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Advances in Surgery for Endocrine Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 1401

Special Issue Editors


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Guest Editor
Department of Surgery, University of California San Diego, La Jolla, CA 92092, USA
Interests: general and gastrointestinal surgery; surgical oncology; thyroid and parathyroid surgery; gastrointestinal cancers; pancreatic cancer

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Guest Editor
Department of Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
Interests: laparoscopic and robotic liver surgery; laparoscopic liver tumor ablation; robotic surgery; conventional and minimally invasive endocrine surgery (thyroid, parathyroid, adrenal and pancreas); robotic thyroidectomy; robotic adrenalectomy and surgical ultrasound

Special Issue Information

Dear Colleagues,

For this Special Issue, entitled “Advances in Surgery for Endocrine Cancers”, we invite submissions detailing recent advancements in surgery for thyroid, parathyroid, adrenal and pancreatic neuroendocrine tumors. The issue will serve as a comprehensive platform for sharing innovative techniques, clinical outcomes and future directions in endocrine surgery. We welcome a wide range of articles, from reviews on novel surgical approaches, intraoperative imaging and navigation to clinical studies examining important oncological outcomes. These outcomes include but are not limited to survival rates, recurrence, margin status, complication prevention and postoperative recovery. Comparative analyses of robotic, laparoscopic and open surgical techniques are also encouraged, along with investigations into cost-effectiveness, training methods, ethical considerations and implementation in diverse healthcare systems. By integrating clinical evidence with technical innovation, this Special Issue will showcase the field's current achievements and chart its future course. Our goal is to highlight key developments and advance best practices, thereby improving surgical outcomes for patients with endocrine cancers.

Prof. Dr. Michael Bouvet
Prof. Dr. Eren Berber
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • thyroid cancer
  • thyroid surgery
  • hyperparathyroidism
  • adrenal tumors
  • adrenal surgery
  • pancreatic neuroendocrine tumors
  • fluorescence guided surgery
  • intraoperative imaging
  • surgical navigation
  • technological innovation

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Published Papers (1 paper)

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Research

14 pages, 2266 KB  
Article
A pH-Sensitive Sprayable Fluorescent Probe Enables Accurate Visualization of Thyroid Cancer Margins for Fluorescence-Guided Surgery in Orthotopic Mouse Models
by Hyungju Kwon, Javier Bravo, Ting-Chun Kuo, Blackberrie Eddins, Siamak Amirfakhri, Jasmin Zaker, Keita Kobayashi, Shinya Yokomizo, Homan Kang, Grace Lin, Md Shamim, Hak Soo Choi, Robert M. Hoffman, Satoshi Kashiwagi, Maged Henary and Michael Bouvet
Cancers 2026, 18(4), 632; https://doi.org/10.3390/cancers18040632 - 15 Feb 2026
Cited by 1 | Viewed by 1106
Abstract
Positive surgical margins (PSMs) are a major predictor of recurrence in thyroid cancer; however, their intraoperative detection remains challenging, particularly for microscopic PSMs. This study aimed to demonstrate that a sprayable pH-sensitive near-infrared fluorescent probe (PH10) could specifically and robustly label thyroid tumors [...] Read more.
Positive surgical margins (PSMs) are a major predictor of recurrence in thyroid cancer; however, their intraoperative detection remains challenging, particularly for microscopic PSMs. This study aimed to demonstrate that a sprayable pH-sensitive near-infrared fluorescent probe (PH10) could specifically and robustly label thyroid tumors in orthotopic mouse models. The pH sensitivity, cytotoxicity, and cellular uptake mechanisms of PH10 were evaluated in papillary thyroid carcinoma (K1) and anaplastic thyroid carcinoma (8505C) cell lines in vitro. Orthotopic thyroid cancer mouse models were then established using both K1 and 8505C cells. In vivo fluorescence following topical spraying of PH10 was quantified after sequential washes to assess tumor-to-background ratios. Fluorescence-guided surgery (FGS) was performed to determine whether PH10 could facilitate complete resection of orthotopically grown thyroid tumors. Complete resection was validated by hematoxylin and eosin histology. PH10 demonstrated low cytotoxicity at clinically relevant concentrations in vitro and showed selective uptake into thyroid cancer cells, predominantly via organic anion transporting polypeptide-mediated transport. Topical spraying of PH10 in orthotopic thyroid cancer mouse models established from K1 and 8505C cell lines generated strong tumor-specific fluorescence. Tumor-to-background ratios were significantly higher than background and remained distinguishable after multiple washes. In both models, PH10 enabled visualization of macroscopic residual tumors and detection of microscopic PSMs, with fluorescence patterns closely corresponding to histologic findings. FGS enabled complete tumor resection, as confirmed by fluorescence and histology. In conclusion, topical application of PH10 provides rapid, tumor-specific fluorescence suitable for identifying PSMs and facilitating complete tumor resection by FGS in thyroid cancer. Full article
(This article belongs to the Special Issue Advances in Surgery for Endocrine Cancers)
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