr 2026 | 3 articles | Viewed by 3030 | Submission Open
Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery
(This special issue belongs to the Section Cancer Therapy)
Real-World Evidence and Emerging Therapeutic Strategies in Refractory Metastatic Colorectal Cancer
edited by
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2892 | Submission Open
Keywords: real-world evidence; refractory metastatic colorectal cancer; treatment resistance; third-line and beyond therapies; targeted therapies; immunotherapy; patient outcomes; clinical practice; biomarkers; precision oncology
(This special issue belongs to the Section Cancer Metastasis)
G Protein-Coupled Receptors in Cancer Progression
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2828 | Submission Open
Keywords: GPCRs; heterotrimeric G proteins; signal transduction; mutations; cancer development
(This special issue belongs to the Section Tumor Microenvironment)
Prostate Cancer Epidemiology and Genetics: 2nd Edition
edited by
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2717 | Submission Open
Keywords: prostate cancer; epidemiology; clinical genetics; aging; population-level databases
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Stem Cell Origin of Cancers: Biological and Clinical Implications of a Unified Theory of Cancer (2nd Edition)
edited by Shi-Ming Tu, Louis L. Pisters and
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2415 | Submission Open
Keywords: cancer stem cells; cancer-initiating cell; progenitor cell; epithelial; Mesenchymal transition; pluripotency; plasticity; heterogeneity; embryogenesis; stem-like; stemness
(This special issue belongs to the Section Cancer Pathophysiology)
Advances in the Treatment of Urological Cancer
edited by Anna Patrikidou
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2383 | Submission Open
Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics
(This special issue belongs to the Section Cancer Therapy)
From Molecular Insights to Cancer Treatments: Progress in Translational Science
edited by , Dhanir Tailor and
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2062 | Submission Open
Keywords: cancer biology; therapeutics; molecular targets; translational research
(This special issue belongs to the Section Cancer Therapy)
The Latest Advancements in Cutaneous Melanoma
edited by Zhenyu Ji
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2024 | Submission Open
Keywords: cutaneous melanoma; skin cancer; immunotherapy; targeted therapy; melanoma biomarkers
(This special issue belongs to the Section Cancer Therapy)
New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1926 | Submission Open
Keywords: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma
(This special issue belongs to the Section Cancer Therapy)
Immune Checkpoint Therapy in Liver Cancer: Current Evidence, Underlying Biology, and What's Next
edited by and
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1908 | Submission Open
Keywords: hepatocellular carcinoma; immunotherapy; immuno-oncology; immune checkpoint inhibitors; clinical trial; immunological microenvironments
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Significance of CAR T-Cell Therapy in Aggressive B-Cell Lymphoma Treatment
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1898 | Submission Open
Keywords: CAR-T therapy; non-hodgkin lymphoma; hodgkin lymphoma; CAR-T persistence; immune-related adverse events (irAEs); resistance mechanisms; combination therapy; tumor microenvironment; multiomics data analysis
(This special issue belongs to the Section Cancer Therapy)
Exosomes in Cancer Metastasis (2nd Edition) submission deadline 30 Apr 2026 | 1 articles | Viewed by 1880 | Submission Open
Keywords: exosomes; biomarkers; cancer metastasis
(This special issue belongs to the Section Cancer Metastasis)
Genetic Screening and Personalized Prevention in Hereditary Gastrointestinal Cancer Syndromes
edited by and Vittoria Disciglio
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1855 | Submission Open
Keywords: hereditary gastrointestinal cancer syndromes; NGS multigene panel tests; pathogenic variant (PV); variant of uncertain significance (VUS); mismatch repair (MMR) genes; gastrointestinal cancer susceptibility; personalized medicine; genetic risk assessment; germline variants; genetic counseling; functional impact of the genetic variant
(This special issue belongs to the Section Cancer Pathophysiology)
Prostate Cancer: Contemporary Standards and Challenges submission deadline 30 Apr 2026 | 1 articles | Viewed by 1680 | Submission Open
Keywords: prostate cancer; molecular pathogenesis; precision oncology; biomarkers; treatment de-escalation
(This special issue belongs to the Section Cancer Therapy)
Immune Biomarkers and Checkpoint Inhibitors: Advancing Immunotherapy in Gynecologic Cancers
edited by Ting-Tai Yen and Eugene Patrick Toy
submission deadline 30 Apr 2026 | 2 articles | Viewed by 1467 | Submission Open
Keywords: immune checkpoints; checkpoint inhibitors; PD-1/PD-L1 pathway; immune biomarkers; tumor microenvironment; immunosuppressive pathways; T-cell activation in solid tumors; gynecologic tumors
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Glioma: From Intracellular Oncogenic Pathways to Targeting Therapeutic Strategies
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1449 | Submission Open
Keywords: glioma; targeted therapies; resistance mechanisms; oncogenic pathways; therapeutic resistance; combination therapies; tumor heterogeneity
(This special issue belongs to the Section Cancer Therapy)
Recent Advances and Strategies for the Management of CIN and HPV Eradication Starategies for the Prevention of Uterine Cervical Cancer
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1440 | Submission Open
Keywords: CIN; 9-valent HPV vaccine; HPV L2-VLP vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT
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