cancers-logo

Journal Browser

Journal Browser

Pain and Palliative Care in Patients with Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 1455

Special Issue Editors


E-Mail Website
Guest Editor
Department of Pathology and Experimental Cancer Research, Faculty of Medicine, Semmelweis University, 1088 Budapest, Hungary
Interests: capsaicin (vanilloid) receptor TRPV1; "thermoTRP" expression in cancer; TRP channels as oncotargets; TRP chan-nels as tumor suppressors; sensory nerve–tumor interactions; oncothermia
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Internal Medicine and Haematology, Semmelweis University, 1088 Budapest, Hungary
Interests: support cancer therapy and palliative care in adults, including lymphedema due to breast cancer, predicting metastatic patient prognosis score, atherosclerosis, pain management

Special Issue Information

Dear Colleagues,

A significant proportion of cancer patients are experiencing difficulties in receiving pain relief and palliative care. The recognition of chronic pain is incomplete, even though it is one of the most severe forms of pain, and the main treatment for chronic pain is major opioids (I.A. evidence). Unfortunately, most patients quickly develop tolerance to opioids, leaving them with few therapeutic alternatives while they struggle with this deadly disease. Therefore, it is necessary to recognize and treat the patient as soon as possible, and to urgently identify the molecular mechanisms that trigger cancer pain so that new analgesic drugs can be developed. Most cancer pain occurs when the tumor destroys tissue or presses on nerves. However, cancer cells can also produce substances that make normally harmless stimuli painful. Furthermore, therapeutic interventions can cause pain as a side effect, as exemplified by chemotherapy-induced peripheral neuropathy.

With this Special Issue, we aim to present the expansion of palliative care, exploring the current state of the field of cancer pain, from basic research to drug discovery and development to clinical trials. Original research articles, reviews, clinical studies, and meta-analyses of clinical trials are all welcome, and we also welcome presentations of new directions and opportunities in palliative care.

Dr. Arpad Szallasi
Dr. Anna Horváth
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer pain
  • palliative care
  • opioid tolerance

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

22 pages, 513 KB  
Review
Evolving Paradigms in Cancer Pain Management: From Opioid-Centric Care to Multimodal and Personalized Strategies
by Isabella Barrios, Sara A. Thomas, Yesenia L. Hernandez, Ana Pagan, Emily Munoz, Kamilah Cespedes and Saurabh Aggarwal
Cancers 2026, 18(9), 1476; https://doi.org/10.3390/cancers18091476 - 3 May 2026
Viewed by 1135
Abstract
Background/Objectives: Cancer-related pain remains one of the most prevalent and distressing symptoms across the disease trajectory, significantly impairing function and quality of life. Although opioids are central to managing moderate to severe pain, their limitations, including adverse effects, dependence risk, and societal concerns, [...] Read more.
Background/Objectives: Cancer-related pain remains one of the most prevalent and distressing symptoms across the disease trajectory, significantly impairing function and quality of life. Although opioids are central to managing moderate to severe pain, their limitations, including adverse effects, dependence risk, and societal concerns, highlight the need for more individualized and comprehensive strategies. This review aims to synthesize current approaches to cancer pain management within a palliative care framework, emphasizing multimodal, mechanism-based, and patient-centered care. Methods: A narrative review was conducted using literature searches of PubMed, Scopus, and Google Scholar. Articles published between 2010 and 2026, with emphasis on recent literature (2020–2026), were included. Search terms included combinations of “cancer pain,” “palliative care,” “multimodal analgesia,” “opioids,” “adjuvant analgesics,” and “neuropathic pain.” Peer-reviewed studies, clinical guidelines, systematic reviews, and meta-analyses relevant to cancer pain mechanisms and management were considered. Results: Cancer pain is heterogeneous, arising from tumor progression and treatment-related injury, and includes neuropathic, visceral, and somatic components. Effective management requires mechanism-based assessment and multimodal strategies. Adjuvant analgesics, such as antidepressants, anticonvulsants, corticosteroids, and topical agents, enhance pain control and reduce opioid reliance. Non-pharmacological interventions and early integration of palliative care further improve symptom management and quality of life. Emerging therapies, including cannabinoid-based treatments and gene-targeted approaches, show promise but require further clinical validation. Conclusions: A multidisciplinary, patient-centered approach that integrates pharmacologic and non-pharmacologic strategies is essential for optimizing cancer pain management. Advancing toward personalized and multimodal care models may improve outcomes, reduce opioid-related risks, and enhance quality of life for patients with cancer. Full article
(This article belongs to the Special Issue Pain and Palliative Care in Patients with Cancers)
Show Figures

Figure 1

Back to TopTop