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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Thyroid Cancer Recurrence: Integrating Surgical, Clinical, and Translational Research

edited by

Nikola Slijepcevic

and Ioannis Koutelidakis

submission deadline 20 Apr 2026 | Viewed by 114 | Submission Open

Keywords: thyroid cancer; recurrence; surgery; clinical management; aggressive subtypes; rare subtypes; biomarkers; imaging; translational research; targeted therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Research on Current Progress in Penile Cancer

edited by Juan J. Chipollini and Ahmet Murat Aydin

submission deadline 25 Apr 2026 | 4 articles | Viewed by 15054 | Submission Open

(This special issue belongs to the Section Cancer Therapy)

Hepatocellular Carcinoma: Current Treatment Strategies for Advanced Disease and Recurrence: 2nd Edition

edited by

Takefumi Kimura

submission deadline 25 Apr 2026 | 2 articles | Viewed by 4474 | Submission Open

Keywords: hepatocellular carcinoma; surgery; anticancer drugs; radiation therapy; recurrence

(This special issue belongs to the Section Cancer Therapy)

Clinical Applications of Integrative Analysis of Validated Somatic and Germline Genomic Results in Oncology

edited by

Arezou A. Ghazani

submission deadline 25 Apr 2026 | 2 articles | Viewed by 4020 | Submission Open

Keywords: tumor and constitutional genome integration; clinical application of somatic and germline findings; precision oncology

(This special issue belongs to the Section Molecular Cancer Biology)

PD-1/PD-L1 Immune Checkpoint Therapy: From Predictive Biomarkers to Noninvasive Imaging 2nd Edition

edited by

Patrizia Ferroni

Fiorella Guadagni

and

Mario Roselli

submission deadline 25 Apr 2026 | Viewed by 459 | Submission Open

Keywords: PD-1; PD-L1; anti-cancer immune response; immune checkpoint; immunotherapy; biomarker; immuno-PET radiotracers; drug combinations

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Clinical Benefit of Hybrid PET/MRI Molecular Imaging in Oncology

edited by Ana María García-Vicente and

Edel Noriega-Álvarez

submission deadline 25 Apr 2026 | Viewed by 149 | Submission Open

Keywords: PET/MRI; hybrid imaging; gynecological cancer; prostate cancer; glioma; brain metastases; brain meningioma; sarcoma; liver cancer; hepato-biliary cancer; pancreatic cancer; rectal cancer; breast cancer

(This special issue belongs to the Section Clinical Research of Cancer)

Surgical Treatment of Hepato-Pancreato-Biliary Cancers

edited by Mariano C. Giglio

submission deadline 27 Apr 2026 | 1 articles | Viewed by 1939 | Submission Open

Keywords: pancreatic cancer; hepatocellular carcinoma; colorectal liver metastases; liver surgery; pancreatic surgery; hepato-biliary cancers

(This special issue belongs to the Section Cancer Therapy)

Head and Neck Cancer: Advanced PET/CT and MRI Imaging with a Focus on Current and Emerging Molecular Theranostics

edited by Bennett Chin, Jorge Oldan and Steven P. Rowe

submission deadline 28 Apr 2026 | 6 articles | Viewed by 19527 | Submission Open

Keywords: head and neck cancer; thyroid cancer; PET/SPECT/CT molecular imaging; radionuclide therapy; nuclear medicine

(This special issue belongs to the Section Cancer Therapy)

Immune Biomarkers in Solid Tumors: From Peripheral Blood Parameters to Tissue-Based Indicators for Prognosis and Therapy Response

edited by

Ioannis P. Trontzas

and

Konstantinos Syrigos

submission deadline 28 Apr 2026 | 2 articles | Viewed by 4211 | Submission Open

Keywords: immune biomarkers; solid tumors; peripheral blood immune parameters; circulating immune cells; cytokines; tissue-based biomarkers; immune checkpoint molecules; prognostic biomarkers; predictive biomarkers; tumor microenvironment; immunotherapy response; translational oncology

(This special issue belongs to the Section Cancer Biomarkers)

Novel Therapeutic Strategies in Salivary Gland Tumor

edited by

Giovanni Salzano

Arianna Di Stadio

and

Luigi Angelo Vaira

submission deadline 30 Apr 2026 | 8 articles | Viewed by 22348 | Submission Open

Keywords: parotid gland; parotid tumors; facial nerve; novel therapeutic options; distant metastasis; liquid biopsy; prognostic factors; parotid robotic surgery; microRNA; imaging

(This special issue belongs to the Section Cancer Therapy)

Advancements in Molecular Research of Prostate Cancer

edited by

Anait S. Levenson

submission deadline 30 Apr 2026 | 7 articles | Viewed by 17672 | Submission Open

Keywords: prostate cancer; molecular targets; tumor heterogeneity; targeted interception and therapies; noninvasive biomarkers; precision oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Immune Microenvironment and Immunotherapy in Malignant Brain Tumors

edited by Masaki Terabe and

Mark R. Gilbert

submission deadline 30 Apr 2026 | 5 articles | Viewed by 16321 | Submission Open

Keywords: glioma; brain metastasis; primary brain cancer; tumor immunity; neuroimmunology; immune microenvi-ronment; T cells; myeloid cells; cancer neuroscience

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in Uveal Melanoma

edited by

Takami Sato

and

Mizue Terai

submission deadline 30 Apr 2026 | 8 articles | Viewed by 14342 | Submission Open

Keywords: uveal melanoma; eye cancer; liver metastasis; Gα q/11 mutations; BAP1; SF3B1; PRAME; dormancy; liver-directed treatment; T-cell engager

(This special issue belongs to the Section Molecular Cancer Biology)

The Future of Machine Learning in Predicting the Treatment Responses of Cancers

edited by Alfredo Vellido,

Ana Candiota

and

Margarida Julia-Sape

submission deadline 30 Apr 2026 | 4 articles | Viewed by 12438 | Submission Open

Keywords: cancer treatment response; medical decision support systems; cancer outcome prediction; personalized medicine; pre-clinical models; artificial intelligence; machine learning; deep learning; progression-free survival; disease-free survival; event-free survival; overall survival; adverse event; quality of life; surrogate endpoint

(This special issue belongs to the Section Methods and Technologies Development)

Quality of Life and Management of Pediatric Cancer

edited by

Luca Giacomelli

and

Momcilo Jankovic

submission deadline 30 Apr 2026 | 5 articles | Viewed by 12171 | Submission Open

Keywords: pediatric palliative care; oncology; quality of life; early management

(This special issue belongs to the Section Pediatric Oncology)

Targeted Therapy in Head and Neck Cancer

edited by

Pietro De Luca

, Angelo Camaioni and Luca de Campora

submission deadline 30 Apr 2026 | 5 articles | Viewed by 11597 | Submission Open

Keywords: salivary glands; thyroid; laryngeal cancer; molecular oncology; reconstruction; microsurgery; oral cancer; HPV; oropharyngeal cancer

(This special issue belongs to the Section Cancer Therapy)

Human Microbiome, Diet and Cancerogenesis

edited by Ewa Brzeziańska-Lasota

submission deadline 30 Apr 2026 | 3 articles | Viewed by 11567 | Submission Open

Keywords: microbiota; dysbiosis; oncobiome; cell disruptors; cell signaling; epigenetics; diet; dietary intervention; microbiota disorders; cancerogenesis

(This special issue belongs to the Section Tumor Microenvironment)

Epidemiology of Cancer and Risk Factors: Pushing Boundaries in Public Health Research and Policy

edited by

The Phuong Nguyen

submission deadline 30 Apr 2026 | 5 articles | Viewed by 9340 | Submission Open

Keywords: cancer epidemiology; risk factors; public health policy; cancer prevention; early detection; genetic determinants; environmental exposures; behavioral health; interdisciplinary approaches; innovative methodologies

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Prognosis and Treatment of Cutaneous Melanoma (2nd Edition)

edited by

Eduardo Nagore

submission deadline 30 Apr 2026 | 3 articles | Viewed by 9263 | Submission Open

Keywords: prognosis; melanoma; adjuvant; germline; somatic; genetic; epigenetic; neoadjuvant

(This special issue belongs to the Section Cancer Therapy)

Surgical Oncology for Hepato-Pancreato-Biliary Cancer

edited by Zaed Z. R. Hamady

submission deadline 30 Apr 2026 | 6 articles | Viewed by 8393 | Submission Open

Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach

(This special issue belongs to the Section Clinical Research of Cancer)

Neuroblastoma: Molecular Insights and Clinical Implications

edited by Mary Beth Madonna

submission deadline 30 Apr 2026 | 2 articles | Viewed by 7443 | Submission Open

Keywords: neuroblastoma; molecular mechanisms; targeted therapies; immunotherapies; small molecule therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Radiomics in Cancer Imaging: Theory and Applications in Solid Tumours

edited by

Francesco Bianconi

and

Barbara Palumbo

submission deadline 30 Apr 2026 | 3 articles | Viewed by 7102 | Submission Open

Keywords: radiomics for the diagnosis; prognostication and treatment planning of solid tumours; methods; translational research and clinical applications; conventional and deep learning radiomics; interpretability of radiomics features and prediction models; image processing (including acquisition; segmentation and feature extraction); imaging methods (including CT; MRI; PET; SPECT and US)

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Combination Therapy in Lymphoma

edited by

Afua Adjeiwaa Mensah

and Alberto Arribas

submission deadline 30 Apr 2026 | 2 articles | Viewed by 6377 | Submission Open

Keywords: combination therapy; non-Hodgkin lymphoma; Hodgkin lymphoma; targeted agents; antibody drug conjugates; bispecific agents; cellular therapies; immune checkpoint inhibitors and epigenetic agents

(This special issue belongs to the Section Cancer Therapy)

Cancer Immunotherapy as Part of Precision Clinical Medicine

edited by

Peter Lang

and

Christo Kole

submission deadline 30 Apr 2026 | 2 articles | Viewed by 4282 | Submission Open

Keywords: cancer; immunotherapy; tumor microenvironment; molecular biology and genetics

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Mesothelioma Epidemiology, Pathogenesis, Emerging Treatments and Pre-Clinical Models

edited by

Francesca Pentimalli

submission deadline 30 Apr 2026 | 3 articles | Viewed by 4130 | Submission Open

Keywords: mesothelioma; epidemiology; pathogenesis; emerging treatments; risk factors; biomarkers; surgical techniques; targeted therapies; immunotherapies; pre-clinical models

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Acute Myeloid Leukemia: Updates on Diagnosis, Treatment and Management

edited by

Francesco Lanza

and

Giovanni Marconi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 4045 | Submission Open

Keywords: acute myeloid leukemia; treatment; targeted therapy; molecular profiling; resistance

(This special issue belongs to the Section Methods and Technologies Development)

Interrogating Molecular Regulators and Chemical Agents in Brain Tumor Progression

edited by Shilpi Singh

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3952 | Submission Open

Keywords: brain tumor progression; molecular mechanisms; small molecule inhibitors; natural compounds; synthetic drugs; biomarkers; oncogenic pathways; metabolic reprogramming

(This special issue belongs to the Section Tumor Microenvironment)

Integrating Bioinformatics, AI, Imaging, and Clinical Informatics in Cancer Research

edited by Jason Li

submission deadline 30 Apr 2026 | 1 articles | Viewed by 3781 | Submission Open

Keywords: bioinformatics; multiomics; genomics; transcriptomics artificial intelligence; deep learning; clinical informatics; medical imaging; functional genomics; multi-discipline

(This special issue belongs to the Section Cancer Informatics and Big Data)

Molecular PET Imaging in Cancer Metabolic Studies

edited by

Aditi Mulgaonkar

and

Sashi Debnath

submission deadline 30 Apr 2026 | 1 articles | Viewed by 3746 | Submission Open

Keywords: PET imaging; PET/CT; PET/MRI; cancer metabolism; tumor microenvironment; cancer antigens; radiotracers

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Molecular and Genetic Biomarkers in Head and Neck Squamous Cell Carcinoma

edited by

Joanna Katarzyna Strzelczyk

and Michal Masternak

submission deadline 30 Apr 2026 | 1 articles | Viewed by 3652 | Submission Open

Keywords: head and neck squamous cell carcinoma (HNSCC); molecular biomarkers; genetic biomarkers; multi-omics approaches; HNSCC carcinogenesis; prognostic biomarkers; translational medicine; molecular pathology

(This special issue belongs to the Section Molecular Cancer Biology)

Biomarkers for Therapy Response in Gastrointestinal Malignancies: Predicting Outcomes and Personalizing Care

edited by

Devalingam Mahalingam

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3205 | Submission Open

Keywords: immunotherapy; biomarkers; resistance mechanisms; predictive markers; clinical trials; translational research

(This special issue belongs to the Section Cancer Biomarkers)

CT/MRI/PET in Cancer

edited by

Dávid Sipos

Ritter Zsombor

and

Elif Hindié

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3091 | Submission Open

Keywords: PET imaging; CT; MRI; cancer; characterization; treatment monitoring; biomarkers; predictive value; AI integration

(This special issue belongs to the Section Methods and Technologies Development)

Myeloma: Pathogenesis and Targeted Therapies

edited by Fenghuang (Frank) Zhan, Gang An and Cody Ashby

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3035 | Submission Open

Keywords: multiple myeloma; drug resistance; car-t cell therapy; immunotherapy targets; biomarkers; genetic alterations; molecular pathogenesis

(This special issue belongs to the Section Tumor Microenvironment)

Health Disparities and Outcomes in Cancer Survivors

edited by

Claire Jungyoun Han

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3030 | Submission Open

Keywords: cancer survivorship; quality of life; social behavioral determinants of health (SBDH); health disparities; symptom management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Chemo-Radio-Immunotherapy for Colorectal Cancer

edited by Shoichi Hazama

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3000 | Submission Open

Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery

(This special issue belongs to the Section Cancer Therapy)

Real-World Evidence and Emerging Therapeutic Strategies in Refractory Metastatic Colorectal Cancer

edited by

Carlo Signorelli

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2881 | Submission Open

Keywords: real-world evidence; refractory metastatic colorectal cancer; treatment resistance; third-line and beyond therapies; targeted therapies; immunotherapy; patient outcomes; clinical practice; biomarkers; precision oncology

(This special issue belongs to the Section Cancer Metastasis)

G Protein-Coupled Receptors in Cancer Progression

edited by

Songhai Chen

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2824 | Submission Open

Keywords: GPCRs; heterotrimeric G proteins; signal transduction; mutations; cancer development

(This special issue belongs to the Section Tumor Microenvironment)

Prostate Cancer Epidemiology and Genetics: 2nd Edition

edited by

Steven Narod

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2710 | Submission Open

Keywords: prostate cancer; epidemiology; clinical genetics; aging; population-level databases

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Stem Cell Origin of Cancers: Biological and Clinical Implications of a Unified Theory of Cancer (2nd Edition)

edited by Shi-Ming Tu, Louis L. Pisters and

John F. Ward

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2407 | Submission Open

Keywords: cancer stem cells; cancer-initiating cell; progenitor cell; epithelial; Mesenchymal transition; pluripotency; plasticity; heterogeneity; embryogenesis; stem-like; stemness

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in the Treatment of Urological Cancer

edited by Anna Patrikidou

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2365 | Submission Open

Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics

(This special issue belongs to the Section Cancer Therapy)

From Molecular Insights to Cancer Treatments: Progress in Translational Science

edited by

Sanjay V. Malhotra

, Dhanir Tailor and

Annah Rolig

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2055 | Submission Open

Keywords: cancer biology; therapeutics; molecular targets; translational research

(This special issue belongs to the Section Cancer Therapy)

The Latest Advancements in Cutaneous Melanoma

edited by Zhenyu Ji

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2019 | Submission Open

Keywords: cutaneous melanoma; skin cancer; immunotherapy; targeted therapy; melanoma biomarkers

(This special issue belongs to the Section Cancer Therapy)

New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas

edited by

Carlo Ronsini

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1917 | Submission Open

Keywords: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma

(This special issue belongs to the Section Cancer Therapy)

Immune Checkpoint Therapy in Liver Cancer: Current Evidence, Underlying Biology, and What's Next

edited by

Luca Marzi

and

Rodolfo Sacco

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1905 | Submission Open

Keywords: hepatocellular carcinoma; immunotherapy; immuno-oncology; immune checkpoint inhibitors; clinical trial; immunological microenvironments

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Significance of CAR T-Cell Therapy in Aggressive B-Cell Lymphoma Treatment

edited by

Wing Keung Chan

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1879 | Submission Open

Keywords: CAR-T therapy; non-hodgkin lymphoma; hodgkin lymphoma; CAR-T persistence; immune-related adverse events (irAEs); resistance mechanisms; combination therapy; tumor microenvironment; multiomics data analysis

(This special issue belongs to the Section Cancer Therapy)

Exosomes in Cancer Metastasis (2nd Edition)

edited by

Theresa L. Whiteside

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1875 | Submission Open

Keywords: exosomes; biomarkers; cancer metastasis

(This special issue belongs to the Section Cancer Metastasis)

Genetic Screening and Personalized Prevention in Hereditary Gastrointestinal Cancer Syndromes

edited by

Candida Fasano

and Vittoria Disciglio

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1832 | Submission Open

Keywords: hereditary gastrointestinal cancer syndromes; NGS multigene panel tests; pathogenic variant (PV); variant of uncertain significance (VUS); mismatch repair (MMR) genes; gastrointestinal cancer susceptibility; personalized medicine; genetic risk assessment; germline variants; genetic counseling; functional impact of the genetic variant

(This special issue belongs to the Section Cancer Pathophysiology)

Prostate Cancer: Contemporary Standards and Challenges

edited by

Filip Ionescu

and

Jingsong Zhang

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1671 | Submission Open

Keywords: prostate cancer; molecular pathogenesis; precision oncology; biomarkers; treatment de-escalation

(This special issue belongs to the Section Cancer Therapy)

Immune Biomarkers and Checkpoint Inhibitors: Advancing Immunotherapy in Gynecologic Cancers

edited by Ting-Tai Yen and Eugene Patrick Toy

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1459 | Submission Open

Keywords: immune checkpoints; checkpoint inhibitors; PD-1/PD-L1 pathway; immune biomarkers; tumor microenvironment; immunosuppressive pathways; T-cell activation in solid tumors; gynecologic tumors

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Glioma: From Intracellular Oncogenic Pathways to Targeting Therapeutic Strategies

edited by

Shilpi Singh

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1441 | Submission Open

Keywords: glioma; targeted therapies; resistance mechanisms; oncogenic pathways; therapeutic resistance; combination therapies; tumor heterogeneity

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 401-450 on page 9 of 25.

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