Special Issue "p21 – An Underestimated Driver for Cancers"

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: 15 June 2019

Special Issue Editor

Guest Editor
Prof. Dr. Regine Schneider-Stock

Head of Experimental Tumorpathology, University Hospital, FAU Erlangen-Nürnberg, Universitätsstr. 22, 91054 Erlangen, Germany
Website | E-Mail
Phone: 0049-9131-8526069
Fax: 0049-9131-8526197
Interests: colorectal cancer, epigenetics, transformation, metastasis

Special Issue Information

Dear Colleagues,

For the first time Gartel et al. (2009) have proposed the idea of antagonistic duality of p21 in cancer. Since nearly all cancer types have defects in cell cycle regulatory proteins a role of p21 in tumor transformation, progression, and invasion is suggested. Dependent on cellular compartment it might play a pro-apoptotic or a survival role. Here, we will collect a series of papers that show how p21 is involved in tumor aggressiveness, in stemness, chemotherapy resistance or phenotypic plasticity of tumor cells. We will show how the modulation of the mdm2-p53-p21 axis contributes to cell death. We will describe the role of p21 gene-editing tools in cancer research. Review and original articles will be presented to highlight the role of p21 in EMT and stemness. The interaction of p21 with other protein kinases and the role of this network in resistance mechanisms will be reviewed. Finally, this special issue will give an overview of the up-to-date knowledge about all fascinating facets of p21 in cancer.

Prof. Dr. Regine Schneider-Stock
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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