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Hepatocellular Carcinoma: Current Treatment Strategies for Advanced Disease and Recurrence:...
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Hepatocellular Carcinoma: Current Treatment Strategies for Advanced Disease and Recurrence: 2nd Edition

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 25 July 2025 | Viewed by 173

Special Issue Editor

Dr. Takefumi Kimura

E-Mail Website
Guest Editor
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto 390-8621, Japan
Interests: hepatitis; liver cirrhosis; hepatitis B; liver diseases; hepatocellular carcinoma; cirrhosis; liver transplantation; liver failure; histology; gastroenterology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue titled “Hepatocellular Carcinoma: Current Treatment Strategies for Advanced Disease and Recurrence”  (https://www.mdpi.com/journal/cancers/special_issues/MB523W9Y7H).

The treatment options for hepatocellular carcinoma (HCC) have expanded significantly with the advent of multi-kinase inhibitors and immune checkpoint inhibitors. In addition to drug therapy, remarkable advances have been made in liver transplantation, minimally invasive surgery, the technology involved in ablation therapy, the choice of embolization materials and anticancer drugs for embolization therapy, and radiation therapy. Modern HCC treatment requires not only curative treatment of early-stage lesions, but also the development of new treatment systems that lead to a cure for advanced HCC and appropriate treatment of recurrent HCC. In addition, NASH and alcoholic liver cancers are expected to increase as viral hepatitis is controlled. The management of side effects in these non-viral HCCs may differ due to differences in drug sensitivity, accompanied with diabetes mellitus and hypertension. In this Special Issue, we call for papers from a wide range of medical, surgical, and radiological perspectives on treatment strategies for advanced disease, approaches to recurrent disease, and management of side effects associated with treatment in the new era of HCC practice.

Dr. Takefumi Kimura
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hepatocellular carcinoma
  • surgery
  • anticancer drugs
  • radiation therapy
  • recurrence

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Published Papers (1 paper)

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14 pages, 2021 KiB  
Systematic Review
Locoregional and Surgical Treatment of Single-Nodule Hepatocellular Carcinoma Recurrence After Liver Transplantation: A Systematic Review and a Meta-Analysis
by Marco Maria Pascale, Camilla Marandola, Francesco Frongillo, Erida Nure and Salvatore Agnes
Cancers 2025, 17(9), 1501; https://doi.org/10.3390/cancers17091501 - 29 Apr 2025
Abstract
Background: Liver transplantation (LT) is regarded as a curative approach for patients with hepatocellular carcinoma (HCC), especially those with underlying advanced liver disease. However, the recurrence of HCC post-LT poses significant challenges, with reported rates of 15–20% within the first two years following [...] Read more.
Background: Liver transplantation (LT) is regarded as a curative approach for patients with hepatocellular carcinoma (HCC), especially those with underlying advanced liver disease. However, the recurrence of HCC post-LT poses significant challenges, with reported rates of 15–20% within the first two years following surgery. Effective management of single-nodule recurrence is critical to improving patient outcomes. Methods: This meta-analysis evaluates the efficacy of surgical resection versus locoregional therapies (LRT) in patients with localized HCC recurrence after LT. We adhered to the PRISMA Statement in conducting a thorough search of relevant studies published from 2009 to 2024, ultimately including ten studies that met our eligibility criteria. Results: The results indicate that patients undergoing surgical treatment displayed superior one-year overall survival (OS) rates compared to those receiving LRT (71% vs. 62%, p = 0.038), as well as higher one-year disease-free survival (DFS) rates (60% vs. 54%, p = 0.042). Notably, patients in the LRT group presented with more advanced HCC characteristics prior to transplantation, including higher rates of microvascular invasion and elevated alpha-fetoprotein levels. Conclusions: Our findings suggest that while surgical resection is associated with better survival outcomes, the choice between surgical and locoregional approaches must be individualized based on tumor characteristics and liver function. The ongoing development of standardized guidelines with the inclusion of immunotherapy or targeted agents will be essential in refining treatment pathways and improving outcomes for patients experiencing HCC recurrence following LT. Full article
(This article belongs to the Special Issue Hepatocellular Carcinoma: Current Treatment Strategies for Advanced Disease and Recurrence: 2nd Edition)
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