Redox Dysregulation and Oxidative Stress in Cancer: Therapeutic Targets and Opportunities

Dear Colleagues,

The paradoxical combination of an age-related increase in cancer incidence and a demographic shift towards senescent populations has greatly exacerbated the role of cancer as a major medical challenge of global proportions, creating an urgent need for the discovery of novel molecular cancer therapeutics. Seminal research has provided cumulative evidence that oncogene-driven tumorigenesis dictates the dysregulated occurrence of cellular oxidative stress and redox stress responses as molecular determinants of tumorigenic initiation and progression. Likewise, it is now understood that tumorigenic progression and outcome depend on the counter-regulatory activation of cytoprotective stress response pathways that may represent a specific mechanistic vulnerability amenable to therapeutic intervention by molecularly targeted redox therapeutics. This Special Issue of Cancers, entitled ‘Redox Dysregulation and Oxidative Stress in Cancer: Therapeutic Targets and Molecular Opportunities’, aims to gather original research and review papers positioned at the forefront of our current understanding of redox dysregulation in cancer, representing both a major pathological driving force and promising therapeutic target, benefitting cancer patients in the near future.

Dr. Georg T. Wondrak
Guest Editor

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