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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Perioperative and Adjuvant Immunotherapy in Lung Cancer: New Strategies, Biomarkers, Patient Selection and Toxicity Management

edited by

Xabier Mielgo Rubio

Felipe Couñago

and Juan Carlos Trujillo-Reyes

submission deadline 31 Jul 2026 | Viewed by 161 | Submission Open

Keywords: non-small-cell lung cancer (NSCLC); immunotherapy; neoadjuvant treatment; adjuvant treatment; perioperatory treatment; chemotherapy; surgery; radiotherapy; toxicity; biomarkers

(This special issue belongs to the Section Tumor Microenvironment)

Disparities in Cancer Care: Advancing Equity Across the Cancer Continuum

edited by

Gladys Asiedu

and Ernie Kaninjing

submission deadline 31 Jul 2026 | Viewed by 157 | Submission Open

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Clinical Trials for Hepatobiliary and Pancreatic Cancer Diagnosis and Treatment (2nd Edition)

edited by

Takuji Okusaka

submission deadline 31 Jul 2026 | Viewed by 136 | Submission Open

Keywords: biliary cancer; liver cancer; pancreatic cancer; clinical trial; diagnosis; surgery; neoadjuvant therapy; adjuvant therapy; radiotherapy; chemotherapy; targeted therapy; precision medicine; immunotherapy; biliary and duodenal stent; psycho-oncology; palliative and supportive care

(This special issue belongs to the Section Clinical Research of Cancer)

Molecular Mechanisms of Resistance to Cancer Therapies

edited by

Amancio Carnero

and

Rikki A.M. Brown

submission deadline 31 Jul 2026 | Viewed by 136 | Submission Open

Keywords: therapy resistance; cancer heterogeneity; drug resistance mechanisms; targeted therapy resistance; immunotherapy resistance; tumor microenvironment; epigenetic reprogramming; biomarkers of resistance; clonal evolution

(This special issue belongs to the Section Molecular Cancer Biology)

Surgical and Non-Surgical Convergence in Hepatocellular Carcinoma

edited by

Alessandro Vitale

submission deadline 31 Jul 2026 | Viewed by 126 | Submission Open

Keywords: hepatocellular carcinoma; conversion therapy; HCC treatment boundaries; surgical– non-surgical convergence; multidisciplinary HCC management

(This special issue belongs to the Section Cancer Therapy)

Hematopoietic Stem Cells and Cancer Immunotherapy

edited by Harinad B. Maganti

submission deadline 31 Jul 2026 | Viewed by 120 | Submission Open

Keywords: hematopoietic stem cell; transplantation; leukemia; cell biology; CAR-T cell therapies; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Electroporation-Based Technologies for Cancer Treatment

edited by

Bostjan Markelc

and

Gregor Sersa

submission deadline 31 Jul 2026 | Viewed by 112 | Submission Open

Keywords: electroporation; electrochemotherapy; gene electrotransfer; interleukin-12; DNA vaccination; irreversible electroporation; cancer immunotherapy; tumor ablation

(This special issue belongs to the Section Methods and Technologies Development)

The Molecular Biology of Cholangiocarcinoma

edited by

Kevin Gaston

and Padma-Sheela Jayaraman

submission deadline 31 Jul 2026 | Viewed by 102 | Submission Open

Keywords: cholangiocarcinoma; biliary tract cancer; early detection; targeted therapy; tumour microenvironment; spatial biology; genomics; transcriptomics; proteomics

(This special issue belongs to the Section Molecular Cancer Biology)

Artificial Intelligence in Radiation Therapy for Head and Neck Cancers: Prediction, Personalization, and Precision

edited by Meysam Tavakoli

submission deadline 31 Jul 2026 | Viewed by 102 | Submission Open

Keywords: head and neck cancer; radiation therapy; artificial intelligence ; machine learning ; deep learning ; toxicity prediction ; radiomics ; dosiomics ; outcome modeling ; personalized radiotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Current Applications and Cutting-Edge Innovations in Neuroendoscopy for Oncological Neurosurgery: Where Are We and Where Are We Going?

edited by Giuseppe Roberto Giammalva, Giovanni Tringali and Giuseppe Cinalli

submission deadline 31 Jul 2026 | Viewed by 97 | Submission Open

Keywords: neuroendoscopy; endoventricular surgery; skull base surgery; endoscopic assisted neurosurgery; innovations

(This special issue belongs to the Section Methods and Technologies Development)

Decoding the Tumor Microenvironment: Immune Cell–Tumor Interplay in Breast Cancer

edited by Abirami Sivapiragasam and Roberto A. Leon Ferre

submission deadline 31 Jul 2026 | Viewed by 95 | Submission Open

Keywords: tumor microenvironment; breast cancer; immune cell– tumor interaction; immunotherapy; T cells; macrophages; dendritic cells; single-cell transcriptomics; spatial transcriptomics; artificial intelligence; prognostic biomarkers; predictive biomarkers; personalized therapy

(This special issue belongs to the Section Tumor Microenvironment)

Mitochondrial Metabolism and Cancer

edited by

Marcos Roberto de Oliveira

submission deadline 31 Jul 2026 | Viewed by 95 | Submission Open

Keywords: mitochondria; mitochondrial metabolism; cancer; bioenergetics; metabolomics; proteomics; mitochondrial dynamics; therapeutic targets; drug resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Epigenetics: A New Approach to Cancer Therapy

edited by

Sibaji Sarkar

submission deadline 31 Jul 2026 | Viewed by 93 | Submission Open

Keywords: epigenetics; targets; cancer; tumor; signaling regulation; inhibitors; drugs

(This special issue belongs to the Section Cancer Therapy)

Microsatellite Instability in Colorectal Cancer

edited by

Joan Maurel

and Vicente Alonso-Orduña

submission deadline 31 Jul 2026 | Viewed by 92 | Submission Open

Keywords: microsatellite instability; colorectal cancer; immune checkpoint inhibitors; immune signatures

(This special issue belongs to the Section Tumor Microenvironment)

Nanomedicine for Cancer Treatment

edited by Youssef Wahib Naguib

submission deadline 31 Jul 2026 | Viewed by 91 | Submission Open

Keywords: cancer nanomedicine; CRISPR/CAS9 nanomedicine; immune checkpoint inhibitors; cancer immunotherapy; targeted therapeutics; targeted nanoparticles; cell-penetrating peptides

(This special issue belongs to the Section Cancer Drug Development)

Perioperative Care and Pain Management in Cancer Patients: From Basic Science to Clinical Practice—2nd Edition

edited by

Dario Bugada

submission deadline 31 Jul 2026 | Viewed by 90 | Submission Open

Keywords: perioperative care; cancer anesthesia; analgesia; pain management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Pheochromocytoma and Paraganglioma: Molecular Insights and Clinical Frontiers

edited by

Ivana Jochmanová

submission deadline 31 Jul 2026 | Viewed by 86 | Submission Open

Keywords: pheochromocytoma and paraganglioma; hereditary cancer syndromes; genetic mutations; genotype– phenotype correlations; functional imaging; molecular diagnostics; biomarkers; precision oncology; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Tumorigenesis and Tumor Microenvironment—Insights and Interventions (TTMII)

edited by

Renu Wadhwa

Sunil C. Kaul

and

Ajaikumar B. Kunnumakkara

submission deadline 31 Jul 2026 | Viewed by 79 | Submission Open

Keywords: tumorigenesis; tumor microenvironment; intervention; stress biology; aging; mortalin; CARF; ashwagandha; propolis; curcumin; natural compounds

(This special issue belongs to the Section Tumor Microenvironment)

Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT) in Patients with Cancers

edited by Caterina Alati and Martina Pitea

submission deadline 31 Jul 2026 | Viewed by 77 | Submission Open

Keywords: hematopoietic stem cell; hematologic malignancies; transplantation; immunotherapy

(This special issue belongs to the Section Transplant Oncology)

Multi-Omics Approaches to Tumor Antigen Discovery and Immunotherapy Target Identification

edited by

Esen Yonca Bassoy

and Parvin Zamani

submission deadline 31 Jul 2026 | Viewed by 64 | Submission Open

Keywords: tumor antigen discovery; multi-omics integration; cancer immunotherapy; spatial transcriptomics; tumor microenvironment; translational immunology

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Cancer After Kidney Transplant

edited by Sławomir Lizakowski

submission deadline 31 Jul 2026 | Viewed by 48 | Submission Open

Keywords: immunosuppression; virus-associated cancer; skin cancer; graft survival; kidney transplantation; post-transplantation lymphoproliferative disorder

(This special issue belongs to the Section Transplant Oncology)

Contemporary Practices in Immunotherapy-Guided Management of Lung Cancer

edited by Eleni Karapanagiotou, Nikolaos Syrigos and Umair Mahmood

submission deadline 31 Jul 2026 | Viewed by 44 | Submission Open

Keywords: lung cancer; immunotherapy; oligoprogressive disease; radiotherapy; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

The Role of Peptidases in Cancer

edited by

Natalia A. Ignatenko

submission deadline 31 Jul 2026 | Viewed by 39 | Submission Open

Keywords: signaling proteases; proteolytic pathways; proteases and tumor microenvironment; protease diagnostic and therapeutic modalities in cancer

(This special issue belongs to the Section Molecular Cancer Biology)

Multiple Myeloma and Immunology: From Pathophysiology to Therapy

edited by Marco Rossi

submission deadline 31 Jul 2026 | Viewed by 38 | Submission Open

Keywords: multiple myeloma microenvironment; immunotherapy; T cell redirecting agents; CAR-T in multiple myeloma

(This special issue belongs to the Section Tumor Microenvironment)

Digital Health and Patient-Reported Outcomes in Cancer Care

edited by Joanne Droney and Joy Ross

submission deadline 31 Jul 2026 | Viewed by 20 | Submission Open

Keywords: patient-reported outcome measures; digital health; remote symptom monitoring; outcome-based healthcare; health-related quality of life (HRQoL); shared decision-making; real-world data collection; data standardization; health equity in digital health

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Combination Therapies in Breast Cancer Chemotherapy: Chemoradiation, Targeted Agents, and Immunotherapy

edited by

Piotr J. Wysocki

submission deadline 31 Jul 2026 | Viewed by 9 | Submission Open

Keywords: breast cancer; combination therapy; endocrine therapy; chemoradiation; monoclonal antibodies; antibody– drug conjugates (ADCs); small-molecule kinase inhibitors; immunotherapy; predictive biomarkers; therapy resistance; precision oncology; translational research

(This special issue belongs to the Section Cancer Therapy)

Novel Therapies in Metastatic Castration-Resistant Prostate Cancer

edited by Kathryn E. Meier

submission deadline 1 Aug 2026 | 1 articles | Viewed by 3560 | Submission Open

Keywords: signal transduction inhibitors; targeted therapies; immunotherapy; radiopharmaceuticals; PARP inhibitors; biomarker-based approaches

(This special issue belongs to the Section Cancer Therapy)

Clinical Trials and Evolving Treatment Paradigms in Urologic Cancers

edited by

Zin War Myint

submission deadline 1 Aug 2026 | Viewed by 84 | Submission Open

Keywords: urologic cancers; clinical trials; prostate cancer; bladder cancer; kidney cancer; testicular cancer; systemic therapy; meta-analysis; biomarkers; oncology innovation

(This special issue belongs to the Section Clinical Research of Cancer)

The Clinical Trials and Management of Acute Myeloid Leukemia: 2nd Edition

edited by

Margaret T. Kasner

submission deadline 7 Aug 2026 | Viewed by 55 | Submission Open

Keywords: acute myeloid leukemia; clinical trials; translational research; targeted therapies; novel agents

(This special issue belongs to the Section Clinical Research of Cancer)

Innovations in Active Surveillance Management of Early Prostate Cancer

edited by

Vincent J. Gnanapragasam

submission deadline 8 Aug 2026 | 1 articles | Viewed by 874 | Submission Open

Keywords: prostate cancer; risk stratification; active surveillance; predictive markers; personalized management; imaging; biomarkers; clinical pathways; patient outcomes; standardizing care; attrition; cohort studies

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Targeted Therapies in Sarcomas: Overcoming Resistance and Improving Outcomes

edited by

Varun Monga

and Mohammed M. Milhem

submission deadline 8 Aug 2026 | Viewed by 70 | Submission Open

Keywords: sarcoma; targeted therapy; resistance mechanisms; combination therapy; biomarkers; precision oncology; translational research; clinical trials

(This special issue belongs to the Section Tumor Microenvironment)

Clinical Surgery for Hepato-Pancreato-Biliary (HPB) Cancer

edited by

Gennaro Nappo

and

Michele Pagnanelli

submission deadline 10 Aug 2026 | 10 articles | Viewed by 14962 | Submission Open

Keywords: pancreatic malignancies; HPB malignancies; pancreatic ductal adenocarcinoma; liver cholangiocarcinoma; HPB surgery; liver resection; pancreatic resection

(This special issue belongs to the Section Cancer Therapy)

Near-Infrared Photoimmunotherapy for Cancer Treatment: 2nd Edition

edited by

Hisataka Kobayashi

submission deadline 10 Aug 2026 | Viewed by 307 | Submission Open

Keywords: NIR-PIT; phototherapy; monoclonal antibody; imaging biomarker; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Bridging Translational and Clinical Oncology in Gastrointestinal Cancers: Molecular Mechanisms to Therapeutic Advances

edited by

Stavros Papadakos

Ioannis Katsaros

and

Stamatios E. Theocharis

submission deadline 10 Aug 2026 | Viewed by 105 | Submission Open

Keywords: gastrointestinal cancers; translational oncology; molecular mechanisms; biomarkers; immunotherapy; radiomics; precision medicine; therapeutic advances

(This special issue belongs to the Section Methods and Technologies Development)

The Tumorigenesis Mechanism of Breast Cancer

edited by Swayam Prabha

submission deadline 10 Aug 2026 | Viewed by 50 | Submission Open

Keywords: breast cancer; tumor microenvironment; myeloid-derived suppressor cells; immune evasion; premetastatic niche; epithelial– mesenchymal transition; PI3K/AKT/mTOR; MAPK/ERK; Wnt/β -catenin; BRCA1/2; TP53; estrogen signaling; targeted therapy; nanomedicine; biologics; precision oncology; translational research

(This special issue belongs to the Section Molecular Cancer Biology)

Research on Clinical Treatment of Mesothelioma: 2nd Edition

edited by

Giulia M. Stella

submission deadline 10 Aug 2026 | Viewed by 47 | Submission Open

Keywords: pleural mesothelioma; targeted therapy; local treatments; radiomics; genetic traits; occupational health; asbestos exposure

(This special issue belongs to the Section Clinical Research of Cancer)

Recent Updates and Future Perspectives on Anti-Cancer Agents

edited by

Santosh Kumar Singh

submission deadline 15 Aug 2026 | 2 articles | Viewed by 2402 | Submission Open

Keywords: cancer; anti-cancer agents; targeted therapy; drug resistance; therapeutic agents; natural compounds; combination therapy; nanotherapy; translational therapy; immunotherapy

(This special issue belongs to the Section Cancer Drug Development)

Rare Genitourinary Cancers

edited by

Luis G Medina

and

Philippe E. Spiess

submission deadline 15 Aug 2026 | Viewed by 126 | Submission Open

Keywords: rare genitourinary tumors; penile cancer; testicular cancer; urethral cancer; adrenal cancer; variant histology; upper tract urothelial carcinoma; extramammary Paget’ s disease; urologic oncology; rare cancers

(This special issue belongs to the Section Clinical Research of Cancer)

Immunotherapy for Hematologic Malignancies

edited by Rajesh Ramakrishnan Nair

submission deadline 15 Aug 2026 | Viewed by 122 | Submission Open

Keywords: immune evasion; immunotherapy; CAR-T cell therapy; BiTEs; immunomodulators; checkpoint; inhibitors; bone marrow microenvironment; refractory/relapsed; drug resistance; gene editing

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Clinical Applications of Advanced MRI Technologies for Cancers

edited by

Nicolò Cardobi

submission deadline 15 Aug 2026 | Viewed by 88 | Submission Open

Keywords: advanced MRI techniques; multiparametric imaging; quantitative biomarkers; artificial intelligence; treatment response assessment; precision oncology; radiomics; cancer diagnosis; functional imaging; molecular imaging

(This special issue belongs to the Section Methods and Technologies Development)

Rare Cancers, Diagnostic Challenges and Personalized Therapeutic Approaches in the 21st Century (2nd Edition)

edited by

Jason Roszik

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2344 | Submission Open

Keywords: rare cancer; biology; diagnosis; classification; personalized therapeutics; markers

(This special issue belongs to the Section Cancer Therapy)

Advances in Clinical, Diagnostic and Neurosurgical Management in Pediatric Neuro-Oncology

edited by

John Ross Crawford

and Michael Levy

submission deadline 20 Aug 2026 | Viewed by 171 | Submission Open

Keywords: neuro-oncology; brain tumors; neuroradiology; proton therapy; pediatric; neurosurgery; treatment; chemotherapy; targeted agents; molecular subtypes; immunotherapy; late effects; radiation therapy

(This special issue belongs to the Section Pediatric Oncology)

Socio-Demographic Factors and Cancer Research: 2nd Edition

edited by

Mitchell S. Fourman

and Amanda N. Goldin

submission deadline 20 Aug 2026 | Viewed by 131 | Submission Open

Keywords: socio-economic disparity; cancer delivery; cancer survival; metastatic cancer; culture-specific cancer outcomes; AI; machine learning

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Surgery for Endocrine Cancers

edited by Michael Bouvet and Eren Berber

submission deadline 20 Aug 2026 | Viewed by 72 | Submission Open

Keywords: thyroid cancer; thyroid surgery; hyperparathyroidism; adrenal tumors; adrenal surgery; pancreatic neuroendocrine tumors; fluorescence guided surgery; intraoperative imaging; surgical navigation; technological innovation

(This special issue belongs to the Section Methods and Technologies Development)

Pain and Palliative Care in Patients with Cancers

edited by

Arpad Szallasi

and

Anna Horváth

submission deadline 20 Aug 2026 | Viewed by 57 | Submission Open

Keywords: cancer pain; palliative care; opioid tolerance

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Diagnostic Biomarkers in Cancers Study

edited by Zejuan Li and

Xin Yi

submission deadline 21 Aug 2026 | 4 articles | Viewed by 6753 | Submission Open

Keywords: cancer; diagnostics; biomarker

(This special issue belongs to the Section Cancer Biomarkers)

Contemporary Diagnosis and Management of Prostate Cancer (2nd Edition)

edited by Thomas Jang

submission deadline 22 Aug 2026 | 1 articles | Viewed by 1300 | Submission Open

Keywords: prostate cancer; diagnosis; management; radical prostatectomy; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Study on Clinical Studies of Colorectal Cancer Surgery

edited by

Konstantinos Perivoliotis

and Ioannis Baloyiannis

submission deadline 25 Aug 2026 | Viewed by 33 | Submission Open

Keywords: colon; rectal; cancer; clinical; trials; evidence; open; laparoscopic; robotic; surgery

(This special issue belongs to the Section Clinical Research of Cancer)

Modern Approach to Oral Cancer

edited by

Maria Maddalena Marrapodi

and

Giuseppe Minervini

submission deadline 30 Aug 2026 | 11 articles | Viewed by 47237 | Submission Open

Keywords: oral cancer; neoplasm; oral surgery oncogenesis; dentistry oral health

(This special issue belongs to the Section Cancer Therapy)

Pathology of Acute Myeloid Leukemia (AML)

edited by Olga K. Weinberg

submission deadline 30 Aug 2026 | Viewed by 1260 | Submission Open

(This special issue belongs to the Section Cancer Pathophysiology)

Displaying special issue 951-1000 on page 20 of 24.

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