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Rare Genitourinary Cancers
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Rare Genitourinary Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 15 August 2026 | Viewed by 893

Special Issue Editors

Dr. Luis G Medina

E-Mail Website
Guest Editor
Department of Urology, Medical University of South Carolina (MUSC), Charleston, SC, USA
Interests: urologic oncology; rare genitourinary malignancies; penile cancer
Dr. Philippe E. Spiess

E-Mail Website
Guest Editor
Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Interests: penile cancer; renal cell cancer; HPV-related cancers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to the upcoming Special Issue of Cancers, titled "Rare Genitourinary Cancers." Rare tumors of the genitourinary tract present unique clinical and research challenges due to their low incidence, biological heterogeneity, and limited evidence base. In recent years, progress in genomics, surgical innovation, and systemic therapies has provided new insights into these malignancies, yet much remains to be clarified to optimize outcomes for affected patients.

This Special Issue aims to highlight the current state of the art and recent advances in the diagnosis, treatment, and multidisciplinary management of rare genitourinary cancers. We welcome original research articles, narrative or systematic reviews, case series, and technical notes that explore these topics across diverse clinical and academic settings.

Suggested themes include, but are not limited to, penile cancer, testicular cancer, urethral cancer, adrenal malignancies, variant histology of kidney and bladder tumors, extramammary Paget’s disease, and upper tract urothelial carcinoma.

We look forward to your contributions.

Dr. Luis G Medina
Dr. Philippe E. Spiess
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • rare genitourinary tumors
  • penile cancer
  • testicular cancer
  • urethral cancer
  • adrenal cancer
  • variant histology
  • upper tract urothelial carcinoma
  • extramammary Paget’s disease
  • urologic oncology
  • rare cancers

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Published Papers (1 paper)

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Research

14 pages, 670 KB  
Article
Histological and Molecular Evaluation of HPV in Primary Tumors and Lymph Node Metastases of Penile Cancer
by Luiza Dorofte, Sabina Davidsson, Jessica Carlsson, Mats G. Karlsson and Gabriella Lillsunde Larsson
Cancers 2026, 18(9), 1350; https://doi.org/10.3390/cancers18091350 - 23 Apr 2026
Viewed by 492
Abstract
Background: Penile squamous cell carcinoma is an uncommon neoplasm that arises via two carcinogenic pathways, one linked to HPV infection and the other to chronic inflammation and p53 alterations. Objective/Methods: We assessed the distribution of HPV genotypes in penile tumors and subsequent inguinal [...] Read more.
Background: Penile squamous cell carcinoma is an uncommon neoplasm that arises via two carcinogenic pathways, one linked to HPV infection and the other to chronic inflammation and p53 alterations. Objective/Methods: We assessed the distribution of HPV genotypes in penile tumors and subsequent inguinal metastases in a cohort of 343 patients, analyzing their concordance with p16 stain and histological subtype, as well as the predictive significance of HPV tumor status and the immunohistochemical expression of p16 and p53 in inguinal lymph node metastasis (ILNM). Results: The overall prevalence of HPV in primary penile tumors was 42.9%, with high-risk HPV genotypes detected in 95.2% of HPV-positive cases. HPV16 was the most prevalent genotype identified in both primary tumors and metastases. However, other genotypes, including the low-risk HPV82, were also found in metastatic disease. We observed good concordance between HPV tumor status and histological subtype and very good concordance between HPV tumor status and p16 staining, with Cohen’s kappa (κ) values of 0.80 (p-value < 0.001) and 0.83 (p < 0.001), respectively. Conclusions: In most HPV-positive metastatic cases, the same HPV genotypes were detected in both the metastasis and the penile tumor. Both p16 staining and histological subtype can serve as surrogates for molecular HPV testing in lower resourced settings. In this dataset, no significant association was found between HPV status, p16 expression, or p53 expression and the presence of ILNM, suggesting their limited utility as predictive markers for ILNM in penile cancer. Full article
(This article belongs to the Special Issue Rare Genitourinary Cancers)
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