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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Integrating Bioinformatics, AI, Imaging, and Clinical Informatics in Cancer Research
edited by Jason Li
submission deadline 30 Apr 2026 | 1 articles | Viewed by 3567 | Submission Open
Keywords: bioinformatics; multiomics; genomics; transcriptomics artificial intelligence; deep learning; clinical informatics; medical imaging; functional genomics; multi-discipline
(This special issue belongs to the Section Cancer Informatics and Big Data)
Acute Myeloid Leukemia: Updates on Diagnosis, Treatment and Management submission deadline 30 Apr 2026 | 2 articles | Viewed by 3483 | Submission Open
Keywords: acute myeloid leukemia; treatment; targeted therapy; molecular profiling; resistance
(This special issue belongs to the Section Methods and Technologies Development)
Interrogating Molecular Regulators and Chemical Agents in Brain Tumor Progression
edited by Shilpi Singh
submission deadline 30 Apr 2026 | 2 articles | Viewed by 3361 | Submission Open
Keywords: brain tumor progression; molecular mechanisms; small molecule inhibitors; natural compounds; synthetic drugs; biomarkers; oncogenic pathways; metabolic reprogramming
(This special issue belongs to the Section Tumor Microenvironment)
Molecular PET Imaging in Cancer Metabolic Studies submission deadline 30 Apr 2026 | 1 articles | Viewed by 3264 | Submission Open
Keywords: PET imaging; PET/CT; PET/MRI; cancer metabolism; tumor microenvironment; cancer antigens; radiotracers
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Molecular and Genetic Biomarkers in Head and Neck Squamous Cell Carcinoma
edited by and Michal Masternak
submission deadline 30 Apr 2026 | 1 articles | Viewed by 3262 | Submission Open
Keywords: head and neck squamous cell carcinoma (HNSCC); molecular biomarkers; genetic biomarkers; multi-omics approaches; HNSCC carcinogenesis; prognostic biomarkers; translational medicine; molecular pathology
(This special issue belongs to the Section Molecular Cancer Biology)
Cancer Immunotherapy as Part of Precision Clinical Medicine
edited by and
submission deadline 30 Apr 2026 | 2 articles | Viewed by 3220 | Submission Open
Keywords: cancer; immunotherapy; tumor microenvironment; molecular biology and genetics
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Health Disparities and Outcomes in Cancer Survivors submission deadline 30 Apr 2026 | 3 articles | Viewed by 2774 | Submission Open
Keywords: cancer survivorship; quality of life; social behavioral determinants of health (SBDH); health disparities; symptom management
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Biomarkers for Therapy Response in Gastrointestinal Malignancies: Predicting Outcomes and Personalizing Care submission deadline 30 Apr 2026 | 3 articles | Viewed by 2703 | Submission Open
Keywords: immunotherapy; biomarkers; resistance mechanisms; predictive markers; clinical trials; translational research
(This special issue belongs to the Section Cancer Biomarkers)
G Protein-Coupled Receptors in Cancer Progression
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2650 | Submission Open
Keywords: GPCRs; heterotrimeric G proteins; signal transduction; mutations; cancer development
(This special issue belongs to the Section Tumor Microenvironment)
Real-World Evidence and Emerging Therapeutic Strategies in Refractory Metastatic Colorectal Cancer
edited by
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2609 | Submission Open
Keywords: real-world evidence; refractory metastatic colorectal cancer; treatment resistance; third-line and beyond therapies; targeted therapies; immunotherapy; patient outcomes; clinical practice; biomarkers; precision oncology
(This special issue belongs to the Section Cancer Metastasis)
Myeloma: Pathogenesis and Targeted Therapies
edited by Fenghuang (Frank) Zhan, Gang An and Cody Ashby
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2510 | Submission Open
Keywords: multiple myeloma; drug resistance; car-t cell therapy; immunotherapy targets; biomarkers; genetic alterations; molecular pathogenesis
(This special issue belongs to the Section Tumor Microenvironment)
CT/MRI/PET in Cancer submission deadline 30 Apr 2026 | 3 articles | Viewed by 2492 | Submission Open
Keywords: PET imaging; CT; MRI; cancer; characterization; treatment monitoring; biomarkers; predictive value; AI integration
(This special issue belongs to the Section Methods and Technologies Development)
Prostate Cancer Epidemiology and Genetics: 2nd Edition
edited by
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2432 | Submission Open
Keywords: prostate cancer; epidemiology; clinical genetics; aging; population-level databases
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Stem Cell Origin of Cancers: Biological and Clinical Implications of a Unified Theory of Cancer (2nd Edition)
edited by Shi-Ming Tu, Louis L. Pisters and
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2194 | Submission Open
Keywords: cancer stem cells; cancer-initiating cell; progenitor cell; epithelial; Mesenchymal transition; pluripotency; plasticity; heterogeneity; embryogenesis; stem-like; stemness
(This special issue belongs to the Section Cancer Pathophysiology)
Chemo-Radio-Immunotherapy for Colorectal Cancer
edited by Shoichi Hazama
submission deadline 30 Apr 2026 | 2 articles | Viewed by 1899 | Submission Open
Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery
(This special issue belongs to the Section Cancer Therapy)
Immune Checkpoint Therapy in Liver Cancer: Current Evidence, Underlying Biology, and What's Next
edited by and
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1843 | Submission Open
Keywords: hepatocellular carcinoma; immunotherapy; immuno-oncology; immune checkpoint inhibitors; clinical trial; immunological microenvironments
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
From Molecular Insights to Cancer Treatments: Progress in Translational Science
edited by , Dhanir Tailor and
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1790 | Submission Open
Keywords: cancer biology; therapeutics; molecular targets; translational research
(This special issue belongs to the Section Cancer Therapy)
New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1780 | Submission Open
Keywords: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma
(This special issue belongs to the Section Cancer Therapy)
Advances in the Treatment of Urological Cancer
edited by Anna Patrikidou
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1777 | Submission Open
Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics
(This special issue belongs to the Section Cancer Therapy)
Exosomes in Cancer Metastasis (2nd Edition) submission deadline 30 Apr 2026 | 1 articles | Viewed by 1712 | Submission Open
Keywords: exosomes; biomarkers; cancer metastasis
(This special issue belongs to the Section Cancer Metastasis)
The Latest Advancements in Cutaneous Melanoma
edited by Zhenyu Ji
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1596 | Submission Open
Keywords: cutaneous melanoma; skin cancer; immunotherapy; targeted therapy; melanoma biomarkers
(This special issue belongs to the Section Cancer Therapy)
Significance of CAR T-Cell Therapy in Aggressive B-Cell Lymphoma Treatment
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1553 | Submission Open
Keywords: CAR-T therapy; non-hodgkin lymphoma; hodgkin lymphoma; CAR-T persistence; immune-related adverse events (irAEs); resistance mechanisms; combination therapy; tumor microenvironment; multiomics data analysis
(This special issue belongs to the Section Cancer Therapy)
Prostate Cancer: Contemporary Standards and Challenges submission deadline 30 Apr 2026 | 1 articles | Viewed by 1480 | Submission Open
Keywords: prostate cancer; molecular pathogenesis; precision oncology; biomarkers; treatment de-escalation
(This special issue belongs to the Section Cancer Therapy)
Genetic Screening and Personalized Prevention in Hereditary Gastrointestinal Cancer Syndromes
edited by and Vittoria Disciglio
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1474 | Submission Open
Keywords: hereditary gastrointestinal cancer syndromes; NGS multigene panel tests; pathogenic variant (PV); variant of uncertain significance (VUS); mismatch repair (MMR) genes; gastrointestinal cancer susceptibility; personalized medicine; genetic risk assessment; germline variants; genetic counseling; functional impact of the genetic variant
(This special issue belongs to the Section Cancer Pathophysiology)
Glioma: From Intracellular Oncogenic Pathways to Targeting Therapeutic Strategies
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1290 | Submission Open
Keywords: glioma; targeted therapies; resistance mechanisms; oncogenic pathways; therapeutic resistance; combination therapies; tumor heterogeneity
(This special issue belongs to the Section Cancer Therapy)
Immune Biomarkers and Checkpoint Inhibitors: Advancing Immunotherapy in Gynecologic Cancers
edited by Ting-Tai Yen and Eugene Patrick Toy
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1269 | Submission Open
Keywords: immune checkpoints; checkpoint inhibitors; PD-1/PD-L1 pathway; immune biomarkers; tumor microenvironment; immunosuppressive pathways; T-cell activation in solid tumors; gynecologic tumors
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Innovations in Endocrine Cancer—Technology, Techniques and Therapy (Second Edition)
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1261 | Submission Open
Keywords: endocrine cancer; thyroid cancer; parathyroid; adrenals; melanoma; pancreas; neoplasms; minimally invasive surgeries
(This special issue belongs to the Section Methods and Technologies Development)
Recent Advances and Strategies for the Management of CIN and HPV Eradication Starategies for the Prevention of Uterine Cervical Cancer
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1000 | Submission Open
Keywords: CIN; 9-valent HPV vaccine; HPV L2-VLP vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT
Radical Pelvic Surgery and Reconstructive Innovations in Pelvic Oncology
edited by Evrim Erdemogľu
submission deadline 30 Apr 2026 | 1 articles | Viewed by 677 | Submission Open
Keywords: pelvic exenteration; LEER; radical pelvic surgery; reconstruction; flap surgery; multivisceral resection; gynecologic oncology; pelvic cancer; surgical outcomes; minimally invasive surgery
(This special issue belongs to the Section Clinical Research of Cancer)
The Role of Human Papillomavirus (HPV) in Cancers: Epidemiology, Molecular Biology, and Advancements in Detection Methods
edited by Peter C. Angeletti
submission deadline 30 Apr 2026 | 1 articles | Viewed by 544 | Submission Open
Keywords: human papillomavirus (HPV); cancer; HPV-related cancer; epidemiology; oncogenesis; molecular mechanisms; diagnostic technologies; epidemiological trends; risk factors; HPV-associated cancers; molecular pathways; cellular pathways; biomarkers; diagnostic tools; immune response; host– pathogen interaction
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in the Molecular Pathogenesis of T-Cell Lymphoma
edited by
submission deadline 30 Apr 2026 | Viewed by 446 | Submission Open
Keywords: pathogenesis; molecular biology; T-cell neoplasia/lymphoma; biomarkers
(This special issue belongs to the Section Cancer Pathophysiology)
Medical Treatment for Urological Cancers submission deadline 30 Apr 2026 | Viewed by 434 | Submission Open
Keywords: prostate cancer; urothelial cancer; renal cancer; antibody– drug conjugates; cytotoxic chemotherapy; immune checkpoint inhibitors
(This special issue belongs to the Section Cancer Therapy)
Advantages and Benefits: Proton Therapy vs. X-Ray Treatment in Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 397 | Submission Open
Keywords: proton therapy; X-ray therapy; foton therapy; in silico dosimetry; in vivo dosimetry; quality assurance; NTCP  models; pediatric cancer patients; vascular biomarkers; hematological biomarkers; hepatic biomarkers; lymphopenia; cardiac toxicity; hepatotoxicity; neurocognition; pneumonitis; long-term sequelae; radiation induced cancer; survival; supportive care; survivors; quality of life; health value; cost 
(This special issue belongs to the Section Cancer Therapy)
The Biomarkers of Oral Cancer
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 379 | Submission Open
Keywords: oral cancer; oral squamous cell carcinoma; oral melanoma; surgery; combination therapy; radiation therapy; immunotherapy; drug resistance; biomarker; liquid biopsy; prognosis
(This special issue belongs to the Section Cancer Biomarkers)
Image-Guided Treatment of Liver Tumors
edited by and Niek Wijnen
submission deadline 30 Apr 2026 | 2 articles | Viewed by 369 | Submission Open
Keywords: liver; thermal ablation; radioembolization; TACE; yttrium-90; portal vein embolization; radiation oncology; interventional oncology
(This special issue belongs to the Section Cancer Therapy)
The Influence of Epigenetic Regulation on the Tumor Microenvironment: Mechanisms and Therapeutic Implications
edited by
submission deadline 30 Apr 2026 | Viewed by 353 | Submission Open
Keywords: tumor microenvironment; epigenetics; cancer; immune system; remodeling mechanisms; therapy; clinical application
(This special issue belongs to the Section Tumor Microenvironment)
Cancer Inhibitory Receptors and Related Cancer Immunotherapy
edited by Keqiang Chen, Feng Zhu and Xin Li
submission deadline 30 Apr 2026 | Viewed by 344 | Submission Open
Keywords: cancer inhibitory receptors; ligands for inhibitor receptors; immune checkpoint inhibitors; cancer cells; immune cells; non-immune cells; inhibitor receptor pathways; immune checkpoint blockade therapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Targeted Therapies for Pediatric Nervous System Tumors
edited by and Nicole Brossier
submission deadline 30 Apr 2026 | Viewed by 340 | Submission Open
Keywords: glioma; ependymoma; medulloblastoma; pediatric brain tumors; targeted therapy; MEK inhibitors; NTRK inhibitors; glioma neuroscience; diffuse intrinsic pontine glioma
(This special issue belongs to the Section Pediatric Oncology)
Current Concept and Management of Pediatric ATRTs—2nd Edition
edited by and Alicia C. Lenzen
submission deadline 30 Apr 2026 | 1 articles | Viewed by 294 | Submission Open
Keywords: atypical teratoid rhabdoid tumors (ATRTs); CNS tumor; embryonal tumors
(This special issue belongs to the Section Pediatric Oncology)
Extracellular Matrix—Role in the Tumor Microenvironment and Impact on Cancer Therapy
edited by Heena Kumra and Makoto Noda
submission deadline 30 Apr 2026 | Viewed by 254 | Submission Open
Keywords: extracellular matrix; stroma; tumor microenvironment; therapy resistance
(This special issue belongs to the Section Cancer Pathophysiology)
Precision Medicine in Hematological Malignancies: Current Insights and Future Directions
edited by Giuseppe Saglio and Mohamed Yassin
submission deadline 30 Apr 2026 | Viewed by 250 | Submission Open
Keywords: hematological malignancies; precision medicine; targeted therapy; next-generation sequencing; biomarkers; molecular profiling
(This special issue belongs to the Section Cancer Therapy)
The Role of Artificial Intelligence in Thyroid, Thoracic and Gastrointestinal Tumors: Transforming the Landscape of Diagnosis and Treatment submission deadline 30 Apr 2026 | Viewed by 229 | Submission Open
Keywords: artificial intelligence; thyroid cancer; thoracic cancer; gastrointestinal cancer; diagnosis; medical imaging; treatment; surgery
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
New Insights into Gynecologic Cancer Screenings and Diagnosis, Prognostic and Predictive Biomarkers
edited by Patriciu Achimas-Cadariu and
submission deadline 30 Apr 2026 | Viewed by 219 | Submission Open
Keywords: breast cancer screening; cervical cancer screening and prophylaxis; predictive biomarkers in ovarian and endometrial cancer; sentinel lymph node in gynecological cancers
Next-Generation Boron Neutron Capture Therapy (BNCT) for Cancer Treatment
edited by Dayron Ramos López, Gabriella Pugliese and Raffaella Radogna
submission deadline 30 Apr 2026 | Viewed by 203 | Submission Open
Keywords: BNCT; boron agents; dosimetry; neutron detectors; cancer therapy; imaging; simulation; neutron sources; treatment planning; medical physics
(This special issue belongs to the Section Methods and Technologies Development)
Epigenetic Dysregulation in Hematological Malignancies: Mechanisms and Therapeutic Implications submission deadline 30 Apr 2026 | Viewed by 171 | Submission Open
Keywords: epigenetic dysregulation; hematologic malignancies; epigenetic therapy; DNA methylation; histone modification; non-coding RNAs; exosomes
(This special issue belongs to the Section Cancer Therapy)
Fatty Acid Synthesis and Mitochondrial Beta-Oxidation in Cancer submission deadline 30 Apr 2026 | Viewed by 169 | Submission Open
Keywords: fatty acid beta-oxidation (FAO); mitochondrial metabolism; metabolic reprogramming
(This special issue belongs to the Section Tumor Microenvironment)
The Changing Paradigms in the Management of Thyroid Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 163 | Submission Open
Keywords: thyroid cancer; targeted therapies; minimally invasive surgery; selective radioiodine use; personalized treatment
(This special issue belongs to the Section Cancer Therapy)
The Role of Ferroptosis in Cancer (2nd Edition)
edited by Wei Li
submission deadline 30 Apr 2026 | Viewed by 150 | Submission Open
Keywords: ferroptosis; cancer; reactive oxygen species; ROS; regulated cell death; RCD; immunogenic cell death; ICD; immunosuppression
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Locally Advanced and Metastatic Kidney Cancer (2nd Edition)
edited by and
submission deadline 30 Apr 2026 | Viewed by 145 | Submission Open
Keywords: kidney cancer; renal cell carcinoma; locally advanced; oligometastatic; metastatic; novel therapeutics; diagnostic imaging; biomarkers; multimodal treatment; cytoreductive nephrectomy
(This special issue belongs to the Section Cancer Metastasis)
Emerging Trends in Health Impact Assessment of Cancer: Innovations in Data Science and Patient-Centered Outcomes
edited by
submission deadline 30 Apr 2026 | Viewed by 138 | Submission Open
Keywords: health impact assessment; cancer outcomes; data science; machine learning; patient-reported outcomes; realist evaluation; implementation science; clinical trials; health equity; digital health; translational research
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
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