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Targeted Therapy in Head and Neck Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 553

Special Issue Editors


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Guest Editor
Otolaryngology Department, Isola Tiberina—Gemelli Isola Hospital, Rome, Italy
Interests: salivary glands; thyroid surgery; laryngeal cancer; molecular oncology; reconstruction; microsurgery; oral cancer; HPV; oropharyngeal cancer
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Head and Neck Department, San Giovanni-Addolorata Hospital, Rome, Italy
Interests: salivary glands; thyroid surgery; laryngeal cancer; molecular oncology; reconstruction; microsurgery; oral cancer; HPV; oropharyngeal cancer
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Otolaryngology Department, San Giovanni-Addolorata Hospital, Rome, Italy
Interests: salivary glands; thyroid surgery; laryngeal cancer; molecular oncology; reconstruction; microsurgery; oral cancer; HPV; oropharyngeal cancer

Special Issue Information

Dear Colleagues,

Head and neck oncology is at a turning point, looking to new horizons, surgical and otherwise. Although rare neoplasms, with the exception (albeit small) of laryngeal cancer, head and neck cancers (oral cavity, oropharyngeal, laryngeal, hypopharyngeal, and nasal–sinus cancers) have a significant 'molecular' delay compared to neoplasms in other districts, and not only when we talk about ‘giants’, such as lung or breast cancer, but also when we look at bigger ‘cousins’, such as cutaneous melanoma (but its incidence varies greatly from continent to continent and even more between states).

The need for targeted therapies that take into account not only clinical and pathological variables, but above all the biology (and thus the molecular receptors expressed) of the tumor, is forcing the entire head and neck community, clinicians and surgeons alike, to confront aspects that have received little attention to date.

In this Special Issue, we aim to stimulate the debate on the new surgical and, above all, molecular options for head and neck cancers in order to provide a detailed overview of therapies specific to the biology of each individual neoplasm.

Retrospective and prospective studies, case series, narrative and systematic reviews with or without meta-analysis, and articles illustrating surgical techniques are welcome.

Dr. Pietro De Luca
Prof. Angelo Camaioni
Dr. Luca de Campora
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • salivary glands
  • thyroid
  • laryngeal cancer
  • molecular oncology
  • reconstruction
  • microsurgery
  • oral cancer
  • HPV
  • oropharyngeal cancer

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Published Papers (2 papers)

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Review

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18 pages, 1110 KiB  
Review
Future Perspectives in Senescence-Based Therapies for Head and Neck Cancer
by Bruna Haddad Palomares, Manoela Domingues Martins, Marco Antonio Trevizani Martins, Cristiane Helena Squarize and Rogerio Moraes Castilho
Cancers 2025, 17(12), 1965; https://doi.org/10.3390/cancers17121965 - 12 Jun 2025
Abstract
Cellular senescence is a complex physiological process in which cells permanently stop dividing and enter a stable state of cell-cycle arrest. This mechanism is typically triggered by various stressors, such as DNA damage, oxidative stress, telomere shortening, and oncogene activation. Senescent cells remain [...] Read more.
Cellular senescence is a complex physiological process in which cells permanently stop dividing and enter a stable state of cell-cycle arrest. This mechanism is typically triggered by various stressors, such as DNA damage, oxidative stress, telomere shortening, and oncogene activation. Senescent cells remain metabolically active and significantly influence their microenvironment through the senescence-associated secretory phenotype (SASP), which includes the secretion of inflammatory cytokines, growth factors, and proteases. While cellular senescence serves as a crucial tumor-suppressive mechanism by preventing the proliferation of damaged or potentially cancerous cells, it also plays a paradoxical role by promoting chronic inflammation, tissue dysfunction, and potentially oncogenesis. Therefore, understanding the regulation and impact of cellular senescence is vital for developing therapeutic interventions that leverage its benefits while minimizing adverse outcomes. In this review, we provide an overview of the current understanding of cellular senescence in cancer biology and discuss the emerging field of senescence-targeted therapies. We focus specifically on the role of senescence in head and neck cancers, examining the potential of induced senescence therapy to mitigate the progression of these tumors. This review aims to correlate the dual nature of senescence with innovative therapeutic strategies, highlighting its promise and challenges in improving treatment outcomes for HNC patients. Full article
(This article belongs to the Special Issue Targeted Therapy in Head and Neck Cancer)
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Other

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17 pages, 5057 KiB  
Systematic Review
Risk Factors for Malignant Transformation in Inverted Sinonasal Papilloma: A Systematic Review and Meta-Analysis
by Andrea Ambrosini-Spaltro, Giulia Querzoli, Anna Caterina Leucci, Angela Camagni, Paolo Farneti, Elisa D’Angelo, Elisa Donini, Alicia Tosoni, Ernesto Pasquini, Paolo Galli and Maria P. Foschini
Cancers 2025, 17(11), 1798; https://doi.org/10.3390/cancers17111798 - 28 May 2025
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Abstract
Background/Objectives: Inverted sinonasal papilloma (IP) is a benign epithelial proliferation that can recur and undergo malignant transformation. We performed a systematic review and meta-analysis to answer the following question: what are the risk factors for malignant transformation in IP? Methods: A [...] Read more.
Background/Objectives: Inverted sinonasal papilloma (IP) is a benign epithelial proliferation that can recur and undergo malignant transformation. We performed a systematic review and meta-analysis to answer the following question: what are the risk factors for malignant transformation in IP? Methods: A search was performed in PubMed and Embase databases. Numbers of affected individuals in exposed versus non-exposed individuals, or odds ratio values, were compared for each specific risk factor examined. The Newcastle–Ottawa Scale (NOS) was used to assess the risk of bias. To assess the overall quality of evidence, we used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Meta-analyses were conducted using the fixed-effects and the random effects models. Heterogeneity of the results was assessed by I2 statistic output. Meta-analyses and forest plots were obtained using Review Manager (RevMan) software version 5.4. Results: After examining 1875 results (942 from PubMed; 933 from Embase), 26 articles were selected. Among the 26 selected articles, the number of cases examined ranged from 14 to 162. All studies examined a population of 1271 IPs, with a carcinoma incidence of 230/1271 (18.1%). Three meta-analyses were performed for the following risk factors: smoking, alcohol, and HPV. Using the fixed-effects model, significant values were obtained for smoking (p = 0.002) and HPV (p < 0.001), with moderate and low quality of evidence, respectively. Alcohol did not reach statistical significance (p = 0.95). Conclusions: This study demonstrates that both smoking and HPV are risk factors for IP malignant transformation. Possible interventions include smoking cessation and HPV vaccination in individuals affected by IP. Full article
(This article belongs to the Special Issue Targeted Therapy in Head and Neck Cancer)
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