Targeted Therapies in Sarcomas: Overcoming Resistance and Improving Outcomes
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 8 August 2026 | Viewed by 1
Special Issue Editors
Interests: novel therapies in sarcoma; immunotherapy; phase 1 clinical trials
Interests: innovative treatments for sarcoma and melanoma; phase 1 clinical trials; cancer
Special Issue Information
Dear Colleagues,
This Special Issue will highlight advances in targeted therapy for sarcomas, a heterogeneous group of rare and aggressive malignancies for which conventional systemic treatments remain limited. Despite recent breakthroughs in understanding sarcoma biology and identifying molecular drivers, therapeutic resistance continues to hinder durable responses.
This Special Issue will focus on the following topics:
- Mechanisms of resistance to targeted therapies, including tumor heterogeneity, adaptive signaling, and the tumor microenvironment;
- Emerging strategies to overcome resistance, such as rational combination therapies, biomarker-driven patient selection, and next-generation inhibitors;
- Novel targets and pathways, including kinase signaling, epigenetic regulators, immune checkpoints, and metabolic vulnerabilities;
- Clinical trial updates and translational studies that bridge laboratory findings and real-world patient outcomes;
- Innovative technologies such as functional genomics, single-cell profiling, and patient-derived models that are shaping the future of sarcoma drug development.
By bringing together cutting-edge preclinical, translational, and clinical research, this Special Issue will provide a comprehensive overview of the current landscape and future directions in targeted therapy in sarcomas. Our aim is to accelerate the progress toward personalized, durable treatment strategies that will improve patient survival and quality of life.
Dr. Varun Monga
Dr. Mohammed M. Milhem
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- sarcoma
- targeted therapy
- resistance mechanisms
- combination therapy
- biomarkers
- precision oncology
- translational research
- clinical trials
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