Redox Dysregulation and Oxidative Stress in Cancer: Therapeutic Targets and Opportunities

Dear Colleagues,

The paradoxical combination of an age-related increase in cancer incidence and a demographic shift towards senescent populations has greatly exacerbated the role of cancer as a major medical challenge of global proportions, creating an urgent need for the discovery of novel molecular cancer therapeutics. Seminal research has provided cumulative evidence that oncogene-driven tumorigenesis dictates the dysregulated occurrence of cellular oxidative stress and redox stress responses as molecular determinants of tumorigenic initiation and progression. Likewise, it is now understood that tumorigenic progression and outcome depend on the counter-regulatory activation of cytoprotective stress response pathways that may represent a specific mechanistic vulnerability amenable to therapeutic intervention by molecularly targeted redox therapeutics. This Special Issue of Cancers, entitled ‘Redox Dysregulation and Oxidative Stress in Cancer: Therapeutic Targets and Molecular Opportunities’, aims to gather original research and review papers positioned at the forefront of our current understanding of redox dysregulation in cancer, representing both a major pathological driving force and promising therapeutic target, benefitting cancer patients in the near future.

Dr. Georg T. Wondrak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.