Targeted Modalities for Individualized Cancer Treatment: Radiotherapy, Chemotherapy, Immunotherapy and Rationales for Their Combination

Dear Colleagues,

The high inter-individual variability in the genetic characteristics of tumor cells as well as differences in micro-environmental and systemic responses to tumors highlight the need for patient-tailored, individualized therapeutic approaches. Combined treatment modalities should maximize the efficiency of the local and systemic cure of the tumor along with minimizing long-term therapy-related toxicities. This can be achieved by the better targeting of the tumor. There are large gaps in our understanding of how radio- and chemotherapy influence the tumor microenvironment, lead to systemic effects, and interact with the immune system.

In this Special Issue, we invite contributions in the form of original articles, case reports, and reviews addressing the following objectives:  

• Basic mechanisms of how radiotherapy and chemotherapy influence the tumor microenvironment and lead to systemic effects and interactions with the immune system;
• Studies in the form of experimental investigations or clinical studies on combined radio-chemotherapy and immunotherapy approaches with improved tumor targeting;
• Studies (experimental or clinical) presenting promising systemic biomarkers of prognosis or therapy response.

Dr. Géza Sáfrány
Dr. Katalin Lumniczky
Guest Editors

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