Prognosis and Treatment of Cutaneous Melanoma (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 756

Special Issue Editor


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Guest Editor
Department of Dermatology, Fundación Instituto Valenciano de Oncología, 46009 Valencia, Spain
Interests: melanoma; genetic testing of melanoma
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Special Issue Information

Dear Colleagues,

In this Special Issue, the most relevant and updated information about characteristics that determine the prognosis of cutaneous melanomas will be addressed. This will include an in-depth analysis of factors related to patients (genetic predispositions), as well as the pathological and molecular characteristics of tumors. A review of the current available evidence on adjuvant and neoadjuvant treatments and the treatment of advanced melanoma are also included in this Special Issue. 

Dr. Eduardo Nagore
Guest Editor

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Keywords

  • prognosis
  • melanoma
  • adjuvant
  • germline
  • somatic
  • genetic
  • epigenetic
  • neoadjuvant

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Published Papers (1 paper)

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Review

18 pages, 1137 KiB  
Review
Recent Developments in Targeting the Cell Cycle in Melanoma
by Christie Hung, Trang T. T. Nguyen, Poulikos I. Poulikakos and David Polsky
Cancers 2025, 17(8), 1291; https://doi.org/10.3390/cancers17081291 - 11 Apr 2025
Viewed by 502
Abstract
Melanoma is an aggressive cancer with rising incidence, particularly among older individuals. Despite advancements in targeted therapies for BRAF and MEK proteins and immunotherapies, many patients either fail to respond or develop resistance. For those progressing on immunotherapy, limited treatment options remain. The [...] Read more.
Melanoma is an aggressive cancer with rising incidence, particularly among older individuals. Despite advancements in targeted therapies for BRAF and MEK proteins and immunotherapies, many patients either fail to respond or develop resistance. For those progressing on immunotherapy, limited treatment options remain. The Cyclin D–CDK4/6–RB pathway is commonly dysregulated in melanoma, with up to 90% of cases showing alterations that activate it. Although targeting Cyclin–CDK complexes has shown promise in preclinical models, clinical responses have been suboptimal. This review explores the molecular mechanisms behind Cyclin–CDK dysregulation in melanoma and the challenges of targeting this pathway. It also discusses strategies to improve the efficacy of CDK4/6 inhibitors, including combination therapies to overcome resistance and enhance patient outcomes. Understanding these mechanisms can guide the development of more effective treatments for melanoma. Full article
(This article belongs to the Special Issue Prognosis and Treatment of Cutaneous Melanoma (2nd Edition))
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